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1. Induction of CD8(+) regulatory T cells protects macaques against SIV challenge

Author

Lu, Wei, Chen, S., Lai, C. H., Guo, W. Z., Fu, L. C., and Andrieu, J. M.

Subjects
animal diseases, viruses, virus diseases
Abstract

Efforts to develop a vaccine against HIV have so far met with limited success. Given that CD4(+) T cell activation drives the initial burst of viral replication, we explored in macaques whether an oral vaccine comprised of Lactobacillus plantarum, a commensal bacterium that favors immune tolerance, and inactivated simian immunodeficiency virus mac239 (SIVmac239) would induce CD4(+) T cell unresponsiveness/tolerance toward SIV antigens and thereby prevent the establishment of SIV infection. The tolerogenic vaccine induced MHC-Ib/E-restricted CD8(+) regulatory T cells (Tregs) that suppressed SIV-harboring CD4(+) T cell activation and ex vivo SIV replication in 15 of 16 animals without inducing SIV-specific antibodies or cytotoxic T lymphocytes. Of 16 macaques that were intrarectally challenged with SIVmac239 or heterologous strain SIVB670, 15 were sterilely protected. In four macaques that were rechallenged intravenously, plasma SIV levels peaked slightly and then dropped to undetectable levels, although the animals subsequently harbored intracellular SIV DNA. Infusion of CD8 antibodies confirmed the role of CD8(+) Tregs in preventing/suppressing SIV in vivo. These findings suggest a new avenue of research toward developing an HIV-1 vaccine.

Published
2012

2. Molecular epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China

Author

Chen, S., Cai, W. P., He, J. Y., Vidal, Nicole, Lai, C. H., Guo, W. Z., He, H. L., Chen, X. J., Fu, L. S., Peeters, Martine, Delaporte, Eric, Andrieu, J. M., and Lu, Louis

Subjects
virus diseases
Abstract

Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, the molecular characteristics of such a regional HIV-1 epidemic remained unknown. Methodology/Principal Findings: By sequencing of HIV-1 pol/env genes and phylogenetic analysis, we performed a molecular epidemiologic study in a representative subset (n = 200) of the 508 HIV-1-seropositive individuals followed up at the center for HIV/AIDS care and treatment of Guangzhou Hospital of Infectious Diseases. Of 157 samples (54.1% heterosexual acquired adults, 20.4% needle-sharing drug users, 5.7% receivers of blood transfusion, 1.3% men who have sex with men, and 18.5% remained unknown) with successful sequencing for both pol and env genes, 105 (66.9%) HIV-1 subtype CRF01_AE and 24 (15.3%) CRF07_BC, 9 (5.7%) B', 5 (3.2%) CRF08_BC, 5 (3.2%) B, 1 (0.6%) C, 3 (1.9%) CRF02_AG, and 5 (3.2%) inter-region recombinants were identified within pol/env sequences. Thirteen (8.3%) samples (3 naives, 6 and 5 received with antiretroviral treatment [ART] 1-21 weeks and >= 24 weeks respectively) showed mutations conferring resistance to nucleoside/nonnucleoside reverse transcriptase inhibitors or protease inhibitors. Among 63 ART-naive patients, 3 (4.8%) showed single or multiple drug resistant mutations. Phylogenetic analysis showed 8 small clusters (2-3 sequences/cluster) with only 17 (10.8%) sequences involved. Conclusion/Significance: This study confirms that sexual transmission with dominant CRF01_AE strain is a major risk for current HIV-1 outbreak in the Guangdong's general population. The transmission with drug-resistant variants is starting to emerge in this region.

Published
2012

3. Strengthened quantum Hamming bound

Author

Yu, Sixia, Lai, C. H., and Oh, C. H.

Subjects
Quantum Physics, FOS: Physical sciences, Quantum Physics (quant-ph), Computer Science::Information Theory
Abstract

We report two analytical bounds for quantum error-correcting codes that do not have preexisting classical counterparts. Firstly the quantum Hamming and Singleton bounds are combined into a single tighter bound, and then the combined bound is further strengthened via the well-known Lloyd's theorem in classical coding theory, which claims that perfect codes, codes attaining the Hamming bound, do not exist if the Lloyd's polynomial has some non-integer zeros. Our bound characterizes quantitatively the improvement over the Hamming bound via the non-integerness of the zeros of the Lloyd's polynomial. In the case of 1-error correcting codes our bound holds true for impure codes as well, which we conjecture to be always true, and for stabilizer codes there is a 1-logical-qudit improvement for an infinite family of lengths., Comment: 5 pages

Published
2010
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4. Visualizing and exploring modular networks based on a probabilistic model

Author

Gong, Xiaofeng and Lai, C. -H.

Subjects
Physics - Physics and Society, Physics - Data Analysis, Statistics and Probability, FOS: Physical sciences, Physics and Society (physics.soc-ph), Data Analysis, Statistics and Probability (physics.data-an)
Abstract

We propose a method to investigate modular structure in networks based on fitted probabilistic model, where the connection probability between nodes is related to a set of introduced local attributes. The attributes, as parameters of the empirical model, can be estimated by maximizing the likelihood function of the observed network. We demonstrate that the distribution of attributes provides an informative visulization of modular networks on low-dimensional space, and suggest the attribute space can be served as a better platform for further network analysis.

