1. Antifungal effects ofStreptococcus mutansextract onCandidastrains susceptible and resistant to fluconazole: Anin vivostudy
- Author
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Luciana Ruano de Oliveira Fugisaki, Liliana Scorzoni, Jéssica Diane dos Santos, Rebeca Previate Medina, Juliana Campos Junqueira, Dulce Helena Siqueira Silva, Mariana de Sá Alves, and Universidade Estadual Paulista (UNESP)
- Subjects
Antifungal Agents ,animal structures ,Candida glabrata ,Microbial Sensitivity Tests ,Complex Mixtures ,Moths ,Microbiology ,Streptococcus mutans ,03 medical and health sciences ,Drug Resistance, Fungal ,Candida krusei ,Candida albicans ,Hemolymph ,medicine ,Animals ,Candida ,030304 developmental biology ,0303 health sciences ,biology ,030306 microbiology ,fungi ,General Medicine ,biology.organism_classification ,Corpus albicans ,Galleria mellonella ,Infectious Diseases ,Larva ,Fluconazole ,medicine.drug - Abstract
Made available in DSpace on 2022-04-29T08:30:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01 Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model. Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)
- Published
- 2021