7 results on '"L.A. Sosa-Lozano"'
Search Results
2. Role of the Envisia Genomic Classifier in Establishing a Diagnosis of Idiopathic Pulmonary Fibrosis
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M. Abdalla, C. Castellani, M. Barash, L.H. Santo Tomas, R.J. Lipchik, J.S. Kurman, L.A. Sosa Lozano, N. Rao, V.S. Ramalingam, and B.S. Benn
- Published
- 2021
3. Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency
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John M. Routes, Carlyne D. Cool, Pippa Simpson, Erin Hammelev, Alyssa Busalacchi, Jeff Woodliff, Amy Rymaszewski, James W. Verbsky, Dhiraj Baruah, Mingen Feng, Nagarjun Rao, Mary T. Bausch-Jurken, Jody Barbeau, Shaoying Chen, L.A. Sosa-Lozano, and Mary Hintermeyer
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,High-resolution computed tomography ,Adolescent ,Immunology ,Azathioprine ,Pulmonary function testing ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,DLCO ,Immunology and Allergy ,Medicine ,Humans ,Enzyme Inhibitors ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Common variable immunodeficiency ,Interstitial lung disease ,Mycophenolic Acid ,medicine.disease ,Respiratory Function Tests ,030104 developmental biology ,Common Variable Immunodeficiency ,Rituximab ,Female ,Radiology ,business ,Complication ,Lung Diseases, Interstitial ,Immunosuppressive Agents ,030215 immunology ,medicine.drug - Abstract
Background Granulomatous and lymphocytic interstitial lung disease (GLILD) is a life-threatening complication in patients with common variable immunodeficiency (CVID), but the optimal treatment is unknown. Objective Our aim was to determine whether rituximab with azathioprine or mycophenolate mofetil improves the high-resolution computed tomography (HRCT) chest scans and/or pulmonary function test results in patients with CVID and GLILD. Methods A retrospective chart review of clinical and laboratory data on 39 patients with CVID and GLILD who completed immunosuppressive therapy was performed. Chest HRCT scans, performed before therapy and after the conclusion of therapy, were blinded, randomized, and scored independently by 2 radiologists. Differences between pretreatment and posttreatment HRCT scan scores, pulmonary function test results, and lymphocyte subsets were analyzed. Whole exome sequencing was performed on all patients. Results Immunosuppressive therapy improved patients' HRCT scan scores (P Conclusions Immunosuppressive therapy improved the radiographic abnormalities and pulmonary function of patients with GLILD. A majority of patients had sustained remissions.
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- 2020
4. Diagnóstico y cuantificación de fibrosis, esteatosis y hepatosiderosis por medio de resonancia magnética multiparamétrica
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A. Loaeza-del Castillo, E. Wolpert-Barraza, E. Kimura-Hayama, Y. Kimura-Fujikami, M. Stoopen-Rometti, R. Favila, C.R. Ramirez-Carmona, E.R. Encinas-Escobar, J.A. Saavedra-Abril, and L.A. Sosa-Lozano
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Hepatitis virales ,business.industry ,Gastroenterology ,Hepatosiderosis ,Fibrosis ,Esteatohepatitis ,030218 nuclear medicine & medical imaging ,Elastografía por resonancia-magnética ,03 medical and health sciences ,0302 clinical medicine ,Esteatosis ,Medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,lcsh:RC799-869 ,business ,Humanities - Abstract
Resumen Antecedentes La presencia de fibrosis hepatica es el denominador comun de numerosas enfermedades cronicas del higado que pueden evolucionar a fibrosis y a hepatocarcinoma. Las mas importantes por su frecuencia son las hepatitis virales y el higado graso no alcoholico, cuya prevalencia aumenta en proporciones epidemicas. La biopsia hepatica, aun cuando imperfecta, continua siendo el estandar de oro que tiende a ser reemplazado en muchas situaciones clinicas por metodos de imagen no invasivos. Objetivos Describir la experiencia obtenida en nuestro departamento de imagen con la tecnica de elastografia por resonancia magnetica, analizar y comentar los resultados publicados por otros autores en la literatura reciente en gastroenterologia, hepatologia y radiologia, complementada con una busqueda en PubMed de los ultimos 10 anos. Resultados y conclusiones La elastografia por resonancia magnetica es un metodo no invasivo y eficaz, cuyos resultados tienen concordancia con la biopsia hepatica, presenta superioridad sobre los metodos de elastografia por ultrasonido debido a que evalua un volumen mucho mayor de tejido hepatico y muestra la distribucion de las lesiones que, a menudo, es heterogenea. La mayor ventaja del protocolo de resonancia magnetica descrito estriba en cuantificar en la misma sesion, ademas de la fibrosis, el contenido de grasa y de hierro, lo cual se realiza en una exploracion dirigida especificamente a este fin, en un tiempo de 25 min y a un costo-beneficio favorable para el paciente y la institucion.
