73 results on '"Kuo-Yang Wang"'
Search Results
2. Case report: The impact of percutaneous atrial septal defect closure in pulmonary hypertension with co-existing cor triatriatum sinister and multiple cardiac comorbidities
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I-Hsin Tai, Tsung-Cheng Shyu, Kai-Sheng Hsieh, Ke-Wei Chen, Wan-Jane Tsai, and Kuo-Yang Wang
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Cardiology and Cardiovascular Medicine - Abstract
Cor triatriatum sinister is a rare congenital anomaly characterized by the left-sided triatrial form of the heart. Diverse theories have been proposed regarding its formation, and the failure of incorporation of the common pulmonary vein into the left atrium (LA) during embryogenesis is the most widely accepted theory. Accordingly, cor triatriatum sinister may be associated with pulmonary venous obstruction and post-capillary pulmonary hypertension in the setting of restricted fenestration. A high proportion of patients with cor triatriatum sinister also have an associated secundum atrial septal defect. Pre-capillary pulmonary hypertension, which is unusual in patients with small atrial septal defects (
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- 2022
3. Association of Major Adverse Cardiac Events and Beta-Blockers in Patients with and without Atherosclerotic Cardiovascular Disease: Long-Term Follow-Up Results of the T-SPARCLE and T-PPARCLE Registry in Taiwan
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Patrick Yan-Tyng Liu, Fang-Ju Lin, Chih-Fan Yeh, Yu-Chung Hsiao, Chin-Feng Hsuan, Wei-Tien Chang, Hsien-Li Kao, Jiann-Shing Jeng, Yen-Wen Wu, I-Chang Hsieh, Ching-Chang Fang, Kuo-Yang Wang, Kuan-Cheng Chang, Tsung-Hsien Lin, Wayne Huey-Herng Sheu, Yi-Heng Li, Wei-Hsian Yin, Hung-I Yeh, Jaw-Wen Chen, and Chau-Chung Wu
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beta-blocker ,major adverse cardiac events ,event-free survival ,Taiwan cohort ,atherosclerotic cardiovascular disease ,General Medicine - Abstract
Beta-blockers are widely used, but the benefit is now challenged in patients at risk of atherosclerotic cardiovascular disease (ASCVD) in the present coronary reperfusion era. We aimed to identify the risk factors of a major adverse cardiac event (MACE) and the long-term effect of beta-blockers in two large cohorts in Taiwan. Two prospective observational cohorts, including patients with known atherosclerosis cardiovascular disease (T-SPARCLE) and patients with at least one risk factor of ASCVD but without clinically evident ASCVD (T-PPARCLE), were conducted in Taiwan. The primary endpoint is the time of first occurrence of a MACE (cardiovascular death, nonfatal stroke, nonfatal myocardial infarction, and cardiac arrest with resuscitation). Between December 2009 and November 2014, with a median 2.4 years follow-up, 11,747 eligible patients (6921 and 4826 in T-SPARCLE and T-PPARCLE, respectively) were enrolled. Among them, 273 patients (2.3%) met the primary endpoint. With multivariate Cox PH model analysis, usage of beta-blocker was lower in patients with MACE (42.9% vs. 52.4%, p < 0.01). In patients with ASCVD, beta-blocker usage was associated with lower MACEs (hazard ratio 0.72; p < 0.001), but not in patients without ASCVD. The event-free survival of beta-blocker users remained higher during the follow-up period (p < 0.005) of ASCVD patients. In conclusion, in ASCVD patients, reduced MACE was associated with beta-blocker usage, and the effect was maintained during a six-year follow-up. Prescribing beta-blockers as secondary prevention is reasonable in the Taiwanese population.
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- 2023
4. The Changing Landscape for Stroke Prevention in AF
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Mercedes Samson, Siegfried Frickel, Hirosi Meno, Niels Gadsbøll, Sébastien Prévôt, Sorin Alexandru Antonescu, Xiaodong Li, Tetsuya Haruna, Zicheng Li, Catarina Fonseca, Ralf Zahn, Shahid Aziz, Takashi Tsutsui, Galal Kerfes, Elisabeth Louise Zeuthen, Lluís Mont, Angelika Tamm, Bogdan Minescu, Eric Lo, Gerardo Ansalone, Malcolm Foster, Tristan Mirault, Nabil Andrawis, Apostolos Katsivas, Imad Kreidieh, Juliano Novaes Cardoso, Margaret Ikpoh, Dimitar Raev, Said Chaaban, Dan Tesloianu, Philippe Loiselet, Joachim Gmehling, Joseph Hakas, Steven Forman, Ernst Günter Vester, Bettina Schmitz, Hassan El-Sayed, Hiroshi Tsutsui, Salvatore Pirelli, Jens Taggeselle, Arnljot Tveit, David Smith, Manuel De Los Rios Ibarra, Rafael Salguero, Jindrich Spinar, Vanja Bašić Kes, Jose Walter Cabrera Honorio, Adrien Salem, Gavino Casu, Jean Michel Quedillac, Ana Fruntelata, Peter Siostrzonek, Dmitry Napalkov, Luthando Adams, Valeria Calvi, Jeff S. Healey, Magnus Forsgren, Larisa Kalinina, Ratika Parkash, P. F.M.M. Bergen van, Carmen Manuela Muresan, H. Gorka, Andreas Mügge, Gustavo Maid, Serge Yvorra, Alexander Paraschos, Bernhard Witzenbichler, Viktor Peršić, Jeong Su Kim, Dong Jin Oh, Yutaka Furukawa, Steve Compton, Ravikiran Korabathina, Tammam Al-Joundi, Muzahir H. Tayebjee, Robert Betzu, David J. Cislowski, Alon Steinberg, Carisi Anne Polanczyk, Sanjiv Petkar, Andy Lam, Mingsheng Wang, Galina Ivanchura, Ruediger Seebass, Thomas Guarnieri, Seth H. Baker, Paula Carvalho, Brian First, Konstantinos Makaritsis, Alex C. Spyropoulos, Mohiburrahman Sirajuddin, Richard Bala, David Goldscher, G. Larsen Kneller, Ki Seok Kim, Sherman Tang, Venkat Iyer, Payman Sattar, Yamile Porro, Gregory Y.H. Lip, Christa Raters, Olivier Gartenlaub, Elizaveta Panchenko, Niccolo' Marcionni, Ole Nyvad, Sibel Zehra Aydin, Kenji Kawajiri, Dipankar Dutta, Gabriel Contreras Buenostro, Shaival Kapadia, Harry J.G.M. Crijns, Miroslav Rubacek, Myriam Brunehaut, Igor Diemberger, Kyle Rickner, Katsumi Tanaka, Moon Hyoung Lee, Pamela Nerheim, Jose Carlos Moura Jorge, Michael Gumbley, Katie Randall, Francesco Melandri, Sunil Chand, Harukazu Iseki, Thalie Traissac, Ningfu Wang, Ghiath Mikdadi, Peter D. Schellinger, Andrew M. Rubin, Conrad Genz, Karl Heinz Seidl, Maurice Pye, Giorgio Annoni, Adalberto Menezes Lorga Filho, William H. Pentz, Lisa Schmitz, Gary Miller, Didier Smadja, Elena Khludeeva, David Hargroves, Hans-Christoph Diener, Tiziano Moccetti, Azlisham Mohd Nor, Kai Koenig, F. A. Rooyer, Kiyoo Mori, Carlos Gonzalez Juanatey, Jan Beyer-Westendorf, Charles Landau, Steven B Eisenberg, Hugh F. McIntyre, Emilio Gonzalez Cocina, Erik May, Gyo-Seung Hwang, Alberto Giniger, Karl-Heinz Kuck, Yan Carlos Duarte Vera, Vladimir Gorbunov, Priya Nair, Shih Ann Chen, Beat J. Meyer, Donghui Zhang, Feng Wang, Richard J.H. Smith, Michele Massimo Gulizia, Darko Pocanic, Abul Azim, Jose Maria Lobos, Patrick Leprince, Peter Vanacker, Marica Bracic Kalan, James Crenshaw, Ewa Nowalany-Kozielska, Ayham Al-Zoebi, Eiji Hishida, Louis Essandoh, Younghoon Kim, Yanmin Yang, Dhiraj Gupta, Fausto J. Pinto, Arnold Pinter, Stanley Koch, Luis Felipe Pezo, Dzifa Wosornu Abban, Martin S. Green, Chrystalenia Kafkala, Zhitao Liu, Jose Luis Llisterri, Su Mei Angela Koh, Lin Chih-Chan, Ruth Davies, Ursula Rauch-Kroehnert, Julio Tallet, Juan Benezet-Mazuecos, Andreas Kastrup, Rohit