Published
2009
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5. Manipulating Quantum States of Molecules Created via Photoassociation of Bose-Einstein Condensates

Author

Zhou, Xiao-Ting, Liu, Xiong-Jun, Jing, Hui, Lai, C. H., and Oh, C. H.

Subjects
Condensed Matter::Quantum Gases, Quantum Physics, Condensed Matter::Other, FOS: Physical sciences, Quantum Physics (quant-ph)
Abstract

We show the quantum state transfer technique in two-color photoassociation (PA) of a Bose-Einstein condensate, where a quantized field is used to couple the free-bound transition from atom state to excited molecular state. Under the weak excitation condition, we find that quantum states of the quantized field can be transferred to the created molecular condensate. The feasibility of this technique is confirmed by considering the atomic and molecular decays discovered in the current PA experiments. The present results allow us to manipulate quantum states of molecules in the photoassociation of a Bose-Einstein condensate., Comment: 4 Pages, 1 figure

Published
2007
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8. Decoding Information by Following Parameter Modulation With Parameter Adaptive Control

Author

Zhou, Changsong and Lai, C. -H.

Subjects
FOS: Physical sciences, Chaotic Dynamics (nlin.CD), Nonlinear Sciences - Chaotic Dynamics
Abstract

It has been proposed to realize secure communication using chaotic synchronization via transmission of binary message encoded by parameter modulation in the chaotic system. This paper considers the use of parameter adaptive control techniques to extract the message, based on the assumptions that we know the equation form of the chaotic system in the transmitter but do not have access to the precise values of the parameters which are kept secret as a secure set. In the case that a synchronizing system can be constructed using parameter adaptive control by the transmitted signal and the synchronization is robust to parameter mismatches, the parameter modulation can be revealed and the message decoded without resorting to exact parameter values in the secure set. A practical local Lyapunov function method for designing parameter adaptive control rules based on originally synchronized systems is presented., Comment: 13 pages, 13 figures

Published
2000
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9. Synchronization With Positive Conditional Lyapunov Exponents

Author

Zhou, Changsong and Lai, C. -H.

Subjects
Nonlinear Sciences::Chaotic Dynamics, FOS: Physical sciences, Chaotic Dynamics (nlin.CD), Nonlinear Sciences - Chaotic Dynamics
Abstract

Synchronization of chaotic system may occur only when the largest conditional Lyapunov exponent of the driven system is negative. The synchronization with positive conditional Lyapunov reported in a recent paper (Phys. Rev. E, {\bf 56}, 2272 (1997)) is a combined result of the contracting region of the system and the finite precision in computer simulations., Comment: 6 pages, 7 figures

Published
2000
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10. Amplification of weak signals and stochastic resonance via on-off intermittency with symmetry breaking

Author

Zhou, Changsong and Lai, C. -H.

Subjects
FOS: Physical sciences, Chaotic Dynamics (nlin.CD), Nonlinear Sciences - Chaotic Dynamics
Abstract

Nonlinear dynamical systems possessing reflection symmetry have an invariant subspace in the phase space. The dynamics within the invariant subspace can be random or chaotic. As a system parameter changes, the motion transverse to the invariant subspace can lose stability, leading to on-off intermittency. Under certain conditions, the bursting behavior is symmetry-breaking. We demonstrate the possibility of observing multiplicative noise(chaos)-induced amplification of weak signal and stochastic resonance via on-off intermittency with symmetry breaking in a general class of symmetrical systems. Differences of this mechanism of stochastic resonance to that in noisy bistable or threshold systems are discussed, Comment: 6 pages, 11 figures

Published
2000
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11. GLC project: Linear collider for TeV physics