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- 2017
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5. Methods for measuring abdominal obesity in the prediction of severe acute pancreatitis, and their correlation with abdominal fat areas assessed by computed tomography
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Á. Saúl, L.A. Sosa-Lozano, Jaime O. Herrera-Caceres, J. Vázquez-Lamadrid, G. Robles-Díaz, C. Hernández-Cárdenas, and A. Duarte-Rojo
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medicine.medical_specialty ,Waist ,Pancreatic disease ,Hepatology ,business.industry ,Gastroenterology ,Anthropometry ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Internal medicine ,medicine ,Abdomen ,Pancreatitis ,Acute pancreatitis ,Pharmacology (medical) ,medicine.symptom ,business ,Body mass index ,Abdominal obesity - Abstract
Aliment Pharmacol Ther 2010; 32: 244–253 Summary Background Obesity increases the risk for severe acute pancreatitis, although abdominal obesity may be a better prognostic marker. Aim To determine if a single anthropometric parameter best predicts severe acute pancreatitis and correlates with intra-abdominal fat. Methods Ninety-nine patients with acute pancreatitis were studied prospectively. Anthropometry included body mass index (BMI) and girths (umbilical/minimum waist, iliac/trochanter hip, thigh). Several waist-to-hip/waist-to-thigh ratios (WHR/WTR) were constructed. A CT-scan with calculation of cross-sectional abdominal fat areas was obtained in 37 cases. Results Severe acute pancreatitis occurred in 25 patients. Waist circumference (WC), WHR and WTR – all using the umbilical reference – most accurately predicted severe acute pancreatitis. Only umbilical WC was retained in multivariate analysis: the risk for severe acute pancreatitis increased 16% with every 1 cm (OR 1.16, 95%CI: 1.1–1.3). Abdominal obesity caused a 6-fold increase in risk. Umbilical WC correlated best with subcutaneous fat area (r = 0.791, P
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- 2010
6. Vascular Invasion in Pancreatic Cancer
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Ada M. Franco-Guzmán, L.A. Sosa-Lozano, Roberto Alfaro-Lara, Norberto C. Chávez-Tapia, Marc Giovannini, Félix I. Téllez-Ávila, Miguel Ángel Ramírez-Luna, Javier Elizondo-Rivera, Gustavo López-Arce, and Carlos Chan-Nuñez
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Male ,Endoscopic ultrasound ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Computed tomography ,Adenocarcinoma ,Sensitivity and Specificity ,Endosonography ,Vascular invasion ,Computed tomographic ,Endocrinology ,Pancreatic cancer ,Multidetector Computed Tomography ,Internal Medicine ,medicine ,Humans ,Neoplasm Invasiveness ,In patient ,Pancreatic lesion ,Aged ,Retrospective Studies ,Hepatology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Predictive value ,Vascular Neoplasms ,digestive system diseases ,Pancreatic Neoplasms ,Female ,Radiology ,business - Abstract
To evaluate the accuracy of endoscopic ultrasound (EUS) to determine vascular invasion in patients with pancreatic cancer.Data were obtained prospectively from patients with a pancreatic lesion who underwent EUS, computed tomographic (CT) imaging, and surgery from March 2005 to March 2010.Fifty patients were included with a mean ± SD age 61 ± 11.5 years; 27 (54%) were women. The sensitivity, specificity, positive predictive value, and negative predictive value for EUS were the following: 61.1 (95% CI, 38.6-79.7), 90.3 (95% CI, 75.1-96.7), 78.6 (95% CI, 52.4-92.4), and 80 (95% CI, 64.1-90), respectively. The area under the curve for EUS and that for CT were 0.80 (95% CI, 0.68-0.92) and 0.74 (95% CI, 0.61-0.86), respectively. The positive predictive value for arterial invasion was 100% (95% CI, 61-100) for EUS and 60% (95% CI, 31.3-83.2) for CT. There were no complications associated with the EUS or the CT.Endoscopic US is a very good option to detect vascular invasion in patients with pancreatic cancer and is especially sensitive for arterial invasion. When it is available, we recommend that it be performed in addition to CT staging.
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- 2012
7. A case of tracheal varices: an unusual but important cause of mural nodules in the trachea
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L.A. Sosa Lozano, Kaushik Shahir, Muhammad Akbar, and Lawrence R. Goodman
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Adult ,Male ,Hemoptysis ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Fatal outcome ,Case Report ,Varicose Veins ,Fatal Outcome ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Failure ,business.industry ,CARDIAC CIRRHOSIS ,General Medicine ,Collateral circulation ,medicine.disease ,Surgery ,Trachea ,cardiovascular system ,Portal hypertension ,Congenital tricuspid atresia ,Radiology ,Varices ,business - Abstract
Tracheal varices (TV) are uncommon but can be an important source of massive or recurrent haemoptysis. We present a case of TV in a 32-year-old patient with a history of Glenn–Fontan surgery, for congenital tricuspid atresia, and portal hypertension owing to cardiac cirrhosis. We discuss TV presenting as tracheal nodules in the presence of extensive mediastinal collateral circulation.
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- 2011
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