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Your search keyword '"Lozano, M. D."' showing total 18 results
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18 results on '"Lozano, M. D."'

1. Un caso de síndrome de mano ajena fronto-calloso

Author

Mallol Sales, R., Geffner, D., López, María Teresa, Martínez Lozano, M. D., Belloch, Vicente, Parcet, Maria Antonia, and Avila, Cesar

Subjects
Psicologia, Publicitat i Relacions Públiques, Humanitats
Abstract

Setenes Jornades de Foment de la Investigació de la FCHS (Any 2001-2002) Diferentes estudios teóricos (Feinberg, y cols., 1992; Baynes y cols. 1997; Doody y Jankovic 1992) han mostrado que el síndrome de la mano ajena (Brion y Jedynak 1972) puede tener dos manifestaciones que son: mano ajena con afectación callosa y mano ajena de afectación fronto-callosa. Este estudio presenta el caso de una mujer de 63 años relacionado con este último síndrome. Ingresada por torpeza en miembros inferiores, alteración del habla, hemiparesia derecha y cefalea. Las técnicas de neuroimagen mostraron signos indirectos de infarto en la arteria cerebral anterior izquierda que afectaban al área motora suplementaria y el cuerpo calloso. Las pruebas neuropsicológicas evaluaron funciones de atención, lenguaje, memoria, gnosias, praxias y funciones ejecutivas. Los resultados de las pruebas indicaron déficits en distintas funciones cognitivas superiores entre las que destacaba el síndrome de utilización compulsiva de objetos. Para profundizar en el análisis de este síndrome se planteó un estudio Resonancia Magnética Funcional del que se desprende que el área premotora contralateral es la responsable de los movimientos de la mano ajena.

Published
2001

17. Global impact of the COVID‐19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries

Author

Pio Zeppa, Gonca Özgün, Eugeniu Cazacu, Franco Fulciniti, Alessandro D’Amuri, Izidor Kern, Philippe Vielh, Reinhard Büttner, Jamal Musayev, Meltem Öznur, Chiara Casadio, Brenda Sweeney, Marianne Engels, Tajana Štoos-Veić, William C. Faquin, Eduardo Alcaraz-Mateos, Birgit Weynand, Esther Diana Rossi, Béatrix Cochand-Priollet, Claudio Bellevicine, Zubair W. Baloch, Betsy Robinson, Paul A. VanderLaan, Fernando Schmitt, Anandi Lobo, Martha B. Pitman, Kennichi Kakudo, Antonio Ieni, Rima Cepurnaite, Sule Canberk, David N. Poller, Arrigo Capitanio, Marie Louise F. van Velthuysen, Dario Bruzzese, Giancarlo Troncone, Francisco Javier Seguí Iváñez, Pamela Michelow, Ivana Kholová, Pasquale Pisapia, Rinus Voorham, Michal Pyzlak, Lukas Bubendorf, Gabriella Fontanini, Umberto Malapelle, Guido Fadda, Pavlina Botsun, Oksana Sulaieva, Sinchita Roy-Chowdhuri, Catarina Eloy, Francisca Maria Peiró Marqués, Antonino Iaccarino, Chinhua Liu, Giovanni Tuccari, Mauro Saieg, Xiaoyin Sara Jiang, Elena Vigliar, Syed Z. Ali, Zahra Maleki, Maria D. Lozano, Massimo Bongiovanni, Patrizia Viola, Paul Hofman, Spasenija Savic Prince, Vigliar, E., Cepurnaite, R., Alcaraz-Mateos, E., Ali, S. Z., Baloch, Z. W., Bellevicine, C., Bongiovanni, M., Botsun, P., Bruzzese, D., Bubendorf, L., Buttner, R., Canberk, S., Capitanio, A., Casadio, C., Cazacu, E., Cochand-Priollet, B., D'Amuri, A., Eloy, C., Engels, M., Fadda, G., Fontanini, G., Fulciniti, F., Hofman, P., Iaccarino, A., Ieni, A., Jiang, X. S., Kakudo, K., Kern, I., Kholova, I., Liu, C., Lobo, A., Lozano, M. D., Malapelle, U., Maleki, Z., Michelow, P., Musayev, J., Ozgun, G., Oznur, M., Peiro Marques, F. M., Pisapia, P., Poller, D., Pyzlak, M., Robinson, B., Rossi, E. D., Roy-Chowdhuri, S., Saieg, M., Savic Prince, S., Schmitt, F. C., Javier Segui Ivanez, F., Stoos-Veic, T., Sulaieva, O., Sweeney, B. J., Tuccari, G., van Velthuysen, M. -L., Vanderlaan, P. A., Vielh, P., Viola, P., Voorham, R., Weynand, B., Zeppa, P., Faquin, W. C., Pitman, M. B., Troncone, G., Erasmus MC other, and Pathology

