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49 results on '"Loussouarn, Delphine"'

1. A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Author

Croce, Sabrina, Devouassoux-Shisheboran, Mojgan, Pautier, Patricia, Ray-Coquard, Isabelle, Treilleux, Isabelle, Neuville, Agnès, Arnould, Laurent, Just, Pierre-Alexandre, Belda, Marie Aude Le Frere, Averous, Gerlinde, Leroux, Agnès, Mery, Eliane, Loussouarn, Delphine, Weinbreck, Nicolas, Le Guellec, Sophie, Mishellany, Florence, Morice, Philippe, Guyon, Frédéric, Genestie, Catherine, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)

Subjects
radioiodination, radiofluorination, tyrosine analogs, TIC(OH), PET/SPECT imaging, [SDV]Life Sciences [q-bio], Drug Discovery, Pharmaceutical Science, Molecular Medicine
Abstract

The use of radiolabeled non-natural amino acids can provide high contrast SPECT/PET metabolic imaging of solid tumors. Among them, radiohalogenated tyrosine analogs (i.e., [123I]IMT, [18F]FET, [18F]FDOPA, [123I]8-iodo-L-TIC(OH), etc.) are of particular interest. While radioiodinated derivatives, such as [123I]IMT, are easily available via electrophilic aromatic substitutions, the production of radiofluorinated aryl tyrosine analogs was a long-standing challenge for radiochemists before the development of innovative radiofluorination processes using arylboronate, arylstannane or iodoniums salts as precursors. Surprisingly, despite these methodological advances, no radiofluorinated analogs have been reported for [123I]8-iodo-L-TIC(OH), a very promising radiotracer for SPECT imaging of prostatic tumors. This work describes a convenient synthetic pathway to obtain new radioiodinated and radiofluorinated derivatives of TIC(OH), as well as their non-radiolabeled counterparts. Using organotin compounds as key intermediates, [125I]5-iodo-L-TIC(OH), [125I]6-iodo-L-TIC(OH) and [125I]8-iodo-L-TIC(OH) were efficiently prepared with good radiochemical yield (RCY, 51–78%), high radiochemical purity (RCP, >98%), molar activity (Am, >1.5–2.9 GBq/µmol) and enantiomeric excess (e.e. >99%). The corresponding [18F]fluoro-L-TIC(OH) derivatives were also successfully obtained by radiofluorination of the organotin precursors in the presence of tetrakis(pyridine)copper(II) triflate and nucleophilic [18F]F− with 19–28% RCY d.c., high RCP (>98.9%), Am (20–107 GBq/µmol) and e.e. (>99%).

Published
2021

2. Supplementary_methods_1 – Supplemental material for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer

Author

Dagher, Elie, Simbault, Laura, Abadie, Jérôme, Loussouarn, Delphine, Campone, Mario, and Nguyen, Frédérique

Subjects
FOS: Clinical medicine, Cell Biology, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_methods_1 for Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer by Elie Dagher, Laura Simbault, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen in Tumor Biology

Published
2020
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3. Additional file 18: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

External TNBC cohort’s clinicopathologic characteristics in function of the three clusters (C’1, C’2, and C’3). (PDF 136 kb)

Published
2019
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4. Additional file 29: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Proposed therapeutic strategies in function of GES and robust subtyping results. (PDF 162 kb)

Published
2019
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5. Additional file 21: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Continuous score GES analyses results in function of external TNBC clusters (C’1, C’2, and C’3). (PDF 228 kb)

Published
2019
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6. Additional file 5: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Fuzzy clustering of 238 TNBC. Distribution of patients based on probability of belonging to cluster: C1, n = 55 (blue); C2, n = 98 (red) and C3, n = 85 (green). Each vertex of the triangle represents a cluster and each point represents a patient, placed as the barycenter of the triangle, weights being the probabilities of belonging to each of the clusters. The closer a point is to one of the vertices, the greater is the probability of the patient to belong to the corresponding cluster. (PDF 86 kb)

Published
2019
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7. Additional file 27: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES distributions in function of external TNBC (C’1, C’2, C’3) and non-TNBC clusters (NTN). (A) CIT, (B) ER-negative and (C) PAM50. (PDF 138 kb)

Published
2019
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8. Additional file 28: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Molecular annotation of external cohort in function of TNBC clusters and non-TNBC. Radar plot showing the segregation of three clusters as a function of 47 continuous score GES. This figure is an illustration of Additional file 26. Each of the 47 radii represents a GES. Black circles represent significantly different levels of expression from low (smallest circle) to high (largest circle). Expression level of each cluster is represented on the corresponding circle as a dark gray (NTN), blue (C’1), red (C’2) or green (C’3) dot. Dots located on same circles correspond to clusters with not significantly different expressions. Dots located on different circles correspond to clusters with significantly different expressions. Dots located in between black circles correspond to a cluster with expression level not significantly different from clusters whose dots are located on both near circles. (PDF 287 kb)

