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1. Additional file 1 of Longitudinal analysis of symptom-based clustering in patients with primary Sjogren’s syndrome: a prospective cohort study with a 5-year follow-up period

Author

Lee, Jennifer Jooha, Park, Young Jae, Park, Misun, Yim, Hyeon Woo, Park, Sung Hwan, and Kwok, Seung-Ki

Abstract

Additional file 1: Table S1. Definition of variables for latent class analysis. Table S2. Fit statistics for latent class analysis. Table S3. Fit statistics for latent transition analysis. Table S4. Variables for latent class analysis performed annually from baseline.

Published
2021
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4. Inhibition of the TWEAK/Fn14 pathway attenuates autoimmune arthritis in a SKG mouse model

Author

Park, Jin Sil, Kim, Sung Min, Jung, Kyung Ah, Lee, Jennifer, Kwok, Seung Ki, Cho, Mi La, and Park, Sung Hwan

Subjects
STAT3, TWEAK, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], IL-17- producing T cells, Angiogenesis, SKG mice
Abstract

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a proinflammatory cytokine that is involved in pathogenesis of abnormal or disregulated inflammation. To verify how TWEAK/fibroblast growth factor-inducible gene 14 (Fn14) signals affect development of Th17 cells in arthritis, we utilized the SKG mouse, which spontaneously develops Th17- mediated autoimmune arthritis. Fn14-Fc was administered to zymosan A-induced arthritogenic SKG mice, and the effects in vivo were examined. Destruction of cartilage and bone damage was assessed by Hematoxylin and Eosin, and safranin O staining of the affected tissues. Phenotypic analysis of cells expressing inflammatory cytokines and angiogenesis-related factors, and the expression of transcription factor STAT3 in the affected joints were determined by immunohistochemistry. Blockade of Fn14 with Fn14-Fc reduced the clinical and histologic scores of inflammatory arthritis in the mouse model of spontaneously developed chronic autoimmune arthritis. Fn14-Fc suppressed production of inflammatory cytokines and angiogenesis-promoting factors, such as vascular endothelial growth factor and matrix metalloproteinase 3. Moreover, blocking of the TWEAK signal inhibited expression of STAT3 as well as interleukin-17 and -21 produced by Th17 cells. These results implicate TWEAK as a potential molecular target for treatment or prevention of inflammatory arthritis and autoimmune diseases such as rheumatoid arthritis.

Published
2017

5. SYSTEMIC SJOGREN PRESENTING WITHOUT SICCA SYNDROME: CHARACTERIZATION OF 240 PATIENTS ACCORDING TO THE NEW 2017 ACR/EULAR CLASSIFICATION CRITERIA

Author

Retamozo, Soledad, Hernandez-Molina, Gabriela, Valim, Valeria, Moca Trevisani, Virginia Fernandes, Pasoto, Sandra G., Acar-Denizli, Nihan, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Ericn, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Damien SENE, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Hammenfors, Daniel, Carsons, Steven E., Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Ramos-Casals, Manuel, and Brito-Zeron, Pilar

6. How the different systemic organ involvements are overlapped in patients with primary Sjogren syndrome: analysis using a mathematical model

Author

Retamozo, Soledad, Kostov, Belchin, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Eric, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Hernandez-Molina, Gabriela, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Valim, Valeria, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Moca Trevisani, Virginia Fernandes, Hammenfors, Daniel, Pasoto, Sandra G., Carsons, Steven E., Gheite, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zeron, Pilar, and Manuel Ramos-Casals

7. Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjogren Syndrome: Analysis of 9302 Patients from the Big Data International Sjogren Cohort

Author

Retamozo, Soledad, Brito-Zeron, Pilar, Zeher, Margit, Sivils, Kathy L., Seror, Raphaele, Mandl, Thomas, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Hernandez-Molina, Gabriela, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Gerli, Roberto, Solans, Roser, Suzuki, Yasunori, Isenberg, David A., Rischmueller, Maureen, Nordmark, Gunnel, Fraile, Guadalupe, Wiland, Piotr, Bootsma, Hendrika, Nakamura, Takashi, Valim, Valeria, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Moca Trevisani, Virginia Fernandes, Hammenfors, Daniel S., Carsons, Steven E., Pasoto, Sandra Gofinet, Morel, Jacques, Gheita, Tamer, Atzeni, Fabiola, Vollenweider, Cristina F., Kostov, Belchin, Mariette, Xavier, and Manuel Ramos-Casals

8. HOW DIFFERENT SYSTEMIC ORGAN INVOLVEMENTS OVERLAP IN PATIENTS WITH PRIMARY SJOGREN SYNDROME: ANALYSIS USING A MATHEMATICAL MODEL

Author

Retamozo, Soledad, Hernandez-Molina, Gabriela, Valim, Valeria, Moca Trevisani, Virginia Fernandes, Pasoto, Sandra G., Acar-Denizli, Nihan, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Ericn, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Damien SENE, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Hammenfors, Daniel, Carsons, Steven E., Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Ramos-Casals, Manuel, and Brito-Zeron, Pilar

9. Isolated Anti-La/SS-B Positivity in Patients Diagnosed with Primary Sjogren Syndrome: Analysis of 222 Patients from the Sjogren Big Data Cohort

