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Additional file 1: Figure S1. The chemical synthesis scheme of DOPE-DOX and DOPE-MMP-CpG. Figure S2. The agarose gel electrophoresis image of free CpG, DOPE-MMP-CpG & MMP9 enzyme and DOPE-MMP-CpG. Figure S3. Distribution of particle size at various proportions in water. Figure S4. The stability assessment of hNPs in PBS. Figure S5. The stability assessment of hNPs in RPMI medium containing 10% FBS. Figure S6. After co-incubated with dying tumor cells or debris treated with various formulations for 48 h, the expression level of CD86 on BMDC was analyzed by flow cytometry. Figure S7. Body weight change of mice treated with PBS, free DOX, free DOX and CpG and hNPs, respectively.