231 results on '"Lanzon, A."'
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2. Frequency Level and Problems encountered by the IBED Faculty in Utilizing the Google Workspace for Education
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ROXANNE CEL LANZON
- Abstract
The majority of global sectors were affected by the pandemic caused by a Coronavirus outbreak. This includes the academic world, which consists of millions of enrolled students and active teachers who previously had regular classes in their institutions but were forced to stay home due to the pandemic. To continue the educational process, most countries implemented online classes. Both teaching and learning take place in this mode using electronic devices and different online platforms relatively new to the teaching-learning community. The study used a quantitative method where the researcher surveyed the IBEd Faculty at St. Mary’s College of Baliuag to determine the frequency of educational technology tools such as Google Workspace for Education. A survey was conducted to evaluate the frequency of utilization and problems encountered by the Faculty in utilizing the Google Workspace Educational Tools. Results showed that the faculty were unfamiliar with some of the tools in Google Workspace and rarely used them in their classroom discussion. Teachers' responses revealed that they still need time to explore more of the different tools in Google Workspace and attend different pieces of training that will teach them how to use the tools. The results of the survey will provide valuable information in the design of professional training programs.
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- 2022
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3. On Local Input-Output Stability of Nonlinear Feedback Systems via Local Graph Separation
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P. Hilborne and A. Lanzon
- Subjects
Control and Optimization ,Control and Systems Engineering - Published
- 2022
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4. On Discrete-Time Output Negative Imaginary Systems
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Alexander Lanzon and Parijat Bhowmick
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Pure mathematics ,Class (set theory) ,Control and Optimization ,Proper transfer function ,Unit circle ,Discrete time and continuous time ,Control and Systems Engineering ,Linear system ,Value (computer science) ,Transfer function ,Domain (mathematical analysis) ,Mathematics - Abstract
This letter introduces the notion of linear Discrete-time Output Negative Imaginary (D-ONI) systems. The D-ONI class is defined in the $z$ -domain and it includes the systems having poles on the unit circle. The proposed definition involves a real parameter $\delta \geq 0$ , which indicates the strictness properties. $\delta > 0$ specifies the strict subset, Discrete-time Output Strictly Negative Imaginary (D-OSNI), within the stable D-ONI class. Interestingly, the new D-ONI class captures the existing D-NI systems while restricted to discrete-time LTI systems having a real, rational and proper transfer function. However, the D-OSNI systems are not identical to the existing strictly D-NI (D-SNI) subset. Instead, these two subsets intersect each other. An LMI-based state-space characterisation is derived to check the strict/non-strict D-ONI properties of a given system relying on the value of $\delta $ . The paper also establishes the connections between the discrete-time Passive and discrete-time NI systems. Finally, a closed-loop stability result is proposed for a positive feedback interconnection of two D-ONI systems without poles at $z = -1$ and $z = +1$ .
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- 2022
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5. Converse negative imaginary theorems
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Khong, Sei Zhen, Zhao, Di, and Lanzon, Alexander
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Optimization and Control (math.OC) ,FOS: Electrical engineering, electronic engineering, information engineering ,FOS: Mathematics ,Systems and Control (eess.SY) ,Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
Converse negative imaginary theorems for linear time-invariant systems are derived. In particular, we provide necessary and sufficient conditions for a feedback system to be robustly stable against various types of negative imaginary (NI) uncertainty. Both marginally stable and exponentially stable uncertain NI systems with restrictions on their static or instantaneous gains are considered. It is shown that robust stability against the former class entails the well-known strict NI property, whereas the latter class entails a new type of output strict NI property that is hitherto unexplored. We also establish a non-existence result that no stable system can robustly stabilise all marginally stable NI uncertainty, thereby showing that the uncertainty class of NI systems is too large as far as robust feedback stability is concerned, thus justifying the consideration of subclasses of NI systems with constrained static or instantaneous gains., Comment: This paper has been submitted for possible publication at Automatica
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- 2023
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6. Robust Cooperative Control of Networked Train Platoons: A Negative-Imaginary Systems’ Perspective
- Author
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Ian R. Petersen, Chunyu Li, Alexander Lanzon, Jiayuan Shan, and Jianan Wang
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Flexibility (engineering) ,Control and Optimization ,Computer Networks and Communications ,Property (programming) ,Computer science ,Control (management) ,Track (rail transport) ,Network topology ,Control and Systems Engineering ,Control theory ,Robustness (computer science) ,Signal Processing ,Line (geometry) ,Train - Abstract
Cooperative control for trains shows great potential in improving line utilization, passenger comfort and operation flexibility.However,the operation of train platoons faces great challenges induced by model uncertainties,unpredictable resistances and time-varying disturbances. To address these problems,a consensus-based robust cooperative control scheme is presented in this paper for both homogeneous and heterogeneous train platoons.Taking the physical connection between carriages into consideration,each train in the platoons is modeled as a negative imaginary(NI) system,and the NI property is rigorously proved in this paper.In the foundation of cooperative control theories of NI systems,robust strictly negative imaginary(SNI) controllers considering the network topology are utilized to track a predefined motion reference.The proposed controllers are robust to both mass uncertainties and external disturbances.Moreover,the line utilization for the railway system and the ride comfort for the passengers are improved using the proposed control schemes.Numerical simulations are given to showcase the effectiveness and robustness of the proposed controllers.
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- 2021
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7. Negative Imaginary Theory for a Class of Linear Time-Varying Systems
- Author
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Suleiman Kurawa, Alexander Lanzon, and Parijat Bhowmick
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Equilibrium point ,Class (set theory) ,Pure mathematics ,Control and Optimization ,Matrix (mathematics) ,LPV negative imaginary systems ,Control and Systems Engineering ,Stability theory ,LTV negative imaginary systems ,Dissipative system ,non autonomous systems ,Differential (infinitesimal) ,global uniform asymptotic stability ,Time complexity ,Realization (systems) ,Mathematics - Abstract
This letter introduces the notion of linear time-varying (LTV) negative imaginary systems. LTV negative imaginary systems are defined using a time-domain dissipative supply rate $w$ ( $u,\dot {y}$ ) that depends on input to the system ( $u$ ), time-derivative of the system’s output ( $\dot {y}$ ) and an index $\delta \geq 0$ . For $\delta > 0$ , it gives rise to a strict subclass within the LTV negative imaginary systems, termed as LTV output strictly negative imaginary systems. For characterizing the proposed class of systems, a set of linear differential matrix inequality conditions is derived based on the given state-space realization. Subsequently, LTV negative imaginary theory is specialized to linear parameter-varying (LPV) cases for which, the differential matrix inequality conditions can easily be avoided by considering the rate of variation of the uncertain parameters as independent LMI variables. Finally, a set of sufficient conditions is derived which ensures that the origin is a globally asymptotically stable equilibrium point of an unforced positive feedback interconnection of two uniformly asymptotically stable LTV negative imaginary systems.
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- 2021
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8. PDIA3 as a potential bridge between immunogenic cell death and autoreactivity
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Maria Perez-Lanzon, Jonathan Pol, Guido Kroemer, and Céleste Plantureux
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Oncology ,Immunology ,Immunology and Allergy - Published
- 2022
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9. Neurofibromin 1 mediates sleep depth in Drosophila
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Elizabeth B. Brown, Jiwei Zhang, Evan Lloyd, Elizabeth Lanzon, Valentina Botero, Seth Tomchik, and Alex C. Keene
- Abstract
Neural regulation of sleep and metabolic homeostasis are critical in many aspects of human health. Despite extensive epidemiological evidence linking sleep dysregulation with obesity, diabetes, and metabolic syndrome, little is known about the neural and molecular basis for the integration of sleep and metabolic function. The RAS GTPase-activating gene Neurofibromin (Nf1) has been implicated in the regulation of sleep and metabolic rate, raising the possibility that it serves to integrate these processes, but the effects on sleep consolidation and physiology remain poorly understood. A key hallmark of sleep depth in mammals and flies is a reduction in metabolic rate during sleep. Here, we use indirect calorimetry to define the role of Nf1 on sleep-dependent changes in metabolic rate. Flies lacking Nf1 fail to suppress metabolic rate during sleep, raising the possibility that loss of Nf1 prevents flies from integrating sleep and metabolic state. Sleep of Nf1 mutant flies is fragmented with a reduced arousal threshold in Nf1 mutants, suggesting Nf1 flies fail to enter deep sleep. The effects of Nf1 on sleep can be localized to a subset of neurons expressing the GABA receptor Rdl. Selective knockdown of Nf1 in Rdl-expressing neurons increases gut permeability and reactive oxygen species (ROS) in the gut, suggesting a critical role for deep sleep in gut homeostasis. Together, these findings suggest Nf1 acts in GABA-sensitive neurons to modulate sleep depth in Drosophila.
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- 2022
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10. Modelling and controller design for a five-link inverted pendulum
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Yarong Zhou, Parijat Bhowmick, Ying Fu, Ye Li, and Alexander Lanzon
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- 2022
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11. Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic
