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Laser-accelerated electrons are promising in producing gamma-photon beams of high peak flux for the study of nuclear photonics, obtaining copious positrons and exploring photon–photon interaction in vacuum. We report on the experimental generation of brilliant gamma-ray beams with not only high photon yield but also low divergence, based on picosecond laser-accelerated electrons. The 120 J 1 ps laser pulse drives self-modulated wakefield acceleration in a high-density gas jet and generates tens-of-MeV electrons with 26 nC and divergence as small as $1.51{}^{\circ}$ . These collimated electrons produce gamma-ray photons through bremsstrahlung radiation when transversing a high-Z solid target. We design a high-energy-resolution Compton-scattering spectrometer and find that a total photon number of $2.2\times {10}^9$ is captured within an acceptance angle of $1.1{}^{\circ}$ for photon energies up to $16\;\mathrm{MeV}$ . Comparison between the experimental results and Monte Carlo simulations illustrates that the photon beam inherits the small divergence from electrons, corresponding to a total photon number of $2.2\times {10}^{11}$ and a divergence of $7.73{}^{\circ}$ .

The actin cytoskeleton is essential for maintaining cell morphology and architecture. Actin-bundling proteins such as fascin cross-link actin filaments into bundles and play critical roles in regulating cell protrusion and motility. Fascin protein expression is low or absent in normal human epithelial cells but high in cancer cells. Elevated fascin levels are correlated with aggressive clinical progression, poor prognosis, and shorter survival outcomes. It is regarded as a cancer progression biomarker and a therapeutic target. We have developed a small molecule fascin inhibitor and shown its efficacy in blocking tumor cell migration, invasion, and metastasis, as well as prolonging the overall survival of mice bearing different types of cancers. Our recent data reveals a new mechanism of this fascin inhibitor in cell cycle regulation of gynecological cancer cells. It blocks the G2/M progression and decreases the mitotic index. Fascin inhibitor treatment also results in aneuploidy, which is a well-known factor for triggering downstream apoptosis. Our data suggests that fascin is involved in maintaining the fidelity of chromosome segregation and cell division. This will advance our understanding of the interplay between actin and microtubule cytoskeleton during cell mitosis. Citation Format: Wanyi Chen, Yufeng Wang, Liangliang Ji, Ming O. Li, Xin-Yun Huang. Fascin inhibitor decreases gynecological cancer cell growth through cell cycle regulation. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4960.

High energy photons can be generated via inverse Compton scattering (ICS) in the collision between energetic electrons and intense laser pulse. The development of laser plasma accelerators promises compact and all-optical gamma-ray sources by colliding the electrons from laser wakefield accelerators to its high-power driving pulse reflected by a plasma mirror. However, the law of optical focusing hinders realization of both high photon yield and monochromatic spectrum in this scenario. We propose an azimuthal spatial-temporal convertor that decouples the focal field strength from laser spot size using helical parabolic geometry. It decomposes the driving laser beam into a pulse train of almost identical divergence angle and focal depth, creating synchronized ICS in the optimized linear regime. The scheme resolves the dilemma between high efficiency and narrow energy spread, facilitating the generation of monochromatic gamma-ray using high power lasers beyond relativistic field strengths., Comment: 14 pages, 7 figures

Spatiotemporal optical vortex (STOV) pulses carrying purely transverse intrinsic orbital angular momentum (TOAM) are attracting increasing attention because the TOAM provides a new degree of freedom to characterize light–matter interactions. In this paper, using particle-in-cell simulations, we present spatiotemporal high-harmonic generation in the relativistic region, driven by an intense STOV beam impinging on a plasma target. It is shown that the plasma surface acts as a spatial–temporal-coupled relativistic oscillating mirror with various frequencies. The spatiotemporal features are satisfactorily transferred to the harmonics such that the TOAM scales with the harmonic order. Benefitting from the ultrahigh damage threshold of the plasma over the optical media, the intensity of the harmonics can reach the relativistic region. This study provides a new approach for generating intense spatiotemporal extreme ultraviolet vortices and investigating STOV light–matter interactions at relativistic intensities.

Herein, we propose a scheme based on collision-less shock acceleration (CSA) involving the use of composite targets comprising a micro-structured foil and a pre-polarized gas for obtaining high-energy polarized proton beams. Femtosecond laser pulses irradiate a microwire-array (MWA) target and efficiently heat the dense plasma, which moves toward the dilute plasma. Shocks are then introduced in the pre-polarized gas to accelerate upstream spin-polarized protons to relativistic velocities. Based on particle-in-cell simulations with added spin dynamics, protons with energies of 30–300 MeV are produced, and the polarization rate of protons in the high-energy region exceeds 90%. The simulations demonstrate an evident increase in the temperature and number of hot electrons owing to the presence of MWA structures, which increase both the longitudinal electric field strength associated with the shock and the energy of the reflected protons. During CSA, the bipolar magnetic field driven by hot-electron currents demonstrates a weak effect on the polarization level of the accelerated protons, resulting in a high polarization rate. The relationship between the energy of the polarized proton beam and the hot-electron temperature enables an optimization of the micro-structured target and other target components to enhance proton quality via the CSA process.