Published
2019
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9. Additional file 20: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES analyses result in function of external TNBC clusters (C’1, C’2 and C’3). (PDF 159 kb)

Published
2019
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10. Additional file 3: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Details of antibodies used for immunohistochemistry. (PDF 84 kb)

Published
2019
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11. Additional file 4: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohorts in the first PCA plane. (A) PACS08 patients (n = 131, [orange]) compared to TNBC patients of a previous study (n = 107, [black]). (B) Each color represents a recruitment site, except for grayish pale green color, which represents one or two patients recruited in different sites (n = 36 patients; 28 sites). Total number of recruitment sites was equal to 45. (PDF 95 kb)

Published
2019
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12. Additional file 9: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 107 kb)

Published
2019
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13. Additional file 6: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Event-free survival analysis of TNBC pooled cohort. This cohort is composed of 427 patients from internal (n = 238) and external (n = 189) cohorts (C1 & C’1 [blue]; C2 & C’2 [red] and C3 & C’3 [green]). (PDF 141 kb)

Published
2019
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14. Additional file 1: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

External TNBC and non-TNBC genomic data. (PDF 87 kb)

Published
2019
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15. Additional file 7: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohort in the first PCA plane. (C1, n = 55 [blue]; C2, n = 98 [red]; C3, n = 85 [green]). (PDF 88 kb)

Published
2019
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16. Additional file 24: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

PCA result representation of external TNBC and non-TNBC data. PCA is computed based on the TNBC data and the values of the two first principal components (PC1 and PC2) are then predicted for the non-TNBC data. All patients are then projected onto the plane generated by PC1 and PC2. Ellipses represent the 95% confidence of belonging to the clusters data (C’1, n = 61 [blue]; C’2, n = 97 [red] and C’3, n = 99 [green]). External non-TNBC data (n = 894) are figured by black points. (PDF 149 kb)

Published
2019
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17. Additional file 19: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Comparison of clinicopathologic characteristics of TNBC cohorts in function of clusters. Internal (C1, n = 55; C2, n = 98; C3, n = 85) and external (C’1, n = 61; C’2, n = 97; C’3, n = 99). (PDF 138 kb)

Published
2019
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18. Additional file 11: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Significant EFS analyses based on GES scores. (A) Internal and (B) external C2 and C3 TNBC patients. (PDF 103 kb)

Published
2019
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19. Additional file 2: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

GES list, characteristics, bioinformatics, and references. (PDF 197 kb)

Published
2019
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20. Additional file 15: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
education
Abstract

Biological gradients between C2 and C3 in our internal cohort. Correlation coefficient calculation between GES score for each internal cohort tumor (x number), and C2 and C3 cluster probability orthogonal projection on C2-C3 axis (y number) (C2 tumor, red; C3 tumor, green). Only correlation coefficient absolute values superior to 0.5 (P

Published
2019
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21. Additional file 16: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Expression of immune checkpoints between basal-like clusters. Internal (C2 vs C3) and external (C’2 vs C’3) cohorts. (PDF 158 kb)

Published
2019
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22. Additional file 14: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

B lymphocyte lineage GenomicScape analysis in function of the three H3 subclusters (H3a, H3b, H3c). Genes upregulated in the given group compared to the overall mean expression are highlighted in red. Genes downregulated in the given group compared to the overall mean expression are highlighted in blue. (PDF 149 kb)

Published
2019
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23. Additional file 26: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Continuous score GES analyses results in function of external TNBC (C’1, C’2, C’3) and non-TNBC clusters (NTN). (PDF 245 kb)

Published
2019
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24. Additional file 6: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Event-free survival analysis of TNBC pooled cohort. This cohort is composed of 427 patients from internal (n = 238) and external (n = 189) cohorts (C1 & C’1 [blue]; C2 & C’2 [red] and C3 & C’3 [green]). (PDF 141 kb)

Published
2019
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25. Additional file 3: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Details of antibodies used for immunohistochemistry. (PDF 84 kb)

Published
2019
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26. Additional file 17: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi, education, health care economics and organizations
Abstract

Comparison of internal and external TNBC cohorts’ clinicopathologic characteristics. (PDF 135 kb)

Published
2019
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27. Additional file 22: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

C’2 vs C’3 CIBERSORT analysis results. (PDF 199 kb)

Published
2019
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28. Additional file 8: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

PCA of internal TNBC cohort. Lists of PC1 and PC2 twenty highest absolute weight probes. (PDF 115 kb)

Published
2019
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29. Additional file 8: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