Subjects
Cancer Research, Biopsy, neoplasms, 0302 clinical medicine, Surveys and Questionnaires, Cytology, Pathology, Surveys and Questionnaire, coronavirus disease 2019 (COVID&#8208, malignancy rate, Societies, Medical, Gastrointestinal tract, Pathology, Clinical, medicine.diagnostic_test, stopnja malignosti, udc:616, Serous fluid, citopatologija, Fine-needle aspiration, Oncology, Biliary tract, 030220 oncology & carcinogenesis, coronavirus disease 2019 (COVID-19), Life Sciences & Biomedicine, Human, medicine.medical_specialty, fine&#8208, Urinary system, Biopsy, Fine-Needle, 030209 endocrinology & metabolism, Workload, Malignancy, cytopathology, fine-needle aspiration, needle aspiration, COVID-19, Communicable Disease Control, Humans, Laboratories, Hospital, SARS-CoV-2, Hospital, Clinical, coronavirus disease 2019, 03 medical and health sciences, novotvorbe, Medical, Internal medicine, medicine, coronavirus disease 2019 (COVID-19), cytopathology, fine-needle aspiration, malignancy rate, tankoigelna biopsija, Science & Technology, koronavirusna bolezen, business.industry, medicine.disease, patologija, Cytopathology, Fine-Needle, pathology, Laboratories, Societies, 19), business
Abstract

BACKGROUND: To the authors' knowledge, the impact of the coronavirus disease 2019 (COVID-19) pandemic on cytopathology practices worldwide has not been investigated formally. In the current study, data from 41 respondents from 23 countries were reported. METHODS: Data regarding the activity of each cytopathology laboratory during 4 weeks of COVID-19 lockdown were collected and compared with those obtained during the corresponding period in 2019. The overall number and percentage of exfoliative and fine-needle aspiration cytology samples from each anatomic site were recorded. Differences in the malignancy and suspicious rates between the 2 periods were analyzed using a meta-analytical approach. RESULTS: Overall, the sample volume was lower compared with 2019 (104,319 samples vs 190,225 samples), with an average volume reduction of 45.3% (range, 0.1%-98.0%). The percentage of samples from the cervicovaginal tract, thyroid, and anorectal region was significantly reduced (P < .05). Conversely, the percentage of samples from the urinary tract, serous cavities, breast, lymph nodes, respiratory tract, salivary glands, central nervous system, gastrointestinal tract, pancreas, liver, and biliary tract increased (P < .05). An overall increase of 5.56% (95% CI, 3.77%-7.35%) in the malignancy rate in nongynecological samples during the COVID-19 pandemic was observed. When the suspicious category was included, the overall increase was 6.95% (95% CI, 4.63%-9.27%). CONCLUSIONS: The COVID-19 pandemic resulted in a drastic reduction in the total number of cytology specimens regardless of anatomic site or specimen type. The rate of malignancy increased, reflecting the prioritization of patients with cancer who were considered to be at high risk. Prospective monitoring of the effect of delays in access to health services during the lockdown period is warranted. ispartof: CANCER CYTOPATHOLOGY vol:128 issue:12 pages:885-894 ispartof: location:United States status: published

Published
2020
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18. Consistency and reproducibility of next-generation sequencing in cytopathology: A second worldwide ring trial study on improved cytological molecular reference specimens