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Glasbey, James C, Omar, Omar, Nepogodiev, Dmitri, Minaya-Bravo, Ana, Bankhead-Kendall, Brittany Kay, Fiore, Marco, Futaba, Kaori, Gabre-Kidan, Alodia, Gujjuri, Rohan R, Isik, Arda, Kaafarani, Haytham MA, Kamarajah, Sivesh K, Li, Elizabeth, Loeffler, Markus W, McLean, Kenneth A, Outani, Oumaima, Ntirenganya, Faustin, Satoi, Sohei, Shaw, Richard, Simoes, Joana FF, Stewart, Grant D, Tabiri, Stephen, Trout, Isobel M, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H, Tiwari, Abhinav, Venn, Mary L, Wilkin, Richard JW, Bhangu, Aneel, Smart, Neil J, Gallo, Gaetano, Moug, Susan, Pata, Francesco, Pockney, Peter, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Griffiths, Ewen A, Evans, Richard PT, Townend, Philip, Roberts, Keith, McKay, Siobhan, Isaac, John, Edwards, John, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Hutchinson, Peter, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Biel, Juan Rey, Batstone, Martin, Ganly, Ian, Vidya, Raghavan, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Sundar, Sudha, Fotopoulou, Christina, Leung, Elaine, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Rajkumar, Shylasree TS, Ng, Joe, Fujiwara, Keiiji, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P, Augestad, Knut Magne, Ayasra, Faris, Azevedo, Jose, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Ghosh, Dhruv, Gomes, Gustavo Mendonca Ataide, Grecinos, Gustavo, Grundl, Madalegna, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jonker, Pascal, Keller, Debby, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Loffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N, Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M, Moore, Rachel, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Roslani, April C, Rutegard, Martin, Segura-Sampedro, Juan Jose, Santos, Irene, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, Allemand, C, Boccalatte, L, Figari, M, Lamm, M, Larranaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Alurralde, C, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, Garcia, JS, Garcia, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, YH, Ong, BS, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Wright, G, Lanner, M, Koenigsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Oefner, D, Tsibulak, I, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Oehlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St John, S, Walkes, K, Flamey, N, Pattyn, P, Oosterlinck, W, Van den Eynde, J, Van den Eynde, R, Gatti, A, Nardi, C, Oliva, R, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Terra, RM, Sokolov, M, Kidane, B, Srinathan, S, Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Dumitra, S, Kouyoumdjian, A, Johnston, B, Russell, C, Demyttenaere, S, Garfinkle, R, Abou-Khalil, J, Nessim, C, Stevenson, J, Heredia, F, Almeciga, A, Fletcher, A, Merchan, A, Puentes, LO, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Krsul, D, Zelic, M, Luksic, I, Mamic, M, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Rakvin, I, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Szubota, I, Zatecky, J, Javurkova, V, Klat, J, Avlund, T, Christensen, P, Harbjerg, JL, Iversen, LH, Kjaer, DW, Kristensen, HO, Mekhael, M, Ebbehoj, AL, Krarup, P, Schlesinger, N, Smith, H, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, Elqasabi, MS, Hewalla, Elsayed ME, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, MS, Ragab, M, Sabry, A, Saifeldin, H, Elkaffas, Saleh Mesbah Mohamed M, Samih, A, Abdelaal, Samir A, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, Abbas, AM, Abd Elazeem, HAS, Abdelkarem, MM, Alaa, S, Ali, AK, Ayman, A, Azizeldine, MG, Elkhayat, H, Elghazaly, MS, Monib, FA, Nageh, MA, Saad, MM, Salah, M, Shahine, M, Yousof, EA, Youssef, A, Eldaly, A, ElFiky, M, Nabil, A, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, Salama, Abdelkader I, Balabel, M, Fayed, Y, Sherif, AE, Bekele, D, Kauppila, J, Sarjanoja, E, Helminen, O, Huhta, H, Kauppila, JH, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, De Simone, B, Bettoni, J, Dakpe, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kun-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, El Aamrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, FR, Truant, S, Zerbib, P, Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J, Bergeat, D, Merdrignac, A, Le Roy, B, Perotto, LO, Scalabre, A, Aime, A, Ezanno, A, Malgras, B, Bouche, P, Tzedakis, S, Cotte, E, Glehen, O, Kepenekian, V, Lifante, J, Passot, G, D'Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B, Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-givelet, A, Tribillon, E, Duchalais, E, Espitalier, F, Ferron, C, Malard, O, Bork, U, Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P, Beyer, K, Kamphues, C, Lauscher, J, Loch, FN, Schineis, C, Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J, Becker, R, Jonescheit, J, Pergolini, I, Reim, D, Boeker, C, Hakami, I, Mall, J, Liokatis, P, Smolka, W, Nowak, K, Reinhard, T, Hoelzle, F, Modabber, A, Winnand, P, Knitschke, M, Kauffmann, P, Wolfer, S, Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R, Bertolani, E, Koenigsrainer, A, Loeffler, MW, Quante, M, Steidle, C, Ueberrueck, L, Yurttas, C, Betz, CS, Bewarder, J, Boettcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, Klatte, TO, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, Uzunoglu, FG, Vollkommer, T, Zeller, N, Battista, MJ, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R, Angelou, K, Haidopoulos, D, Rodolakis, A, Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A, Antonopoulou, MI, Manatakis, DK, Tasis, N, Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P, Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G, Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, Ntziovara, AM, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D, Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G, Karaitianos, I, Tsirlis, T, Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D, Athanasakis, E, Chrysos, E, Tsiaoussis, J, Xenaki, S, Xynos, E, Futaba, K, Ho, MF, Hon, SF, Mak, TWC, Ng, SSM, Foo, CC, Banky, B, Susztak, N, Aremu, M, Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L, Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, O'Brien, S, O'Leary, P, Syed, WAS, Vernon, L, Callanan, D, Huang, L, Ionescu, A, Sheahan, P, Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, McCartan, D, McDermott, EW, Prichard, RS, Winter, D, Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, EM, Donlon, N, Donohue, C, Fahey, BA, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, JO, Lennon, P, Maguire, PJ, Mccormick, P, Mehigan, BJ, Mohan, H, Nugent, T, O'Sullivan, H, Ravi, N, Reynolds, JV, Rogers, A, Shokuhi, P, Smith, J, Smith, LA, Timon, C, Bashir, Y, Bass, G, Connelly, T, Creavin, B, Earley, H, Elliott, JA, Gillis, A, Kavanagh, D, Neary, P, O'riordan, J, Reynolds, IS, Rice, D, Ridgway, P, Umair, M, Whelan, M, Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nizami, K, Ryan, E, Samy, A, Coffey, JC, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S, Hardy, N, O'Malley, S, Ryan, M, Macina, S, Mariani, NM, Opocher, E, Ceretti, Pisani A, Ferrari, F, Odicino, F, Sartori, E, Cotsoglou, C, Granieri, S, Bianco, F, Camillo', A, Colledan, M, Tornese, S, Zambelli, MF, Bissolotti, G, Fusetti, S, Lemma, F, Marino, MV, Mirabella, A, Vaccarella, G, Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, MN, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R, Bassi, C, Bortolasi, L, Campagnaro, T, 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V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, McEwen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Jones, SEF, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, McEvoy, K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgro, A, Stewart, KE, Turnbull, A, Gonzalez, Aguilar M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Loehrer, A, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, K, Osterberg, EC, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, DiLalla, G, Hwang, ES, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, Gabre-Kidan, A, Jenny, HE, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Ganly, I, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, Oh, JS, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, 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A., Bretherton, C., Buarque, I. L., Burke, J., Chaar, M., Christensen, P., Cox, D., Cukier, M., Cunha, M. F., Davidson, G. H., Drake, T. M., Edwards, J. G., Elhadi, M., Emile, S., Shebani, F., Fitzgerald, J. E., Garmanova, T., Ghosh, D., Gomes, G. M. A., Grecinos, G., Griffiths, E. A., Grundl, M., Halkias, C., Harrison, E. M., Hisham, I., Hutchinson, P. J., Hwang, S., Jonker, P., Keller, D., Kolias, A., Lawani, I., Lederhuber, H., Litvin, A., Loehrer, A., Lorena, M. A., Modolo, M. M., Major, P., Martin, J., Mashbari, H. N., Mazingi, D., Metallidis, S., Mohan, H. M., Moore, R., Moszkowicz, D., Ng-Kamstra, J. S., Niquen, M., Ntirenganya, F., Olivos, M., Oussama, K., Outani, O., Parreno-Sacdalanm, M. D., Rivera, C. J. P., Pinkney, T. D., Plas, W. V. D., Qureshi, A., Radenkovic, D., Medina, A. R. -D. L., Roslani, A. C., Rutegard, M., Segura-Sampedro, J. J., Santos, I., Sayyed, R., Schnitzbauer, A. A., Seyi-Olajide, J. 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N., Schineis, C., Albertsmeier, M., Angele, M., Kappenberger, A., Niess, H., Schiergens, T., Werner, J., Becker, R., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Liokatis, P., Smolka, W., Nowak, K., Reinhard, T., Holzle, F., Modabber, A., Winnand, P., Knitschke, M., Kauffmann, P., Wolfer, S., Kleeff, J., Lorenz, K., Michalski, C., Ronellenfitsch, U., Schneider, R., Bertolani, E., Konigsrainer, A., Quante, M., Steidle, C., Uberruck, L., Yurttas, C., Betz, C. S., Bewarder, J., Bottcher, A., Burg, S., Busch, C., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Koenig, D., Moeckelmann, N., Nitschke, C., Priemel, M., Smeets, R., Speth, U., Thole, S., Uzunoglu, F. G., Vollkommer, T., Zeller, N., Battista, M. 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M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I., Diamantis, A., Gkrinia, E., Hajiioannou, J., Korais, C., Koukoura, O., Perivoliotis, K., Saratziotis, A., Skoulakis, C., Symeonidis, D., Tepetes, K., Tzovaras, G., Zacharoulis, D., Alexoudi, V., Antoniades, K., Astreidis, I., Christidis, P., Deligiannidis, D., Grivas, T., Ioannidis, O., Kalaitsidou, I., Loutzidou, L., Mantevas, A., Michailidou, D., Paraskevopoulos, K., Politis, S., Stavroglou, A., Tatsis, D., Tilaveridis, I., Vahtsevanos, K., Venetis, G., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Mpaili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Anthoulakis, C., Christou, C., Papadopoulos, V., Tooulias, A., Tsolakidis, D., Zouzoulas, D., Athanasakis, E., Chrysos, E., Tsiaoussis, J., Xenaki, S., Xynos, E., Ho, M. F., Hon, S. F., Mak, T. W. C., Ng, S. S. M., Foo, C. 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T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone, F. N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De, P. G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni', A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Cioffi, S. P. B., Citterio, D., Comini, L. 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R., Fumagalliromario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De, M. G. A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino, C. L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di, M. 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T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De, N. P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De, C. E., De, I. P., Dondi, G., Frio, F., Jovine, E., Mineo, B. F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di, M. G. 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S., Ramesh, P., Butt, U., Kashif, M., Khan, W. H., Umar, M., Warisfarooka, M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De, S. X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz, P. R., Vieira, B., Almeida, J. I., Correia, D. S. T., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., Lima, D. S. C., Lopes, L., Machado, N., Marialva, J., Nunes, C. M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athaydenemesio, R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., Costa, M., De, B. J., De, O. L. A., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Martins, R., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., Simoes, J., Valente, D. C. A., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes, M. M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., Gomes, D. C. A., Lobo, A. I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., Martins, D. S. G., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Soares, A., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Dias, B., Fazenda, A., Melo, N. J. P., Policarpo, F., Sampaio, D. N. G. M. I., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., Figueiredo, D. B. I., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira, N. I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre, P. A., Peralta, F. M., Ribeiro, J., Rio, R. L., Sousa, F. M., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira, P. L. A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., Abreu, D. S. A., Claro, M., Costa, S. D., Deus, A. C., Grilo, J. V., Borges, F., Corte, R. J., Henriques, S., Lima, M. J., Matos, C. P., Brito, D. S. F., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins, J. D., Vieira, C. T., Messias, J., Millan, A., Salgado, I., Santos, P., Baia, C., Canotilho, R., Correia, A. M., Ferreira, P. A. P., Peyroteo, M., Videira, J. F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Alshahrani, M., Alsharif, F., Eskander, M., Al, R. R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al, A. S., Alghamdi, M., Alnumani, T., Nasser, M., Said, B. A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M., Abdelrahman, S., Althobaiti, W., Al, H. H., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes, G. 