Malhotra, Serge Timsit, Thierry Frappé, Kostas Oikonomou, Ameer Kabour, Kishor Vora, Douglas Roberts, Carlos Scherr, Pedro Dionísio, Nicoleta Violeta Miu, Eve Gillespie, Petr Povolny, F.R. Grondin, Philippe Lyrer, Raymond Fisher, Philip O'Donnell, Nima Amjadi, Juan Vazquez, Lynn Corbett, Patrick Peters, Jing Zhou, Thomas Kümler, Danny H.K. Wong, Evaldas Giedrimas, William McGarity, Frank L. Silver, Emmanuel Touzé, Ana Leitão, Suk keun Hong, Marwan Salfity, Constantin Militaru, S T Matskeplishvili, Johannes A. Kragten, Sam Henein, Anthony D'Souza, B. J. Krenning, Francesco Chiarella, Rene Casanova, Stephan Willems, Yong Keun Cho, Tae Joon Cha, Stewart Pollock, Rajendra Moodley, Rosa Ysabel Cotrina Pereyra, Volker Laske, Zhanquan Li, Kenneth B. Harris, Johnny Dy, Gabriele Guardigli, Hisham Kashou, Norberto Matadamas Hernandez, Zdravka Poljaković, E. Decoulx, Paul Wakefield, Sung Ho Her, Fatma Qaddoura, Giuseppe Boriani, Younus Ismail, Franz Goss, Shigeru Fujii, J. R. Groot de, Ming Shien Wen, Rui Candeias, Thomas Rebane, Juan Carlos Arias, Robert Jobe, Nicolas Ley, Taishi Sasaoka, Luigi Ria, Jonathan Banayan, Paul McLaughlin, Sergei Zenin, Luis E. Martinez, Thuraia Nageh, Fabrizio Ammirati, M. E.W. Hemels, Yutaka Shimizu, Elina Trendafilova, Maxime Fayard, Randeep Suneja, Attilia Maria Pizzini, Mark B. Abelson, Rabih R. Azar, Jian Zhou, Valerie Bockisch, Martin Koschutnik, James Hitchcock, Vlad Ciobotaru, Didier Irles, Patrik Michel, Witold Streb, John F. Corrigan, Ajit Singh Khaira, Marco Antônio Mota Gomes, Richard Tytus, Christian Hall, Antonius Ziekenhuis, Catherine Mallecourt, David J. Williams, Doo Il Kim, Brian Gordon, Salvatore Novo, Soufian Al Mahameed, Anil Shah, N. Joseph Deumite, Brent T. McLaurin, Ruth H. Strasser, Somnath Kumar, Genshan Ma, Aurel Cracan, Rajiv Mallik, Anthony Vlastaris, Francesco Perticone, Julio Alberto Aguilar Linares, Angel Moya, William Ashcraft, Steven Lupovitch, Renate Weinrich, Ralph F. Bosch, Gerald Ukrainski, Jon Arne Sparby, Norbert Schön, Pierre Jean Scala, Steven E. Hearne, Mark Roman, Ramin Farsad, Werner Rieker, Guillaume Cayla, Ramon Freixa, Hidemitsu Nakagawa, Kunihiro Nishida, Thomas J. Mulhearn, Tak W. Kwan, Jeffrey Shanes, Tiziana Tassinari, Ka Sing Lawrence Wong, Kneale Metcalf, Dominique Lejay, Daniel Savard, Pierre Chevallereau, Gilles O'Hara, Milan Mikus, Hiroshi Fukunaga, Olga Korennova, Xavier Ducrocq, Edvard Berngard, Mario Bo, Hoi Fan Chow, E. Ronner, Yuriy Grinshstein, Amparo Mena, Sidiqullah Rahimi, Axel Brandes, Shigenobu Bando, Freddy Del-Carpio Munoz, Jonathan L. Halperin, Ronald D. Jenkins, Carlos Rodríguez Pascual, Alain Lacroix, Sergio Agosti, Franklin Handel, Aylmer Tang, Nan Jiang, Diana A. Gorog, Dimitrios Stakos, Gerald Greer, Dudley Goulden, Martin Grond, Oran Corey, Stellan Bandh, Efrain Gonzalez, Alexander Klein, Jacques Scemama, Amelie Elsaesser, Nathan Foster, Francesco Fedele, Dinesh Mistry, Alberto Caccavo, Bjørn Bratland, Jean Marc Davy, D. J. Boswijk, Abdullah Al Ali, Muhammad Khalid, Terry McCormack, Clare Seamark, Enrico Passamonti, Zoran Olivari, Simon W Dubrey, Wlodzimierz Musial, Antonio Martín Santana, Jianqiu Liang, Manuel de Mora, Dmitry Dupljakov, Nicholas Jones, Mohamed Alshehri, Paul Charbel, John Bullinga, Petr Polasek, Hossein Almassi, Reza Mehzad, Gamal Hussein, Marcus Wiemer, Ali Sharareh, Alexandra Finsen, David Huckins, Denis Angoulvant, Matthias Leschke, Craig Vogel, Stefan Schuster, Juan E. Mesa, Yong Seog Oh, Axel De La Briolle, Jacek Kowalczyk, Louise Shaw, Eduardo de Teresa, Stefan Naydenov, Hubert Vial, Ian I Joffe, Christoph Kleinschnitz, Takeshi Yamashita, A. Salvioni, Aman M. Shah, Michael Renzi, Claude Brunschwig, Ioannis Styliadis, Ravi Bhagwat, Julian Coronel, Asok Venkataraman, Zayd Eldadah, Dinesh Singal, Byung Chun Jung, Michael Lillestol, Mirza S. Baig, Jose Polo, Ira Dauber, Olga Barbarash, Kristina Zint, Pavel Galin, P. J. A. M. Brouwers, Ki Byeong Nam, Andrey Ezhov, Kevin F. Browne, Iveta Sime, Tetsuo Sakai, Jean Louis Georges, Manish Jain, Alexey Nizov, Jean Dillinger, Arif Elvan, John Barton, Rainer Zimmermann, Junji Kanda, Clare Holmes, Werner Jung, Aurélien Miralles, Tatiana Novikova, Steven Georgeson, Yorihiko Higashino, Akira Yamada, David Sprigings, Haroon Rashid, J. W.M. Eck van, Bernard Erickson, Barry Seidman, Koji Kajiwara, Kannappan Krishnaswamy, Daniel Ferreira, Sébastien Armero, Brian Wong, Dong Gu Shin, Ludovic Chartier, Priit Kampus, Francisco Marín, Rickey Manning, Martin Köhrmann, Edward J. Kosinski, Bengt Johansson, Y. S. Tuininga, Simon Cattan, Sergio Dubner, Imran Dotani, Wenchi Kevin Tsai, Gregorio Sanchez, Edwin Blumberg, Charles Crump, Frank Jäger, Christoforos Olympios, Matthew Hoghton, Xinwen Zhao, Derek Muse, Alexandre Guignier, Toby Black, Yuichiro Takagi, Phil Keeling, Richard A. Bernstein, Omar Elhag, Jean Ernst Poulard, Fernando Gabriel Manzur Jattin, James Hampsey, Shahid Mahmood, Steffen Behrens, Tianlun Yang, Elena Dotcheva, Krishnan Challappa, Nam Ho Kim, Claudio Cavallini, Eric Espaliat, Martin James, June Soo Kim, Marc Roelke, Harold Thomas, Charles A. Shoultz, Rami El Mahmoud, José Francisco Kerr Saraiva, Jürgen vom Dahl, Xuebo Liu, Dong Ju Choi, Sergio Mondillo, Ian Parker, Kazuya Yamamoto, Rafael Martin Suarez, Karla M. Kurrelmeyer, Akber Mohammed, Nikitas Moschos, Benoit Coutu, Georgios Hananis, Hamed M. Zuhairy, Giovanni Baula, Suchdeep Bains, Menno V. Huisman, Heng Jiang, Jaroslaw Sek, Yoto Yotov, Malik Ali, Dalmo Antonio Ribeiro Moreira, Torben Larsen, Raed Osman, Marie Paule Houppe Nousse, Shulin Wu, Arturo Raisaro, Efrain Alonso Gomez Lopez, Violeta Cindea Nica, Eduardo Julián José Roberto Chuquiure Valenzuela, Wladmir Faustino Saporito, Changsheng Ma, Francesco Romeo, Jorge Martínez, M. Shakil Aslam, Kenneth J. Rothman, Kamal Al Ghalayini, Magdy Mikhail, Charles Augenbraun, Andreas Wilke, Peter Goethals, John D. McClure, Humberto Rodriguez Reyes, Peter Schoeniger, Nabil Jarmukli, Elizabeth S. Kaufman, Nathalie Duvilla, Jens Wicke, Kausik Chatterjee, Philippe Audouin, Dragan Kovacic, Xingwei Zhang, Brad Frandsen, Alberto Conti, Francisco Aguilar, Sasalu Deepak, Geir Heggelund, David S. Rosenbaum, Sergey P. Golitsyn, Alessandro Capucci, Rodolfo Sotolongo, Begoña Sevilla, François Poulain, Thomas Ronzière, Naseem Jaffrani, Dominik Michalski, Jose Lopez-Sendon, Silvia Di Legge, Bernard Jouve, Chang Sheng Ma, Robert Parris, Sumeet K. Mainigi, Jing Yao, Lars Udo Krause, Ulrich Tebbe, Quansan Zhang, Mathieu Amelot, Peter Crean, Benzy J. Padanilam, Nicolas Breton, Fernando Tomas Lanas Zanetti, Subhash Banerjee, Andrew I. Cohen, Michel Galinier, Jacek Miarka, Gerian Grönefeld, Vicente Bertomeu, Mariusz Gierba, Danny, Anna Ferrier, Luciano Marcelo Backes, Lianqun Cui, Eun-Seok Shin, Andreas Meinel, Jay Koons, Jen Yuan Kuo, Brett Graham, Antonio Garcia Quintana, Michael Hill, Sylvain Destrac, Janko Szavits-Nossan, Shanglang Cai, Joaquín Osca, Luis Aguinaga, Hemal M. Nayak, Chander Arora, Shinji Tayama, Diana Delić Brkljačić, Tiemin Jiang, Miguel Agustin Reyes Rocha, Ronan Collins, Davide Imberti, Kwang Soo Cha, Matthias Gabelmann, Alfredo Astesiano, Christian Weimar, William Eaves, Tatiana