Author

Brito-Zeron, Pilar, Acar-Denizli, Nihan, Zeher, Margit, Rasmussen, Astrid, Seror, Raphaele, Theander, Elke, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Kruize, Aike A., Valim, Valeria, Kvarnstrom, Marika, Damien SENE, Gerli, Roberto, Praprotnik, Sonja, Isenberg, David A., Solans, Rorer, Rischmueller, Maureen, Kwok, Seung-Ki, Nordmark, Gunnel, Suzuki, Yasunori, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Bombardieri, Michele, Hofauer, Benedikt, Bootsma, Hendrika, Brun, Johan G., Fraile, Guadalupe, Carsons, Steven E., Gheita, Tamer, Morel, Jacques, Vollenweider, Cristina F., Atzeni, Fabiola, Retamozo, Soledad, Horvath, Ildike-Fanny, Sivils, Kathy, Mandl, Thomas, Sandhya, Pulukool, Vita, Salvatore, Sanchez-Guerrero, Jorge, Heijden, Eefje, Trevisano, Virginia Moca, Wahren-Herlenius, Marie, and Ramos-Casals, Manuel

10. HOW ETHNICITY MODIFIES SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: ANALYSIS OF BASELINE ESSDAI SCORES IN A MULTI-ETHNIC INTERNATIONAL COHORT

Author

Retamozo, Soledad, Hernandez-Molina, Gabriela, Valim, Valeria, Moca Trevisani, Virginia Fernandes, Pasoto, Sandra G., Acar-Denizli, Nihan, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Ericn, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Hammenfors, Daniel, Carsons, Steven E., Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Manuel Ramos-Casals, and Brito-Zeron, Pilar

11. CLINICAL AND IMMUNOLOGICAL PRIMARY SJOGREN SYNDROME' DISEASE PATTERNS ARE DRIVEN BY GENDER AND AGE AT DIAGNOSIS

Author

Retamozo, Soledad, Hernandez-Molina, Gabriela, Valim, Valeria, Moca Trevisani, Virginia Fernandes, Pasoto, Sandra G., Acar-Denizli, Nihan, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Ericn, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Hammenfors, Daniel, Carsons, Steven E., Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Manuel Ramos-Casals, and Brito-Zeron, Pilar

12. How Does Primary Sjogren Syndrome Present in Biopsy-Proven Patients without Circulating Ro/La Autoantibodies? Characteristics at Diagnosis of 2073 Patients from the SjoGren Big Data Project

Author

Brito-Zeron, Pilar, Acar-Denizli, Nihan, Zeher, Margit, Rasmussen, Astrid, Seror, Raphaele, Theander, Elke, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Kruize, Aike A., Valim, Valeria, Kvarnstrom, Marika, Sene, Damien, Gerli, Roberto, Praprotnik, Sonja, Isenberg, David A., Solans, Roser, Rischmueller, Maureen, Kwok, Seung-Ki, Nordmark, Gunnel, Suzuki, Yasunori, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Bombardieri, Michele, Hofauer, Benedikt, Bootsma, Hendrika, Brun, Johan G., Fraile, Guadalupe, Carsons, Steven E., Gheita, Tamer, More, Jacques, Vollenweider, Cristina F., Atzeni, Fabiola, Retamozo, Soledad, Horvath, Ildike-Fanny, Sivils, Kathy, Mand, Thomas, Sandhya, Pulukool, Vita, Salvatore, Sanchez-Guerrero, Jorge, Heijden, Eefje, Trevisano, Virginia Moca, Wahren-Herlenius, Marie, Mariette, Xavier, and Manuel Ramos-Casals

13. Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis

Author

Retamozo, Soledad, Kostov, Belchin, Zeher, Margit, Sivils, Kathy, Mandl, Thomas, Seror, Raphaele, Li, Xiaomei, Baldini, Chiara, Mariette, Xavier, Gottenberg, Jacques-Eric, Danda, Debashish, Priori, Roberta, Quartuccio, Luca, Hernandez-Molina, Gabriela, Armagan, Berkan, Kruize, Aike A., Kwok, Seung-Ki, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Rischmueller, Maureen, Solans, Roser, Suzuki, Yasunori, Isenberg, David, Valim, Valeria, Wiland, Piotr, Nordmark, Gunnel, Fraile, Guadalupe, Bootsma, Hendrika, Nakamura, Takashi, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele, Moca Trevisani, Virginia Fernandes, Hammenfors, Daniel, Pasoto, Sandra G., Carsons, Steven E., Gheita, Tamer A., Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zeron, Pilar, and Manuel Ramos-Casals

14. Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)

Author

Brito-Zeron, Pilar, Retamozo, Soledad, Zeher, Margit, Rasmussen, Astrid, Seror, Raphaele, Theander, Elke, Li, Xiaomei, Baldini, Chiara, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Kruize, Aike A., Valim, Valeria, Kvarnstrom, Marika, Damien SENE, Gerli, Roberto, Praprotnik, Sonja, Isenberg, David A., Solans, Roser, Rischmueller, Maureen, Kwok, Seung-Ki, Nordmark, Gunnel, Suzuki, Yasunori, Giacomelli, Roberto, Devauchelle, Valerie, Bombardieri, Michele, Hofauer, Benedikt, Bootsma, Hendrika, Brun, Johan G., Fraile, Guadalupe, Carsons, Steven E., Gheita, Tamer, Morel, Jacques, Vollenweider, Cristina F., Atzeni, Fabiola, Acar-Denizli, Nihan, Horvath, Ildike-Fanny, Sivils, Kathy, Mandl, Thomas, Sandhya, Pulukool, Vita, Salvatore, Sanchez-Guerrero, Jorge, Heijden, Eefje, Trevisano, Virginia Moca, Wahren-Herlenius, Marie, Mariette, Xavier, and Ramos-Casals, Manuel

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