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Frankel A., Bowman S., Guerra G.R., Bolt J., Buddingh K., Dudi-Venkata N.N., Jog S., Kroon H.M., Sammour T., Smith R., Stranz C., Lah K., McGahan W., Mitchell D., Morton A., Pearce A., Roberts M., Sheahan G., Swinson B., Alam N., Banting S., Chong L., Choong P., Clatworthy S., Foley D., Fox A., Hii M.W., Knowles B., Mack J., Read M., Rowcroft A., Ward S., Wright G., Lanner M., Konigsrainer I., Bauer M., Kafka M., Messner F., Ofner D., Tsibulak I., Emmanuel K., Grechenig M., Gruber R., Harald M., Ohlberger L., Presl J., Wimmer A., Namazov I., Samadov E., Barker D., Boyce R., Corbin S., Doyle A., Eastmond A., Gill R., Haynes A., Millar S., O'Shea M., Padmore G., Paquette N., Phillips E., John S., Walkes K., Flamey N., Pattyn P., Oosterlinck W., Van D.E.J., Van D.E.R., Gatti A., Nardi C., Oliva R., De C.R., Cecconello I., Gregorio P., Pontual L.L., Ribeiro J.U., Takeda F., Terra R.M., Sokolov M., Kidane B., Srinathan S., Boutros M., Caminsky N., Ghitulescu G., Jamjoum G., Moon J., 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Saifeldin H., Saleh M.M.E.M., Samih A., Samir A.A., Shehata S., Shenit K., Attia D., Kamal N., Osman N., Abbas A.M., Abd E.H., Abdelkarem M.M., Alaa S., Ali A.K., Ayman A., Azizeldine M.G., Elkhayat H., Melghazaly S., Monib F.A., Nageh M.A., Saad M.M., Salah M., Shahine M., Yousof E.A., Youssef A., Eldaly A., Elfiky M., Nabil A., Amira G., Sallam I., Sherief M., Sherif A., Abdelrahman A., Aboulkassem H., Ghaly G., Hamdy R., Morsi A., Sherif G., Abdeldayem H., Abdelkader S.I., Balabel M., Fayed Y., Sherif A.E., Bekele D., Kauppila J., Sarjanoja E., Helminen O., Huhta H., Kauppila J.H., Beyrne C., Jouffret L., Lugans L., Marie-Macron L., Chouillard E., De S.B., Bettoni J., Dakpe S., Devauchelle B., Lavagen N., Testelin S., Boucher S., Breheret R., Gueutier A., Kahn A., Kun-Darbois J., Barrabe A., Lakkis Z., Louvrier A., Manfredelli S., Mathieu P., Chebaro A., Drubay V., El A.M., Eveno C., Lecolle K., Legault G., Martin L., Piessen G., Pruvot F.R., Truant S., Zerbib P., Ballouhey Q., 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S., Kleeff J., Lorenz K., Michalski C., Ronellenfitsch U., Schneider R., Bertolani E., Konigsrainer A., Quante M., Steidle C., Uberruck L., Yurttas C., Betz C.S., Bewarder J., Bottcher A., Burg S., Busch C., Gosau M., Heuer A., Izbicki J., Klatte T.O., Koenig D., Moeckelmann N., Nitschke C., Priemel M., Smeets R., Speth U., Thole S., Uzunoglu F.G., Vollkommer T., Zeller N., Battista M.J., Gillen K., Hasenburg A., Krajnak S., Linz V., Schwab R., Angelou K., Haidopoulos D., Rodolakis A., Antonakis P., Bramis K., Chardalias L., Contis I., Dafnios N., Dellaportas D., Fragulidis G., Gklavas A., Konstadoulakis M., Memos N., Papaconstantinou I., Polydorou A., Theodosopoulos T., Vezakis A., Antonopoulou M.I., Manatakis D.K., Tasis N., Arkadopoulos N., Danias N., Economopoulou P., Kokoropoulos P., Larentzakis A., Michalopoulos N., Selmani J., Sidiropoulos T., Tsaousis V., Vassiliu P., Bouchagier K., Klimopoulos S., Paspaliari D., Stylianidis G., Baxevanidou K., Bouliaris K., Chatzikomnitsa P., Efthimiou M., Giaglaras A., Kalfountzos C., Koukoulis G., Ntziovara A.M., Petropoulos K., Soulikia K., Tsiamalou I., Zervas K., Zourntou S., Baloyiannis I., Diamantis A., Gkrinia E., Hajiioannou J., Korais C., Koukoura O., Perivoliotis K., Saratziotis A., Skoulakis C., Symeonidis D., Tepetes K., Tzovaras G., Zacharoulis D., Alexoudi V., Antoniades K., Astreidis I., Christidis P., Deligiannidis D., Grivas T., Ioannidis O., Kalaitsidou I., Loutzidou L., Mantevas A., Michailidou D., Paraskevopoulos K., Politis S., Stavroglou A., Tatsis D., Tilaveridis I., Vahtsevanos K., Venetis G., Karaitianos I., Tsirlis T., Charalabopoulos A., Liakakos T., Mpaili E., Schizas D., Spartalis E., Syllaios A., Zografos C., Anthoulakis C., Christou C., Papadopoulos V., Tooulias A., Tsolakidis D., Zouzoulas D., Athanasakis E., Chrysos E., Tsiaoussis J., Xenaki S., Xynos E., Ho M.F., Hon S.F., Mak T.W.C., Ng S.S.M., Foo C.C., Banky B., Susztak N., Aremu M., Canas-Martinez A., Cullivan O., Murphy C., Owens P., Pickett L., Akmenkalne L., Byrne J., Corrigan M., Cullinane C., Daly A., Fleming C., Jordan P., Killeen S., Lynch N., McCarthy A., Mustafa H., O'Brien S., O'Leary P., Syed W.A.S., Vernon L., Callanan D., Huang L., Ionescu A., Sheahan P., Balasubramanian I., Boland M., Conlon K., Evoy D., Fearon N., Gallagher T., Geraghty J., Heneghan H., Kennedy N., Maguire D., McCartan D., McDermott E.W., Prichard R.S., Winter D., Alazawi D., Barry C., Boyle T., Butt W., Connolly E.M., Donlon N., Donohue C., Fahey B.A., Farrell R., Fitzgerald C., Kinsella J., Larkin J.O., Lennon P., Maguire P.J., McCormick P., Mehigan B.J., Mohan H., Nugent T., O'Sullivan H., Ravi N., Reynolds J.V., Rogers A., Shokuhi P., Smith J., Smith L.A., Timon C., Bashir Y., Bass G., Connelly T., Creavin B., Earley H., Elliott J.A., Gillis A., Kavanagh D., Neary P., O'Riordan J., Reynolds I.S., Rice D., Ridgway P., Umair M., Whelan M., Carroll P., Collins C., Corless K., Finnegan L., Fowler A., Hogan A., Kerin M., Lowery A., McAnena P., McKevitt K., Nizami K., Ryan E., Samy A., Coffey J.C., Cunningham R., Devine M., Nally D., Peirce C., Tormey S., Hardy N., O'Malley S., Ryan M., MacIna S., Mariani N.M., Opocher E., Pisani C.A., Ferrari F., Odicino F., Sartori E., Cotsoglou C., Granieri S., Bianco F., Camillo' A., Colledan M., Tornese S., Zambelli M.F., Bissolotti G., Fusetti S., Lemma F., Marino M.V., Mirabella A., Vaccarella G., Agostini C., Alemanno G., Bartolini I., Bergamini C., Bruscino A., Checcucci C., De V.R., Di B.A., Fambrini M., Fortuna L., Maltinti G., Muiesan P., Petraglia F., Prosperi P., Ringressi M.N., Risaliti M., Sorbi F., Taddei A., Tucci R., Bassi C., Bortolasi L., Campagnaro T., Casetti L., De P.M., Esposito A., Fontana M., Guglielmi A., Landoni L., Malleo G., Marchegiani G., Nobile S., Paiella S., Pedrazzani C., Rattizzato S., Ruzzenente A., Salvia R., Turri G., Tuveri M., Bellora P., D'Aloisio G., Ferrari M., Francone E., Gentilli S., Nikaj H., Bianchini M., Chiarugi M., Coccolini F., Di F.G., Furbetta N., Gianardi D., Guadagni S., Morelli L., Palmeri M., Tartaglia D., Anania G., Carcoforo P., Chiozza M., De T.A., Koleva R.M., Portinari M., Sibilla M.G., Urbani A., Fabbri N., Feo C.V., Gennari S., Parini S., Righini E., Ampollini L., Bellanti L., Bergonzani M., Bertoli G., Bocchialini G., D'Angelo G., Lanfranco D., Musini L., Poli T., Santoro G.P., Varazzani A., Aguzzoli L., Borgonovo G., Castro R.C., Coiro S., Falco G., Mandato V.D., Mastrofilippo V., Montella M.T., Annessi V., Zizzo M., Grossi U., Novello S., Romano M., Rossi S., Zanus G., Esposito G., Frongia F., Pisanu A., Podda M., Belluco C., Lauretta A., Montori G., Moras L., Olivieri M., Bussu F., Carta A.G., Cossu M.L., Cottu P., Fancellu A., Feo C.F., Ginesu G.C., Giuliani G., Madonia M., Perra T., Piras A., Porcu A., Rizzo D., Scanu A.M., Tedde A., Tedde M., Delrio P., Rega D., Badalamenti G., Campisi G., Cordova A., Franza M., Maniaci G., Rinaldi G., Toia F., Calabro M., Farnesi F., Lunghi E.G., Muratore A., Pipitone F.N.S., Bambina F., D'Andrea G., Familiari P., Picotti V., De P.G., Luglio G., Pagano G., Tropeano F.P., Baldari L., Beltramini G.A., Boni L., Cassinotti E., Gianni' A., Pignataro L., Torretta S., Abatini C., Baia M., Biasoni D., Bogani G., Cadenelli P., Capizzi V., Cioffi S.P.B., Citterio D., Comini L.V., Cosimelli M., Folli S., Gennaro M., Giannini L., Zweroncy A., Guaglio M., MacChi A., Martinelli F., Mazzaferro V., Mosca A., Pasquali S., Piazza C., Raspagliesi F., Rolli L., Salvioni R., Sarpietro G., Sarre C., Sorrentino L., Agnes A., Alfieri S., Belia F., Biondi A., Cozza V., D'Amore A., D'Ugo D., De S.V., Gasparini G., Gordini L., Litta F., Lombardi C.P., Lorenzon L., Marra A.A., Marzi F., Moro A., Parello A., Perrone E., Ratto C., Rosa F., Saponaro G., Scambia G., Scrima O., Sganga G., Tudisco R., Belli A., Granata V., Izzo F., Palaia R., Patrone R., Carrano F.M., Carvello M.M., De V.A., Di C.F., Ferreli F., Gaino F., Mercante G., Rossi V., Spriano G., 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I., Lofgren N., Sund M., Arigoni M., Bernasconi M., Christoforidis D., Di G.M., La R.D., Mongelli F., Chevallay M., Dwidar O., Gialamas E., Sauvain M., Klenke F., Kollar A., Kurze C., Bachler T., Crugnale A.S., Giardini M., Guglielmetti L., Peros G., Solimene F., Aghayeva A., Hamzaoglu I., Sahin I., Akaydin E., Aliyeva Z., Aytac E., Baca B., Dulgeroglu O., Ozben V., Ozmen B.B., Uras C., Arikan A.E., Bilgin I.A., Bozkirli B., Ceyhan G.O., Kara H., Karahasanoglu T., Celik H., Meydanli M.M., Akilli H., Ayhan A., Kuscu E., Onan M.A., Akgor U., Dincer H.A., Erol T., Gultekin M., Orhan N., Ozgul N., Salman M.C., Soyak B., Alhamed A., Ergun S., Ozcelik M.F., Sanli A.N., Uludag S.S., Velidedeoglu M., Zengin A.K., Bozkurt M.A., Kara Y., Kocatas A., Cimenoglu B., Demirhan R., Saracoglu K., Azamat I.F., Balik E., Bugra D., Giray B., Kulle C.B., Taskiran C., Vatansever D., Gozal K., Guler S.A., Koken H., Tatar O.C., Utkan N.Z., Yildirim A., Yuksel E., Akin E., Altintoprak F., Bayhan Z., Cakmak G., Capoglu R., Celebi F., Demir H., Dikicier E., Firat N., Gonullu E., Kamburoglu M.B., Kocer B., Kucuk I.F., Mantoglu B., Colak E., Kucuk G.O., Uyanik M.S., Goksoy B., Bozkurt E., Citgez B., Mihmanli M., Tanal M., Yetkin G., Akalin M., Arican C., Avci E.K., Aydin C., Demirliatici S., Emiroglu M., Kaya T., Kebabci E., Kilinc G., Kirmizi Y., Ogucu H., Salimoglu S., Sert I., Tugmen C., Tuncer K., Uslu G., Yesilyurt D., Karaman E., Kolusari A., Yildiz A., Benson O., Lule H., Agilinko J., Ahmeidat A., Barabasz M., Bekheit M., Cheung L.K., Colloc T., Cymes W., Elhusseini M., Gradinariu G., Hannah A., Kamera B.S., Mignot G., Shaikh S., Sharma P., Abu-Nayla I., Agrawal A., Al-Mohammad A., Ali S., Ashcroft J., Azizi A., Baker O., Balakrishnan A., Byrne M., Cotter A., Coughlin P., Davies R.J., Durrani A., Elshaer M., Fordington S., Forouhi P., Georgiades F., Grimes H., Habeeb A., Hudson V., Irune E., Jah A., Khan D.Z., Kyriacou H., Liau S., Luke L., Mahmoud R., Mannion R., Masterson L., Mitrofan C.G., Mohan M., Morris A., Murphy S., O'Neill R., Price S., Pushpa-Rajah J., Raby-Smith W., Ramzi J., Rooney S., Santarius T., Singh A., Tan X.S., Townson A., Tweedle E., Walker C., Waseem S., Yordanov S., Jones T., Kattakayam A., Loh C., Lunevicius R., Pringle S., Schache A., Sheel A., Rossborough C., Angelou D., Choynowski M., McAree B., McCanny A., Neely D., Tutoveanu G., Ahad S., De L.C.M.M., Mosley F., Oktseloglou V., Alanbuki A., Patel M., Shabana A., Perera E., Raveendran D., Ravi-Shankar K., Thiruchelvam J., Arrowsmith L., Campbell W., Grove T., Kontovounisios C., Warren O., Rolland P., Aggarwal A., Brown S., Jelley C., Neal N., Clifford R., Eardley N., Krishnan E., Manu N., Martin E., Roy M.S., Serevina O.L., Smith C., Bordenave M., Houston R., Putnam G., Robson A., Tustin H., Emslie K., Labib P.L., Miller D., Minto G., Natale J., Nwinee H., Panahi P., Rogers L., Abubakar A., Akhter R.M., Ko K.Y.K., O'Brien H., Sasapu K., Woodun H., Inglis R., Ng H.J., De G.R.A., Ghazali N., Lambert J., Markose G., Math S., Sarantitis I., Shrestha D., Sultana A., Taggarsi M., Timbrell S., Vaz O.P., Vitone L., Day A., Dent H., Fahim M., Waheed S., Hunt A., Laskar N., Gupta A., Steinke J., Thrumurthy S., Massie E., McGivern K., Rutherford D., Wilson M., Hardie J., Kazzaz S., Handa S., Kaushal M., Kler A., Patel P., Redfern J., Tezas S., Aawsaj Y., Amonkar S., Blackwell L., Blake D., Carter J., Emerson H., Fisher A., Katory M., Korompelis P., McCormick W., Mustafa A., Pearce L., Ratnavelu N., Reehal R., Kretzmer L., Lalou L., Manku B., Parwaiz I., Stafford J., Abdelkarim M., Asqalan A., Gala T., Ibrahim S., Maw A., Mithany R., Morgan R., Sundaram V.G., Ang K., Chowdhry M.F., Mohammad A., Nakas A., Rathinam S., Boal M., Brown O., Dwerryhouse S., Higgs S., Boyd E., Irvine V., Kirk A., Bakolas G., Boulton A., Chandock A., Kumar M., Agoston P., Bille A., Challacombe B., Fraser S., Harrison-Phipps K., King