PCA of internal TNBC cohort. Lists of PC1 and PC2 twenty highest absolute weight probes. (PDF 115 kb)

Published
2019
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30. Additional file 4: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohorts in the first PCA plane. (A) PACS08 patients (n = 131, [orange]) compared to TNBC patients of a previous study (n = 107, [black]). (B) Each color represents a recruitment site, except for grayish pale green color, which represents one or two patients recruited in different sites (n = 36 patients; 28 sites). Total number of recruitment sites was equal to 45. (PDF 95 kb)

Published
2019
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31. Additional file 12: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
nervous system
Abstract

ToppGene GOEA based on heatmap gene clusters, internal cohort (1843 probes) and external cohorts (454 probes). Identical GO terms per cluster of highly expressed genes are indicated in bold characters. (PDF 143 kb)

Published
2019
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32. Additional file 10: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Continuous score GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 176 kb)

Published
2019
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33. Additional file 23: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Biological gradients between C2 and C3 in an external cohort. Correlation coefficient calculation between GES score for each external cohort tumor (x number), and C’2 and C’3 cluster probability orthogonal projection on C’2-C’3 axis (y number) (C’2 tumor, red; C’3 tumor, green). Only correlation coefficient absolute values superior to 0.5 (P

Published
2019
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34. Additional file 5: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Fuzzy clustering of 238 TNBC. Distribution of patients based on probability of belonging to cluster: C1, n = 55 (blue); C2, n = 98 (red) and C3, n = 85 (green). Each vertex of the triangle represents a cluster and each point represents a patient, placed as the barycenter of the triangle, weights being the probabilities of belonging to each of the clusters. The closer a point is to one of the vertices, the greater is the probability of the patient to belong to the corresponding cluster. (PDF 86 kb)

Published
2019
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35. Mitotic index, microvascular proliferation, and necrosis define 3 pathological subgroups of prognostic relevance among 1p/19q co-deleted anaplastic oligodendrogliomas

Author

Figarella-Branger, Dominique, Mokhtari, Karima, Dehais, Caroline, Carpentier, Catherine, Colin, Carole, Jouvet, Anne, Uro-Coste, Emmanuelle, Forest, Fabien, Maurage, Claude-Alain, Vignaud, Jean-Michel, Polivka, Marc, Lechapt-Zalcman, Emmanuèle, Eimer, Sandrine, Viennet, Gabriel, Quintin-Roué, Isabelle, Aubriot-Lorton, Marie-Hélène, Diebold, Marie-Danièle, Loussouarn, Delphine, Lacroix, Catherine, Rigau, Valérie, Laquerrière, Annie, Vandenbos, Fanny, Michalak, Sophie, Sevestre, Henri, Peoc'H, Michel, Labrousse, François, Christov, Christo, Kemeny, Jean-Louis, Chenard, Marie-Pierre, Chiforeanu, Danchristian, Ducray, François, Idbaih, Ahmed, Delattre, Jean-Yves, Network, POLA, Service d’Anatomie Pathologique et de Neuropathologie, APHM, Hôpital de la Timone, Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neuropathologie Raymond Escourolle, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [APHP], Service de neurologie 2 [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon (HCL), Service d'anatomie pathologique et histologie-cytologie [Rangueil], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'Anatomie et de Cytologie Pathologique, CHU Saint-Etienne-Hôpital Bellevue, Service d'Anatomie Pathologique, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d’Anatomie Pathologique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), CHU de Bordeaux Pellegrin [Bordeaux], Histologie et Pathologie Moléculaire des Tumeurs, Université Bordeaux Segalen - Bordeaux 2-EA 2406, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Service d'anatomie et de cytologie pathologiques, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital Robert Debré, Hôpital Guillaume-et-René-Laennec [Saint-Herblain], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Laboratoire d'anatomie cytologie pathologiques, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Service d'Anatomie et Cytologie Pathologique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Hospitalier Universitaire de Nice (CHU Nice), Département de pathologie cellulaire et tissulaire, CHU d'Angers, 4, rue Larrey, 49100 Angers, France., Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Service d'anatomie et cytopathologie, CHU Amiens-Picardie, Service d'Anatomie Pathologique [CHU Limoges], CHU Limoges, CHU Henri Mondor, CHU Clermont-Ferrand, Service d'Anatomie Pathologique Générale, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Service d'anatomie et cytologie pathologiques [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service d'Anatomie et Cytologie Pathologique [CHU Rouen], Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], CHU Pontchaillou [Rennes], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neuropathologie Raymond Escourolle [CHU Pitié-Salpétriêre], Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Henri Mondor [Créteil], Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Aix Marseille Université (AMU), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
microvascular proliferation, Male, Cancer Research, Pathology, medicine.medical_specialty, Mitotic index, Necrosis, [SDV]Life Sciences [q-bio], Oligodendroglioma, Anaplastic oligodendroglioma, 1p/19q co-deletion, 03 medical and health sciences, 0302 clinical medicine, medicine, Mitotic Index, Humans, mitoses, Survival rate, Mitosis, Pathological, Letter to the Editor, Neovascularization, Pathologic, business.industry, Brain Neoplasms, Middle Aged, medicine.disease, Prognosis, Isocitrate Dehydrogenase, 3. Good health, Survival Rate, Isocitrate dehydrogenase, Oncology, Chromosomes, Human, Pair 1, 030220 oncology & carcinogenesis, Female, Neurology (clinical), anaplastic oligodendrogliomas, medicine.symptom, Chromosome Deletion, business, Chromosomes, Human, Pair 19, 030217 neurology & neurosurgery
Abstract

