1. An immunologically friendly classification of non-peptidic ligands
- Author
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Randi Vita, Alessandro Sette, Lindy Edwards, Rebecca C. Jackson, Nina Blazeska, James A. Overton, and Bjoern Peters
- Subjects
0303 health sciences ,Hierarchy (mathematics) ,Computer science ,030302 biochemistry & molecular biology ,Proteins ,Computational biology ,Ligands ,General Biochemistry, Genetics and Molecular Biology ,Epitope ,NCBI Taxonomy ,Set (abstract data type) ,Epitopes ,03 medical and health sciences ,Vocabulary, Controlled ,AcademicSubjects/SCI00960 ,Original Article ,User interface ,Databases, Protein ,General Agricultural and Biological Sciences ,030304 developmental biology ,Information Systems - Abstract
The Immune Epitope Database (IEDB) freely provides experimental data regarding immune epitopes to the scientific public. The main users of the IEDB are immunologists who can easily use our web interface to search for peptidic epitopes via their simple single-letter codes. For example, ‘A’ stands for ‘alanine’. Similarly, users can easily navigate the IEDB’s simplified NCBI taxonomy hierarchy to locate proteins from specific organisms. However, some epitopes are non-peptidic, such as carbohydrates, lipids, chemicals and drugs, and it is more challenging to consistently name them and search upon, making access to their data more problematic for immunologists. Therefore, we set out to improve access to non-peptidic epitope data in the IEDB through the simplification of the non-peptidic hierarchy used in our search interfaces. Here, we present these efforts and their outcomes. Database URL: http://www.iedb.org/
- Published
- 2021
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