J., Mehra G., Mills L., Najdy M., Nath R., Okiror L., Pilling J., Rizzo V., Routledge T., Sayasneh A., Stroman L., Wali A., Fehervari M., Habib N., Hamrang-Yousefi S., Jawad Z., Jiao L., Pai M., Ploski J., Rajagopal P., Saso S., Sodergren M., Spalding D., Laws S., Hardie C., McNaught C., Alam R., Budacan A., Cahill J., Kalkat M., Karandikar S., Kenyon L., Naumann D., Ayorinde J., Chase T., Cuming T., Ghanbari A., Humphreys L., Tayeh S., Aboelkassem I.A., Bichoo R., Cao H., Chai A.K.W., Choudhury J., Evans C., Fitzjohn H., Ikram H., Langstroth M., Loubani M., McMillan A., Nazir S., Qadri S.S.A., Robinson A., Ross E., Sehgal T., Dixon J., Dunning J., Freystaetter K., Jha M., Lester S., Madhavan A., Thulasiraman S.V., Viswanath Y., Curl-Roper T., Delimpalta C., Liao C.C.L., Velchuru V., Westwood E., Belcher E., Bond-Smith G., Chidambaram S., Fasanmade K., Fraser L., Fu H., Ganau M., Gore S., Graystone J., Jeyaretna D., Khatkar H., Lami M., Maher M., Mastoridis S., Mihai R., Piper R., Prabhu S., Risk O.B.F., Selbong U., Shah K., Smillie R., Soleymanimajd H., Sravanam S., Stavroulias D., Tebala G.D., Vatish M., Verberne C., Wallwork K., Winter S., Bhatti M.I., Boyd-Carson H., Elsey E., Gemmill E., Herrod P., Jibreel M., Lenzi E., Saafan T., Sapre D., Sian T., Watson N., Athanasiou A., Bourke G., Bradshaw L., Coe P., Costigan F., Elkadi H., Johnstone J., Kanatas A., Kantola V., Kaufmann A., Laios A., Lam S., MacInnes E., Munot S., Nahm C., Otify M., Pompili C., Smith I., Theophilou G., Toogood G., Wade R., Ward D., West C., Annamalai S., Ashmore C., Boddy A., Hossain T., Kourdouli A., Gvaramadze A., Jibril A., Prusty L., Thekkinkattil D., Askari A., Cirocchi N., Kudchadkar S., Patel K., Sagar J., Shaw S., Talwar R., Abdalla M., Edmondson R., Ismail O., Jones D., Newton K., Stylianides N., Aderombi A., Andaleeb U., Bajomo O., Beatson K., Garrett W., Mehmood M., Ng V., Al-Habsi R., Divya G.S., Keeler B., Al-Sarireh B., Egan R., Harries R., Henry A., Kittur M., Li Z., Parkins K., Soliman F., Spencer N., Thompson D., Burgess C., Gemmell C., Grieco C., Hollyman M., Hunt L., Morrison J., Ojha S., Ryan N., Abbadessa F., Barnard S., Dawe N., Hammond J., Mahmoud A.F., McPherson I., Mellor C., Moir J., Pandanaboyana S., Powell J., Rai B., Roy C., Sachdeva A., Saleh C., Tingle S., Williams T., Manickavasagam J., McDonald C., McGrath N., McSorley N., Ragupathy K., Ramsay L., Solth A., Kakisi O., Seebah K., Shaikh I., Sreedharan L., Youssef M., Shah J., Ameerally P., McLarty N., Mills S., Shenfine A., Sahnan K., Abu J., Addae-Boateng E., Bratt D., Brock L., Burnside N., Cadwell-Sneath S., Gajjar K., Gan C., Grundy C., Hallam K., Hassell K., Hawari M., Joshi A., Khout H., Konstantinidi K., Lee R.X.N., Nunns D., Schiemer R., Walton T., Weaver H., Whisker L., Williamson K., McVeigh J., Myatt R., Williams M.A., Kaur R., Michel M., Patil S., Ravindran S., Sarveswaran J., Scott L., Edmond M., King E., Bhangu A., Breik O., Cato L.D., Griffiths E., Idle M., Kamal M., Kisiel A., Kulkarni R., Mak J.K.C., Martin T., Parente A., Parmar S., Pathanki A.M., Phelan L., Praveen P., Saeed S., Singh J., Vijayan D., Geddes A., McCaul J., McMahon J., Khan A.H., Khan F., Mansuri A., Mukherjee S., Sarigul M., Singh S., Tan K.L., Woodham A., Adiamah A., Brewer H., Chowdhury A., Evans J., Humes D., Jackman J., Koh A., Lewis-Lloyd C., Oyende O., Reilly J., Worku D., Cool P., Cribb G., Shepherd K., Bisset C., Elson N., Faulkner G., Saleh P., Underwood C., Brixton G., Findlay L., Majkowska A., Manson J., Potter R., Bhalla A., Chia Z., Daliya P., Goyal A., Grimley E., Hamad A., Kumar A., Malcolm F.L., Theophilidou E., Bowden J., Campain N., Daniels I., Fowler G., John J., Massey L., McDermott F., McLennan A., Ng M., Pascoe J., Rajaretnam N., Bulathsinhala S., Davidson B., Fusai G., Hidalgo S.C., MacHairas N., Pissanou T., Pollok J.M., Raptis D.A., Soggiu F., Tzerbinis H., Xyda S.E., Beamish A., Davies E., Foulkes R., Magowan D., Nassa H., Ooi R., Price C., Smith L., Solari F., Tang A., Williams G., Al-Tamimi Y., Bacon A., Beasley N., Chew D., Crank M., Ilenkovan N., MacDonald M., Narice B., Rominiyi O., Thompson A., Varley I., Drake T., Harrison E., Linder G., Mayes J., McGregor R., Skipworth R., Zamvar V., Hawkin P., Raymond T., Ryska O., Baron R., Dunne D., Gahunia S., Halloran C., Howes N., McKinney R., McNicol F., Russ J., Szatmary P., Tan J.R., Thomas A., Whelan P., Anzak A., Banerjee A., Fuwa O., Hughes F., Jayasinghe J.D., Knowles C., Kocher H., Leal S.I., Ledesma F.S., Minicozzi A., Navaratne L., Rahman R., Ramamoorthy R., Sohrabi C., Thaha M., Thakur B., Venn M., Yip V., Baumber R., Parry J., Evans S., Jeys L., Morris G., Parry M., Ahmadi N., Aresu G., Barrett-Brown Z.M., Durio Y.H., Gearon D., Hogan J., King M., Peryt A., Pradeep I.S., Adishesh M., Atherton R., Baxter K., Brocklehurst M., Chaudhury M., Krishnamohan N., McAleer J., Owens G., Parkin E., Patkar P., Phang I., Aladeojebi A., Ali M., Barmayehvar B., Gaunt A., Gowda M., Halliday E., Kitchen M., Mansour F., Thomas M., Zakai D., Abbassi-Ghadi N., Assalaarachchi H., Currie A., Flavin M., Frampton A., Hague M., Hammer C., Hopper J., Horsnell J., Humphries S., Kamocka A., Madhuri T.K., Preston S., Singh P., Stebbing J., Tailor A., Walker D., Aljanadi F., Jones M., Mhandu P., O'Donnell C., Turkington R., Al-Ishaq Z., Bhasin S., Bodla A.S., Burahee A., Crichton A., Fossett R., Pigadas N., Pickford S., Rahman E., Snee D., Yassin N., Fountain D., Hasan M.T., Karabatsou K., Laurente R., Pathmanaban O., Al-Mukhtar A., Giblin A., Kelty C., Lee M., Lye G., Newman T., Sharkey A., Steele C., Sureshkumar S.N., Whitehall E., Athwal R., Baker A., Jones L., Konstantinou C., Ramcharan S., Vatish J., Wilkin R., Ethunandan M., Sekhon G.K., Shields H., Singh R., Wensley F., Lyons A., Abbott T., Anwar S., Ghufoor K., Chung E., Hagger R., Hainsworth A., Karim A., Owen H., Ramwell A., Williams K., Baker C., Davies A., Gossage J., Kelly M., Knight W., Hall J., Harris G., James G., Kang C., Lin D.J., Rajgor A.D., Royle T., Scurrah R., Steel B., Watson L.J., Choi D., Hutchison R., Jain A., Luoma V., Marcus H., May R., Menon A., Pramodana B., Webber L., Aneke I.A., Asaad P., Brown B., Collis J., Duff S., Khan A., Moura F., Wadham B., Warburton H., Elmoslemany T., Jenkinson M., Millward C., Zakaria R., McCluney S., Parmar C., Shah S., Allison J., Babar M.S., Collard B., Goodrum S., Lau K., Scott R., Thomas E., Whitmore H., Balasubramaniam D., Jayasankar B., Kapoor S., Ramachandran A., Elhamshary A., Imam S.M.B., Kapriniotis K., Lindsay J., Rakhshani-Moghadam S., Beech N., Chand M., Green L., Kalavrezos N., Kiconco H., McEwen R., Schilling C., Sinha D., Pereca J., Chopra S., Egbeare D., Thomas R., Combellack T., Jones S.E.F., Kornaszewska M., Mohammed M., Sharma A., Tahhan G., Valtzoglou V., Williams J., Eskander P., Gash K., Gourbault L., Hanna M., MacCabe T., Newton C., Olivier J., Rozwadowski S., Teh E., West D., Al-Omishy H., Baig M., Bates H., Di T.G., Dickson K., Dunne N., Gill C., Howe D., Jeevan D., Khajuria A., Martin-Ucar A., McEvoy K., Naredla P., Robertson S., Sait M., Sarma D.R., Shanbhag S., Shortland T., Simmonds S., Skillman J., Tewari N., Walton G., Akhtar M.A., Brunt A., McIntyre J., Milne K., Rashid M.M., Sgro A., Stewart K.E., Turnbull A., Aguilar G.M., Talukder S., Boyle C., Fernando D., Gallagher K., Laird A., Tham D., Bath M., Patki P., Tanabalan C., Arif T., Magee C., Nambirajan T., Powell S., Vinayagam R., Flindall I., Hanson A., Mahendran V., Green S., Lim M., MacDonald L., Miu V., Onos L., Sheridan K., Young R., Alam F., Griffiths O., Houlden C., Jones R., Kolli V.S., Lala A.K., Leeson S., Peevor R., Seymour Z., Chen L., Henderson E., Brown K., Fleming D., Heron C., Hill C., Kay H., Leede E., McElhinney K., Olson K., Osterberg E.C., Riley C., Srikanth P., Thornhill M., Blazer D., Dilalla G., Hwang E.S., Lee W., Lidsky M., Plichta J., Rosenberger L., Scheri R., Turnage K., Visgauss J., Zani S., Farma J., Clark J., Kwon D., Etchill E., Gabre-Kidan A., Jenny H.E., Kent A., Ladd M., Long C., Malapati H., Margalit A., Rapaport S., Rose J., Stevens K., Tsai L., Vervoort D., Yesantharao P., Dehal A., Klaristenfeld D., Huynh K., Brown L., Mullinax J., Gusani N., Hazelton J., Maines J., Oh J.S., Ssentongo A., Ssentongo P., Azam M., Choudhry A., Marx W., Fleming J., Fuson A., Gigliotti J., Ovaitt A., Ying Y., Abel M.K., Andaya V., Bigay K., Boeck M.A., Chern H., Corvera C., El-Sayed I., Glencer A., Ha P., Hamilton B.C.S., Heaton C., Hirose K., Jablons D.M., Kirkwood K., Kornblith L.Z., Kratz J.R., Lee R., Miller P.N., Nakakura E., Nunez-Garcia B., O'Donnell R., Ozgediz D., Park P., Robinson B., Sarin A., Sheu B., Varma M., Wai K., Wustrack R., Xu M.J., Beswick D., Goddard J., Manor J., Song J., Fullmer T., Gaskill C., Gross N., Kiong K., Roland C.L., Zafar S.N., Abdallah M., Abouassi A., Almasri M., Kulkarni G., Marwan H., Mehdi M., Aoun S., Ban V.S., Batjer H.H., Caruso J., Abbott D., Acher A., Aiken T., Barrett J., Foley E., Schwartz P., Hawkins A., Maiga A., Laufer J., Scasso 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S., Mahmoud Ali F., Rxn L., Jkc M., Pathanki A. M., Khan A. H., Tan K. L., Malcolm F. L., Hidalgo Salinas C., Machairas N., Pollok J. M., Raptis D. A., Xyda S. E., Macdonald M., Tan J. R., Leal Silva I., Ledesma F. S., Barrett-Brown Z. M., Durio Yates H., Pradeep I. S., Madhuri T. K., Bodla A. S., Hasan M. T., Al-mukhtar A., Sureshkumar Shah N., Sekhon G. K., Lin D. J., Rajgor A. D., Watson L. J., Aneke I. A., Mccluney S., Smb I., Sef J., Maccabe T., Al-omishy H., Di Taranto G., Sarma D. R., Stewart K. E., Aguilar Gonzalez M., Kolli V. S., Lala A. K., Osterberg E. C., Hwang E. S., Jenny H. E., Oh J. S., Abel M. K., El-sayed I., Bcs H., Kornblith L. Z., Kratz J. R., Miller P. N., Xu M. J., Roland C. L., Zafar S. N., Ban V. S., Batjer H. H., Apollo - University of Cambridge Repository, and Collaborative, COVIDSurg
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Lung Diseases ,Male ,AcademicSubjects/MED00910 ,COVID-19/diagnosis ,Settore MED/18 - CHIRURGIA GENERALE ,neoplasms ,030230 surgery ,minorsurgical procedures ,Medical and Health Sciences ,Lung Disease ,0302 clinical medicine ,Postoperative Complications ,030202 anesthesiology ,aged ,aged, 80 and over ,COVID-19 ,elective surgical procedures ,female ,humans ,lung diseases ,male ,middle aged ,Nasopharynx ,pandemics ,postoperative complications ,risk assessment ,SARS-CoV-2 ,COVID-19 nucleic acid testing ,Neoplasms ,80 and over ,030212 general & internal medicine ,610 Medicine & health ,Lung ,Cancer ,Aged, 80 and over ,Incidence (epidemiology) ,Confounding ,Pulmonary Complication ,Lung Diseases/*etiology ,Neoplasms/surgery ,General Medicine ,Middle Aged ,Elective Surgical Procedures/adverse effects ,Oncology ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,COVID-19 Nucleic Acid Testing ,Original Article ,Female ,Patient Safety ,AcademicSubjects/MED00010 ,Elective Surgical Procedure ,6.4 Surgery ,Human ,Cohort study ,medicine.medical_specialty ,preoperative caresurgical procedures ,Preoperative care ,Risk Assessment ,Article ,COVIDSurg Collaborative ,NO ,Vaccine Related ,03 medical and health sciences ,Clinical Research ,Biodefense ,medicine ,Nasopharynx/*virology ,Humans ,Nasopharynx/virology ,Elective surgery ,Adverse effect ,Pandemics ,LS7_4 ,Aged ,Pandemic ,business.industry ,Surgery, Sars Cov2 ,Prevention ,No key words available ,electivesurgical procedures ,Lung Diseases/etiology ,Evaluation of treatments and therapeutic interventions ,Postoperative complication ,operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic ,Odds ratio ,medicine.disease ,Confidence interval ,Surgery ,COVID-19/*diagnosis ,Emerging Infectious Diseases ,Good Health and Well Being ,Neoplasm ,Postoperative Complication ,preoperative caresurgical procedures, electivesurgical procedures, minorsurgical procedures, operativenasopharynxsurgery specialtypulmonary complicationscancer surgerysars-cov-2covid-19coronavirus pandemic ,Elective Surgical Procedures/*adverse effects ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Background Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. Results Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. Conclusion Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas., This was an international cohort study of 8784 patients undergoing elective cancer surgery during the COVID-19 pandemic. Preoperative nasopharyngeal swab testing for SARS-CoV-2 was associated with a reduction in postoperative pulmonary complications. This was consistent for major surgery and in high-incidence areas, but with no proven benefit before minor surgery in low-incidence areas.