Ionova, Khalid Almuti, Thierry Schaupp, Bernhard Paul Lodde, Darlene Elias, Yuichiro Nakamura, Raed Al-Dallow, Eric Parrens, Weihua Li, Alan Bell, Noah Israel, Nadezda Rozkova, Nediljko Pivac, Nooshin Bazargani, Armando Pineda-Velez, Hyung Wook Park, Amin Karim, Clemens Steinwender, Davor Milicic, Gonzalo Barón, Robert Topkis, Mehrdad Ariani, Craig S. Barr, Paulo Bettencourt, Roberto Zanini, Andrew Moriarty, Pascal Goube, Fausto Rigo, Irene Madariaga, Atsushi Sueyoshi, Małgorzata Lelonek, Kevin R. Wheelan, Richard Huntley, Donald Brautigam, Jacek Gniot, Ido Lori, Dragos Vinereanu, Daniel Lee, Kouki Watanabe, Michael Vargas, Natalya Koziolova, James S. Zebrack, Basel Hanbali, Cesare Greco, José Luis Zamorano, Rajesh Patel, Fernando Carvalho Neuenschwander, Sergio Luiz Zimmermann, Shuiping Zhao, Pedro Adragão, Karl Heinz Schmitz, Abdelfatah Alasfar, Olga Ferreira de Souza, David N. Pham, Mark Dayer, Thomas Davee, Yoshiki Hata, Mika Skeppholm, Martin O'Donnell, David Molony, Joe Hargrove, Hani Sabbour, Pascal Defaye, Jochen Bott, Dora Ines Molina de Salazar, Anthony Clay, Giancarlo Landini, Michael McGuire, Dae Kyeong Kim, A. Shekhar Pandey, Bouziane Benhalima, Serge Cohen, Aamir Cheema, Matthias Claus, Marcus L. Williams, Qiangsun Zheng, Karim Bakhtiar, Hailong Lin, Sergio Berti, David Hartley, Libor Nechvatal, Rami Mihail Chreih, Domingo Pozzer, James Capo, John Floyd, Bhola Rama, Harald Darius, Ioannis Mantas, Pareed Aliyar, Carlos Barrera, Galina Ketova, Mark Chang, Alan J. Bank, José Ferreira Santos, Samir Turk, Lakshmanan Sekaran, Adam Ellery, Aurélie Buhl, Naomasa Miyamoto, Kuo Ho Yeh, Nicolas Mousallem, Hassan Soda, Dimitrios J. Richter, Zhaohui Wu, Tim Edwards, Kai Sukles, Koji Maeno, Huanyi Zhang, Paolo Verdecchia, Alexandros Gkotsis, Joe Pouzar, Philippe Berdagué, Edoardo Gronda, Olesya Rubanenko, Cristian Podoleanu, Mariano Ruiz Borret, Guillermo Llamas Esperon, Iveta Mintale, Hideki Shimomura, Dadong Zhang, Angelo Amato Vicenzo de Paola, Kenneth Butcher, Pascal Tessier, Minang Turakhia, Peter Svensson, Shabbir Reza, Herbert Pardell, Wilfried Lang, Holger Poppert, Alan Ackermann, Olivier Citerne, Emil Hayek, Yang Zheng, Jin bae Kim, Lorenzo Fácila, Tetsuo Hisadome, Li Sun, Panagiotis Vardas, Angel Grande, Piers Clifford, C. Zwaan van der, Nicki Law, Ilsbe Salecker, Steven Isserman, Shozo Tanaka, Dorothee B. Bartels, Yann Hemery, Susanna Cary, Mehiar El-Hamdani, Indira Natarajan, Miney Paquette, C. Wilson Sofley, Charles C. Gornick, Fu-Tien Chiang, Ellen Bøhmer, Hiroki Yamanoue, Toru Nakayama, Chakri Yarlagadda, Ciro Indolfi, Narendra Singh, Juan Carlos Nunez Fragoso, Eisho Kyo, Laurent Deluche, Andreas Götte, Stephen Phlaum, Jong Sung Park, Paresh Mehta, Terrence C. Hack, Fred Cucher, Olivier Dibon, Chia Theng Daniel Oh, Shannon Twiddy, Sean Connors, Edo Bottacchi, Beata Wożakowska-Kapłon, Ronald B. Goldberg, Jordi Bruguera, James J. Kmetzo, Jeanne Wei, John Kazmierski, Pilar Mazón, M Frais, Kazuya Kawai, Dimitrios Alexopoulos, Abayomi Osunkoya, Wanda Sudnik, Ramon Horacio Limon Rodriguez, William J. French, Ira Lieber, Rajesh Aggarwal, Stuart W. Zarich, John A. Puleo, David Cudmore, Jost Henner Wirtz, Ute Altmann, Kyung Tae Jung, Jennifer Litchfield, Jei Keon Chae, Rainer Dziewas, James Neiman, Karin Rybak, Galina Chumakova, Riccardo Pini, Richard Oliver, Benoit Lequeux, Athanasios J. Manolis, Luisa Fonseca, César A. Jardim, Katsuhiro Matsuda, Paul Hermany, Ming Luo, Ronnie Garcia, Oscar Pereira Dutra, John Culp, Amrit Pal Singh Takhar, Victor Howard, Oyidie Igbokidi, Kuo Yang Wang, Britta Goldmann, Thomas Walter, Mohamed K. Al-Obaidi, Antonio Pose, Christine Teutsch, Arthur J. Labovitz, Thomas Folk, Nell Wyatt, A. Huizenga, Benhur Henz, Konstantin Protasov, Petra Maskova, Ioannis Goudevenos, Kier Huehnergarth, Elena Kinova, Georgios Stergiou, Guohai Su, Hüseyin Ince, Chi Hung Huang, Winfried Haerer, Saad Al Ismail, Michael Gabris, Brian Carlson, Feng Liu, Yansheng Li, Luis Gustavo Gomes Ferreira, Radosław Lenarczyk, Ruben Omar Iza Villanueva, Nandkishore Ranadive, Yong Xu, Oscar Saenz Morales, Wayne Turner, Aleksey Khripun, Paul G. Grena, Yusuke Fujino, Abraham Salacata, Aleksandar Knezevic, Fouad Elghelbazouri, Hamid Bayeh, Mikhail Torosoff, Martin Cooper, Alenka Mavri, Marina Freydlin, Vassilios Vassilikos, Naresh Ranjith, Laurent Prunier, E. Hoffer, George Mitchell, Javier León Jiménez, S.S. Kabbani, Waldemar Krysiak, Emmanuel Nsah, John Ip, Charles B. Eaton, Jérome Thevenin, Dimitrios Chrysos, Asaad Bakbak, L. Steven Zukerman, Maria Grazia Bongiorni, Matthias von Mering, Lisa Alderson, Jean Joseph Muller, Yann Jamon, Roger Moore, Harinath Chandrashekar, Athanasios Pras, Venkatesh Nadar, B. J. Berg van den, Tomas Ripoll, Eric Van De Graaff, Patrick Dary, Peter L. Schwimmbeck, James Poock, Robert Schnitzler, Rohit Arora, Vuong DuThinh, Uwe Gremmler, Nuno Raposo, Chirag Sandesara, Ping Yen Bryan Yan, Junya Shite, Andrea Berz, Isabel Egocheaga, Karine Lavandier, Jose M. Teixeira, Ewart Jackson-Voyzey, Mayar Jundi, Ignacio Iglesias, Stephen Bloom, Hans Rickli, Rudolph Evonich, Giulio Molon, Vinay Shah, Salvador Bruno Valdovinos Chavez, Walter Ageno, Mauro Esteves Hernandes, Ali Ghanbasha, Stefan Regner, Luc De Wolf, Abdel El Hallak, Mohammad Shoukfeh, Francesco Musumeci, Pablo Andres Sepulveda Varela, Gershan Davis, Xianyan Jiang, Matthew Ebinger, Xiangdong Xu, Andreas Winkler, T. A. Simmers, Olivier Dascotte, Dominique Magnin, Karen Mahood, Carolina Guevara Caiedo, Zulu Wang, Hung-Fat Tse, John Camm, Didier Cadinot, Javier Aguila Marin, Juan Jose Olalla, Tamara Everington, Sherryn Roth, Feliz Alvaro Medina Palomino, Gregg Coodley, Wenhui Liu, G. Y. H. Lip, Ricky Ganim, Paul Ainsworth, Luiz Eduardo Fonteles Ritt, Yalin Liu, Sung Won Jang, Percy Berrospi, Dhananjai Menzies, Julien Pineau, Robert J. Jeanfreau, Hervé Buathier, John D. Osborne, Ted S. N. Lo, Li Fern Hsu, Xi Su, Beate Wild, Alvaro Rabelo Alves, Tomas Cieza-Lara, Neeraj Prasad, Yoshinori Seko, Jaydutt Patel, Malte Kuniss, Guy Chouinard, Jacek Morka, Frank Rubalcava, Fran Adams, Ignacio Rodriguez Briones, Vivek Sharma, Xinhua Wang, Amir Malik, Walid Amara, Adnan El Jabali, José Arturo Maldonado Villalon, Frederic Georger, Hong Ma, Steffen Schnupp, Nolan Mayer, Adam Sokal, Nasser Abdul, Gérald Phan Cao Phai, Jorge Hugo Blanco Ibaceta, Ramakrishnan Iyer, Yves Cottin, Barry Troyan, Achim Küppers, Anastas Stoikov, Jasjit Walia, Bruce Iteld, Abdul Alawwa, Christos Milonas, Frank Mibach, Mahfouz El Shahawy, H.William Stites, Neerav Shah, Clifford Ehrlich, Zia Ahmad, Furio Colivicchi, and Laszlo Karolyi
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medicine.medical_specialty ,business.industry ,Atrial fibrillation ,030204 cardiovascular system & hematology ,medicine.disease ,Dabigatran ,03 medical and health sciences ,0302 clinical medicine ,Stroke prevention ,Antithrombotic ,Emergency medicine ,medicine ,In patient ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,Intensive care medicine ,Prospective cohort study ,business ,Stroke ,Fibrinolytic agent ,medicine.drug - Abstract
Background: GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic t...
