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Additional file 1: Table S1. Number of subjects screened/excluded/included and reason for exclusion. Figure S1. Venn diagram showing variations in self-reported improvement in health status. Table S2. Univariate analysis of various clinical and laboratory parameters vs treatment success. Table S3. Rates of Adverse Events (AE)/Serious Adverse Event (SAE) among patients treated with pivmecillinam 400 mg QID for 1 week (ITT, n = 53).

Authors’ original file for figure 1

Authors’ original file for figure 3

Authors’ original file for figure 2

Table S5. Adjusted MLR showing the effects of each prognostic indicator on pain (VAS) at each study time point (based on P ≤ 0.20 from the univariate analysis). (PDF 192 kb)

Table S3. Adjusted multilevel logistic regression showing the effects of each prognostic indicator on treatment success (based on P ≤ 0.05 from the univariate analysis). (PDF 96 kb)

Characteristics of selected articles using quantitative methods. (PDF 35 kb)

Characteristics of selected articles using qualitative or mixed methods. (PDF 23 kb)