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- 2021
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12. Nanofluids of Amphiphilic Kaolinite-Based Janus Nanosheets for Enhanced Oil Recovery: The Importance of Stable Emulsion
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Yixuan Mao, Alain Luigi Lanzon, Botuo Zheng, Zhengxiao Xu, Jiatong Jiang, David Harbottle, Kai Yu, Mingfeng Chen, Yu Sheng, and Huagui Zhang
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nanofluid ,Janus nanosheets ,clay ,enhanced oil recovery ,rheology ,poly(N-Isopropylacrylamide) ,Polymers and Plastics ,General Chemistry - Abstract
To meet the increasing global demand for energy, better recovery of crude oil from reservoirs must be achieved using methods that are economical and environmentally benign. Here, we have developed a nanofluid of amphiphilic clay-based Janus nanosheets via a facile and scalable method that provides potential to enhance oil recovery. With the aid of dimethyl sulfoxide (DMSO) intercalation and ultrasonication, kaolinite was exfoliated into nanosheets (KaolNS) before being grafted with 3-methacryloxypropyl-triemethoxysilane (KH570) on the Alumina Octahedral Sheet at 40 and 70 °C to form amphiphilic Janus nanosheets (i.e., KaolKH@40 and KaolKH@70). The amphiphilicity and Janus nature of the KaolKH nanosheets have been well demonstrated, with distinct wettability obtained on two sides of the nanosheets, and the KaolKH@70 was more amphiphilic than the KaolKH@40. Upon preparing Pickering emulsion in a hydrophilic glass tube, the KaolKH@40 preferentially stabilized emulsions, while the KaolNS and KaolKH@70 tended to form an observable and high-strength elastic planar interfacial film at the oil–water interface as well as films climbing along the tube’s surface, which were supposed to be the result of emulsion instability and the strong adherence of Janus nanosheets towards tube’s surface. Subsequently, the KaolKH was grafted with poly(N-Isopropylacrylamide) (PNIPAAm), and the prepared thermo-responsive Janus nanosheets demonstrated a reversible transformation between stable emulsion and the observable interfacial films. Finally, when the samples were subjected to core flooding tests, the nanofluid containing 0.01 wt% KaolKH@40 that formed stable emulsions showed an enhanced oil recovery (EOR) rate of 22.37%, outperforming the other nanofluids that formed observable films (an EOR rate ~13%), showcasing the superiority of Pickering emulsions from interfacial films. This work demonstrates that KH-570-modified amphiphilic clay-based Janus nanosheets have the potential to be used to improve oil recovery, especially when it is able to form stable Pickering emulsions.
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- 2023
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13. Formation-containment tracking and scaling for multiple quadcopters with an application to choke-point navigation
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Yu-Hsiang Su and Alexander Lanzon
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- 2022
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14. Properties of positive feedback interconnected negative imaginary systems
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Parijat Bhowmick, Hsueh-Ju Chen, and Alexander Lanzon
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- 2022
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15. A case of oral foreign‐body granuloma due to diatoms
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Katerina Yale, Lee J. Slater, Gabrielle Brody, Jesse Lanzon, Bruce D. Ragsdale, and David L Carey
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medicine.medical_specialty ,Pathology ,Histology ,Granuloma formation ,Topical uses ,Dermatology ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Rare case ,Medicine ,Oral mucosa ,Allergic contact dermatitis ,biology ,business.industry ,fungi ,Oral foreign body ,biology.organism_classification ,medicine.disease ,Diatom ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Granuloma ,business - Abstract
Diatoms are photosynthetic algae with a siliceous exoskeleton. Diatoms are utilized by a wide array of industries for applications such as filtration and pest control. Unsubstantiated claims have also propelled their societal reach to trendy oral and topical uses. This case highlights a rare case of an oral granuloma secondary to diatoms. An 80-year-old woman presented with a mobile, firm, asymptomatic submucosal mass on her lower left mandibular vestibular mucosa. Histopathology showed a non-caseating granulomatous reaction to diatoms. Her only verified contact with a diatomaceous earth product was a dental impression using alginate after upper front teeth trauma five months before. While there have been several cases of allergic contact dermatitis (ACD) attributed to diatoms, there are no reported cases of diatom-induced granuloma formation found in the literature. There are, however, ample data on granulomas initiated by silica. Given the silica-based composition of diatoms, and the broad use of diatoms in industry and alternative medicine, it is unclear why diatom-induced granulomas are not more widely described. This report may alert clinicians to the existence of diatom granulomas and incline them to tailor their history to cover questions about possible exposure when evaluating patients presenting with a localized oral lesion. This article is protected by copyright. All rights reserved.
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- 2020
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16. Two‐layer distributed formation‐containment control strategy for linear swarm systems: Algorithm and experiments
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Alexander Lanzon, Parijat Bhowmick, and Junyan Hu
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swarm system ,robotics ,Lyapunov stability ,Containment (computer programming) ,formation-containment ,Computer science ,business.industry ,cooperative control ,Mechanical Engineering ,General Chemical Engineering ,Control (management) ,Biomedical Engineering ,Two layer ,Aerospace Engineering ,Swarm behaviour ,Robotics ,Industrial and Manufacturing Engineering ,Control and Systems Engineering ,Control theory ,Artificial intelligence ,Electrical and Electronic Engineering ,business - Abstract
This paper addresses the problem of designing a two-layer distributed formation containment control scheme for linear time-invariant swarm systems with directed communication topology, where the states of the leaders attain a pre-specified timevarying/stationary formation and the states of the followers converge into the convex hull spanned by the states of the leaders. To achieve formation-containment, a set of distributed control protocols is developed utilizing the neighbouring state information, which enables the proposed scheme operate without using global information about the entire interaction topology. The conditions to achieve formation containment are suggested and a theoretical proof of the proposed scheme is also derived exploiting the Lyapunov stability approach. An algorithm is written to provide systematic guidelines on how to implement the control protocols in practice. It is argued that the consensus problem, formation tracking problem, and containmentcontrol problem can all be viewed as special cases of formation-containment. A simulation case study has been presented to demonstrate the usefulness and effectiveness of the proposed scheme and moreover, lab-based hardware experiments involving networked mobile robots were performed to test the feasibility of the scheme in real-time implementation.
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- 2020
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17. Development and stabilization of a low-cost single-tilt tricopter
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Alexander Lanzon, Daniel Abara, and Somasundar Kannan
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0209 industrial biotechnology ,Rotor (electric) ,Computer science ,020208 electrical & electronic engineering ,Mode (statistics) ,CAD ,02 engineering and technology ,Moment of inertia ,law.invention ,Computer Science::Robotics ,020901 industrial engineering & automation ,Tilt (optics) ,Computer Science::Systems and Control ,Control and Systems Engineering ,law ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Development (differential geometry) ,Actuator ,Servo - Abstract
In this paper, a low-cost single-tilting tricopter aerial vehicle is developed with optical flow estimation for indoor navigation. A dynamic model is derived and experimental data is used to obtain the actuator constants. A CAD model is then developed and is used to obtain the moments of inertia with respect to the three main axes. A control allocation algorithm is also proposed to solve the problem of the number of control inputs being more than the number of actuators since the single rotor tilt tricopter has only four actuators (3 rotors and 1 servo). A cascaded-PID control scheme is then used to stabilize the tricopter in hover mode. The simulation results yield realistic control inputs and the outputs have acceptable performance. The feasibility of the proposed scheme is then validated with some experiments on the developed tricopter platform in hover.
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- 2020
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18. Controller synthesis to achieve robust stability against bicoprime factor uncertainty: an LMI approach
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Alexander Lanzon and Mihalis Tsiakkas
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0209 industrial biotechnology ,Computer science ,Iterative method ,020208 electrical & electronic engineering ,Linear matrix inequality ,Stability (learning theory) ,Context (language use) ,02 engineering and technology ,020901 industrial engineering & automation ,Control and Systems Engineering ,Control theory ,Factor (programming language) ,0202 electrical engineering, electronic engineering, information engineering ,Stabilizing controller ,Robust control ,computer ,computer.programming_language - Abstract
In this paper, a Linear Matrix Inequality approach is presented for synthesizing controllers that robustly stabilize a plant against Bicoprime Factor uncertainty. Following the development of the general case, non-normalized results, the usefulness of normalized Bicoprime Factorizations is studied in this context and shown to be beneficial in deducing the existence of a robustly stabilizing controller for given robust stability margin. Finally, a numerical example is provided to demonstrate the practical applicability of the developed methodology.
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- 2020
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19. Sensor blending and Control allocation for non-square linear systems to achieve negative imaginary dynamics
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Alexander Lanzon and Parijat Bhowmick
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0209 industrial biotechnology ,Computer science ,020208 electrical & electronic engineering ,Linear system ,Structure (category theory) ,02 engineering and technology ,Square (algebra) ,Allocator ,020901 industrial engineering & automation ,Control and Systems Engineering ,Control theory ,Simple (abstract algebra) ,0202 electrical engineering, electronic engineering, information engineering ,Actuator ,Constant (mathematics) ,Design methods - Abstract
This paper deals with the design of static pre- and post- compensators to transform stable, non-square LTI systems into the class of strongly strict negative imaginary systems. The pre-compensator plays the role of a control allocator while the post-compensator does sensor blending in order to make a non-square system square along with satisfying the strongly strict negative imaginary property. A specific structure of the post-compensator is also given that guarantees a feasible solution of the LMI conditions when applied to systems with number of outputs greater than or equal to number of inputs. The proposed pre- and post- compensators can also stabilize a non-square plant in closed-loop upon satisfying a particular DC-gain condition and furthermore, they can be utilized to develop a simple constant input tracking framework for non-square systems. The LMI-based design methodology offers a numerically tractable solution framework and hence the easy implementation of the proposed scheme in practical applications. Illustrative examples are provided throughout the paper to demonstrate the usefulness of the proposed results in widening the scope of the negative imaginary theory to non-square LTI systems (e.g. safety-critical systems having redundant sensors and actuators).
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- 2020
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20. Exposure to non-esterified fatty acids in vitro results in changes in the ovarian and follicular environment in cattle
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Pedroza, Gabriela H., Lanzon, Lawrence F., Rabaglino, Maria B., Walker, Wendy L., Vahmani, Payam, and Denicol, Anna C.
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endocrine system ,Granulosa Cells ,Cow ,Ovary ,General Medicine ,Fatty Acids, Nonesterified ,Fatty acid ,NEFA ,Fertility ,Endocrinology ,Oogenesis ,Food Animals ,Preantral follicle ,Oocytes ,Animals ,Animal Science and Zoology ,Cattle ,Female - Abstract
Negative energy balance (NEB) in the postpartum period of dairy cows is associated with reduced fertility to insemination later in lactation. We hypothesized that elevated non-esterified fatty acids (NEFA) levels that occur during NEB result in accumulation of fatty acids within the ovarian tissue and preantral follicles, causing changes in ovarian gene expression that would indicate a response to injury. We performed ovarian cortex culture and oocyte maturation in medium containing a combination of palmitic, oleic and stearic acid (NEFA). Ovarian cortex was subjected to RNA sequencing and lipid content analysis via Nile Red staining and gas chromatography; oocytes were analyzed for maturation rate and mitochondrial mass and localization following in vitro maturation (IVM). Accumulation of lipids associated with the plasma membrane was increased in granulosa cells of preantral follicles exposed to NEFA in vitro; RNA sequencing revealed changes in biological functions associated with metabolic disease, stimulation of an inflammatory response, and reduction in glucose uptake. Oocyte maturation under high NEFA compromised nuclear, but not cytoplasmic maturation. These data demonstrate that exposure to NEFA in vitro affects the ovary, preantral follicles and cumulus-oocyte complexes, and provides further insight into the potential links between metabolic imbalance and infertility.
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- 2021
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21. LOCALIZED APPETIZER AND DESSERTS IN ENHANCING THE COOKERY SKILLS OF GRADE 9 STUDENTS
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LANZON, MICHELLE H. and VERSANO, DOLORES D.
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Cookery Skills, Cultural Practices, Food, Historical, Locality ,education - Abstract
Food does not only provide the purpose of sustaining the needs of the human body rather, it is also a way of knowing the culture, climate, and inclinations in a certain locality and its people. In the province of Quezon, the preparation and cooking of food from ingredients present in the locality further shows the place’s distinct historical and cultural practices. However, as time passed by there is an evident change in the dietary patterns of the people in the municipality of San Antonio, Quezon. People chose to eat food that are from fast food restaurants, convenience food products, and highly processed food wherein, this clearly shows that the practice of cooking at home is constantly decreasing. Hence the purpose of this study is to of carry out a comprehensive study in order to assess the cookery skills among the Grade 9 students of Juanito C. Wagan National High School S.Y: 2020 – 2021. This paper assessed the perception of the student’s responding on the localized appetizer and dessert recipe that they possessed in terms of Selection with the overall mean of 3.80, Organization gained an overall mean of 3.82, Interpretations’ overall mean is 3.81, Ingredients with the overall mean of 3.85, Methods of preparation gained an overall mean of 3.82 and Nutritive Profile overall mean is 3.87 and the learners cooking skills in terms of Personal Entrepreneurial with an overall mean of 3.78, Technical and Mechanical having an overall mean of 3.75, and Creative and Organizational overall mean of 3.76 . Based form the result of this study, there is a significant relationship between all the variables given between the localized appetizer and desserts and the cooking skills of the learners and there is a direct relationship between the localized appetizer and desserts and cooking skills as taken to the responses of the learner respondents. Thus, it has been concluded that the hypotheses presented in this study were not supported by evidence and therefore. With this, it is recommended that educators may train their students the cooking skills, plan for future growth, and appreciate the importance of cooking skills that will enable the people to remember the locality’s culture in cooking. With the limited resources the schools may not be able to provide all the necessary things for young student aspirants for their training to gain skills towards cooking, it is proposed that the teachers may ask support in giving enough resources for the learners and may be given training that will enhance their cooking skills.