We report on experimental observation of non-laminar proton acceleration modulated by a strong magnetic field in laser irradiating micrometer aluminum targets. The results illustrate the coexistence of ring-like and filamentation structures. We implement the knife edge method into the radiochromic film detector to map the accelerated beams, measuring a source size of 30–110 μm for protons of more than 5 MeV. The diagnosis reveals that the ring-like profile originates from low-energy protons far off the axis whereas the filamentation is from the near-axis high-energy protons, exhibiting non-laminar features. Particle-in-cell simulations reproduced the experimental results, showing that the short-term magnetic turbulence via Weibel instability and the long-term quasi-static annular magnetic field by the streaming electric current account for the measured beam profile. Our work provides direct mapping of laser-driven proton sources in the space-energy domain and reveals the non-laminar beam evolution at featured time scales.

We applied 3D-printed microwire-array (MWA) structure to boost the energy conversion efficiency of laser proton acceleration. The advanced nano-printing technique allows precise control on the spacing and geometrical size of 3D structures at 100-500 nm resolution. Under irradiation of high contrast laser pulse (15J, 35fs), the MWA target generates over 1.2×1012 protons (> 1MeV) with cut-off energies extending to 25MeV, corresponding to top-end of 8.7% energy conversion efficiency from femtosecond lasers. When comparing to flat foils the efficiency is enhanced by three times, while the cut-off energy is increased by 30-70% depending on their thicknesses. By precisely controlling the array period via 3D nano-printing, we found the dependence of proton energy/conversion-efficiency on the spacing of the MWA. The experimental trend is well reproduced by hydrodynamic and Particle-In-Cell simulations, which reveal for the first time the modulation of pre-plasma profile induced by laser diffraction within the fine structures. Optimal geometry for laser-proton acceleration is therefore strongly modified. Our work validates the use of 3D-printed micro-structures to produce high efficiency laser-driven particle sources and pointed out the new effect in optimizing the experimental conditions.

A localized nanoparticle insertion scheme is developed to decouple electron injection from laser evolution in laser wakefield acceleration. Here we report the experimental realization of a controllable electron injection by the nanoparticle insertion method into a plasma medium, where the injection position is localized within the short range of 100 μm. Nanoparticles were generated by the laser ablation process of a copper blade target using a 3-ns 532-nm laser pulse with fluence above 100 J/cm2. The produced electron bunches with a beam charge above 300 pC and divergence of around 12 mrad show the injection probability over 90% after optimizing the ablation laser energy and the temporal delay between the ablation and the main laser pulses. Since this nanoparticle insertion method can avoid the disturbing effects of electron injection process on laser evolution, the stable high-charge injection method can provide a suitable electron injector for multi-GeV electron sources from low-density plasmas.

Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets with distinct origins and functions. Here, we examined how cancer impacts mononuclear phagocytic APCs in a murine model of breast cancer. Tumors induced the expansion of monocyte-derived tumor-associated macrophages (TAMs) and the activation of type 1 dendritic cells (DC1s), both of which expressed and required the transcription factor interferon regulatory factor-8 (IRF8). Although DC1s mediated cytotoxic T lymphocyte (CTL) priming in tumor-draining lymph nodes, TAMs promoted CTL exhaustion in the tumor, and IRF8 was required for TAMs' ability to present cancer cell antigens. TAM-specific IRF8 deletion prevented exhaustion of cancer-cell-reactive CTLs and suppressed tumor growth. Tumors from patients with immune-infiltrated renal cell carcinoma had abundant TAMs that expressed IRF8 and were enriched for an IRF8 gene expression signature. Furthermore, the TAM-IRF8 signature co-segregated with CTL exhaustion signatures across multiple cancer types. Thus, CTL exhaustion is promoted by TAMs via IRF8.