Author

Abe, Koya, Abe, Toshinori, Aihara, Hiroaki, Akasaka, Nobumasa, Akeroyd, Andrew G., Anami, Shozo, Arai, Yasuo, Araki, Sakae, Araya, Mamoru, Arhrib, Abdesslam, Arogancia, Dennis C., Asai, Shoji, Asakawa, Eri, Asano, Yuzo, Aso, Tsukasa, Baba, Hitoshi, Bacala, Angelina M., Bae, Saebyok, Balakin, Vladimir, Ban, Syuichi, Banerjee, Sunanda, Bhandari, Rakesh K., Bhawalkar, Dilip Devidas, Chang, Yuan-Hann, Chen, June-Rong, Cheung, Kingman, Chikamatsu, Takeshi, Chin, Yong Ho, Choi, Byung-Ho, Choi, Jinhyuk, Choi, Jong Bum, Choi, Seong-Yeol, Francois Corriveau, Delrue, Nicolas, Dobashi, Katsuhiro, Duc, Dao Vong, Endo, Ichita, Endo, Kuninori, Enomoto, Atsushi, Fang, Shouxian, Fu, Yu, Fujii, Keisuke, Fujii, Yoshiaki, Fujimoto, Daijiro, Fujimoto, Junpei, Fujiwara, Kouhei, Fukuda, Masafumi, Fukuda, Shigeki, Funahashi, Yoshisato, Furukawa, Kazuro, Furuta, Fumio, Furuya, Takaaki, Gao, Yuanning, Ghosh, Dilip K., Godbole, Rohini M., Gooc, Hermogenes Jr C., Guo, Zhi Yuan, Guoxi, Pei, Gurtu, Atul, Haba, Junji, Hagiwara, Kaoru, Hamaguchi, Koichi, Hamatsu, Ryosuke, Han, Bo Young, Han, Tao, Hara, Kazuhiko, Hara, Takanori, Hasegawa, Katsushi, Hasegawa, Takuya, Hashiguchi, Hidenori, Hashimoto, Shoji, Hashimoto, Yoshinori, Hayano, Hitoshi, Hayasaka, Takaya, Hayashii, Hisaki, He, Mao, Hemmi, Yasuo, Hidaka, Keisho, Higashi, Norio, Higashi, Yasuo, Higo, Toshiyasu, Higuchi, Masato, Hikasa, Ken-Ichi, Hinode, Fujio, Hioki, Zenro, Hirose, Tachishige, Hirose, Tomonori, Hisano, Junji, Hitomi, Nobuteru, Honda, Yousuke, Hong, Kim Shim, Hori, Michihiro, Horinaka, Hiromichi, Hoshina, Kotoyo, Hosoyama, Kenji, Hou, George W. S., Hsu, Kuotung, Huang, Chao-Shang, Huang, Hsuan-Cheng, Huang, Tao, Hui, He Duo, Hwang, Pauchy W-Y, Ichizaki, Yohei, Igi, Keiji, Iijima, Hokuto, Iijima, Toru, Ikegami, Masahiro, Ikematsu, Katsumasa, Imai, Takayuki, Inami, Takeo, Ishida, Takuya, Ishihara, Nobuhiro, Ishihara, Satoshi, Ishii, Koji, Ishii, Takehiko, Ishikawa, Tadashi, Ishino, Masaya, Ishizawa, Yoshio, Ito, Ikuo, Iwai, Go, Iwasaki, Masako, Iwashita, Yoshihisa, Iwata, Seigi, Jackson, Dave, Jagannathan, Ramaswamy, Javanmardi, Farhad, Jimbo, Masato, Jin, L. H., Jogolev, Pavel, Joshi, Satish C., Kajikawa, Ryoichi, Kajino, Fumiyoshi, Kamada, Masao, Kamada, Susumu, Kamitani, Takuya, Kamiya, Yoshio, Kamiya, Yousuke, Kamiya, Yukihide, Kamiyama, Takashi, Kamoshita, Jun-Chi, Kaneko, Toshiaki, Kanemura, Shinya, Kang, Joo Hwan, Kang, Joo Sang, Kanzaki, Jun-Ichi, Karataev, Pavel, Karita, Yukio, Kasai, Tadashi, Kashiwagi, Shigeru, Kato, Kiyoshi, Kato, Shigeki, Kato, Yukihiro, Katoh, Tadahiko, Katou, Yoshiaki, Kawabata, Setsuya, Kawagoe, Kiyotomo, Kawai, Hideyuki, Kawamoto, Tatsuo, Kazakov, Sergei, Khalatyan, Norik, Khan, Sameen Ahmed, Khiem, Le