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- 2021
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22. A Direct Proof of the Equivalence of Side Conditions for Strictly Positive Real Matrix Transfer Functions
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Augusto Ferrante, Alexander Lanzon, Bernard Brogliato, Universita degli Studi di Padova, University of Manchester [Manchester], Modélisation, simulation et commande des systèmes dynamiques non lisses (TRIPOP), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and Università degli Studi di Padova = University of Padua (Unipd)
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high frequency condition ,0209 industrial biotechnology ,Pure mathematics ,input-output methods ,Passivity ,02 engineering and technology ,strictly positive real systems ,Transfer function ,side conditions ,Computer Science Applications ,Control systems analysis ,multivariable linear systems ,passivity ,020901 industrial engineering & automation ,Control and Systems Engineering ,[INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering ,Frequency domain ,[INFO.INFO-SY]Computer Science [cs]/Systems and Control [cs.SY] ,Direct proof ,Electrical and Electronic Engineering ,Strictly Positive transfer Functions ,Equivalence (measure theory) ,Multivariable linear systems ,Mathematics - Abstract
International audience; This brief note proves in a direct way that two different side conditions, which have been used in the literature to characterize strictly positive real matrix transfer functions in the frequency domain, are equivalent.
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- 2020
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23. Distributed robust stabilization of networked multiagent systems with strict negative imaginary uncertainties
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Ola Skeik and Alexander Lanzon
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Computer science ,Mechanical Engineering ,General Chemical Engineering ,Multi-agent system ,Distributed computing ,Negative imaginary systems ,Biomedical Engineering ,Aerospace Engineering ,Industrial and Manufacturing Engineering ,distributed control ,Control and Systems Engineering ,multi-agent systems ,Electrical and Electronic Engineering ,Robust control ,robust control ,The Imaginary - Abstract
This paper deals with the distributed robust stabilization problem for networkedmulti-agent systems with strict negative imaginary uncertainties (SNI). Communication among agents in the network is modelled by an undirected graph with at least one self-loop. A protocol based on relative state measurements of neighbouring agents and absolute state measurements of a subset of agents is considered. This paper shows how to design the protocol parameters such that the uncertain closed-loop networked multi-agent system is robustly stable against any SNI uncertainty within a certain set for various different network topologies. Tools from negative imaginary (NI) theory are used as an aid to simplify the problem and synthesise the protocol parameters. We show that a state, input and output transformation preserves the NI property of the network. Consequently, a necessary and sufficient condition for the transfer function matrix of the nominal closed-loop networked system to be NI and satisfy a DC gain condition is that multiple reduced-order equivalent systems be NI and satisfy a DC gain condition simultaneously. Based on the reduced-order systems, we derive sufficient conditions in an LMI framework which ensure the existence of a protocol satisfying the desired objectives. A numerical example is given to confirm the effectivenesses of the proposed results.
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- 2019
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24. Beyond Teachable Moments: Professors and Student Reflect on the Marjory Stoneman Douglas Shooting
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Laura L. Vernon, Elizabeth Lanzon, and Kevin Lanning
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Teachable moment ,Psychoanalysis ,0502 economics and business ,05 social sciences ,050301 education ,General Medicine ,Sociology ,050207 economics ,0503 education - Abstract
As academics, it is a sadly common experience to have students undergo personal trials or tragedies, including the death of loved ones. The shootings at Marjory Stoneman Douglas (MSD) High School i...
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- 2019
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25. Biological compatibility, thermal and in vitro simulated degradation for poly(p-dioxanone)/poly(lactide-co-glycolide)/poly(ethylene succinate-co-glycolide)
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Mingfeng Chen, Jingwei Lin, Liu Yihao, Gang Zhong, Huagui Zhang, Li Xu, Canpei Liu, and Alain Luigi Lanzon
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Materials science ,Biocompatibility ,Polymers ,Biomedical Engineering ,Biocompatible Materials ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Cell Line ,Biomaterials ,Dioxanes ,Hydrolysis ,chemistry.chemical_compound ,Mice ,Tissue engineering ,Materials Testing ,Copolymer ,Animals ,Polyglactin 910 ,chemistry.chemical_classification ,technology, industry, and agriculture ,Biomaterial ,Succinates ,Polymer ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,PLGA ,Chemical engineering ,chemistry ,Poly(ethylene succinate) ,Rabbits ,Polyethylenes ,0210 nano-technology - Abstract
Bio-absorbable polymers are widely desired to be applied and used as biomaterials for surgery hemostatic and medical tissue engineering devices. Ring-opening copolymerization reaction was applied to synthesize poly(ethylene succinate-co-glycolide) (PES-b-PGA). Stannous octoate was used as a catalyst whereas poly(ethylene succinate) was used as a macro-initiator to react with glycolide. PES-b-PGA was then used as a compatibilizer to prepare the blend biomaterial of PPDO/PLGA/PES-b-PGA by melt blending poly(p-dioxanone) (PPDO) with poly(lactide-co-glycolide) (PLGA). This would enhance the interactions of the inter-molecular chains and intra-molecular segments thus improving the compatibility. To obtain the biomaterial of PPDO/PLGA/PES-b-PGA with a regulated and controlled degradation and/or hydrolysis period, various ratios of PPDO, PLGA, and PES-b-PGA was blended. Behaviors of the thermal and in vitro simulated degradation, biological compatibility, cytotoxicity and subcutaneous implantation of PPDO/PLGA/PES-b-PGA were investigated. The results show that the in vitro hydrolytic degradation cycle is consistent with the wound healing time and that the biomaterial has slight cytotoxicity and it will do good to the cell proliferation, with 1 grade of cytotoxicity and the relative growth rate being the range from 92.5% to 96.2%. The implantation of the biomaterial into the rabbits' ears will not adversely affect the wound healing and the tissues surrounding the implanted sites. Therefore, the biomaterial has good biocompatibility and potential applications in medical tissue engineering devices.
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- 2021
26. MPA/DMBA-driven mammary carcinomas
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Aitziber Buqué, Takahiro Yamazaki, Guido Kroemer, Lorenzo Galluzzi, Juliette Humeau, Giulia Petroni, Norma Bloy, Maria Perez-Lanzon, and Ai Sato
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0303 health sciences ,medicine.medical_treatment ,Medroxyprogesterone ,DMBA ,Immunosuppression ,Immunotherapy ,Biology ,Immune checkpoint ,Immunosurveillance ,03 medical and health sciences ,Hormone receptor ,Cancer research ,medicine ,biology.protein ,Cyclin-dependent kinase 6 ,030304 developmental biology ,medicine.drug - Abstract
The polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA, D) administered per os to wild-type female mice bearing slow-release medroxyprogesterone (MPA, M) pellets s.c. drives the formation of mammary carcinomas that recapitulate numerous immunobiological features of human luminal B breast cancer. In particular, M/D-driven mammary carcinomas established in immunocompetent C57BL/6 female mice (1) express hormone receptors, (2) emerge by evading natural immunosurveillance and hence display a scarce immune infiltrate largely polarized toward immunosuppression, (3) exhibit exquisite sensitivity to CDK4/CDK6 inhibitors, and (4) are largely resistant to immunotherapy with immune checkpoint blockers targeting PD-1. Thus, M/D-driven mammary carcinomas evolving in immunocompetent female mice stand out as a privileged preclinical platform for the study of luminal B breast cancer. Here, we provide a detailed protocol for the establishment of M/D-driven mammary carcinomas in wild-type C57BL/6 female mice. This protocol can be easily adapted to generate M/D-driven mammary carcinomas in female mice with most genetic backgrounds (including genetically-engineered mice).
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- 2021
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27. Robust Formation Control of Train Platoons for Interval Maintaining
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Jiayuan Shan, Alexander Lanzon, Ian R. Petersen, Chunyu Li, and Jianan Wang
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050210 logistics & transportation ,0209 industrial biotechnology ,Computer science ,05 social sciences ,02 engineering and technology ,Interval (mathematics) ,Track (rail transport) ,Network topology ,Transfer function ,020901 industrial engineering & automation ,Control theory ,0502 economics and business ,Realization (systems) ,Block (data storage) - Abstract
Train coordination technology in moving block signaling (MBS) systems has a huge potential in maximizing line utilization and railways safe operation [1]. However, the realization of reliable cooperative control is a nontrivial task, facing challenges such as environmental uncertainties, unpredictable and time-varying disturbances. This paper investigates the robust cooperative control problem of networked homogeneous trains with physically connected carriages using the cooperative control theories for Negative Imaginary (NI) systems. The coupling between trains within the overall system is described by a network topology. A local robust Strictly Negative Imaginary (SNI) controller is designed to track a prescribed reference and maintain a pre-defined formation. Numerical simulations are provided to demonstrate the effectiveness of the proposed controller.
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- 2020
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28. Time-domain output negative imaginary systems and its connection to dynamic dissipativity
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Parijat Bhowmick and Alexander Lanzon
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0209 industrial biotechnology ,Pure mathematics ,Class (set theory) ,020208 electrical & electronic engineering ,Linear system ,02 engineering and technology ,Characterization (mathematics) ,Transfer function ,LTI system theory ,020901 industrial engineering & automation ,Simple (abstract algebra) ,0202 electrical engineering, electronic engineering, information engineering ,Dissipative system ,Connection (algebraic framework) ,Mathematics - Abstract
This paper introduces the notion of time-domain output (not necessarily strictly) negative imaginary systems that encompasses all the existing (not only stable) subsets of the negative imaginary systems class. A time-domain dynamic dissipative framework is developed in this paper to describe the full class of output negative imaginary systems (i.e. including systems having poles on the imaginary axis). This dynamic dissipative framework also leads to an LMI-based state-space characterization which can be conveniently used to test the output negative imaginary property of a given LTI system. It is further established that for time-domain output negative imaginary systems, the proposed dynamic dissipative framework is equivalent to the classical dissipative property of this class of systems with respect to the supply rate $w(u,\dot {\bar {y}})$. Interestingly, the class of time-domain output strictly negative imaginary systems now captures systems that are not necessarily stable – it is found that the majority of the SISO, LTI transfer functions with a simple pole at the origin satisfy this property. Numerical examples are provided throughout the paper for better illustration.
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- 2020
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29. 95 Home parental nutrition for palliative patients. A review of five years of experience at milton keynes university hospital
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Jane Wale, Marrison Marwood, and Lynfa Lanzon-Miller
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medicine.medical_specialty ,business.industry ,General surgery ,Artificial nutrition ,Bioethics ,University hospital ,medicine.disease ,Bowel obstruction ,Parenteral nutrition ,Advanced disease ,Medicine ,In patient ,General hospital ,business - Abstract
Background Parenteral Nutrition (PN) is the intravenous administration of nutrition and can be used in patients whose gastrointestinal tract is unable to function. It is a treatment that is relatively easy to initiate, but it is a difficult treatment to continue outside of hospital and can also be, ethically and morally, a difficult treatment to stop. Recent ESPEN guidelines (2016) state that ‘the bioethical aspects of feeding patients with advanced disease should be considered.... There are data showing benefits of home artificial nutrition in cancer patients .... even in advanced cancer patients. Home parenteral nutrition is a complex therapy and selecting patients for this treatment a demanding task’. Method Patients for whom home parenteral nutrition had been a goal were identified. A retrospective review of these patients‘ clinical records was undertaken. Results Between 2014 and 2019 six palliative patients had PN commenced at Milton Keynes University Hospital, a medium sized District General Hospital. One further patient had PN started at a tertiary centre. All patients had ongoing bowel obstruction secondary to peritoneal metastases. The mean age of patients was 49 years (range 35–81 years). The average time from starting PN to hospital discharge was 47 days for the MKUH patients compared to 14 days for the patient who was started on PN at a tertiary centre. The average time from staring PN to death was 435 days (range 28 – 1825 days). One patient remains alive, 2 died in the hospital, 2 in the hospice, 2 at home. Conclusion Carefully selected palliative patients can benefit from home PN, but in a district general hospital this requires a lengthy hospital admission to achieve. The decision to start PN should be multidisciplinary and the goals of treatment should be clearly defined and reviewed regularly.
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- 2020
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30. Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity
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Borja Lanzon, Marina Martin-Taboada, Victor Castro-Alves, Rocio Vila-Bedmar, Ignacio González de Pablos, Daniel Duberg, Pilar Gomez, Elias Rodriguez, Matej Orešič, Tuulia Hyötyläinen, Enrique Morales, Francisco J. Ruperez, and Gema Medina-Gomez
- Subjects
severe obesity ,bariatric surgery ,Endocrinology, Diabetes and Metabolism ,urologic and male genital diseases ,Microbiology ,metabolomics ,Biochemistry ,QR1-502 ,Article ,female genital diseases and pregnancy complications ,CKD ,lipidomics ,Molecular Biology - Abstract
Severe obesity is a major risk for chronic kidney disease (CKD). Early detection and careful monitoring of renal function are critical for the prevention of CKD during obesity, since biopsies are not performed in patients with CKD and diagnosis is dependent on the assessment of clinical parameters. To explore whether distinct lipid and metabolic signatures in obesity may signify early stages of pathogenesis toward CKD, liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-high resolution accurate mass-mass spectrometry (GC-HRAM-MS) analyses were performed in the serum and the urine of severely obese patients with and without CKD. Moreover, the impact of bariatric surgery (BS) in lipid and metabolic signature was also studied, through LC-MS and GC-HRAM-MS analyses in the serum and urine of patients with severe obesity and CKD before and after undergoing BS. Regarding patients with severe obesity and CKD compared to severely obese patients without CKD, serum lipidome analysis revealed significant differences in lipid signature. Furthermore, serum metabolomics profile revealed significant changes in specific amino acids, with isoleucine and tyrosine, increased in CKD patients compared with patients without CKD. LC-MS and GC-HRAM-MS analysis in serum of patients with severe obesity and CKD after BS showed downregulation of levels of triglycerides (TGs) and diglycerides (DGs) as well as a decrease in branched-chain amino acid (BCAA), lysine, threonine, proline, and serine. In addition, BS removed most of the correlations in CKD patients against biochemical parameters related to kidney dysfunction. Concerning urine analysis, hippuric acid, valine and glutamine were significantly decreased in urine from CKD patients after surgery. Interestingly, bariatric surgery did not restore all the lipid species, some of them decreased, hence drawing attention to them as potential targets for early diagnosis or therapeutic intervention. Results obtained in this study would justify the use of comprehensive mass spectrometry-based lipidomics to measure other lipids aside from conventional lipid profiles and to validate possible early markers of risk of CKD in patients with severe obesity.