The hypothetical axion and axion-like particles, feebly coupled with photon, have not yet been found in any experiment. With the improvement of laser technique, much stronger but shorter quasi-static electric and magnetic fields can be created in laboratory using laser-plasma interaction, compared to the fields of large magnets, to help the search of axion. In this article, we discuss the feasibility of ALPs exploration using planarly or cylindrically symmetric laser-plasma fields as background and an x-ray free-electron laser as probe. Both the probe and the background fields are polarized such that the existence of ALPs in the corresponding parameter space will cause polarization rotation of the probe, which can be detected with high accuracy. Besides, a structured field in the plasma creates a tunable transverse profile for the interaction and improves the signal-to-noise ratio via phase-matching mechanism. The ALP mass discussed in this article ranges from $10^{-3}$ eV to 1 keV. Some simple schemes and estimations on ALP production and polarization rotation of probe photon are given, which reveals the possibility of future laser-plasma ALP source in laboratory., Comment: Accepted manuscript to be published in Physica Scripta. A major revision in summer 2022 contains 22 pages and updated 5 figures

When a circularly polarized (CP) Gaussian beam normally irradiates a solid plasma target, the spin angular momentum of the CP beam transforms into the orbital angular momentum (OAM) of the high-order harmonics through the spin-orbital interaction; this provides a promising way to obtain intense attosecond pulses carrying OAM. However, normal irradiation faces realistic challenges in experiments, as one cannot extract the harmonic without interfering with the driving laser. Here, we propose a feasible scheme to generate vortex high-order harmonics by using a CP Gaussian beam obliquely incident to the target. Theoretical analyses and simulation results show that the $n\mathrm{th}$-order harmonic is composed of vortex modes with topological charges from $l=0$ to $|l|=n\ensuremath{-}1$. The composition ratio depends on the laser focal size and the incident angle. The obtained number of vortex photons is comparable to the normal incidence case at up to an incident angle of ${10}^{\ensuremath{\circ}}$, which greatly facilitates the experimental arrangement.

A novel scheme for obtaining high-energy polarized proton beams by the interaction of a femtosecond laser pulse with a foil-gas composite target has been proposed. The carbon plasmas heated by the laser pulse expand toward the prepolarized HCl gas and excite shock waves in the gas target, reflecting and accelerating spin-polarized protons. According to the results from particle-in-cell simulations with the addition of spin dynamics, protons of several MeV are produced with the polarization rate remaining above 90% in the high energy region. The simulation results show that a large number of the reflected protons are subjected to a weak azimuthal magnetic field and with less depolarization. The intensity of laser pulses and the thickness of foils also affect the strength of the azimuthal magnetic field, which affects the depolarization of the proton beams.

We explore radiative polarization of electrons in a standing-wave formed by two circularly-polarized laser pulses irradiating a thin layer. Here the electron radiative spin dynamics in external electromagnetic fields is described by the generalized Sokolov–Ternov model implemented in the particle-in-cell simulations. We find that significant polarization is established in roughly one laser period from the circular motion in the standing wave. However, such motion is unstable at the magnetic nodes such that electrons migrate to different phases. The beam polarization is then transferred to transverse directions following the T-BMT precession and splits into two groups with opposite signs. The induced polarization distribution allows for filtering out electron population of high polarization purity via certain emitting angles and energies, approaching maximum of 78% polarization at light intensities of the order ∼1023 W cm−2.

High energy positrons can be efficiently created through high-energy photons splitting into electron-positron pairs under the influence of the Coulomb field. Here we show that a new degree of freedom-the intrinsic orbital angular momentum (OAM) can be introduced into relativistic positrons when the incident photons are twisted. We developed the full-twisted scattering theory to describe the transfer of angular momentum before and after the interaction. It is found that the total angular momentum (TAM) of the photon is equally distributed among the positron and electron. For each photon TAM value, the generated leptons gain higher average OAM number when the photon spin is anti-parallel to its TAM. The impact of photon polarization on the OAM spectrum profile and the scattering probability is more significant at small photon TAM numbers, owing to the various interaction channels influenced by flipping the photon spin. Our work provides the theoretical basis to study OAM physics in particle scattering and to obtain copious relativistic vortex positrons through the Beth-Heitler process., Comment: 15 pages, 4 figures

We propose obtaining polarized proton beams based on CO2-laser-driven collisionless shock acceleration (CSA) of the pre-polarized HCl gas. By tailoring the density profile of the pre-polarized HCl gas, the intense CO2laser pulse heats the plasma target and forms a strong shock that reflects the polarized protons to high energy. According to particle-in-cell simulations implemented with the spin dynamics, directional proton beams of several MeV were generated at a total beam polarization of over 80%. Simulations showed that proton spin precession occurred in the azimuthal magnetic fields generated by the Biermann effect and plasma currents. The latter was the main depolarization mechanism in the early stage of shock wave formation. For CSA at CO2laser intensities around 1017–1018W/cm2, the proton depolarization was insignificant and the beam polarization purity was preserved. As pre-polarized hydrogen targets were available at gaseous densities in-state-of-art facilities, CSA driven by relatively long wavelength lasers provided a feasible solution for obtaining ultra-fast polarized proton sources.

