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Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI.

Besides a library's own collection, there is also an increasing use of web-based scientific information resources in library research and development services. The ever-increasing volume of such information, its fragmented location (in various databases, information retrieval systems, etc.) actualize the interest in automating processes when dealing with such scientific resources. The paper presents the functions of a software package for infometric diagnostics of the publication flow to serve users of the Belarus Agricultural Library (BelAL), which is being developed at the United Institute of Informatics Problems of the National Academy of Sciences of Belarus and BelAL. The software package is designed to automate the information servicing of BelAL users in terms of search, delivery and analytical processing of scientific Internet publications on agriculture.

The article presented the basic parameters of a software complex of multi-streaming processing of scientific information for servicing the users of the Belarus Agricultural Library developed at the United Institute of Informatics Problems of the National Academy of Sciences of Belarus.