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13 results on '"Lieubeau, Blandine"'

1. Additional file 5 of Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways

Author

Charrier, Marine, Lorant, Judith, Contreras-Lopez, Rafael, T��j��dor, Gautier, Blanquart, Christophe, Lieubeau, Blandine, Schleder, Cindy, Leroux, Isabelle, Deshayes, Sophie, Fonteneau, Jean-Fran��ois, Babarit, Candice, Hamel, Antoine, Magot, Armelle, P��r��on, Yann, Viau, Sabrina, Delorme, Bruno, Luz-Crawford, Patricia, Lamirault, Guillaume, Djouad, Farida, and Rouger, Karl

Abstract

Additional file 5: Figure S2. Dose effect of human MuStem cells on the proliferation of CD3+ lymphocytes cultured with irradiated peripheral blood mononucleated cells.

Published
2022
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2. Additional file 1 of Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways

Author

Charrier, Marine, Lorant, Judith, Contreras-Lopez, Rafael, T��j��dor, Gautier, Blanquart, Christophe, Lieubeau, Blandine, Schleder, Cindy, Leroux, Isabelle, Deshayes, Sophie, Fonteneau, Jean-Fran��ois, Babarit, Candice, Hamel, Antoine, Magot, Armelle, P��r��on, Yann, Viau, Sabrina, Delorme, Bruno, Luz-Crawford, Patricia, Lamirault, Guillaume, Djouad, Farida, and Rouger, Karl

Abstract

Additional file 1: Methods S1. Immunosuppression assay.

Published
2022
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3. Additional file 4 of Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways

Author

Charrier, Marine, Lorant, Judith, Contreras-Lopez, Rafael, T��j��dor, Gautier, Blanquart, Christophe, Lieubeau, Blandine, Schleder, Cindy, Leroux, Isabelle, Deshayes, Sophie, Fonteneau, Jean-Fran��ois, Babarit, Candice, Hamel, Antoine, Magot, Armelle, P��r��on, Yann, Viau, Sabrina, Delorme, Bruno, Luz-Crawford, Patricia, Lamirault, Guillaume, Djouad, Farida, and Rouger, Karl

Abstract

Additional file 4: Figure S1. Expression profile for cell lineage-specific surface markers by human MuStem cell.

Published
2022
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4. Additional file 2: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

HervÊ, Julie, Terenina, Elena, HaurognÊ, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, MormèDe, Pierre, and Lieubeau, Blandine

Abstract

Table S1. Variableâ s contributions to the first two dimensions of the PCA. Variables that contributed to more than 10% to one axis are underlined. (PDF 35 kb)

Published
2019
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5. Additional file 1: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Abstract

Figure S1. PCA variables’ correlogram. Correlations of each variable to the first two dimensions of the PCA are shown. CTL, CD8αhi cytotoxic T lymphocytes. (PDF 129 kb)

Published
2019
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6. Additional file 3: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches

Author

Saury, Charlotte, Lardenois, Aurélie, Schleder, Cindy, Leroux, Isabelle, Lieubeau, Blandine, David, Laurent, Charrier, Marine, Guével, Laëtitia, Viau, Sabrina, Delorme, Bruno, and Rouger, Karl

Subjects
body regions, nervous system, fungi
Abstract

Table S3. List of primers used for RT-qPCR analysis (PDF 14 kb)

Published
2018
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8. Additional file 2: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches

Author

Saury, Charlotte, Lardenois, Aurélie, Schleder, Cindy, Leroux, Isabelle, Lieubeau, Blandine, David, Laurent, Charrier, Marine, Guével, Laëtitia, Viau, Sabrina, Delorme, Bruno, and Rouger, Karl

Subjects
body regions, nervous system, fungi
Abstract

Table S2. List of antibodies used for hMuStem cell characterization by immunocytochemistry analysis (PDF 11 kb)

Published
2018
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9. Additional file 1: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches

Author

Saury, Charlotte, Lardenois, Aurélie, Schleder, Cindy, Leroux, Isabelle, Lieubeau, Blandine, David, Laurent, Charrier, Marine, Guével, Laëtitia, Viau, Sabrina, Delorme, Bruno, and Rouger, Karl