With the forthcoming 10–100PW laser facilities, laser-driven electron–positron-pair production has gained particular interest. Here, a scheme to enhance the generation of dense electron–positron-pairs is proposed and numerically demonstrated, employing double laser pulses at the intensity level of 10 23 W c m − 2 . The first laser accelerates a thin foil to a relativistic speed via the radiation-pressure-acceleration mechanism and a counter-propagating laser irradiates this flying plasma layer. The simulation results indicate that a high-yield and well-collimated positron beam ( ∼ 5.5 × 10 10 positrons/pulse, 8.8 nC/pulse) is generated with a large peak density 1.1 × 10 21 c m − 3 by using tens-of-PW laser pulses.

Ion pumping microbial rhodopsins are photochemically active membrane proteins, converting light energy into ion-motive-force for ATP synthesis. Nonlabens dokdonensis rhodopsin 2 (NdR2), was recently identified as a light-driven Na+ pump. However, few functional studies on NdR2 have been conducted to elucidate its mechanism of ion transport. By reconstituting NdR2 into liposomes, we proved that NdR2 functions as a light-driven Na+/H+ pump. As Na+ concentration increased, the dominant H+ pump activity switched to the Na+ pump activity at neutral pH. The inversion of pH change by the addition of CCCP at low Na+ further suggested that the transport of Na+ and H+ should coexist in NdR2. By increasing H+ concentration, the affinity for Na+ lowered, which was indicated by an increase in KM from ~31mM at pH ~7.5, to ~74mM at pH ~6.5. These results demonstrated that Na+ transport competed with H+ transport in NdR2, which was confirmed by the dominant H+ pump activity at pH ~5.7. Kinetic experiments using pyranine uncovered a transient H+ uptake, followed by an H+ release at the millisecond time scale in both Na+ and K+ solutions. Therefore, these NdR2 results may provide functional and kinetic insights into the ion transport mechanism in light-driven Na+ pumps.

Immune responses are often accompanied by radical changes of cellular metabolism of immune cells. On the other hand, an ever increasing number of metabolic pathways and products have been found to possess immune regulatory functions. The field of immunometabolism that investigates the interplay between metabolism and immunity has developed rapidly during the past decade. In this chapter, we attempt to summarize the recent progresses by scientists in China on metabolic regulation of innate immunity from the following three perspectives: metabolic regulation of myeloid cell functions, metabolic adaptations of tissue resident myeloid cells, and metabolism and immunity at the mucosal surfaces.

Transcription factor RBP-J in intestinal macrophages dynamically controls antibacterial immunity by interfacing with T cells and ILCs. Macrophage-intrinsic RBP-J supports intestinal Th17 cell responses via IL-6 production, whereas RBP-J deficiency unexpectedly reveals a compensatory role for ILC3 late during infection., Macrophages play pleiotropic roles in maintaining the balance between immune tolerance and inflammatory responses in the gut. Here, we identified transcription factor RBP-J as a crucial regulator of colonic macrophage–mediated immune responses against the enteric pathogen Citrobacter rodentium. In the immune response phase, RBP-J promoted pathogen clearance by enhancing intestinal macrophage-elicited Th17 cell immune responses, which was achieved by maintenance of C/EBPβ-dependent IL-6 production by overcoming miRNA-17∼92–mediated suppressive effects. RBP-J deficiency–associated phenotypes could be genetically corrected by further deleting miRNA-17∼92 in macrophages. In the late phase, noneradicated pathogens in RBP-J KO mice recruited abundant IL-1β–expressing CD64+Ly6C+ colonic macrophages and thereby promoted persistence of ILC3-derived IL-22 to compensate for the impaired innate and adaptive immune responses, leading to ultimate clearance of pathogens. These results demonstrated that colonic macrophage–intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages., Graphical Abstract

Immune responses are often accompanied by radical changes of cellular metabolism of immune cells. On the other hand, an ever increasing number of metabolic pathways and products have been found to possess immune regulatory functions. The field of immunometabolism that investigates the interplay between metabolism and immunity has developed rapidly during the past decade. In this chapter, we attempt to summarize the recent progresses by scientists in China on metabolic regulation of innate immunity from the following three perspectives: metabolic regulation of myeloid cell functions, metabolic adaptations of tissue resident myeloid cells, and metabolism and immunity at the mucosal surfaces.

Formation of memory T cells is coupled with changes of metabolic status, yet how environmental metabolites affect the transition remains largely unknown. In this issue of Immunity, Bachem et al. (2019) report that microbiota-derived butyrate enhances the memory potential of CD8+ T cells via rewiring cellular metabolism.

