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Background: The Model for End-Stage Liver Disease (MELD)-based allocation system was implemented in Korea in July 2016 without a mandatory abstinence period for liver transplantation (LT) listing. However, the impact of the allocation policy has not been evaluated in patients with severe alcoholic hepatitis (AH). Methods: A total of 81 consecutive patients with severe AH between January 2014 and December 2018 were analyzed. The clinical course of patients before and after the im plementation of the MELD-based allocation system was assessed. Results: More patients received LT (25%-65%) after the MELD allocation system was implemented. The increase in patients receiving deceased donor LT was dramatic (17%-51%, P=0.001) compared to patients receiving living donor LT (7%-14%, P=0.30). The overall survival was better for those who received LT (88% vs. 44% at 1 year, P

Additional file 4: Table S2. Clinicopathological features associated with response to pembrolizumab (p value by Fisher���s exact test). Table S3. Safety profiles. Fig. S1. Survival analysis. (A-B) PFS and OS of all patients (n = 60). (C-D) PFS and OS according to PR vs. SD/PD. (E-F) PFS and OS according to PD vs. PR/SD. Fig. S2. Prevalence of tumor-infiltrating lymphocytes (A) and PD-L1 expression level (B) based on CTNNB1 somatic mutation. Fig. S3. Summary of nonsynonymous mutations in 47 HCC patients. Fig. S4. Correlation between the expression of neutrophil gene markers and NLR (A). Expression level of neutrophil gene markers according to NLR (B). Fig. S5. GSEA plots representing CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP pathway (A) and CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN pathway (B) were enriched in responders (PR). Patients with CTNNB1 mutation showed the higher expression levels of CTNNB1_UP geneset (C) and the lower expression levels of CTNNB1_DN geneset (D)

Additional file 2: The protocol revision history.

Additional file 1: The study protocol.

TableS1. The most frequent post-recurrent treatment modality was transarterial chemoembolization, followed by radiofrequency ablation and surgical resection. (DOCX 15 kb)