- Published
- 2017
5. The effect of an anaesthetic patient information video on perioperative anxiety
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Hung-An Huang, Hon-Yi Shi, Kuo-Yang Wang, Shun-Yuan Lin, Yuan-Ting Huang, and Sung-Chun Lin
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Adult ,Male ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Time Factors ,Treatment outcome ,Taiwan ,Video Recording ,MEDLINE ,Health knowledge ,Anxiety ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Patient Education as Topic ,Randomized controlled trial ,Risk Factors ,030202 anesthesiology ,law ,Surveys and Questionnaires ,Patient information ,medicine ,Humans ,Anesthesia ,030212 general & internal medicine ,Aged ,business.industry ,Perioperative ,Middle Aged ,Treatment Outcome ,Anesthesiology and Pain Medicine ,Patient Satisfaction ,Surgical Procedures, Operative ,Physical therapy ,Female ,medicine.symptom ,business - Abstract
Despite growing evidence that an educational anaesthesia video can effectively reduce perioperative anxiety, the ideal medium for addressing perioperative anxiety is unclear.The purpose of this study was to investigate the effect of viewing an anaesthetic patient information video on anxiety levels in patients scheduled to undergo surgery.A randomised controlled trial.Pingtung Christian Hospital (PTCH), Taiwan.One hundred patients were randomised to either an experimental group (n = 50) or a control group (n = 50).At the preoperative clinic, the experimental group watched the an 8 minute educational anaesthetic video, whereas the control group received a standard 8-min verbal briefing on anaesthesia after preoperative assessment.The Chinese version of the Spielberger state trait anxiety inventory, which included a state scale (STAI-S) and a trait scale (STAI-T), was performed in the preoperative clinic (T1) before anaesthetic preassessment, at the preoperative holding area just before surgery (T2) and again on the third day after surgery (T3). Scores for overall satisfaction with medical care were obtained on the third day after surgery. For two time interval comparisons, effect size was used to standardise the extent of change as measured by STAI-S.After the educational intervention, state anxiety was lower in the experimental group than in the control group at both T2 (42.9 ± 6.5 vs. 45.0 ± 12.7) and T3 (40.2 ± 5.3 vs. 48.8 ± 8.5). Compared with control group, the experimental group had a larger effect size at T2 and T3 (-0.65 and -0.36, respectively). Overall satisfaction was significantly higher in the experimental group than in the control group (P 0.05).Perioperative anxiety was significantly reduced and overall patient satisfaction increased after viewing a preoperative educational anaesthesia video compared with a standard verbal briefing on anaesthesia.
- Published
- 2016
6. Atrial fibrillation, CHA2DS2-VASc score, antithrombotics and risk of non-traffic-, non-cancer-related bone fractures: A population-based cohort study
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Chia Ning Liu, Wen Lieng Lee, Chi Hsiang Chung, Tsu Juey Wu, Wu-Chien Chien, Tsun Jui Liu, Hui Chin Lai, and Kuo Yang Wang
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Osteoporosis ,Taiwan ,Poison control ,Lower risk ,Risk Assessment ,Cohort Studies ,Fractures, Bone ,Fibrinolytic Agents ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,Internal Medicine ,medicine ,Humans ,Cumulative incidence ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,Proportional hazards model ,business.industry ,Incidence ,Anticoagulant ,Atrial fibrillation ,Prognosis ,medicine.disease ,Surgery ,Hospitalization ,Stroke ,CHA2DS2–VASc score ,Accidental Falls ,Female ,business - Abstract
Accidental bone fractures are a major cause of premature disabilities and death. Whether atrial fibrillation (AF) treated with or without antithrombotics correlates with occurrence of such events remains under-investigated.Patients ≥18 years with newly diagnosed AF between 2005 and 2009 without previous cancers or traffic injury were identified from the "Longitudinal Health Insurance Database 2005" (1 million beneficiaries) of Taiwan's National Health Research Institutes and served as the AF group. A fourfold number of age-, gender-, and comorbidity-matched patients but without AF served as the non-AF controls. Patients were followed, and cumulative incidence of hospitalization-requiring bone fractures was compared between groups. Predictors of accidental bone fractures were determined by Cox regression analysis.Within a mean follow-up of 3.6 years, bone fractures, especially those involving neck/trunk and lower limbs, were significantly more frequent in patients with AF (N=6925) than in those without (N=27,700) (7.0 vs. 3.8 per 1000 person-years, log-rank p=0.001, adjusted HR=1.85, 95% CI=1.50-2.30, p0.001). Cox models identified female gender, previous stroke, and CHA2DS2-VASc score≧1 as risk factors for bone fractures in AF patients, whereas oral anticoagulants (HR=0.62, 95% CI=0.35-0.91, p=0.034), especially when used in patients with CHA2DS2-VASc score≧1 but not antiplatelet therapy (p=0.39) as negative predictors.Patients with AF are more vulnerable to non-traffic-, non-cancer-related bone fractures especially when with specified characteristics. For those with higher CHA2DS2-VASc scores, the use of anticoagulant but not antiplatelet agents could be associated with lower risk of such events.
- Published
- 2015
7. Sinus Venosus Interatrial Communication, Anomalous Pulmonary Venous Return, Pulmonary Artery Aneurysm With Left Main Compression: Complex Case With Complex Management
- Author
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Kae-Woei Liang, Kuo-Yang Wang, and Hao-Ji Wei
- Subjects
Adult ,medicine.medical_specialty ,Hypertension, Pulmonary ,Partial anomalous pulmonary venous return ,030204 cardiovascular system & hematology ,Pulmonary Artery ,Heart Septal Defects, Atrial ,Angina Pectoris ,Angina ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Multidetector Computed Tomography ,medicine ,Anomalous pulmonary venous return ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Sinus venosus ,Pulmonary artery aneurysm ,business.industry ,Angiography ,Surgical correction ,medicine.disease ,Aneurysm ,Shunting ,medicine.anatomical_structure ,Pulmonary Veins ,Vascular resistance ,Cardiology ,Female ,Stents ,Vascular Resistance ,Cardiology and Cardiovascular Medicine ,business - Abstract
A young female patient was referred for pulmonary arterial hypertension (PAH). Catheterization revealed a large sinus venosus interatrial communication (SVIAC), partial anomalous pulmonary venous return (PAPVR), pulmonary vascular resistance (PVR) 15 Wood units, and bidirectional shunting. She was then put on target medication for PAH. Two years later, she had angina and underwent computed tomography examination, which showed pulmonary arterial aneurysm compressing the left main coronary. Coronary stenting was performed, which successfully relieved the compression and angina. Meanwhile, PVR lowered to 3.5 Wood units after medical therapy. Surgical correction for SVIAC and PAPVR was done successfully 5 years after diagnosis.
- Published
- 2018
8. Atrial fibrillation increases medical cost and complicates hospital outcome of traffic accident-related physical trauma—A nationwide population-based study
- Author
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Hui Chin Lai, Wu-Chien Chien, Tsun Jui Liu, Chi Hsiang Chung, Kuo Yang Wang, Chia Ning Liu, and Wen Lieng Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,National Health Programs ,Taiwan ,Poison control ,Suicide prevention ,Occupational safety and health ,Young Adult ,Atrial Fibrillation ,Injury prevention ,medicine ,Humans ,Aged ,Aged, 80 and over ,Multiple Trauma ,Traffic accident ,business.industry ,Accidents, Traffic ,Human factors and ergonomics ,Atrial fibrillation ,Health Care Costs ,Middle Aged ,medicine.disease ,Hospitalization ,Treatment Outcome ,Hospital outcomes ,Population Surveillance ,Emergency medicine ,Female ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business - Abstract
Traffic accidents account substantially for premature disability and deaths in the modern world. Whether atrial fibrillation complicates the outcome of traffic injury remains under-investigated.From 1998 to 2010, all inpatient records stored in the Taiwan National Health Insurance database were screened. Those related with traffic accidents were aggregated to individuals and enrolled. The medical expenses and hospital outcomes were compared between patients with atrial fibrillation (AF group) and either the rest patients (No-AF group) or the propensity-matched patients without atrial fibrillation (No-AF-matched group). Prognostic predictive variables for adverse in-hospital events were further identified by multivariate regression analysis.Within the 13-year time span, of the 776,620 individuals ever admitted for traffic accidents, there were 1233 patients with AF. Compared with No-AF and No-AF-matched groups respectively, AF patients stayed longer in hospital (10.9 ± 10.6 vs. 6.8 ± 7.2 and vs. 8.2 ± 8.7 days, both p0.001), more often required surgical operations (73.2% vs. 69.5%, p = 0.006 and vs. 68.9%, p = 0.021), and consumed larger medical expenses (US$ 2384 ± 3174 vs. 1246 ± 2024, or 91.3% higher; and vs. 1406 ± 2172, or 69.6% higher, both p0.001), yet developed more postoperative complications (8.8% vs. 1.2% and vs. 3.2%, both p0.001) and deaths (2.5% vs. 0.9%, p0.001 and vs. 1.6%, p = 0.015). Identified by regression analysis, CHA2DS2-VASC score and representative demographic/injury-related variables predict in-hospital adverse events in these AF group patients.For patients suffering traffic accidents, those with AF consume more surgical resources and medical expenses yet end up with poorer hospital outcome, especially those with higher CHA2DS2-VASC scores and other relevant variables.
- Published
- 2014
9. Familial clustering of congenital deafness, patent ductus arteriosus, Eisenmenger complex, and differential cyanosis: A case report
- Author
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Chih-Wei Tseng, Kuo-Yang Wang, Ting-Wei Lin, Chi-Yao Huang, and Kae-Woei Liang
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Eisenmenger complex ,medicine.medical_treatment ,education ,Familial clustering ,Physical examination ,030204 cardiovascular system & hematology ,Deafness ,congenital deafness ,Diagnosis, Differential ,03 medical and health sciences ,patent ductus arteriosus ,0302 clinical medicine ,030225 pediatrics ,Ductus arteriosus ,Multidetector computed tomography ,medicine ,Humans ,Clinical Case Report ,Ductus Arteriosus, Patent ,Cardiac catheterization ,Cyanosis ,medicine.diagnostic_test ,business.industry ,Siblings ,General Medicine ,Cardiology clinic ,medicine.disease ,differential cyanosis ,medicine.anatomical_structure ,Eisenmenger syndrome ,Eisenmenger Complex ,business ,Research Article - Abstract
Rationale: Few studies had reported syndromes that include patent ductus arteriosus (PDA) with Eisenmenger syndrome and congenital deafness clustered in male siblings without facial, skeletal, or mental abnormalities. Patient concerns: Two brothers, who were deaf and had PDA with Eisenmenger complex, were first seen at our Cardiology clinic at the ages of 25 and 41, respectively. They presented with progressive dyspnea on exertion. Upon physical examination, both brothers had clubbing and/or cyanotic toes, normal fingers, and without facial, skeletal, ophthalmological, or mental abnormalities. Diagnoses and interventions: Echocardiography and multidetector computed tomography revealed large PDAs in both brothers. Cardiac catheterization showed bidirectional shunting via the PDA. Outcomes and lessons: Familial clustering of Eisenmenger PDA and congenital deafness is rare. Further studies are warranted to define possible genetic links.