High brightness gamma rays can be generated by colliding an ultra-intense laser pulse with a high energy electron beam. This collision phenomenon also represents a powerful approach to explore new physics in the exotic strong field Quantum Electro-Dynamics (QED) regime. Here we show that in the cross-collision geometry, there exists a barrier induced by the classical radiation-reaction force that prohibits electrons of arbitrarily high energies to pass. However, such classical barrier vanishes in the QED picture, where electrons can be well reflected (transmitted) in the regimes forbidden by classical theory. This effect can be measured in the up-coming 10–100 PW laser facilities for laser intensities at 2 × 1023 W cm−2 and electron energies of ~102 MeV. The results are capable of identifying the boundaries between classical and QED approaches in the strong field regime and confirming the various models describing this fundamental process. The study of electron dynamics in relativistic laser fields is a subject of major interest within the strong field physics community and has inspired several key applications aimed at accelerating charged particles. The authors present a theoretical study, and propose an experimental design, that address the interaction of electrons with intense lasers in the transition regime from classical to quantum and show that stochastic processes in the quantum regime allow electrons to be transmitted/reflected across/by the laser in the parameter region prohibited by classical dynamics.

Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool. Here, we report mitocytosis, a migrasome-mediated mitochondrial quality-control process. We found that, upon exposure to mild mitochondrial stresses, damaged mitochondria are transported into migrasomes and subsequently disposed of from migrating cells. Mechanistically, mitocytosis requires positioning of damaged mitochondria at the cell periphery, which occurs because damaged mitochondria avoid binding to inward motor proteins. Functionally, mitocytosis plays an important role in maintaining mitochondrial quality. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential (MMP) and mitochondrial respiration; conversely, blocking mitocytosis causes loss of MMP and mitochondrial respiration under normal conditions. Physiologically, we demonstrate that mitocytosis is required for maintaining MMP and viability in neutrophils in vivo. We propose that mitocytosis is an important mitochondrial quality-control process in migrating cells, which couples mitochondrial homeostasis with cell migration.

The upper limit of the laser field strength in a perfect vacuum is usually considered as the Schwinger field, corresponding to ∼ 10 29 W / cm 2 . We investigate such limitations under realistic nonideal vacuum conditions and find that intensity suppression appears starting from 10 25 W / cm 2 , showing an upper threshold at 10 26 W / cm 2 level if the residual electron density in chamber surpasses 10 9 cm − 3 . This is because the presence of residual electrons triggers the avalanche of quantum electrodynamics cascade that creates copious electron and positron pairs. The leptons are further trapped within the driving laser field due to radiation reaction, which significantly depletes the laser energy. The relationship between the attainable intensity and the vacuity is given according to particle-in-cell simulations and theoretical analysis. These results answer a critical problem on the achievable light intensity based on present vacuum conditions and provide a guideline for future hundreds of petawatt class laser development.

The generation of polarized particle beams still relies on conventional particle accelerators, which are typically very large in scale and budget. Concepts based on laser-driven wake-field acceleration have strongly been promoted during the last decades. Despite many advances in the understanding of fundamental physical phenomena, one largely unexplored issue is how the particle spins are influenced by the huge magnetic fields of plasma and, thus, how highly polarized beams can be produced. The realization of laser-plasma based accelerators for polarized beams is now being pursued as a joint effort of groups from Forschungszentrum J\"ulich (Germany), University of Crete (Greece), and SIOM Shanghai (China) within the ATHENA consortium. As a first step, we have theoretically investigated and identified the mechanisms that influence the beam polarization in laser-plasma accelerators. We then carried out a set of Particle-in-cell simulations on the acceleration of electrons and proton beams from gaseous and foil targets. We could show that intense polarized beams may be produced if pre-polarized gas targets of high density are employed. In these proceedings we further present that the polarization of protons in HT and HCl gas targets is largely conserved during laser wake-field acceleration, even if the proton energies enter the multi-GeV regime. Such polarized sources for electrons, protons, deuterons and $^{3}$He ions are now being built in J\"ulich. Proof-of-principle measurements at the (multi-)PW laser facilities PHELIX (GSI Darmstadt) and SULF (Shanghai) are in preparation., Comment: submitted to IOP

We propose a new approach based on an all-optical set-up for generating relativistic polarized electron beams via vortex Laguerre-Gaussian (LG) laser-driven wakefield acceleration. Using a pre-polarized gas target, we find that the topology of the vortex wakefield resolves the depolarization issue of the injected electrons. In full three-dimensional particle-in-cell simulations, incorporating the spin dynamics via the Thomas-Bargmann Michel Telegdi equation, the LG laser preserves the electron spin polarization by more than 80% at high beam charge and flux. The method releases the limit on beam flux for polarized electron acceleration and promises more than an order of magnitude boost in peak flux, as compared to Gaussian beams. These results suggest a promising table-top method to produce energetic polarized electron beams., Comment: We replace some results and revise some descriptions