Hong, Kikuchi, Mitsuo, Kim, Choong Sun, Kim, Eun-San, Kim, Hong Joo, Kim, Hyunwoo, Kim, K. W., Kim, M. G., Kim, Shinhong, Kim, Sun Kee, Kimura, Yoshitaka, Kitano, Ryuichiro, Kitazawa, Yoshihisa, Kiyo, Yuichiro, Kiyoura, Shingo, Ko, Pyungwon, Kobayakawa, Hisashi, Kobayashi, Katsuyuki, Kobayashi, Makoto, Kodaira, Jiro, Koike, Shigeaki, Koiso, Haruyo, Koizumi, Susumu, Komamiya, Sachio, Komatsubara, Takeshi, Komine, Shinji, Kon, Tadashi, Kondo, Kenjiro, Kuang, Yu Ping, Kubo, Kiyoshi, Kuboshima, Rie, Kudoh, Noboru, Kumada, Masayuki, Kumano, Satoshi, Kume, Tatsuya, Kumita, Tetsuro, Kuno, Yoshitaka, Kurashige, Hisaya, Kurata, Masakazu, Kurihara, Yoshimasa, Kuriki, Masao, Kuroda, Masaaki, Kuroda, Ryunosuke, Kuroda, Shigeru, Kuroiwa, Hirotoshi, Kurokawa, Shin-Ichi, Kuwahara, Makoto, Kwon, Young Joon, Lai, C. H., Lai, Hung-Liang, Larionov, Alexei, Lee, Jae Sik, Lee, Jungil, Lee, Kang Young, Lee, Su Kyoung, Lee, Tae-Yeon, Li, Chong-Sheng, Li, Hsiang-Nan, Liao, Yi, Lin, Chih-Hsun, Lin, Guey-Lin, Lin, Willis T., Lin, Zhi-Hai, Long, Hoang N., Lu, Hong-Liang, Lunin, Andrei, Luo, Minxing, Luo, Xiaoan, Ma, Bo-Qiang, Ma, Wen-Gan, Maeno, Tadashi, Magallanes, Jingle B., Maki, Akihiro, Masaike, Akira, Mashimo, Tetsuro, Masuyama, Atsuhiko, Masuzawa, Mika, Matsuda, Takeshi, Matsui, Takayuki, Matsukado, Koji, Matsumoto, Hiroshi, Matsumoto, Shuji, Matsunaga, Hiroyuki, Matsushita, Takashi, Matsuyama, Tetsuya, Michizono, Shinichiro, Mihara, Satoshi, Minh, Tran Thanh, Mitsuhashi, Toshiya, Miyabayashi, Kenkichi, Miyamoto, Akiya, Miyamoto, Masaharu, Miyano, Kazumasa, Miyata, Hitoshi, Mizuno, Hajime, Mizuno, Ryu, Mori, Toshinori, Moroi, Takeo, Morozumi, Takuya, Morozumi, Yuichi, Munehisa, Tomo, Murayama, Hitoshi, Muto, Masafumi, Muto, Toshiya, Nagamine, Tadashi, Nagashima, Yorikiyo, Naito, Takashi, Nakai, Koji, Nakajima, Kazuhisa, Nakajima, Noriko, Nakamura, Isamu, Nakamura, Miwako, Nakamura, Shogo, Nakanishi, Tsutomu, Nakano, Eiichi, Nakata, Yuichi, Nakayama, Hisayoshi, Nakazawa, Nobuya, Namito, Yoshihito, Namkung, Won, Naumenko, Gennady, Nguyen, Anh Ky, Nguyen, Do, Ninomiya, Masao, Nishiguchi, Hajime, Nishikawa, Koichiro, Nishitani, Tomohiro, Nitoh, Osamu, Niwa, Koyu, Nojiri, Mihoko, Nomura, Daisuke, Nozaki, Mituaki, Odagiri, Jun-Ichi, Odagiri, Kosuke, Odaka, Shigeru, Ogawa, Yujiro, Oh, Jong-Seok, Oh, Sejong, Oh, Sunkun, Ohama, Taro, Ohgaki, Tomomi, Ohkuma, Kazumasa, Ohsawa, Satoshi, Ohshima, Takayoshi, Ohta, Shigemi, Ohya, Keiji, Oide, Katsunobu, Okada, Yasuhiro, Okugi, Toshiyuki, Okumi, Shoji, Okuno, Hideki, Okusawa, Tohru, Omori, Tsunehiko, Onishi, Yukiyoshi, Ono, Hiroaki, Ootani, Wataru, Orito, Shuji, Ozaki, Toshiyuki, Ozone, Kenji, Pairsuwan, Weerapong, Park, Chul-Hi, Park, Hwan-Bae, Park, Il Hung, Park, Seong