- Published
- 2021
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31. Career and Professional Satisfaction of Oral and Maxillofacial Surgery Residents, Academic Surgeons, and Private Practitioners: Does Gender Matter?
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Sean P. Edwards, Marita R. Inglehart, Jesse Lanzon, and Kyriaki C. Marti
- Subjects
Response rate (survey) ,medicine.medical_specialty ,business.industry ,education ,030206 dentistry ,General Medicine ,Career satisfaction ,03 medical and health sciences ,Professional satisfaction ,0302 clinical medicine ,Nursing ,Private practice ,Family medicine ,Scale (social sciences) ,medicine ,Oral and maxillofacial surgery ,Survey data collection ,Job satisfaction ,030212 general & internal medicine ,business - Abstract
The aims of this study were to determine whether male vs. female oral and maxillofacial surgery (OMS) residents, academic surgeons (i.e., faculty members), and private practitioners in the U.S. differed in their general career satisfaction and job/professional satisfaction. Survey data were collected in 2011-12 from 267 OMS residents (response rate 55%), 271 OMS academic surgeons (response rate 31%), and 417 OMS private practitioners (response rates 13% web-based survey and 29% postal mail survey). The results showed that while the male vs. female OMS private practitioners and academic surgeons did not differ in their career satisfaction, the female residents had a lower career satisfaction than the male residents (on four-point scale with 4=most satisfied: 3.03 vs. 3.65; p
- Published
- 2017
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32. Dynamic Output Feedback Controller Synthesis using an LMI-based α- Strictly Negative Imaginary Framework
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Suleiman Kurawa, Alexander Lanzon, and Parijat Bhowmick
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0301 basic medicine ,Output feedback ,Scheme (programming language) ,Computer science ,Stability (probability) ,Set (abstract data type) ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Control theory ,Full state feedback ,computer ,030217 neurology & neurosurgery ,The Imaginary ,computer.programming_language ,Loop gain - Abstract
This paper deals with the dynamic output feedback controller synthesis utilizing the α - strictly negative imaginary systems property. The proposed scheme ensures robust stability in closed-loop against the set of all stable, strictly proper negative imaginary uncertainties that satisfies the DC loop gain condition pertaining to negative imaginary stability. In addition to that, a prescribed decay rate in the closed-loop time response is also enforced via α - pole placement. Two illustrative examples have been studied to demonstrate the usefulness of the proposed controller synthesis scheme.
- Published
- 2019
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33. Bicoprime Factor Robust Control Synthesis via Reduced Dimension Algebraic Riccati Equations
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Alexander Lanzon and Mihalis Tsiakkas
- Subjects
0209 industrial biotechnology ,020208 electrical & electronic engineering ,02 engineering and technology ,020901 industrial engineering & automation ,Dimension (vector space) ,Control theory ,Factor (programming language) ,0202 electrical engineering, electronic engineering, information engineering ,Applied mathematics ,Algebraic number ,Robust control ,High order ,Control (linguistics) ,computer ,Mathematics ,computer.programming_language - Abstract
Bicoprime factorizations of the plant have recently resurfaced in control theory, after being a largely dormant subject for three decades. Recent results have shown that bicoprime factorizations can be beneficial in solving some control problems. In this paper, an additional advantage is presented where the use of bicoprime factorizations of the plant allows for robust control synthesis via reduced dimension algebraic Riccati equations by discarding some (or all) of the stable dynamics of the plant. This is a major advantage in the stabilisation of high order systems for which robust control synthesis can become computationally intractable.
- Published
- 2019
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34. Unique identities
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Theresa B. Oehmke, Xiao-Yu Wu, Juliet Tegan Johnston, Christopher Gutiérrez, Dhruv Patel, Eric Britt Moore, Elizabeth Lanzon, Michelle Micarelli Struett, Ana Gabriela Vergara, Thomas A. Agbaedeng, Edmond Sanganyado, Jonathan Joon-Young Park, Stephanie Jan Halmhofer, Athanasia Nikolaou, Sasha Mikhailova, Kristy A. Winter, Luis B. Gómez Luciano, Zhongliang Yang, Kristine Marie Lang, and Michael Tran Duong
- Subjects
Multidisciplinary ,early career researchers ,science - Published
- 2019
35. Applying negative imaginary systems theory to non-square systems with polytopic uncertainty
- Author
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Alexander Lanzon and Parijat Bhowmick
- Subjects
LMIs ,0209 industrial biotechnology ,Observer (quantum physics) ,020208 electrical & electronic engineering ,Negative imaginary systems ,02 engineering and technology ,Decentralised integral controllability ,Non-square plants ,Polytopic uncertainty ,Square (algebra) ,Compensation (engineering) ,Controllability ,Nonlinear system ,020901 industrial engineering & automation ,Systems theory ,Control and Systems Engineering ,Simple (abstract algebra) ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,DC-gain ,Constant (mathematics) ,Observer-based control ,Mathematics - Abstract
This paper aims to apply Negative Imaginary (NI) systems theory to non-square LTI systems, for example, flexible structure systems with redundant sensors and actuators. The paper proposes static pre- and post-compensation schemes to transform stable fat (i.e. no. of inputs more than the no. of outputs) and tall (i.e. no. of outputs more than the no. of inputs) LTI plants into the class of Strongly Strict Negative Imaginary (SSNI) systems, a subset of the Strictly Negative Imaginary (SNI) systems. The proposed compensators can also stabilise a non-square or a non-NI square plant in a positive feedback loop . Moreover, the compensators can be utilised to design a simple constant reference tracking scheme exploiting the integral controllability propoerty of SSNI systems. Subsequently, observer-based pre- and post-compensators are developed to handle the cases when some of the system states are not available for direct measurement. Then, the compensation schemes are extended to stable, non-square or non-NI square systems with polytopic uncertainty . Finally, the post-compensation technique is applied to stabilise a class of tall/square uncertain LTI plants preceded by a slope-restricted nonlinearity.
- Published
- 2021
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36. Strictly negative imaginary state feedback control with a prescribed degree of stability
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Alexander Lanzon, James Dannatt, and Ian R. Petersen
- Subjects
Lyapunov function ,0209 industrial biotechnology ,Feedback control ,020208 electrical & electronic engineering ,Perturbation (astronomy) ,02 engineering and technology ,symbols.namesake ,020901 industrial engineering & automation ,Schur decomposition ,Control and Systems Engineering ,Full state feedback ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,Applied mathematics ,Electrical and Electronic Engineering ,Robust control ,Perturbation method ,The Imaginary ,Mathematics - Abstract
This paper presents conditions for the synthesis of a strictly negative imaginary closed-loop system with a prescribed degree of stability under the assumption of full state feedback. A perturbation method is used to ensure the closed-loop system has both the strict negative imaginary property and a prescribed degree of stability. This approach involves the real Schur decomposition of a matrix followed by the solution to two Lyapunov equations. Also, we present and clarify the perturbation properties of strictly negative imaginary systems.
- Published
- 2020
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37. Robust output consensus of homogeneous multi-agent systems with negative imaginary dynamics
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Alexander Lanzon and Ola Skeik
- Subjects
0209 industrial biotechnology ,networked systems ,Computer science ,Multi-agent system ,020208 electrical & electronic engineering ,02 engineering and technology ,Stability result ,020901 industrial engineering & automation ,Consensus ,consensus ,Control and Systems Engineering ,Homogeneous ,0202 electrical engineering, electronic engineering, information engineering ,Applied mathematics ,Electrical and Electronic Engineering ,Robust control ,negative imaginary systems ,robust control ,Intuition - Abstract
This paper addresses the robust output consensus problem for multiple homogeneous negative imaginary (NI) systems subject to L 2 external disturbances and model uncertainties. The principal aim of this paper is to extend and overcome limitations in previous studies which had required restrictive assumptions to be imposed and thereby derive necessary and sufficient conditions for robust output consensus of networked NI systems when such assumptions do not hold. In doing so, the recently published robust NI stability results are utilised. An advantage of the derived conditions is that they depend on the dc and infinite frequency gains of the systems as well as the network graph but not on the precise dynamics of the systems. Furthermore, it is shown that the derived conditions specialise to the earlier results in literature either by imposing the same assumptions or by imposing different ones which had not been known previously. It is also shown that the derived conditions simplify in the single-input single-output case and an intuition about these results is provided. Finally, examples are given which demonstrate the effectiveness of the proposed results over earlier results when earlier assumptions are not met.
- Published
- 2020
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38. Controller Synthesis to Render a Closed Loop Transfer Function Strongly Strictly Negative Imaginary
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Ian R. Petersen, Alexander Lanzon, and Gabriela Salcan-Reyes
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Closed-loop transfer function ,0209 industrial biotechnology ,Class (set theory) ,Interconnection ,Existential quantification ,020208 electrical & electronic engineering ,02 engineering and technology ,020901 industrial engineering & automation ,Transformation (function) ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Closed loop ,The Imaginary ,Mathematics - Abstract
In this paper, we show that there exists an alternative transformation from the class of negative imaginary to the class of positive real systems. We use this to offer a solution to the problem of designing a controller such that the closed loop is strongly strictly negative imaginary and its associated linear fractional interconnection is internally stable.
- Published
- 2018
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39. From the Ground Up: The Alpine and Cross-Country Sportscapes of Gatineau Park, 1910-1967
- Author
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Quinn Lanzon
- Published
- 2018
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40. Cooperative Control of Innovative Tri-Rotor Drones Using Robust Feedback Linearization
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Alexander Lanzon and Junyan Hu
- Subjects
0209 industrial biotechnology ,Adaptive control ,Computer science ,Rotor (electric) ,020208 electrical & electronic engineering ,Swarm behaviour ,02 engineering and technology ,Drone ,law.invention ,020901 industrial engineering & automation ,Control theory ,law ,Control system ,0202 electrical engineering, electronic engineering, information engineering ,Feedback linearization ,Torque vectoring - Abstract
This paper presents a novel distributed formation control architecture for innovative tri-rotor drones. The three rotors of this novel aerial robotic platform can be tilted independently to obtain full force and torque vectoring authority, such that the tri-rotor drone is able to overcome the limitations of a classic quadrotor UAV that can not change its attitude while hovering at a stationary position. In the flight control systems design, a robust feedback linearization controller is first developed to handle the highly coupled and nonlinear dynamics and a distributed adaptive formation control tracking protocol is then designed to control a swarm of tri-rotor UAVs. The 3D position and 3D attitude of each vehicle can be controlled independently to follow a desired formation. The effectiveness of the proposed control strategy is shown via a realistic virtual reality simulation environment that the networked tri-rotor drones are robust to aerodynamic disturbances and model uncertainties.
- Published
- 2018
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41. On negative imaginary synthesis via solutions to Riccati equations
- Author
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Alexander Lanzon and Gabriela Salcan-Reyes
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Set (abstract data type) ,Output feedback ,0209 industrial biotechnology ,020901 industrial engineering & automation ,Property (philosophy) ,Control theory ,020208 electrical & electronic engineering ,0202 electrical engineering, electronic engineering, information engineering ,Order (ring theory) ,02 engineering and technology ,Realization (systems) ,Transfer function ,Mathematics - Abstract
This paper tackles the problem of finding conditions for the existence of an output feedback controller such that the closed-loop system becomes strictly negative imaginary (SNI) and internally stable. In order to achieve this objective, we derive a set of necessary and sufficient conditions to check the SNI property of systems with a non necessarily minimal state-space realization. Then, we propose a set of sufficient conditions for the controller synthesis problem and we also provide a formula for such controller.
- Published
- 2018
- Full Text
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42. Normalized Bicoprime Factorizations
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Alexander Lanzon and Mihalis Tsiakkas
- Subjects
Normalization (statistics) ,Controllability ,0209 industrial biotechnology ,020901 industrial engineering & automation ,Aerospace electronics ,Factorization ,Iterative method ,020208 electrical & electronic engineering ,0202 electrical engineering, electronic engineering, information engineering ,02 engineering and technology ,Observability ,Algorithm ,Mathematics - Abstract
This paper introduces the concept of normalized bicoprime factorizations. The notion of a normalized bicoprime factorization is first defined and conditions for normalization are given in state space. Algorithms that can be used to obtain a normalized bicoprime factorization of the plant are presented.