Positron acceleration in plasma wakefield faces significant challenges, as the positron beam must be pre-generated and precisely coupled into the wakefield and, most critically, suffers from defocusing issues. Here we propose a scheme that utilizes laser-driven electrons to produce, inject, and accelerate positrons in a single setup. The high-charge electron beam from wakefield acceleration creates copious electron–positron pairs via the Bethe–Heitler process, followed by enormous coherent transition radiation due to the electrons’ exiting from the metallic foil. Simulation results show that the coherent transition radiation field reaches up to tens of GV m−1, which captures and accelerates the positrons to cut-off energy of 1.5 GeV with energy peak of 500 MeV (energy spread ~ 24.3%). An external longitudinal magnetic field of 30 T is also applied to guide the electrons and positrons during the acceleration process. This proposed method offers a promising way to obtain GeV fast positron sources.

The objective of the present study is to investigate the mechanism of tetracyclines and macrolieds absorption on Taihu Lake sediments. In the study, batch technique was used to study the adsorptive behavior of three pharmaceutical antibiotics (tetracycline, oxytetracycline and tylosin) from several sediments of Taihu Lake, Zhushan Bay, Western Lakeshore, Lake Center, Southern Lakeshore, East Tai Lake, Eastern Lakeshore, Gonghu Bay and Meiliang Bay. The eight sediments showed extraordinarily high absorption affinity for all the tested antibiotics. However, especially the sediments of East Tai Lake was exceptional. The observed sorbent to solution distribution coefficient (K(d), 1 kg(-1)) was 10(2)-10(4) . The sediment of East Tai Lake showed highest organic carbon content and cation exchange capacity. A remarkably strong sorption of antibiotics to the sediment of East Tai Lake can be attributed to the cation exchange and complexation reactions between the functional groups of antibiotics and the respective charged and polar sites of the sorbents. The sorption affinity of tetracycline and oxytetracycline from the eight sediments was higher than tylosin. Tetracycline and oxytetracycline had multiple polar and ionizable functional groups. In the study within the tested pH, the zwitterion speciation is predominated; therefore, the sorption interaction (cation exchange and surface complexation) between tetracycline and sediments was expected stronger than tylosin.

According to the thermodynamics analysis, the molar enthalpy change, the molar entropy increase, the Gibbs free energy change and the balance constant of indium iodide polycrystal synthesis reaction were calculated in order to evaluate the feasibility of reaction temperature on 653 K. After the temperature 653 K was applied in the synthesis experiment, indium iodide polycrystal was successfully obtained by the two-zone vapor transporting method. The result of X-ray diffraction analysis indicates the temperature 653K can be used for indium iodide polycrystal synthesis.

Pyrene-terminated liquid crystalline polymers (poly [8-(4-cyano-4′-biphenyl)-1-octanoylacrylate] and poly [6-(4-cyano-4′-biphenyl)-1-hexanoylacrylate]) were synthesized and used to functionalize graphene sheets via π–π interactions. The resulting liquid crystalline polymers functionalized graphene sheets were characterized by UV–vis spectroscopy, fluorescence spectroscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, X-ray diffraction, atomic force microscopy and Raman spectroscopy. It was found that an intercalated layer structure was formed when polymer was grafted onto graphene sheets. The liquid crystalline polymers were able to effectively disperse graphene in N,N-dimethylformamide that were stable for months. Additionally, a remarkable smaller distance of adjacent mesogenic units was observed, which is attributed to the confinement of the polymer chains between 2D reduced graphene oxide sheets.

A series of narrowly distributed diblock copolymers composed of amorphous components and side-chain liquid crystalline (LC) polymer, poly (butyl acrylate)- block -poly [8-(4-cyano-4′-biphenyl)-1-octanoyl acrylate] (PBA- b -PCBOA), with side-chain LC block weight fraction ( f w,PCBOA ) ranging from 25% to 87%, were synthesized by atom transfer radical polymerization (ATRP). Their thermal property, LC behavior, bulk phase behavior and thin film morphology were studied by differential scanning calorimetry (DSC), polarizing optical microscope (POM), small-angle X-ray scattering (SAXS) techniques and atomic force microscopy (AFM), respectively. The results show the diblock copolymers with different composition could present sphere, lamellar and cylinder morphologies before the order–disorder transition. As the mesogen units self-organize to form smectic phase, the lamellar morphology dominates during the majority LC block weight fraction range ( f w,PCBOA = 46%–77%) to minimized the surface energy. Interestingly, for spin-coated thin film, the lamella phase separation size decreased with increasing annealing time. For the copolymer with f w,PCBOA of 67%, a thermoreversible order–order transition (OOT) and lamella to lamella/modified layer (L/ML), were observed.