Chan, Perret-Gallix, Denis, Potylitsyn, Alexandere, Qing, Qin, Rindani, Saurabh D., Roy, Amit, Roy, Probir, Saito, Kotaro, Saito, Yoshio, Sakai, Hiroshi, Sakai, Izumi, Sakamoto, Yutaka, Sakanaka, Shogo, Sanchez, Allister Levi C., Sanda, Ichiro, Sanuki, Tomoyuki, Sasaki, Ken, Sasao, Noboru, Sekiguchi, Katsumi, Senaha, Eibun, Sendai, Hiroshi, Sezaki, Tadashi, Shang, Renchang, Shen, Xiaoyan, Shidara, Tetsuo, Shimizu, Yasuhiro, Shimizu, Yoshimitsu, Shintake, Tsumoru, Shioden, Masaomi, Shirakabe, Yoshihisa, Sirai, Miyuki, Solidum, Ruelson S., Son, Dongchul, Song, Jeonghyeon, Stefanov, Konstantin, Sugahara, Ryuhei, Sugamoto, Akio, Sugawara, Hirotaka, Sugimoto, Shojiro, Sugimoto, Yasuhiro, Sugiyama, Akira, Sugiyama, Harue, Sumi, Yoshio, Sumino, Yukinari, Suzuki, Chihiro, Suzuki, Shiro, Suzuki, Toshikazu, Takahashi, Chikako, Takahashi, Shinya, Takahashi, Tamotsu, Takahashi, Tohru, Takano, Mikio, Takasaki, Eichi, Takasaki, Fumihiko, Takashima, Yoshifumi, Takasu, Yuko, Takata, Koji, Takatomi, Toshazu, Takayama, Hiroya, Takayanagi, Yuichi, Takeda, Hiroshi, Takeda, Seishi, Takeda, Shigeru, Takeshita, Tohru, Takeuchi, Yasunori, Takikawa, Koji, Tamura, Fumihiko, Tamura, Norio, Tanabe, Kenji, Tanaka, Hidekazu, Tanaka, Junichi, Tanaka, Kazuhiro, Tanaka, Manobu, Tanaka, Minoru, Tanaka, Reisaburo, Tanaka, Senku, Tauchi, Toshiaki, Tawada, Masafumi, Tejima, Masami, Teramoto, Yoshiki, Terazawa, Hidezumi, Terunuma, Nobuhiro, Teryaev, Vladimir, Tobimatsu, Keijiro, Togawa, Kazuaki, Toge, Nobukazu, Tokumoto, Shuichi, Tong, Guoling, Toomi, Nobuko, Totsuka, Yoji, Tovey, Stuart N., Tseng, Jie-Jun, Tsuchiya, Kiyosumi, Tsukamoto, Toshifumi, Tsukamoto, Toshio, Tsutsui, Hiroshi, Uehara, Yosuke, Ueno, Koji, Uesaka, Misturu, Umeda, Yoshiaki, Uozumi, Satoru, Urakawa, Junji, Usiroda, Yutaka, Vicente, Ian Ceasar M., Vogel, Vladimir, Wada, Kenji, Wada, Koji, Wang, Jian-Xiong, Wang, Jiu Qing, Wang, Minzu, Wang, Qing, Washio, Masakazu, Watanabe, Isamu, Watanabe, Osamu, Watanabe, Takashi, Watanabe, Yuichi, White, John W., Won, Eunil, Wu, Yue-Liang, Xiaoan, Luo, Yamada, Sakue, Yamada, Youichi, Yamaguchi, Akira, Yamaguchi, Masahiro, Yamaguchi, Seiya, Yamaki, Tetsuji, Yamamoto, Hitoshi, Yamamoto, Masahiro, Yamamoto, Naoto, Yamamoto, Noboru, Yamamoto, Yasuchika, Yamamura, Taiki, Yamanaka, Taku, Yamaoka, Hiroshi, Yamashita, Satoru, Yamauchi, Masanori, Yamazaki, Yoshishige, Yang, Hey Young, Yang, Jin Min, Yang, Jong Mann, Yano, Yoshiharu, Yasui, Yoshiaki, Yeh, G. P., Yokoya, Kaoru, Yoshida, Mitsuhiro, Yoshida, Tetsuya, Yoshioka, Arifumi, Yoshioka, Masakazu, Yu, Geumbong, Yuan, C. -P, Yuasa, Fukuko, Zhang, Chuang, Zhang, De-Hong, Zhang, Xinmin, Zhang, Xueyao, Zhao, Ding Da, Zhao, Zheng-Guo, Zhou, Hong-Yi, Zhu, Shou-Hua, and Zhu, Yong-Sheng