Author

Umberto Malapelle, Daniel Stieber, Elena Vigliar, Michel Bihl, Giancarlo Troncone, Reinhard Büttner, David H. Hwang, Birgit Weynand, Matteo Fassan, Miguel Angel Molina-Vila, Sonika Saddar, Fernando Schmitt, Francesco Pepe, Rajyalakshmi Luthra, Philippe Vielh, Massimo Barberis, Alessandra Rappa, Lukas Bubendorf, Yuri E. Nikiforov, Cristiana Lupi, Qi Zheng, Rafael Rosell, Catherine I. Dumur, Giovanni Tallini, Marina N. Nikiforova, Massimo Bongiovanni, Sinchita Roy-Chowdhuri, Lynette M. Sholl, Dario Bruzzese, Claudio Bellevicine, Gabriella Fontanini, Gianluca Roma, Carlos E. de Andrea, Massimo Rugge, Clara Mayo-de-las-Casas, Sabine Merkelbach-Bruse, Dario de Biase, Spasenija Savic, Maria D. Lozano, Bettina Bisig, Pasquale Pisapia, Sara Vander Borght, Pisapia P., Malapelle U., Roma G., Saddar S., Zheng Q., Pepe F., Bruzzese D., Vigliar E., Bellevicine C., Luthra R., Nikiforov Y.E., Mayo-de-Las-Casas C., Molina-Vila M.A., Rosell R., Bihl M., Savic S., Bubendorf L., de Biase D., Tallini G., Hwang D.H., Sholl L.M., Vander Borght S., Weynand B., Stieber D., Vielh P., Rappa A., Barberis M., Fassan M., Rugge M., De Andrea C.E., Lozano M.D., Lupi C., Fontanini G., Schmitt F., Dumur C.I., Bisig B., Bongiovanni M., Merkelbach-Bruse S., Buttner R., Nikiforova M.N., Roy-Chowdhuri S., Troncone G., Pisapia, P., Malapelle, U., Roma, G., Saddar, S., Zheng, Q., Pepe, F., Bruzzese, D., Vigliar, E., Bellevicine, C., Luthra, R., Nikiforov, Y. E., Mayo-de-Las-Casas, C., Molina-Vila, M. A., Rosell, R., Bihl, M., Savic, S., Bubendorf, L., de Biase, D., Tallini, G., Hwang, D. H., Sholl, L. M., Vander Borght, S., Weynand, B., Stieber, D., Vielh, P., Rappa, A., Barberis, M., Fassan, M., Rugge, Luigi, De Andrea, C. E., Lozano, M. D., Lupi, C., Fontanini, G., Schmitt, F., Dumur, C. I., Bisig, B., Bongiovanni, M., Merkelbach-Bruse, S., Buttner, R., Nikiforova, M. N., Roy-Chowdhuri, S., and Troncone, G.

Subjects
Proto-Oncogene Proteins B-raf, Cancer Research, Concordance, Cytodiagnosis, DNA Mutational Analysis, medicine.disease_cause, Proto-Oncogene Mas, DNA sequencing, Proto-Oncogene Proteins p21(ras), Cytology, Neoplasms, medicine, Biomarkers, Tumor, Humans, Allele frequency, business.industry, CYTOCENTRIFUGE, High-Throughput Nucleotide Sequencing, Reproducibility of Results, Molecular biology, DNA extraction, ErbB Receptors, lung cancer, cytological molecular reference, Oncology, molecular cytopathology, Cytopathology, Mutation, cytology, next-generation sequencing, KRAS, business
Abstract

Background: Artificial genomic reference standards in a cytocentrifuge/cytospin format with well-annotated genomic data are useful for validating next-generation sequencing (NGS) on routine cytopreparations. Here, reference standards were optimized to be stained by different laboratories before DNA extraction and to contain a lower number of cells (2 × 10 5 ). This was done to better reflect the clinical challenge of working with insufficient cytological material. Methods: A total of 17 worldwide laboratories analyzed customized reference standard slides (slides A-D). Each laboratory applied its standard workflow. The sample slides were engineered to harbor epidermal growth factor receptor (EGFR) c.2235_2249del15 p.E746_A750delELREA, EGFR c.2369C>T p.T790M, Kirsten rat sarcoma viral oncogene homolog (KRAS) c.38G>A p.G13D, and B-Raf proto-oncogene, serine/threonine kinase (BRAF) c.1798_1799GT>AA p.V600K mutations at various allele frequencies (AFs). Results: EGFR and KRAS mutation detection showed excellent interlaboratory reproducibility, especially on slides A and B (10% and 5% AFs). On slide C (1% AF), either the EGFR mutation or the KRAS mutation was undetected by 10 of the 17 laboratories (58.82%). A reassessment of the raw data in a second-look analysis highlighted the mutations (n=10) that had been missed in the first-look analysis. BRAF c.1798_1799GT>AA p.V600K showed a lower concordance rate for mutation detection and AF quantification. Conclusions: The data show that the detection of low-abundance mutations is still clinically challenging and may require a visual inspection of sequencing reads to detect. Genomic reference standards in a cytocentrifuge/cytospin format are a valid tool for regular quality assessment of laboratories performing molecular studies on cytology with low-AF mutations.

Published
2019

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