- Published
- 2017
10. Applications of PCA and SVM-PSO Based Real-Time Face Recognition System
- Author
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Ming-Yuan Shieh, Juing-Shian Chiou, Yu-Chia Hu, and Kuo-Yang Wang
- Subjects
Article Subject ,Computer science ,General Mathematics ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Feature selection ,Machine learning ,computer.software_genre ,Facial recognition system ,Facial expression ,business.industry ,lcsh:Mathematics ,Dimensionality reduction ,General Engineering ,Swarm behaviour ,Pattern recognition ,lcsh:QA1-939 ,Support vector machine ,ComputingMethodologies_PATTERNRECOGNITION ,lcsh:TA1-2040 ,Computer Science::Computer Vision and Pattern Recognition ,Principal component analysis ,Combinatorial optimization ,Artificial intelligence ,lcsh:Engineering (General). Civil engineering (General) ,business ,Classifier (UML) ,computer - Abstract
This paper incorporates principal component analysis (PCA) with support vector machine-particle swarm optimization (SVM-PSO) for developing real-time face recognition systems. The integrated scheme aims to adopt the SVM-PSO method to improve the validity of PCA based image recognition systems on dynamically visual perception. The face recognition for most human-robot interaction applications is accomplished by PCA based method because of its dimensionality reduction. However, PCA based systems are only suitable for processing the faces with the same face expressions and/or under the same view directions. Since the facial feature selection process can be considered as a problem of global combinatorial optimization in machine learning, the SVM-PSO is usually used as an optimal classifier of the system. In this paper, the PSO is used to implement a feature selection, and the SVMs serve as fitness functions of the PSO for classification problems. Experimental results demonstrate that the proposed method simplifies features effectively and obtains higher classification accuracy.
- Published
- 2014
11. Rotavirus is associated with decompensated diarrhea among young rhesus macaques (Macaca mulatta )
- Author
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Kari L. Christe, Jeffrey A. Roberts, Kuo Yang Wang, Jo Ann Yee, and Amir Ardeshir
- Subjects
Rotavirus ,Male ,Rotavirus Antigen ,idiopathich chronic diarrhea ,Antibodies, Viral ,medicine.disease_cause ,California ,Feces ,Viral ,Animal Husbandry ,Antigens, Viral ,Pediatric ,biology ,Monkey Diseases ,colony management ,Foodborne Illness ,Rotavirus infection ,Diarrhea ,Rhesus macaque ,Infectious Diseases ,Female ,Sample collection ,medicine.symptom ,gastroenteritis ,medicine.medical_specialty ,Behavioral Science & Comparative Psychology ,Article ,Rotavirus Infections ,Antibodies ,Internal medicine ,medicine ,Animals ,Decompensation ,Antigens ,Ecology, Evolution, Behavior and Systematics ,enterocolitis ,business.industry ,ICD ,Prevention ,biology.organism_classification ,Macaca mulatta ,Multivariate logistic regression model ,Cross-Sectional Studies ,Emerging Infectious Diseases ,Case-Control Studies ,Anthropology ,Animal Science and Zoology ,Digestive Diseases ,business ,Zoology - Abstract
Diarrhea with secondary decompensation is the main cause of morbidity and mortality in captive young rhesus macaque (Macaca mulatta) colonies. Approximately 25% of diarrhea cases with secondary decompensation are considered to be idiopathic chronic diarrhea. The purpose of this study was to investigate the suspected but not systematically examined association between rotavirus infection and diarrhea with secondary decompensation among young rhesus macaques at the California National Primate Research Center (CNPRC). Blood and stool samples were collected from 89 randomly selected young animals (age range: 6 months to 1.5 years) and were tested for the presence of rotavirus antibody, and rotavirus antigen, respectively, using enzyme-linked immunosorbent assays (ELISA’s). Test and clinical data were analyzed using Fisher’s exact tests and multivariate logistic regression model. Our analysis indicates that rotavirus is endemic among young outdoor-housed rhesus macaques at the CNPRC. Although the relationship between detectable rotavirus antigen in stool and symptomatic diarrhea with secondary decompensation was not significant, there was a significant association between rotavirus seropositivity and a history of diarrhea with secondary decompensation within the past 6 months. While our cross-sectional and case-control study suggests an association between rotavirus infection and diarrhea with secondary decompensation among captive rhesus macaques, more extensive longitudinal studies on larger cohorts and with more intensive sample collection are needed to confirm these findings.
- Published
- 2019
12. TCTAP C-017 STEMI Caused by Left Main Trunk Total Occlusion and Rescued by Primary PCI+TPM+IABP+PCPS
- Author
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Kuo-Yang Wang and Feng-Ching Liao
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Conventional PCI ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Total occlusion ,Trunk - Published
- 2015
13. Different Mid-Term Prognostic Predictors of Major Adverse Events in Diabetic and Nondiabetic Peripheral Artery Disease Presenting With Critical Limb Ischemia
- Author
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Kae Woei Liang, Chen Rong Tsao, Kuo Yang Wang, Tsun Jui Liu, Wei Wen Lin, Chih Tai Ting, Wen Lieng Lee, and Hsun Nan Kuo
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Critical Illness ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Disease ,030204 cardiovascular system & hematology ,Revascularization ,Severity of Illness Index ,Amputation, Surgical ,Peripheral Arterial Disease ,03 medical and health sciences ,0302 clinical medicine ,Ischemia ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Odds Ratio ,medicine ,Humans ,Renal Insufficiency, Chronic ,Adverse effect ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chi-Square Distribution ,business.industry ,Endovascular Procedures ,Odds ratio ,Critical limb ischemia ,Middle Aged ,Limb Salvage ,medicine.disease ,Surgery ,Logistic Models ,Treatment Outcome ,Lower Extremity ,Amputation ,Multivariate Analysis ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Vascular Surgical Procedures ,Diabetic Angiopathies ,Kidney disease - Abstract
We compared midterm prognostic predictors of peripheral artery disease (PAD) with or without diabetes mellitus (DM) presenting with critical lower limb ischemia (CLI). A total of 172 patients with PAD (109 DM; 63 non-DM) were enrolled. The major adverse events (MAEs) were death or amputation. The diabetic group had a higher MAE rate (39% vs 22%, P = .042) with a mean follow-up duration of 30 ± 19 months. In a multivariate binary logistic regression analysis, revascularization (odds ratio = 0.289, P = .006) and higher serum cholesterol (odds ratio=0.988, P = .027) predicted a lower MAE rate in the DM group. In contrast, the presence of severe chronic kidney disease (stage 4 or 5, odds ratio = 5.238, P = .025) was a positive predictor of MAEs in the nondiabetic group. In conclusion, the prognostic predictors of MAE in diabetic and nondiabetic patients with PAD and CLI were different.
- Published
- 2013
14. A secure and rapid method for orotracheal intubation of laboratory rats utilising handy instruments
- Author
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Hsio Wei Lee, Wen Lieng Lee, Chih Tai Ting, Ya Ling Yang, Chieh Shou Su, Tsun Jui Liu, Kuo Yang Wang, Chu Ying Peng, Hui Chin Lai, and Lee Chuan Wang
- Subjects
Catheters ,Time Factors ,business.industry ,medicine.medical_treatment ,Tracheal intubation ,Equipment Design ,Epithelium ,Rats ,Rats, Sprague-Dawley ,Trachea ,Sprague dawley ,Anesthesiology and Pain Medicine ,Anesthesia ,Orotracheal intubation ,Intubation, Intratracheal ,medicine ,Animals ,Feasibility Studies ,Intubation ,business - Abstract
Tracheal intubation of anaesthetised rats for laboratory experiments remains an essential yet challenging procedure.We aimed to investigate whether tracheal intubation can be safely and securely accomplished in laboratory rats employing only handy instruments and with minimal experience.The feasibility and safety of a modified orotracheal intubation method was evaluated in rats undergoing open-chest surgery as part of another research protocol, and compared with an existing technique.The study was carried out in a tertiary medical centre-affiliated animal laboratory.Eighty-five rats weighing 250 to 350 g anaesthetised with intraperitoneal pentobarbital (60 mg kg(-1)).Orotracheal intubation was performed on 35 animals (group Jou) using a previously reported technique and then on another 50 rats (group New) using the modified method employing a 3-ml syringe-derived intubation wedge, a 0.025-inch guidewire and a 16-gauge 45-mm-long intravenous catheter.The time for completion, the number of attempts and the incidence of difficulties and complications were recorded. The intubated tracheas were subsequently examined macroscopically and microscopically to determine position of the intubation catheter and the integrity of epithelial lining.Compared with the previous technique, the new method was completed more rapidly (1 ± 0.2 vs. 5 ± 2.4 min; P0.001), more smoothly (difficulties encountered in 8 vs. 74%; P0.001), with greater overall success (100 vs. 86%; P=0.022) and with fewer attempts [1 (1 to 1) vs. 2 (2 to 4); P0.001) for the new and Jou techniques, respectively, and with a lower incidence of procedure-related complications. Postmortem analysis confirmed there was no microscopic injury to the tracheal epithelial lining with the new technique in contrast to 57% in those using the Jou technique (P0.001).Tracheal intubation for laboratory rats can be securely and safely completed with the modified method employing a short learning curve and easily available devices.