12. GLD Detector Outline Document: Version 1.2

Author

Abe, Koh, Abe, Koya, Abe, Toshinori, Ando, Shinichiro, Andricek, Laci, Anraku, Kazuaki, Arogancia, Dennis C., Asakawa, Eri, Asano, Yuzo, Asaoka, Yoichi, Aso, Tsukasa, Bacala, Angelina M., Bae, Saebyok, Banerjee, Sunanda, Brau, James E., Calderini, Giovanni, Chang, Ming-Chuan, Chang, Paoti, Chang, Yuan-Hann, Checchia, Paolo, Cheon, Byung Gu, Chi, Yamkun, Chikamatsu, Takeshi, Choi, Jong Bum, Choi, Seong Youl, Choi, Youngil, Corriveau, Francois, Cremaldi, Lucien, Damerell, Chris, Delerue, Nicolas, Dixit, Madhu, Eckerlin, Guenter, Fleischer, Manfred, Fujii, Yoshiaki, Fujikawa, Tomoaki, Fujimoto, Daijiro, Fujimoto, Junpei, Fuke, Hideyuki, Gao, Yuanning, Joel Goldstein, Graf, Norman, Groot, Nicolo, Gurtu, Atul, Ha, Hyun Cheong, Haino, Sadakazu, Han, Bo Young, Hara, Kazuhiko, Hasegawa, Takuya, Gooc, Hermogenes C., Heusch, Clemens, Higuchi, Masato, Hillert, Sonja, Hioki, Zenro, Hoshina, Kotoyo, Hou, George W. S., Hsiung, Yee Bob, Huang, Chao-Shang, Huang, Hsuan-Cheng, Huang, Tao, Hwang, Pauchy W-Y, Hyun, Hyojung, Ikegami, Masahiro, Ikematsu, Katsumasa, Imhof, Andreas, Ishihara, Nobuhiro, Ishii, Koji, Ishizawa, Yoshio, Itoh, Saori, Iwasaki, Masako, Iwashita, Yoshihisa, Jackson, Dave, Jaros, John, Kah, Dongha, Kajikawa, Ryoichi, Kajino, Fumiyoshi, Kang, Joo Hwan, Kang, Joo Sang, Kanzaki, Jun-Ichi, Kato, Kiyoshi, Kato, Yukihiro, Katou, Yoshiaki, Kawabata, Setsuya, Kawagoe, Kiyotomo, Khalatyan, Norik, Khan, Sameen Ahmed, Kim, Dong Hee, Kim, Gui Nyun, Kim, Hongjoo, Kim, Shinghong, Kim, Sun Kee, Kim, Youngim, Kobayashi, Makoto, Komamiya, Sachio, Komine, Shinji, Kuang, Yu Ping, Kubo, Kiyoshi, Kumada, Masayuki, Kurashige, Hisaya, Kurihara, Yoshimasa, Kuroda, Shigeru, Kwon, Young Joon, Ky, Nguyen Anh, Lai, C. H., Ledu, Patrick, Lee, Jik, Lee, Kang Young, Li, Weiguo, Lin, Chih-Hsun, Lin, Willis T., Lin, Zhi-Hai, Luo, Minxing, Magallanes, Jingle B., Majumder, Gobinda, Maki, Akihiro, Mashimo, Tetsuro, Matsuda, Shinya, Matsuda, Takeshi, Matsui, Nagataka, Matsui, Takayuki, Matsumoto, Hiroshi, Matsumoto, Takeshi, Matsunaga, Hiroyuki, Mihara, Satoshi, Mihara, Takanori, Mikhailichenko, Alexander A., Miyamoto, Akiya, Miyata, Hitoshi, Mondal, Naba K., Moretti, Stefano, Morgunov, Vasily, Mori, Toshinori, Moser, Hans-Guenther, Nagamine, Tadashi, Nagano, Ai, Nagashima, Yorikiyo, Nakajima, Noriko, Nakamura, Isamu, Nakamura, Miwako, Nakanishi, Tsutomu, Nakano, Eiichi, Nam, Shinwoo, Namito, Yoshihito, Nauenberg, Uriel, Nishiguchi, Hajime, Nitoh, Osamu, Nozaki, Mitsuaki, Oh, Sunkun, Oh, Youngdo, Ohama, Taro, Oide, Katsunobu, Okada, Nobuchika, Okada, Yasuhiro, Okuno, Hideki, Omori, Tsunehiko, Ono, Hiroaki, Onuki, Yoshiyuki, Ootani, Wataru, Ozone, Kenji, Park, Chawon, Park, Hwanbae, Park, Il Hung, Proulx, Joseph, Reserva, Rosario L., Riles, Keith, Ronan, Mike, Saito, Kotaro, Sakai, Kazuyuki, Sanchez, Allister Levi C., Sanuki, Tomoyuki, Sekiguchi, Katsumi, Sendai, Hiroshi, Seryi, Andrei, Settles, Ron, Shang, Rencheng, Shen, Xiaoyan, Shikaze, Yoshiaki, Shioden, Masaomi, Si, Zongguo, Siddiqui, Azher M., Sirai, Miyuki, Solidum, Ruelson S., Son, Dongchul, Stoeck, Holger, Sugawara, Hirotaka, Sugimoto, Yasuhiro, Sugiyama, Akira, Sukhanov, Alexander, Suzuki, Shiro, Suzuki, Takashi, Takahashi, Tamotsu, Takahashi, Tohru, Takeda, Hiroshi, Takeda, Seishi, Takeshita, Tohru, Tamura, Norio, Tanabe, Kenji, Tani, Nobuhiro, Tauchi, Toshiaki, Teramoto, Ii Yoshiki, Thomson, Mark, Tovey, Stuart, Trimpl, Marcel, Tsuchiya, Kiyosumi, Tsukamoto, Toshifumi, Ueno, Koji, Ujiie, Norihiko, Uozumi, Satoru, Kooten, Rick J., Wang, Jian-Xiong, Wang, Minzu, Watanabe, Isamu, Watanabe, Takashi, White, Andy, Wilson, Graham W., Wing, Matthew, Won, Eunil, Yamada, Sakuei, Yamaguchi, Atsushi, Yamamoto, Hitoshi, Yamamoto, Noboru, Yamamoto, Sumie, Yamamura, Taiki, Yamaoka, Hiroshi, Yamashita, Satoru, Yamauchi, Shin, Yang, Hey Young, Yang, Jongman, Yokoya, Kaoru, Yoshida, Tetsuya, Yoshioka, Tamaki, Yu, Geumbong, Yu, Intae, Zhang, De-Hong, Zhang, Xinmin, Zhao, Zheng-Guo, and Zhu, Yong-Sheng

22. Preoperative Portal Vein Embolization for Hilar Cholangiocarcinoma - a Comparative Study

Author

Bin Yi, Xu Ai-Min, Eric, Lai C. H., Qu Zeng-Qiang, Cheng Qing-Bao, Liu Chen, Luo Xiang-Ji, Yu Yong, Qiu Ying-He, Wang Xiao-Yan, Cheng Hong-Yan, Zhang Bai-He, Shen Feng, Yee, Lau Wan, Wu Meng-Chao, and Jiang Xiao-Qing

