1. Programmed cell death 1 ligand 1 (PD-L1) expression is associated with poor prognosis of malignant pleural mesothelioma patients with good performance status
- Author
-
Eltjona Rrapaj, Ottavio Rena, Renzo Boldorini, Guido Baselli, Paolo Spina, Michela Salvo, Elena Trisolini, Claudia Veggiani, and Lorenzo Giacometti
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Programmed cell death ,Pleural Neoplasms ,Disease ,B7-H1 Antigen ,Pathology and Forensic Medicine ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,PD-L1 ,Internal medicine ,Biopsy ,Gene expression ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,Performance status ,biology ,business.industry ,Mesothelioma, Malignant ,Middle Aged ,Prognosis ,Immunohistochemistry ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Italy ,030220 oncology & carcinogenesis ,biology.protein ,Biomarker (medicine) ,Female ,business ,Biomarkers - Abstract
Malignant pleural mesothelioma (MPM) is often associated with a poor prognosis and options for the treatment of this disease are few. To date, the important role of the immune microenvironment in modifying the disease natural history is well established. The programmed cell death pathway (PD-1/PD-L1) limits the T lymphocyte activation in peripheral tissues when an inflammatory response occurs, and controls the tumour immune escape. PD-L1 is broadly expressed in several malignant tumours and associated with poor clinical outcomes. Thus, the aim of our study is to investigate the potential role of PD-L1 expression in MPM prognosis. Biopsy samples from 198 patients diagnosed with MPM were examined by immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) to evaluate PD-L1 protein and gene expression. For PD-L1 protein expression we consider at least 5% membranous staining as positive. Gene expression levels were calculated with ΔΔCt method. Positive expression of PD-L1 by IHC was correlated with worse overall survival (OS; p=0.0225) in MPM patients. PD-L1 positive status was correlated with worse OS in the subgroup of patients with ECOG score
- Published
- 2021