- Published
- 2012
15. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Efficacy and Safety of Ethyl-Ester Omega-3 Fatty Acid in Taiwanese Hypertriglyceridemic Patients
- Author
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Kuo-Chin Huang, Kuo-Liong Chien, Kuo Yang Wang, Runar Vige, Fu-Tien Chiang, Ta-Chen Su, Min Ji Charng, Lian-Yu Lin, Chuen Den Tseng, José Emilio Ruiz Olivar, Wei-Chuan Tsai, and Juey-Jen Hwang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Eicosapentaenoic acid ,Docosahexaenoic Acids ,Taiwan ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Placebo ,Gastroenterology ,Severity of Illness Index ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Internal medicine ,Fatty Acids, Omega-3 ,Internal Medicine ,medicine ,Clinical endpoint ,Omega-3 fatty acids ,Humans ,Adverse effect ,Omega 3 fatty acid ,Life Style ,Triglycerides ,Hypolipidemic Agents ,Omacor ,Hypertriglyceridemia ,Triglyceride ,business.industry ,Ethnic chinese ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Drug Combinations ,Docosahexaenoic acid ,Treatment Outcome ,chemistry ,Biochemistry ,Dietary Supplements ,Female ,Original Article ,Safety ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aim: Information regarding the effects of omega-3 fatty acid on hypertriglyceridemic patients in Chinese is still limited. This study aimed to investigate the efficacy and safety of Omacor®, a prescription ethyl-ester omega-3 fatty acid for the treatment of hypertriglyceridemia, administered at doses of 2 g/day and 4 g/day to Taiwanese hypertriglyceridemic patients. Methods: A multicenter, randomized, double-blind, placebo-controlled, parallel study in adults with hypertriglyceridemia was conducted. After a five-week diet lead in period patients with triglycerides = 200–1000 mg/dL were randomized to receive Omacor®, a concentrated preparation of omega-3 eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) in a dose of 1 g twice daily (2 g Omacor ®), 2 g twice daily (4 g Omacor®) or placebo, for eight weeks. The primary endpoint was the percentage change in triglyceride serum levels from baseline to the end of treatment. Results: A total of 253 Taiwanese patients were randomized, of which 65.6% (166) were men. At the end of the treatment, the percentage change in triglyceride serum levels in both the Omacor® 4 g/day (−32.1%) and 2 g/day (−29.7%) groups was larger than in the placebo group (−5.4%) (p < 0.001). The incidence of drug-related adverse events was as follows: 0.0%, 1.2%, and 0.0% in Omacor ® 4 g/day, Omacor® 2 g/day, and placebo groups, respectively. No drug-related serious adverse events were reported during the study. Conclusions: Omacor® may be a feasible option to treat hypertriglyceridemia in Taiwanese patients.
- Published
- 2016
16. Atrial fibrillation, liver disease, antithrombotics and risk of cerebrovascular events: A population-based cohort study
- Author
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Chi Hsiang Chung, Hui Chin Lai, Wen Lieng Lee, Wu-Chien Chien, Tsun Jui Liu, Chia Ning Liu, Tsu Juey Wu, and Kuo Yang Wang
- Subjects
Male ,medicine.medical_specialty ,Taiwan ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,Liver disease ,Population based cohort ,0302 clinical medicine ,Fibrinolytic Agents ,Risk Factors ,Internal medicine ,Antithrombotic ,Atrial Fibrillation ,medicine ,Humans ,Cumulative incidence ,Longitudinal Studies ,Stroke ,Aged ,Aged, 80 and over ,Proportional hazards model ,business.industry ,Liver Diseases ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Cerebrovascular Disorders ,Population Surveillance ,Cohort ,Cardiology ,030211 gastroenterology & hepatology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Whether patients with atrial fibrillation (AF) and liver disease are also prone to cerebrovascular events and respond similarly favorably to antithrombotic therapy remains under-investigated.Patients ≥18years with newly-diagnosed AF in the period 2005 to 2009 were scrutinized from the "Longitudinal Health Insurance Database 2005" (1 million beneficiaries) of Taiwan's National Health Insurance Institute. Patients were categorized into the Liver (N=433) or the Non-liver (N=3490) cohort according to whether they had a diagnosis of advanced liver disease. Patients were then followed to determine cumulative incidence of hospitalization-requiring cerebrovascular events, preventive effects of antithrombotics, and predictors of cerebrovascular events by Cox regression analysis.Within a mean follow-up of 3.3±1.4years, ischemic stroke (89.2 vs. 50.3 per 1000 person-years, adjusted HR 1.502, 95% CI 1.207-1.868, p0.001) and overall cerebrovascular events (102.3 vs. 56.4 per 1000 person-years, adjusted HR 1.535, 95% CI 1.251-1.883, p0.001) occurred significantly more often in the Liver than in the Non-liver cohort. Cox models identified aging (≥65years), DM, and CHA2DS-VASc score≥2 points as risk factors for overall cerebrovascular events in the Liver cohort, whereas antiplatelet agents (HR 0.932, 95% CI 0.128-6.803, p=NS) and vit-K antagonistic anticoagulants (HR 1.087, 95% CI 0.150-7.862, p=NS) showed no correlation.AF patients comorbid with advanced liver disease are more vulnerable to ischemic and therein overall cerebrovascular events, especially in those with old age, DM, or high CHA2DS-VASc scores. This propensity to cerebrovascular events, however, can't be altered by antithrombotic therapy.
- Published
- 2016
17. Lack of Association between High-Density Lipoprotein Cholesterol and Angiographic Coronary Lesion Severity in Chinese Patients with Low Background Low-Density Lipoprotein Cholesterol
- Author
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Chieh-Shou, Su, Kuan-Ju, Chen, Wayne Huey-Herng, Sheu, Ya-Ling, Yang, Tsun-Jui, Liu, Wei-Chun, Chang, Kuo-Yang, Wang, and Wen-Lieng, Lee
- Subjects
Original Article - Abstract
The atheroprotective role of high-density lipoprotein (HDL-C) particles as measured by HDL-C level in coronary arterial disease (CAD) remains unsettled. The aim of our study was to ascertain whether HDL-C was associated with the development and severity of coronary artery disease in Chinese patients who underwent coronary angiogram with low background Low-density lipoprotein (LDL-C) levels, which has not been previously investigated.Between March 1995 and May 2000, 566 consecutive patients (408 males, 66.7 ± 11.3 years of age) with background LDL-C less than 100 mg/dl who underwent coronary artery angiography at our cath lab for suspected CAD were retrospectively recruited into the study. The severity of coronary lesions was measured by conventional coronary angiography and modified Gensini scores.In those subjects with significant coronary lesions, there were more males and conventional CAD risk factors of diabetes mellitus, smoking, and chronic renal disease. They were also older compared to those in the control group. However, total cholesterol, LDL-C, HDL-C, triglyceride levels and use of statins were similar in both groups. In those subjects with significant coronary lesions, there was no difference in conventional coronary lesion severity or modified Gensini score between the quartered HDL-C subgroups. Furthermore, there was no significant correlation between serum HDL-C level and modified Gensini scores. In linear regression analysis, HDL-C was not an independent predictor for modified Gensini scores. Furthermore, HDL-C was also not an independent risk factor for the presence of significant coronary lesions in low LDL-C patients in logistic regression analysis.In Chinese patients with low background LDL-C, serum HDL-C was not associated with development of CAD or lesion severity in patients with suspected CAD. Therefore, HDL-C did not appear to be atheroprotective in these patients.Coronary artery disease; Gensini score; High-density lipoprotein cholesterol.
- Published
- 2016
18. Falls and Atrial Fibrillation in Elderly Patients
- Author
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Chen-Ying, Hung, Tsu-Juey, Wu, Kuo-Yang, Wang, Jin-Long, Huang, El-Wui, Loh, Yi-Ming, Chen, Chu-Sheng, Lin, Ching-Heng, Lin, Der-Yuan, Chen, and Yih-Jing, Tang
- Subjects
Original Article - Abstract
Atrial fibrillation is a common heart rhythm disorder in older adults, and its prevalence has increased rapidly in recent years. The health issues associated with atrial fibrillation are not limited to physiological problems, as it also contributes to an increased risk of falls, which may be related to cardiovascular co-morbidities and medication use. The aim of this study was to determine which cardiovascular co-morbidities and medication use are associated with falls in older adults with atrial fibrillation.Four hundred and one patients 75 years of age or older (82.2 ± 0.2 years) were enrolled in a geriatric evaluation and management unit in Taiwan. Events associated with patient falls and medication use were recorded, and comprehensive geriatric assessment was conducted during admission.Among the study participants, 66 (16.5%) patients had atrial fibrillation and 234 (58.4%) patients had a history of fall. We found a significantly higher prevalence of falls in patients with atrial fibrillation [odds ration (OR) 1.98, 95% confidence interval (CI) 1.08-3.63, p = 0.026] compared with those without atrial fibrillation. Using multivariate logistic regression, we found that benzodiazepine use (OR 18.22, 95% CI 2.71-122.38, p = 0.003), a history of paroxysmal atrial fibrillation (OR 12.18, 95% CI 1.37-108.70, p = 0.025) and hypertension (OR 9.49, 95% CI 1.19-75.57, p = 0.034) were independent factors for falls in atrial fibrillation patients.A diagnosis of atrial fibrillation in elderly patients is associated with falls. Benzodiazepine use, history of paroxysmal atrial fibrillation, and hypertension were associated with a high falling prevalence among patients with atrial fibrillation.Atrial fibrillation; Benzodiazepine; Falls; Hypertension.