Subjects
Male, Chi-Square Distribution, Portal Vein, Hepatic Duct, Common, Middle Aged, Combined Modality Therapy, Embolization, Therapeutic, Postoperative Complications, Treatment Outcome, Bile Duct Neoplasms, Liver Function Tests, Hepatectomy, Humans, Female, Klatskin Tumor
Abstract

Preoperative portal vein embolization (PVE) allows potentially curative hepatic resection to be carried out in patients with hepatobiliary malignancies who are otherwise not candidates for resection because of the small size of the future liver remnant (FLR). However, there have only been a few reports on PVE before hepatectomy for hilar cholangiocarcinoma due to the small number of patients who can be treated with radical surgery.Between January 2007 and March 2009, 49 consecutive patients with hilar cholangiocarcinoma who were planned to have hemi-hepatectomy/extended hemi-hepatectomy plus caudate lobe resection in our tertiary referral center were studied. The change in size of the FLR and the operative outcomes were compared between patients with or without PVE.All patients had liver dysfunction as a result of biliary obstruction due to hilar cholangiocarcinoma although they had all received percutaneous transhepatic biliary drainage. PVE was used in 16 patients with an estimated FLR of50%, while no PVE was carried out in 33 patients with an estimated FLR of50%. Complications after PVE occurred in 3 patients (18.8%), which included bile leakage (n=1) and coil displacement (n=2). No complication precluded liver resection. The FLR to total liver volume (TLV) ratio at presentation was significantly smaller in patients who underwent PVE than those who did not undergo PVE (40.3 +/- 7.4% vs. 56.6 +/- 5.0%; p0.001). After PVE, the FLR to TLV ratio increased significantly (40.3 +/- 7.4% vs. 43.1 +/- 7.0%; p0.001) at a mean time of 14.2 +/- 3.5 days. The mean +/- S.D. increase in FLR was 4.6 +/- 3.0 cm3/day. At surgery, the FLR volume was still significantly smaller in the PVE group than the non-PVE (802 +/- 216 cm3 vs. 979 +/- 202 cm3; p = 0.007). In the PVE group, insufficient hypertrophy of the FRL prevented one patient from having surgery, while local tumor progression and peritoneal dissemination precluded hepatectomy in 2 more patients. Finally, 13 patients (81.3%) underwent radical surgery. The PVE group had similar complication and mortality rates compared with the non-PVE group (complication rate, 69.2% vs. 63.6%; mortality rate, 0.0% vs. 9.1%). The 1- and 2-year overall survivals for the PVE group (with intent-to-treat analysis), PVE group (radical surgery only) and the non-PVE group were 57.3% and 43.0%; 71.3% and 53.5%; 70.4% and 54.4%, respectively. There was no significant difference in the survival outcomes.The results suggested that PVE is a safe and efficacious procedure in inducing adequate hypertrophy of the FLR before major hepatic resection for hilar cholangiocarcinoma with obstructive jaundice which had been relieved by percutaneous transhepatic biliary drainage.