A biologically inspired, multilayer laminate structural design is deployed in composite films of polystyrene (PS) grafted graphene oxide (GO) synthesized by a Ce(IV)/HNO3 redox system in aqueous solution. Artificial hybrid films are fabricated using a vacuum-assisted filtration macroscopic assembly method, using nacre as the structural model, GO as the inorganic building blocks and PS as glue. The resulting multilayer structure and the mechanical properties of the nanopaper were studied by scanning electron microscopy, X-ray diffraction and stress–strain measurements. The resulting multilayer GO–PS films with low polymer content (

A new spin-dependent deflection mechanism is revealed by considering the spin-correlated radiation-reaction force during laser-electron collision. We found that such deflection originates from the non-zero work done by the radiation-reaction force along the laser polarization direction in each half-period, which is larger/smaller for spin-anti-paralleled/spin-paralleled electrons. The resulted anti-symmetric deflection is further accumulated when the spin-projection onto the laser magnetic field is reversed in adjacent half-periods. The discovered mechanism dominates over the Stern–Gerlach deflection for electrons of several hundreds of MeV and 10 PW-level laser peak power. The results provide a new perspective to study the strong-field QED physics in quantum radiation-reaction regime and an approach to leverage the study of radiation-dominated and strong-field QED physics via particle spins.

A one-pot method is introduced to construct three-dimensional (3D) nanohybrid composites by combining one-dimensional (1D) carbonaceous polypyrrole nanotubes with two-dimensional (2D) graphene sheets. The morphologies of 3D nanostructure can be controlled by adjusting the raw material ratio of pyrrole to GO. Interestingly, when the ratio is suitable, the interconnected structured formed. Nanotubes tend to be covered by nanosheets and interacted with each other tightly. The resulting material has a Brunauer-Emmett-Teller (BET) surface area of 1173 m 2 g −1 , a total pore volume of 0.66 cm 3 g −1 , and an average pore diameter of 3.0 nm. And this material used as supercapacitor shows high specific capacitance, good rate capability and still retains 94.5% of the initial capacitance even after 10,000 cycles.

Interaction of laser plulses with intensities up to 1025 W/cm2 with overdense plasma targets is investigated via three-dimensional particle-in-cell simulations. At these intensities, radiation of electrons in the laser field becomes important. Electrons transfer a significant fraction of their energy to γ-photons and obtain strong feedbacks due to radiation reaction (RR) force. The RR effect on the distribution of laser energies among three main species: electrons, ions and photons is studied. The RR and electron-positron pair creation are implemented by a QED model. As the laser intensity inreases, the ratio of laser energy coupled to electrons drops while the one for γ-photons reaches up to 35%. Two distinctive plasma density regimes of the high-density carbon target and low-density solid hydrogen target are identified from the laser energy partitions and angular distributions of photons. The power-laws of absorption efficiency versus laser intensity and the transition of photon divergence are revealed. These show enhanced generation of γ-photon beams with improved collimation in the relativistically transparent regime. A new effect of transverse trapping of electrons inside the laser field caused by the RR force is observed: electrons can be unexpectedly confined by the intense laser field when the RR force is comparable to the Lorentz force. Finally, the RR effect and different regions of photon emission in laser-foil interactions are clarified.

Summary Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respectively. The third metabolic fate of L-arginine is the generation of creatine that acts as a key source of cellular energy reserve, yet little is known about the role of creatine in the immune system. Here, genetic, genomic, metabolic, and immunological analyses revealed that creatine reprogrammed macrophage polarization by suppressing M(interferon-γ [IFN-γ]) yet promoting M(interleukin-4 [IL-4]) effector functions. Mechanistically, creatine inhibited the induction of immune effector molecules, including iNOS, by suppressing IFN-γ-JAK-STAT1 transcription-factor signaling while supporting IL-4-STAT6-activated arginase 1 expression by promoting chromatin remodeling. Depletion of intracellular creatine by ablation of the creatine transporter Slc6a8 altered macrophage-mediated immune responses in vivo. These results uncover a previously uncharacterized role for creatine in macrophage polarization by modulating cellular responses to cytokines such as IFN-γ and IL-4.