- Published
- 2016
19. Moderate Hypothermia (33 °C) Decreases the Susceptibility to Pacing-Induced Ventricular Fibrillation Compared with Severe Hypothermia (30 °C) by Attenuating Spatially Discordant Alternans in Isolated Rabbit Hearts
- Author
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Yu-Cheng, Hsieh, Shien-Fong, Lin, Jin-Long, Huang, Chen-Ying, Hung, Jiunn-Cherng, Lin, Ying-Chieh, Liao, Chu-Pin, Lo, Kuo-Yang, Wang, and Tsu-Juey, Wu
- Subjects
Original Article - Abstract
Severe hypothermia (SH, 30 °C) increases the risk of pacing-induced ventricular fibrillation (PIVF) by enhancing spatially discordant alternans (SDA). Whether moderate hypothermia (MH, 33 °C), which is clinically used for therapeutic hypothermia, also facilitates SDA remains unclear. We hypothesized that MH attenuates SDA occurrence compared with that achieved by SH, and decreases the susceptibility of PIVF.Using an optical mapping system, action potential duration (APD)/conduction velocity restitutions and thresholds of APD alternans were determined by S1 pacing in Langendorff-perfused isolated rabbit hearts. In the MH group (n = 7), S1 pacing was performed at baseline (37 °C), after 5-min MH, and after 5-min rewarming (37 °C). In the SH group (n = 9), pacing was also performed at baseline (37 °C), after 5-min SH, and after 5-min rewarming (37 °C). The thresholds of APD alternans were defined as the longest S1 pacing cycle length at which APD alternans were detected.Although the thresholds of APD alternans were not different between the MH (273 ± 46 ms) and the SH (300 ± 35 ms) (p = 0.281) groups, SDA threshold was shorter (at a faster heart rate) during MH (228 ± 33 ms) than that during SH (289 ± 42 ms) (p = 0.028). At APD alternans threshold, SH hearts showed more SDA than that during MH (SH: 7 hearts, MH: 2 hearts, p = 0.049). SDA could be induced in all 9 SH hearts (100%), while only 4 MH hearts (57%) had SDA (p = 0.029). The PIVF inducibility during SH (44 ± 53%) was higher than that during MH (0%) (p = 0.043).Compared with SH, the MH group showed greater attenuation of SDA and decreased the susceptibility of PIVF. Therefore, MH is safer as a procedural guideline for use in clinical therapeutic hypothermia than SH.Cardiac alternans; Conduction velocity; Hypothermia; Optical mapping.
- Published
- 2016
20. Propofol ameliorates doxorubicin-induced oxidative stress and cellular apoptosis in rat cardiomyocytes
- Author
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Wen-Lieng Lee, Tsun-Jui Liu, Angie Wu, Yueh-Chiao Yeh, Chih-Tai Ting, H.W. Lee, L.C. Wang, Kuo-Yang Wang, Chieh Shou Su, and H.C. Lai
- Subjects
Cell Survival ,SOD1 ,SOD2 ,Apoptosis ,Oxidative phosphorylation ,Pharmacology ,Toxicology ,medicine.disease_cause ,Antioxidants ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Animals ,Medicine ,Myocytes, Cardiac ,Doxorubicin ,Propofol ,Cells, Cultured ,Membrane Potential, Mitochondrial ,Antibiotics, Antineoplastic ,business.industry ,Reactive Nitrogen Species ,Rats ,Oxidative Stress ,Animals, Newborn ,chemistry ,Anesthesia ,Trypan blue ,Reactive Oxygen Species ,business ,Anesthetics, Intravenous ,Oxidative stress ,medicine.drug - Abstract
Background Propofol is an anesthetic with pluripotent cytoprotective properties against various extrinsic insults. This study was designed to examine whether this agent could also ameliorate the infamous toxicity of doxorubicin, a widely-used chemotherapeutic agent against a variety of cancer diseases, on myocardial cells. Methods Cultured neonatal rat cardiomyocytes were administrated with vehicle, doxorubicin (1 μM), propofol (1 μM), or propofol plus doxorubicin (given 1 h post propofol). After 24 h, cells were harvested and specific analyses regarding oxidative/nitrative stress and cellular apoptosis were conducted. Results Trypan blue exclusion and MTT assays disclosed that viability of cardiomyocytes was significantly reduced by doxorubicin. Contents of reactive oxygen and nitrogen species were increased and antioxidant enzymes SOD1, SOD2, and GPx were decreased in these doxorubicin-treated cells. Mitochondrial dehydrogenase activity and membrane potential were also depressed, along with activation of key effectors downstream of mitochondrion-dependent apoptotic signaling. Besides, abundance of p53 was elevated and cleavage of PKC-δ was induced in these myocardial cells. In contrast, all of the above oxidative, nitrative and pro-apoptotic events could be suppressed by propofol pretreatment. Conclusions Propofol could extensively counteract oxidative/nitrative and multiple apoptotic effects of doxorubicin in the heart; hence, this anesthetic may serve as an adjuvant agent to assuage the untoward cardiac effects of doxorubicin in clinical application.
- Published
- 2011
21. Dry Needling for Myofascial Pain: Prognostic Factors
- Author
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Shun-Yuan Lin, Yuan-Ting Huang, Choo-Aun Neoh, Kuo-Yang Wang, Yen-Hsuan Jean, and Hon-Yi Shi
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Adult ,Male ,Sleep Wake Disorders ,medicine.medical_specialty ,Acupuncture Therapy ,Taiwan ,Psychological intervention ,Myofascial pain syndrome ,Muscle Stretching Exercises ,Surveys and Questionnaires ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Myofascial Pain Syndromes ,Generalized estimating equation ,Pain Measurement ,Dry needling ,business.industry ,Myofascial pain ,Trigger Points ,Middle Aged ,Prognosis ,medicine.disease ,Clinical trial ,Treatment Outcome ,Pain Clinics ,Complementary and alternative medicine ,Needles ,Physical therapy ,Female ,business - Abstract
The study objectives were to evaluate outcomes in patients who have received dry needling treatments and to identify predictors of pain and disability.The study was a prospective cohort follow-up design.The study was conducted at the Pain Clinic at Pingtung Christian Hospital, Taiwan.Ninety-two (92) patients sick-listed for 3 months or longer for myofascial pain syndrome.From February to October 2008, participants were treated at the pain clinic with dry needling of trigger points and muscle stretches of the involved muscles.Data were collected by self-administered questionnaires to assess changes in pain intensity and pain interference. Data collection was performed at baseline and after 2, 4, and 8 weeks. Sociodemographic variables, symptom characteristics, and baseline outcome measures were analyzed using generalized estimating equation methodology.The proposed dry-needling protocol reduced pain intensity and pain interference. Long duration of pain symptoms, high pain intensity, poor quality of sleep, and repetitive stress were associated with poor outcomes.Dry needling is an effective treatment for reducing pain and pain interference. However, long pain duration, high pain intensity, poor quality of sleep, and repetitive stress are associated with poor outcomes. Treatment outcome depends not only on the dry needling protocol, but also on disease characteristics and patient demographic profile.
- Published
- 2011
22. Comparisons of Mechanical Versus Phase-array Intracardiac Echocardiography-assisted Transseptal Puncture in Patients With Dilated Left Atrium Undergoing Percutaneous Transvenous Mitral Commissurotomy
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Kuo-Yang Wang, Wei-Wen Lin, Chih-Tai Ting, Yun-Ching Fu, Wen-Lieng Lee, Sheng-Ling Jan, I-Hsiang Lin, and Kae-Woei Liang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cardiac Catheterization ,Intracardiac echocardiography ,echocardio-graphy (intracardiac echocardiography, ICE) ,Left atrium ,Punctures ,cardiac catheterization (transseptal, percutaneous transvenous mitral commissurotomy, PTMC) ,Mitral valve stenosis ,medicine ,Effective treatment ,Humans ,Fossa ovalis ,In patient ,Heart Atria ,Aged ,Medicine(all) ,lcsh:R5-920 ,Percutaneous transvenous mitral commissurotomy ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Stenosis ,medicine.anatomical_structure ,Echocardiography ,Female ,Radiology ,mitral valve stenosis ,business ,lcsh:Medicine (General) ,Dilatation, Pathologic - Abstract
Background Percutaneous transvenous mitral commissurotomy (PTMC) is an effective treatment for mitral stenosis, but transseptal puncture carries a certain risk of complications. Our previous report has shown the effectiveness of phase-array intracardiac echocardiography (ICE)-guided transseptal puncture in patients with dilated left atrium undergoing PTMC. However, there are few reports comparing the new-generation mechanical versus phase-array ICE-guided transseptal puncture in PTMC. Methods Between March 2007 and March 2008, 6 consecutive patients with symptomatic mitral stenosis with dilated left atrium (range, 4.1–6.1 cm) underwent transseptal puncture by mechanical ICE guidance in PTMC by the same experienced operator. The procedural, echocardiographic and clinical results were retrospectively retrieved and analyzed. In addition, phase-array ICE-guided transseptal cases ( n = 7), which included consecutive cases from May to December 2008, were compared. Results All 6 patients could have fossa ovalis visualized by ICE, and none of them had false transseptal puncture. Mechanical ICE provided a panoramic wider view of the interatrium septum, and offered better knowledge of the needle's geographic contact to the fossa ovalis than did the phase-array system. The fluoroscopic time of PTMC in the mechanical ICE-guided group (37 ± 9 minutes, n = 6) was similar ( p = 0.465) to that of phase-array guidance (31 ± 15 minutes, n = 7). Conclusion Mechanical ICE is effective in guiding transseptal puncture in PTMC.
- Published
- 2010
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23. Vascular Plugging for the Enlarging Pulmonary Arteriovenous Malformation in a Patient With Idiopathic Pulmonary Artery Hypertension
- Author
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Sheng-Ling Jan, Kuo-Yang Wang, Kae-Woei Liang, and Chi-Yao Huang
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Arteriovenous fistula ,Pulmonary Artery ,Brain Ischemia ,Brain ischemia ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,medicine ,Humans ,Familial Primary Pulmonary Hypertension ,Vascular closure device ,030212 general & internal medicine ,Embolization ,Incidental Findings ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Hypoxia (medical) ,medicine.disease ,Embolization, Therapeutic ,Magnetic Resonance Imaging ,Patient Care Management ,Stroke ,Treatment Outcome ,medicine.anatomical_structure ,030228 respiratory system ,Pulmonary Veins ,Arteriovenous Fistula ,Pulmonary artery ,Cardiology ,Vascular resistance ,Female ,Vascular Resistance ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Vascular Closure Devices - Abstract
The coexistence of idiopathic pulmonary artery hypertension with pulmonary arteriovenous malformation (PAVM) is challenging because although the PAVM causes hypoxia and polycythemia with potential thrombotic complications, closing the PAVM increases pulmonary artery pressure. We report on a lady with PAVM and idiopathic pulmonary artery hypertension who, within 2 years of diagnosis, had an ischemic stroke, PAVM enlargement from 20 × 20 × 30 mm to 30x × 40 × 40 mm and oximetry decrease to 90%. Transcatheter occlusion of PAVM with a vascular plug was successful. A year later, she had no flow via the PAVM and systemic oximetry improved to 97%, but pulmonary vascular resistance increased to 1.5-fold of baseline.