30. Particle physics experiments at JLC

Author

Abe, Koh, Abe, Koya, Abe, Toshinori, Akeroyd, Andrew G., Anraku, Kazuaki, Araya, Mamoru, Arhrib, Abdesslam, Arogancia, Dennis C., Asai, Shoji, Asakawa, Eri, Asano, Yuzo, Asaoka, Yoichi, Aso, Tsukasa, Bacala, Angelina M., Bae, Sae-Byok, Banerjee, Sunanda, Chang, Yuan-Hann, Cheung, King-Man, Chikamatsu, Takeshi, Choi, Jong Bum, Choi, Seong Yeol, Corriveau, Francois, Dobashi, Katsuhiro, Duc, Dao Vong, Endo, Ichita, Fu, Yu, Fujii, Keisuke, Fujii, Yoshiaki, Fujikawa, Motoharu, Fujimoto, Daijiro, Fujimoto, Junpei, Fuke, Hideyuki, Gao, Yuan-Ning, Ghosh, Dilip K., Godbole, Rohini M., Jiang, Yi, Jimbo, Masato, Gooc, Hermogenes C., Gurtu, Atul, Hagiwara, Kaoru, Haino, Sadakazu, Han, Bo Young, Han, Tao, Hara, Kazuhiko, Hashiguchi, Hidenori, Hayasaka, Takaya, He, Mao, Hemmi, Yasuo, Hidaka, Keisho, Higuchi, Masato, Hikasa, Ken-Ichi, Hioki, Zenro, Hirose, Tachishige, Hori, Michihiro, Hoshina, Kotoyo, Hou, George W. S., Huang, Chao-Shang, Huang, Hsuan-Cheng, Huang, Tao, Hwang, Pauchy W. Y., Ichizaki, Yohei, Ikematsu, Katsumasa, Ishida, Takuya, Ishihara, Nobuhiro, Ishihara, Satoshi, Ishizawa, Yoshio, Ito, Ikuo, Iwata, Seigi, Izumi, Kosuke, Jackson, Dave, Jagannathan, Ramaswamy, Javanmardi, Farhad, Kajikawa, Ryoichi, Kajino, Fumiyoshi, Kamoshita, Jun-Ichi, Kanemura, Shinya, Kang, Joo Hwan, Kang, Joo Sang, Kanzaki, Jun-Ichi, Kato, Kiyoshi, Kato, Yukihiro, Katou, Yoshiaki, Kawabata, Setsuya, Kawagoe, Kiyotomo, Khalatyan, Norik, Sameen Khan, Khiem, Le Hong, Kim, Choong Sun, Kim, Hong Joo, Kim, Hyun-Woo, Kim, Shing-Hong, Kim, Sun Kee, Kiyoura, Shingo, Kiyo, Yuichiro, Ko, Pyung-Won, Kobayashi, Katsuyuki, Kobayashi, Makoto, Kodaira, Jiro, Komamiya, Sachio, Komine, Shinji, Kon, Tadashi, Kuang, Yu Ping, Kubo, Kiyoshi, Kuboshima, Rie, Kumano, Satoshi, Kundu, Anirban, Kurashige, Hisaya, Kurihara, Yoshimasa, Kuroiwa, Hirotoshi, Kwon, Young Joon, Lai, C. H., Lai, Hung-Liang, Lee, Hong-Seok, Lee, Jae Sik, Lee, Jungil, Lee, Kang Young, Lee, Su Kyoung, Li, Chong-Sheng, Li, Hsiang-Nan, Li, Xue-Qian, Liao, Yi, Lin, Chih-Hsun, Lin, Willis T., Lin, Zhi-Hai, Long, Hoang Ngoc, Lu, Hong-Liang, Luo, Min-Xing, Ma, Bo-Qiang, Ma, Wen-Gan, Magallanes, Jingle B., Mashimo, Tetsuro, Masuyama, Atsuhiko, Matsuda, Shinya, Matsuda, Takeshi, Matsui, Nagataka, Matsui, Takayuki, Matsukado, Koji, Matsumoto, Hiroshi, Matsunaga, Hiroyuki, Mihara, Satoshi, Mitsuhashi, Toshiya, Miyamoto, Akiya, Miyata, Hitoshi, Mori, Toshinori, Moroi, Takeo, Morozumi, Takuya, Muto, Toshiya, Nagamine, Tadashi, Nagashima, Yorikiyo, Nakajima, Noriko, Nakamura, Isamu, Nakamura, Miwako, Nakanishi, Tsutomu, Nakano, Eiichi, Nakata, Yuichi, Namito, Yoshihito, Anh Ky, Nguyen, Nishiguchi, Hajime, Nitoh, Osamu, Nojiri, Mihoko, Nozaki, Mitsuaki, Odagiri, Kosuke, Oh, Sun-Kun, Ohama, Taro, Ohgaki, Tomomi, Oide, Katsunobu, Okada, Yasuhiro, Okuno, Hideki, Omori, Tsunehiko, Onuki, Yoshiyuki, Ootani, Wataru, Ozone, Kenji, Park, Chul-Hi, Park, Hwan-Bae, Park, Il Hung, Park, Seong Chan, Rindani, Saurabh D., Roy, Probir, Roy, Sourov, Saito, Kotaro, Sanchez, Allister Levi C., Sanuki, Tomoyuki, Sekiguchi, Katsumi, Sendai, Hiroshi, Sezaki, Tadashi, Shang, Ren-Cheng, Shen, Xiao-Yan, Shikaze, Yoshiaki, Shioden, Masaomi, Sirai, Miyuki, Solidum, Ruelson S., Song, Jeong-Hyeon, Song, H. S., Sonoda, Tomohiro, Stefanov, Konstantin, Sugimoto, Yasuhiro, Sugiyama, Akira, Sumino, Yukinari, Suzuki, Shiro, Takahashi, Shinya, Takahashi, Tamotsu, Takahashi, Tohru, Takeda, Hiroshi, Takeshita, Tohru, Tamura, Norio, Tauchi, Toshiaki, Teramoto, Yoshiki, Togawa, Kazuaki, Tong, Guo-Ling, Tovey, Stuart N., Tsuchiya, Kiyosumi, Tsukamoto, Toshifumi, Tsukamoto, Toshio, Uehara, Yosuke, Ueno, Koji, Umeda, Yoshiaki, Uozumi, Satoru, Wang, Jian-Xiong, Wan, Lang-Hui, Wang, Min-Zu, Wang, Qing, Watanabe, Isamu, Watanabe, Takashi, Won, Eu-Nil, Wu, Yue-Liang, Yamada, Youichi, Yamamoto, Hitoshi, Yamamoto, Noboru, Yamamoto, Yasuchika, Yamaoka, Hiroshi, Yamashita, Satoru, Yang, Hey Young, Yang, Jin Min, Yanga, Danilo, Yasui, Yoshinori, Yeh, G. P., Yokoya, Kaoru, Yoshida, Tetsuya, Yu, Chae-Hyn, Yu, Geum-Bong, Zhang, De-Hong, Zhang, Xin-Min, Zhang, Xue-Yao, Zhao, Zheng-Guo, Zhou, Fei, Zhou, Hong-Yi, Zhu, Shou-Hua, and Zhu, Yong-Sheng

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