CERVOXY COLL; International audience

Published
2016

38. Additional file 6: Table S6. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with specific survival (SS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 35 kb)

Published
2015
Full Text
View/download PDF

39. Additional file 2: Table S2. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Subjects
body regions
Abstract

Significant associations between IGF1R expression and clinicopathological features of 47 luminal canine mammary carcinomas. IGF1R score 0–1+ is considered as the reference for each parameter. IGF1R Insulin-like Growth Factor type 1 Receptor. LVI: Lymphovascular Invasion. OR: Odd Ratio. 95 % CI: 95 % Confidence Interval. (DOC 30 kb)

Published
2015
Full Text
View/download PDF

40. Additional file 1: Table S1. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Abstract

Primary antibodies and immunohistochemical protocols (Benchmark XT Ventana, Roche Diagnostics). All dilutions were performed using a commercially available diluent (Ventana Medical Systems). aUltraview and bOptiview Universal DAB detection kit: multimer-technology based detection system. cIView Universal DAB detection kit: biotin streptavidin system. ERα: Estrogen Receptor alpha, PR: Progesterone Receptor, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like growth factor type 1 receptor. CC1: Cell Conditioning 1. (DOC 33 kb)

Published
2015
Full Text
View/download PDF

41. Additional file 3: Table S3. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with overall survival (OS) in 47 Luminal canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like Growth Factor type 1 Receptor. (DOC 35 kb)

Published
2015
Full Text
View/download PDF

42. Additional file 5: Table S5. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with overall survival (OS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 38 kb)

Published
2015
Full Text
View/download PDF

43. Additional file 1: Table S1. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Abstract

Primary antibodies and immunohistochemical protocols (Benchmark XT Ventana, Roche Diagnostics). All dilutions were performed using a commercially available diluent (Ventana Medical Systems). aUltraview and bOptiview Universal DAB detection kit: multimer-technology based detection system. cIView Universal DAB detection kit: biotin streptavidin system. ERα: Estrogen Receptor alpha, PR: Progesterone Receptor, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like growth factor type 1 receptor. CC1: Cell Conditioning 1. (DOC 33 kb)

Published
2015
Full Text
View/download PDF

44. Additional file 3: Table S3. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with overall survival (OS) in 47 Luminal canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like Growth Factor type 1 Receptor. (DOC 35 kb)

Published
2015
Full Text
View/download PDF

45. Additional file 5: Table S5. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with overall survival (OS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 38 kb)

Published
2015
Full Text
View/download PDF

46. Additional file 4: Table S4. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with specific survival (SS) in 47 Luminal canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, HER2: Epidermal Growth Factor type 2 Receptor, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. (DOC 33 kb)

Published
2015
Full Text
View/download PDF

47. Additional file 2: Table S2. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, Jérome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and Nguyen, Frédérique

Subjects
body regions
Abstract

Significant associations between IGF1R expression and clinicopathological features of 47 luminal canine mammary carcinomas. IGF1R score 0–1+ is considered as the reference for each parameter. IGF1R Insulin-like Growth Factor type 1 Receptor. LVI: Lymphovascular Invasion. OR: Odd Ratio. 95 % CI: 95 % Confidence Interval. (DOC 30 kb)

Published
2015
Full Text
View/download PDF

48. Additional file 4: Table S4. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with specific survival (SS) in 47 Luminal canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, HER2: Epidermal Growth Factor type 2 Receptor, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. (DOC 33 kb)

Published
2015
Full Text
View/download PDF

49. Additional file 6: Table S6. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Author

Jaillardon, Laetitia, JĂŠrome Abadie, Godard, Tiffanie, Campone, Mario, Loussouarn, Delphine, Siliart, Brigitte, and FrĂŠdĂŠrique Nguyen

Abstract

Factors associated with specific survival (SS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 35 kb)

Published
2015
Full Text
View/download PDF

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