- Published
- 2018
- Full Text
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43. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis
- Author
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Brad H. Rovin, Neil Solomons, William F. Pendergraft, Mary Anne Dooley, James Tumlin, Juanita Romero-Diaz, Lidia Lysenko, Sandra V. Navarra, Robert B. Huizinga, Ihar Adzerikho, Elena Mikhailova, Natalya Mitkovskaya, Sergey Pimanov, Nikolay Soroka, Boris Iliev Bogov, Boriana Deliyska, Valentin Ikonomov, Eduard Tilkiyan, Ruth Almeida, Fernando Jimenez, Faud Teran, Irma Tchokhonelidze, Nino Tsiskarishvili, Maynor Herrera Mendez, Nilmo Noel Chavez Perez, Arturo Reyes Loaeza, Sergio Ramon Gutierrez Urena, Juanita Romero Diaz, Rodolfo Araiza Casillas, Magdalena Madero Rovalo, Stanislaw Niemczyk, Antoni Sokalski, Andrzej Wiecek, Marian Klinger, Olga V. Bugrova, Tatiana M. Chernykh, Tatiana R. Kameneva, Lidia V. Lysenko, Tatiana A. Raskina, Olga V. ReshEtko, Natalia N. Vezikova, Tatiana V. Kropotina, Adelya N. Maksudova, Vyacheslav Marasaev, Vladimir A. Dobronravov, Ivan Gordeev, Ashot M. EssAian, Alexey Frolov, Rosa Jelacic, Dragan Jovanovic, Branka Mitic, Gordana Pekovic, Milan Radovic, Goran Radunovic, Patricia Carreira, Federico Diaz Gonzalez, Xavier Fulladosa, Eduardo Ucar, Shamila De Silva, Chula Herath, Anura Hewageegana, Abdul Latiff Mohamed Nazar, A.W.M. Wazil, Iryna Dudar, Olga Godlevska, Svitlana Korneyeva, ViktoriIa Vasylets, Nataliya Sydor, Mykola Kolesnyk, Samir V. Parikh, Nancy Olsen, Ellen M. Ginzler, James A. Tumlin, Amit Saxena, Ramesh Saxena, Richard Alan Lafayette, William Franklin Pendergraft, Amber S. Podoll, Annie A. Arrey-Mensah, Michael Bubb, Jennifer Grossman, Alejandro I. Oporta, Alireza Nami, Md. Mujibur Rahman, Syed Atiqul Haq, Tak Mao Daniel Chan, Mok Mo Yin Temy, Harold Michael P. Gomez, James Bermas, Bernadette Heizel Reyes, Llewellyn T. Hao, Linda Charmaine Roberto, Eric Amante, Allan E. Lanzon, Jung-Yoon Choe, Tae Young Kang, Yon Su Kim, Seung-Geun Lee, Ji Soo Lee, Jason Choo Chon Jun, Archana Vasudevan, Shue-Fen Luo, Tien-Tsai Cheng, Bancha Satirapoj, and Kajohnsak Noppakun
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Calcineurin Inhibitors ,030232 urology & nephrology ,Lupus nephritis ,Placebo ,Mycophenolate ,Gastroenterology ,Drug Administration Schedule ,03 medical and health sciences ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,Double-Blind Method ,Internal medicine ,medicine ,Clinical endpoint ,Humans ,Adverse effect ,Glucocorticoids ,Proteinuria ,Dose-Response Relationship, Drug ,business.industry ,Remission Induction ,Mycophenolic Acid ,medicine.disease ,Lupus Nephritis ,Voclosporin ,Calcineurin ,030104 developmental biology ,Treatment Outcome ,chemistry ,Nephrology ,Cyclosporine ,Drug Therapy, Combination ,Female ,medicine.symptom ,business ,Immunosuppressive Agents - Abstract
Calcineurin inhibitors added to standard-of-care induction therapy for lupus nephritis (LN) may increase complete renal remission (CRR) rates. The AURA-LV study tested the novel calcineurin inhibitor voclosporin for efficacy and safety in active LN. AURA-LV was a Phase 2, multicenter, randomized, double-blind, placebo-controlled trial of two doses of voclosporin (23.7 mg or 39.5 mg, each twice daily) versus placebo in combination with mycophenolate mofetil (2 g/d) and rapidly tapered low-dose oral corticosteroids for induction of remission in LN. The primary endpoint was CRR at 24 weeks; the secondary endpoint was CRR at 48 weeks. Two hundred sixty-five subjects from 79 centers in 20 countries were recruited and randomized to treatment for 48 weeks. CRR at week 24 was achieved by 29 (32.6%) subjects in the low-dose voclosporin group, 24 (27.3%) subjects in the high-dose voclosporin group, and 17 (19.3%) subjects in the placebo group (OR=2.03 for low-dose voclosporin versus placebo). The significantly greater CRR rate in the low-dose voclosporin group persisted at 48 weeks, and CRRs were also significantly more common in the high-dose voclosporin group compared to placebo at 48 weeks. There were more serious adverse events in both voclosporin groups, and more deaths in the low-dose group compared to placebo and high-dose voclosporin groups (11.2%, 1.1%, and 2.3%, respectively). These results suggest that the addition of low-dose voclosporin to mycophenolate mofetil and corticosteroids for induction therapy of active LN results in a superior renal response compared to mycophenolate mofetil and corticosteroids alone, but higher rates of adverse events including death were observed.
- Published
- 2018
44. Organoids for Modeling Genetic Diseases
- Author
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Maria, Perez-Lanzon, Guido, Kroemer, and Maria Chiara, Maiuri
- Subjects
Organoids ,Organ Specificity ,Genetic Diseases, Inborn ,Animals ,Humans ,Models, Biological - Abstract
In less than a decade, organoid systems have emerged as an innovative and valid in vitro method to mimic in vivo pathophysiology. Organoids are 3D structures constituted by multiple organ-specific cell types that self-organize and can function as miniature organs. Organoids have quickly become an important tool for basic and translational research with wide applications for disease modeling, drug screening, drug optimization, and personalized and regenerative medicine. In this review, we summarize the recent utilization of organoids for modeling human genetic diseases, a research area with promising biomedical applications.
- Published
- 2018
45. Weight selection in robust control : an optimisation approach
- Author
-
Lanzon, Alexander
- Abstract
This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk., The Library can supply a digital copy for private research purposes; interested parties should submit the request form here: http://www.lib.cam.ac.uk/collections/departments/digital-content-unit/ordering-images, Please note that print copies of theses may be available for consultation in the Cambridge University Library's Manuscript reading room. Admission details are at http://www.lib.cam.ac.uk/collections/departments/manuscripts-university-archives, The primary purpose of this thesis is to present optimisation algorithms which facilitate the selection of weights in robust control techniques. The robust control paradigms investigated in this thesis are ?-synthesis and H? loop-shaping, as these techniques offer a systematic framework for synthesising sensible controllers that meet performance objectives and guarantee robustness to model uncertainty and unmeasured disturbances. This dissertation is essentially composed of two parts. In the first part of the thesis, a conceptually new approach to the ?-synthesis robust performance problem is presented, whereby an optimisation problem is proposed whichmaximises the performance weights in the frequency ranges of interest subject to the existence of an internally stabilising controller that guarantees robust performance with respect to these maximised weights. Thus, performance weights and a robustly stabilising controller are simultaneously synthesised by one algorithm in a systematic way. Two solution algorithms are given for the posed optimisation problem - one being pointwise in frequency and the other using state-space techniques. The latter solution eliminates all of the disadvantages of the pointwise approach and considerably enhances the benefits of this type of optimisation based weight selection. The resulting conceptually novel method for performing ?-synthesis robust performance based design is a valuable alternative to the standard D-K iterative procedure. In the second part of the thesis, several steps of the standard H1 loop-shaping design procedure are combined into one optimisation problem that maximises the robust stability margin over the loop-shaping weights subject to constraints which ensure that the loop-shape and the singular values/ condition numbers of the weights lie in pre-specified regions. In this framework, loop-shaping weights, which can be required to have either a diagonal or a non-diagonal structure, and a robustly stabilising controller are simultaneously synthesised by one algorithm systematically. Correspondingly, the proposed algorithms greatly simplify the design of 'good' performance weights and loop-shaping weights, and hence allow the designer to concentrate on more fundamental design issues. These algorithms also give an indication of what performance is achievable, although further research is required in that direction.
- Published
- 2018
- Full Text
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46. Enhanced Tracking for Nanopositioning Systems Using Feedforward/Feedback Multivariable Control Design
- Author
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Mohamed Kara-Mohamed, William P. Heath, and Alexander Lanzon
- Subjects
Feedback, feedforward, multivariable control design, nanopositioning, tracking ,Engineering ,Adaptive control ,business.industry ,Multivariable calculus ,Open-loop controller ,Feed forward ,Control engineering ,Transfer function ,Factorization ,Control and Systems Engineering ,Control theory ,Robustness (computer science) ,Feedforward neural network ,Electrical and Electronic Engineering ,business - Abstract
This paper proposes a systematic synthesis method- ology for a combined feedforward/feedback architecture to control multiple-input, multiple-output nanopositioning systems. Coprime factorization of the open loop model is used to design the reference and feedforward filters of the proposed control scheme to achieve enhanced tracking, eliminate the limitation of the feed- back on tracking performance, and increase the bandwidth of the closed-loop system. Two types of coprime factorization, namely inner–outer factorization and normalized coprime factorization are discussed. A case study based on hardware experiment is presented to analyze the proposed control architecture and demonstrate its superiority over feedback-only control. In addi- tion to the no-load case, the performance of the system is also tested with loads on the nanopositioning stage.
- Published
- 2015
- Full Text
- View/download PDF
47. A generalized negative imaginary lemma and Riccati-based static state-feedback negative imaginary synthesis
- Author
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Ian R. Petersen, Alexander Lanzon, Mohamed A. Mabrok, and Abhijit G. Kallapur
- Subjects
Lemma (mathematics) ,General Computer Science ,Control and Systems Engineering ,Mechanical Engineering ,Feedback control ,Mathematical analysis ,Uncertain systems ,Electrical and Electronic Engineering ,System definition ,The Imaginary ,Mathematics ,Algebraic Riccati equation - Abstract
In this paper, we present a generalized negative imaginary lemma based on a generalized negative imaginary system definition. Then, an algebraic Riccati equation method is given to determine if a system is negative imaginary. Also, a state feedback control procedure is presented that stabilizes an uncertain system and leads to the satisfaction of the negative imaginary property. The controller synthesis procedure is based on the proposed negative imaginary lemma. Using this procedure, the closed-loop system can be guaranteed to be robustly stable against any strict negative imaginary uncertainty, such as in the case of unmodeled spill-over dynamics in a lightly damped flexible structure. A numerical example is presented to illustrate the usefulness of the results.
- Published
- 2015
- Full Text
- View/download PDF
48. Bicoprime Factor Stability Criteria and Uncertainty Characterisation∗∗This work was financially supported by the UK Engineering and Physical Sciences Research Council (EPSRC) through a Doctoral Training Award (DTA)
- Author
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Alexander Lanzon and Mihalis Tsiakkas
- Subjects
Algebra ,Factorization ,Rank (linear algebra) ,Coprime integers ,Control and Systems Engineering ,Control theory ,Factor (programming language) ,Dimension (graph theory) ,Stability (learning theory) ,Structure (category theory) ,computer ,Mathematics ,computer.programming_language - Abstract
Bicoprime factorisations can be considered a generalisation of the well known coprime factorisations. This paper deals with the possible applications of such factorisations in control theory. The concept of minimal dimension bicoprime factorisations is introduced and shown to be especially beneficial in the case of normal rank deficient and redundant control systems. Some methods of obtaining a bicoprime factorisation for a plant are given based on state-space data, right or left coprime factorisations and left or right standard factorisations. Finally, bicoprime factor uncertainty is characterised and shown to have an interesting structure closely resembling the standard four-block uncertainty.
- Published
- 2015
- Full Text
- View/download PDF
49. H-infinity-PID controller for an open-loop unstable system
- Author
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Alexander Lanzon and Daniel N. Abara
- Subjects
Setpoint ,H-infinity methods in control theory ,Control theory ,Cascade ,Computer science ,Frequency domain ,Open-loop controller ,PID controller ,Ball and beam - Abstract
This paper proposes a H-infinity-PID cascade control technique for the control of an open-loop unstable system, the ball and beam system. This property of being open-loop unstable makes this system ideal for investigating the performance of different control techniques. A 5th order nonlinear model of the ball and beam plant is derived to include the actuation mechanism. A H-infinity-PID controller is proposed and applied to the system using a cascade structure. The control goal is to drive the ball to any desired position on the beam. A check for robustness of the closed loop is also performed using frequency domain methods. The results show that the proposed controller robustly stabilizes the system and equally achieves the setpoint tracking goal. The control voltage which is the control input is also found to be within practicable limits.
- Published
- 2017
- Full Text
- View/download PDF
50. Conditions for preserving negative imaginary properties in feedback interconnections and an application to multi-agent systems
- Author
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Alexander Lanzon, Hsueh-Ju Chen, and Ian R. Petersen
- Subjects
0209 industrial biotechnology ,Interconnection ,Multi-agent system ,Stability (learning theory) ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Transfer function ,020901 industrial engineering & automation ,Control theory ,C++ string handling ,0210 nano-technology ,The Imaginary ,Mathematics ,Positive feedback ,Loop gain - Abstract
We derived necessary and sufficient conditions for a feedback interconnection of negative imaginary systems to have negative imaginary properties. We first consider two negative imaginary systems (or strictly negative imaginary systems) which are interconnected via positive feedback. Then necessary and sufficient conditions for determining whether the feedback interconnection has negative imaginary properties are presented. These conditions are specialised to a dc loop gain that is easy to check under some assumptions. Together with stability results in the literature, these conditions could be applied to check the stability of a string of several coupled negative imaginary subsystems. Such an example is given toillustrate the usefulness of our proposed results.
- Published
- 2017
- Full Text
- View/download PDF
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