Subjects
body regions, nervous system, fungi
Abstract

Table S1. List of antibodies used for hMuStem cell characterization by flow cytometry analysis (PDF 16 kb)

Published
2018
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10. Additional file 6: of Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches

Author

Saury, Charlotte, Lardenois, Aurélie, Schleder, Cindy, Leroux, Isabelle, Lieubeau, Blandine, David, Laurent, Charrier, Marine, Guével, Laëtitia, Viau, Sabrina, Delorme, Bruno, and Rouger, Karl

Abstract

Figure S1. Influence of heparin on hMuStem cell proliferation rates. hMuStem cellsHS cultured for 6 days in HS-GM without heparin or with increasing doses of heparin (0.5–5 IU/ml). Population doublings (PDs) determined in three independent cell batches (ap

Published
2018
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11. Additional file 3: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Subjects
3. Good health
Abstract

Figure S2. Gating strategy for non B-lymphocyte subsets analysis. Representative flow cytometry profile is shown. Nucleated single cells were identified as DRAQ5-positive cells. Among SSC-Alo cells, CD4/CD8α/CD3 co-staining allowed the determination of 6 lymphocyte subsets as mentioned on the plots. (PDF 935 kb)

12. Additional file 3: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Subjects
3. Good health
Abstract

Figure S2. Gating strategy for non B-lymphocyte subsets analysis. Representative flow cytometry profile is shown. Nucleated single cells were identified as DRAQ5-positive cells. Among SSC-Alo cells, CD4/CD8α/CD3 co-staining allowed the determination of 6 lymphocyte subsets as mentioned on the plots. (PDF 935 kb)

13. β2-adrenoreceptor stimulation dampens the LPS-induced M1 polarization in pig macrophages

Author

Karine Haurogné, Jean-Marie Bach, Marie Allard, Julie Hervé, Grégoire Mignot, Elodie Bacou, Blandine Lieubeau, Immuno-Endocrinologie Cellulaire et Moléculaire (IECM), Ecole Nationale Vétérinaire de Nantes-Université de Nantes (UN)-Institut National de la Recherche Agronomique (INRA), Hervé, Julie, Lieubeau, Blandine, and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)-Ecole Nationale Vétérinaire de Nantes

Subjects
Lipopolysaccharides, 0301 basic medicine, medicine.medical_specialty, Swine, Macrophage, [SDV]Life Sciences [q-bio], Immunology, Adrenoreceptor, beta 2-agonist, Pig, Stimulation, Biology, 03 medical and health sciences, Catecholamines, 0302 clinical medicine, Immune system, Anti-Infective Agents, Internal medicine, medicine, Animals, Secretion, Interleukin 8, Adrenergic beta-2 Receptor Agonists, Innate immune system, Tumor Necrosis Factor-alpha, Macrophages, Interleukin-8, Immunity, Innate, Interleukin-10, Up-Regulation, Interleukin 10, 030104 developmental biology, Endocrinology, Tumor necrosis factor alpha, Receptors, Adrenergic, beta-2, 030217 neurology & neurosurgery, Developmental Biology
Abstract

The cross-talk between sympatho-adreno-medullar axis and innate immunity players was mainly studied in rodents. In intensive husbandry, pigs are exposed to multiple stressors inducing repeated releases of catecholamines that bind to adrenoreceptors (AR) on target cells. Among adrenoreceptors, the (beta 2-AR is largely expressed by immune cells including macrophages. We report herein on the effects of catecholamines, through (beta 2-AR stimulation, on pig macrophage functions activated by LPS. beta 2-AR stimulation of porcine macrophages prevented the LPS-induced increase in TINF alpha and IL-8 secretion while increasing IL-10 secretion. In contrast, treatment with a beta 2-agonist had no effect on anti-microbial functions. Lastly, beta 2-AR stimulation of macrophages reduced the expression of genes up regulated by LPS. Altogether, we demonstrated that (beta 2-AR stimulation of porcine macrophages prevented polarization towards a pro-inflammatory phenotype. Since porcine macrophages are a suitable model for human macrophages, our results might be relevant to appreciate catecholamine effects on human macrophages.

Published
2017

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