1. [Association of fatty acid metabolism with systemic inflammatory response in chronic respiratory diseases]
- Author
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Antonuk Mv, Lobanova Eg, Tatyana P. Novgorodtseva, E. P. Kalinina, Yuliya K. Denisenko, and Zhukova Nv
- Subjects
0301 basic medicine ,Adult ,Male ,Leukotriene B4 ,Systemic inflammation ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Lipoxygenase ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,medicine ,Humans ,chemistry.chemical_classification ,Inflammation ,Arachidonic Acid ,biology ,Fatty acid metabolism ,business.industry ,Fatty acid ,General Medicine ,Lipoxygenases ,Eicosapentaenoic acid ,Asthma ,Thromboxane B2 ,030104 developmental biology ,030228 respiratory system ,Eicosanoid ,chemistry ,Biochemistry ,Eicosapentaenoic Acid ,Prostaglandin-Endoperoxide Synthases ,Case-Control Studies ,Immunology ,biology.protein ,Arachidonic acid ,Female ,medicine.symptom ,business - Abstract
We examined composition of plasma non-esterified fatty acids (NFAs), erythrocyte fatty acids, levels of eicosanoids in patients with asthma and chronic obstructive pulmonary disease (COPD) with different type of the inflammatory response. The results of our study show that asthma and COPD in remission are associated with changes in the composition NFAs of plasma, FA of erythrocytes, level eicosanoid despite the difference in the regulation of immunological mechanisms of systemic inflammation. These changes are characterized by excessive production of arachidonic acid (20:4n-6) and cyclooxygenase and lipoxygenase metabolites (thromboxane B2, leukotriene B4) and deficiency of their functional antagonist, eicosapentaenoic acid (20:5n-3). The recognized association between altered fatty acid composition and disorders of the immune mechanisms of regulation of systemic inflammation in COPD and asthma demonstrated the important role of fatty acids and their metabolites in persistence of inflammatory processes in diseases of the respiratory system in the condition of remission.Izuchen sostav zhirnykh kislot (ZhK) plazmy krovi i membran éritrotsitov, uroven' éĭkozanoidov u bol'nykh bronkhial'noĭ astmoĭ (BA) i khronicheskoĭ obstruktivnoĭ bolezn'iu legkikh (KhOBL) pri raznom tipe vospalitel'noĭ reaktsii. Ustanovleno, chto techenie BA i KhOBL v period remissii, nesmotria na razlichie immunologicheskikh mekhanizmov reguliatsii sistemnogo vospaleniia, soprovozhdaetsia odnonapravlennymi izmeneniiami sostava neéterifitsirovannykh zhirnykh kislot plazmy krovi i ZhK membran éritrotsitov, urovnia éĭkozanoidov, kharakterizuiushchimisia povyshennoĭ produktsieĭ arakhidonovoĭ kisloty (20:4n-6) i ee tsiklooksigenaznykh i lipoksigenaznykh metabolitov (tromboksan V2, leĭkotrien V4) na fone defitsita funktsional'nogo antagonista – éĭkozapentaenovoĭ kisloty (20:5n-3). Obnaruzhennaia assotsiatsiia mezhdu modifikatsieĭ sostava zhirnykh kislot krovi i narusheniem immunnykh mekhanizmov reguliatsii sistemnogo vospaleniia pri KhOBL i BA svidetel'stvuet o vazhnom znachenii zhirnykh kislot i ikh metabolitov v persistentsii vospalitel'nogo protsessa pri zabolevaniiakh bronkholegochnoĭ sistemy v period remissii.
- Published
- 2016