By the reactive self-degraded template-directed synthesis and further carbonization, N- and O-doped carbonaceous nanotubes from conducting polymer (polypyrrole) precursor have been prepared. After being chemically activated by KOH, specially, with the weight ratio of KOH to polypyrrole nanotubes of 2 and 4, two samples of activated carbonaceous polypyrrole nanotubes (ACPN-2 and ACPN-4) with an uncapped morphology were obtained. The ACPN-4 possesses high heteroatom content (14.85%) and specific surface area (1226 m 2 g −1 ), and exhibits a reversible capacitance of 470 F g −1 at the current density of 0.2 A g −1 , and 280 F g −1 even at a higher current density of 10 A g −1 . Moreover, these nanotubular structured materials have also shown excellent cycling performance with no capacitance loss over 10,000 cycles. Furthermore, these carbonaceous nanotubes achieved a high CO 2 adsorption uptake of 3.9 mmol g −1 at 273 K and 2.5 mmol g −1 at 298 K.

Plasma wakefield excited by a short TeV-scale proton beam is investigated in the highly nonlinear regime. Analysis of the “bubble” field illustrates that transverse expelling force of the wakefield can be compensated by the attractive force, which originates from the co-propagating electrons within the proton bunch, leading to a collimation effect that stabilizes the beam propagation. The protons located in the beam tail can be well-confined and accelerated forward for a long distance. Two-dimensional simulations show that after a 1-TeV proton bunch propagating through plasma for a distance, several percentages of the protons achieve a remarkable energy gain. This scheme presents a potential that proton beams from conventional accelerators may gain considerable additional energy through plasmas wakefields.

We demonstrated here the lyotropic liquid crystalline behavior of an aqueous solution of graphene oxide (GO) sheets. Scanning electron microscope experiments revealed GO sheets self-assembled into fiber-like or sheet-like structures at different concentrations under flow conditions. As a result, the solution viscosity decreased dramatically with increasing shear stress.

Ion pumping microbial rhodopsins are photochemically active membrane proteins, converting light energy into ion-motive-force for ATP synthesis. Nonlabens dokdonensis rhodopsin 2 (NdR2), was recently identified as a light-driven Na

The improved laser-to-pedestal contrast ratio enabled by current high-power laser pulse cleaning techniques allows the fine features of the target survive before the main laser pulse arrives. We propose to introduce the nano-fabrication technologies into laser–plasma interaction to explore the novel effects of micro-structures. We found out that not only laser-driven particle sources but also the laser pulse itself can be manipulated by specifically designed micro-cylinder and -tube targets, respectively. The proposal was supported by full-3D particle-in-cell simulations and successful proof-of-principle experiments for the first time. We believe this would open a way to manipulate relativistic laser–plasma interaction at the micro-size level.

Graphenes are an emerging class of carbon nanomaterials whose adsorption properties toward organic compounds have not been well understood. In the present study, graphene nanosheets were prepared by reoxidation and abrupt heating of graphite oxide, which was prepared by sequential chemical oxidation of commercial nonporous graphite powder. Adsorption properties of three aromatic compounds (naphthalene, 2-naphthol, and 1-naphthylamine) and one pharmaceutical compound (tylosin) on graphene nanosheets and graphite oxide were examined to explore the potential of these two adsorbents for the removal of organic contaminants from aqueous solutions. Compared with the literature data of adsorption on carbon nanotubes, adsorption of bulky, flexible tylosin on graphene nanosheets exhibited markedly faster adsorption kinetics, which can be attributed to their opened-up layer structure. Graphene nanosheets and graphite oxide showed similar sequences of adsorption affinity: 1-naphthylamine > 2-naphthol > tylosin > naphthalene (with much larger differences observed on graphite oxide). It was proposed that the strong adsorption of the three aromatic compounds was mainly due to π-π electron donor-acceptor interactions with the graphitic surfaces of adsorbents. Additionally, Lewis acid-base interaction was likely an important factor contributing to the strong adsorption of 1-naphthylamine and tylosin, especially for the O-functionality-abundant graphite oxide. After being normalized on the basis of adsorbent surface area, adsorption affinities of all four tested adsorbates on graphene nanosheets were very close to those on nonporous graphite powder, reflecting complete accessibility of the adsorbent surface area in adsorption.

An optical vortex with orbital angular momentum (OAM) enriches the light and matter interaction process, and helps reveal unexpected information in relativistic nonlinear optics. A scheme is proposed for the first time to explore the origin of photons in the generated harmonics, and produce relativistic intense harmonics with expected frequency and an optical vortex. When two counter-propagating Laguerre-Gaussian laser pulses impinge on a solid thin foil and interact with each other, the contribution of each input pulse in producing harmonics can be distinguished with the help of angular momentum conservation of photons, which is almost impossible for harmonic generation without an optical vortex. The generation of tunable, intense vortex harmonics with different photon topological charge is predicted based on the theoretical analysis and three-dimensional particle-in-cell simulations. Inheriting the properties of OAM and harmonics, the obtained intense vortex beam can be applied in a wide range of fields, including atom or molecule control and manipulation.