- Published
- 2018
24. Correctness of multi-detector-row computed tomography for diagnosing mechanical prosthetic heart valve disorders using operative findings as a gold standard
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Hao-Ji Wei, Yung-Kai Lin, Chung-Chi Wang, Yun-Ching Fu, I-Chen Tsai, Clayton Chi-Chang Chen, Hung-Wen Tsai, Kuo-Yang Wang, Yen Chang, Sheng-Ling Jan, Min-Chi Chen, and Shih-Rong Hsieh
- Subjects
Adult ,Male ,Aortic valve ,medicine.medical_specialty ,Adolescent ,Prosthesis Design ,Pseudoaneurysm ,Suture (anatomy) ,Occlusion ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,cardiovascular diseases ,Aged ,Neuroradiology ,Heart Valve Prosthesis Implantation ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Interventional radiology ,General Medicine ,Gold standard (test) ,Middle Aged ,medicine.disease ,Prosthesis Failure ,Surgery ,medicine.anatomical_structure ,Echocardiography ,Aortic Valve ,Heart Valve Prosthesis ,cardiovascular system ,Female ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
The purpose was to compare the findings of multi-detector computed tomography (MDCT) in prosthetic valve disorders using the operative findings as a gold standard. In a 3-year period, we prospectively enrolled 25 patients with 31 prosthetic heart valves. MDCT and transthoracic echocardiography (TTE) were done to evaluate pannus formation, prosthetic valve dysfunction, suture loosening (paravalvular leak) and pseudoaneurysm formation. Patients indicated for surgery received an operation within 1 week. The MDCT findings were compared with the operative findings. One patient with a Björk-Shiley valve could not be evaluated by MDCT due to a severe beam-hardening artifact; thus, the exclusion rate for MDCT was 3.2% (1/31). Prosthetic valve disorders were suspected in 12 patients by either MDCT or TTE. Six patients received an operation that included three redo aortic valve replacements, two redo mitral replacements and one Amplatzer ductal occluder occlusion of a mitral paravalvular leak. The concordance of MDCT for diagnosing and localizing prosthetic valve disorders and the surgical findings was 100%. Except for images impaired by severe beam-hardening artifacts, MDCT provides excellent delineation of prosthetic valve disorders.
- Published
- 2008
25. Application of a hybrid controller to a mobile robot
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Kuo-Yang Wang and Juing-Shian Chiou
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Engineering ,business.industry ,Open-loop controller ,Mobile robot ,Control engineering ,Computer Science::Robotics ,Support vector machine ,Model predictive control ,Hardware and Architecture ,Control theory ,Position (vector) ,Modeling and Simulation ,Robot ,business ,Software ,Membership function - Abstract
This paper presents the application of a hybrid controller to the optimization of the movement of a mobile robot. Through hybrid controller processes, the optimal angle and velocity of a robot moving in a work space was determined. More effective movement resulted from these hybrid controller processes. The experimental scenarios involved a five-versus-five soccer game and a MATLAB simulation, where the proposed system dynamically assigned the robot to the target position. The hybrid controller was able to choose a better position according to the circumstances encountered. The hybrid controller that is proposed includes a support vector machine and a fuzzy logic controller. We used the method of generalized predictive control to predict the target position, and the support vector machine to determine the optimal angle and velocity required for the mobile robot to reach the goal. First, we used the generalized predictive control to predict the target position. Then, the support vector machine is used to classify the angle that must be followed by the mobile robot to reach the goal. Next, a fuzzy logic controller is designed to determine the velocity of the left and right wheels of the mobile robot. Thus generated, the velocity was optimized according to the measures obtained by the support vector machine. Finally, based on the optimal velocity of robot, the output membership function was modified. Consequently, the proposed hybrid controller allowed the robot to reach the goal quickly and effectively.
- Published
- 2008
26. Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes
- Author
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Wen-Lieng Lee, Hui-Chun Lai, Tsun-Jui Liu, Hsiao-Wei Lee, Kuo-Yang Wang, Chih-Tai Ting, Li-Chuan Wang, Hui-Chin Lai, and Yueh-Chiao Yeh
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Heart Diseases ,Cell Survival ,Physiology ,Apoptosis ,Pharmacology ,Mitochondrion ,Mitochondria, Heart ,Rats, Sprague-Dawley ,In vivo ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,Myocyte ,Myocytes, Cardiac ,Ginkgoales ,Doxorubicin ,Cells, Cultured ,Membrane Potential, Mitochondrial ,biology ,Caspase 3 ,Plant Extracts ,Ginkgo biloba ,Cytochromes c ,Cardiovascular Agents ,biology.organism_classification ,Cytoprotection ,Rats ,Disease Models, Animal ,Endocrinology ,Animals, Newborn ,Proto-Oncogene Proteins c-bcl-2 ,Tumor Suppressor Protein p53 ,Cardiology and Cardiovascular Medicine ,medicine.drug - Abstract
Aims The objective of this study was to investigate whether a cytoprotective herb-derived agent, Ginkgo biloba extract (EGb) 761, could have a beneficial effect on doxorubicin-induced cardiac toxicity in vitro and in vivo . Methods and results Primary cultured neonatal rat cardiomyocytes were treated with the vehicle, doxorubicin (1 µM), EGb761 (25 µg/mL), or EGb761 plus doxorubicin. After 24 h, doxorubicin upregulated p53 mRNA expression, disturbed Bcl-2 family protein balance, disrupted mitochondrial membrane potential, precipitated mitochondrion-dependent apoptotic signalling, induced apoptotic cell death, and reduced viability of cardiomyocytes, whereas EGb761 pretreatment suppressed all the actions of doxorubicin. Similarly, rats treated with doxorubicin [3 mg/kg intraperitoneally (i.p.) three doses every other day] displayed retarded growth of body and heart as well as elevated apoptotic indexes in heart tissue at both 7 and 28 days after exposure, whereas EGb761 pretreatment (5 mg/kg i.p. 1 day before each dose of doxorubicin) effectively neutralized the aforementioned gross and cellular adverse effects of doxorubicin. Conclusion Doxorubicin impairs viability of cardiomyocytes at least partially by activating the p53-mediated, mitochondrion-dependent apoptotic signalling. EGb761 can effectively and extensively counteract this action of doxorubicin, and may potentially protect the heart from the severe toxicity of doxorubicin.
- Published
- 2008
27. True outcomes for patients on antiretroviral therapy who are lost to follow-up in Malawi
- Author
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Anthony D. Harries, Chao-Sung Chang, Kuo-Yang Wang, Erik J Schouten, Solomon Chih-Cheng Chen, Joseph Kwong-Leung Yu, and Simon D Makombe
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Adult ,Male ,Malawi ,Pediatrics ,medicine.medical_specialty ,Patient Dropouts ,Adolescent ,Anti-HIV Agents ,Population ,Developing country ,HIV Infections ,Health Services Accessibility ,Acquired immunodeficiency syndrome (AIDS) ,Poverty Areas ,Humans ,Medicine ,Lost to follow-up ,education ,education.field_of_study ,business.industry ,Public health ,Mortality rate ,Public Health, Environmental and Occupational Health ,medicine.disease ,Treatment Outcome ,Clinical research ,Lessons from the Field ,Family medicine ,Female ,business ,Contact tracing - Abstract
PROBLEM: In many resource-poor countries that are scaling up antiretroviral therapy (ART), 5-25% of patients are reported as "lost to follow-up". This figure is 9% in Malawi. There is no published information about the true outcome status of these patients. APPROACH: In four facilities in northern Malawi, ART registers and master cards were used to identify patients who had not attended the facility for 3 months or more and were thus registered as "lost to follow-up". Clinic staff attempted to trace these patients and ascertain their true outcome status. LOCAL SETTING: Of 253 patients identified as "lost to follow-up", 127 (50%) were dead, 58% of these having died within 3 months of their last clinic visit. Of the 58 patients (23%) found to be alive, 21 were still receiving ART and 37 had stopped treatment (high transport costs being the main reason for 13 patients). Sixty-eight patients (27%) could not be traced, most commonly because of an incorrect address in the register. Fewer patients were alive and more patients could not be traced from the central hospital compared with the peripheral hospitals. RELEVANT CHANGES:Better documentation of patients’ addresses and prompt follow-up of patients who are late for their appointments are required. LESSONS LEARNED: ART clinics in resource-poor countries should ensure that patients’ addresses are correct and comprehensive. Clinics should also undertake contact tracing as soon as possible in the event of non-attendance, consider facilitating access to ART clinics and take loss to follow-up into consideration when assessing death rates.
- Published
- 2007
28. Mitral regurgitation complicates postoperative outcome of noncardiac surgery
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Hui Chin Lai, Wen Lieng Lee, Hui Chun Lai, Tsun Jui Liu, Chih Tai Ting, and Kuo Yang Wang
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Postoperative Complications ,Risk Factors ,Internal medicine ,Mitral valve ,medicine ,Humans ,Local anesthesia ,cardiovascular diseases ,Adverse effect ,Aged ,Aged, 80 and over ,Mitral regurgitation ,Ejection fraction ,business.industry ,Tracheal intubation ,Mitral Valve Insufficiency ,Atrial fibrillation ,Perioperative ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Whether and how mitral regurgitation impacts perioperative outcome of noncardiac surgery remains unclear. Methods From November 1999 to August 2004, all patients undergoing noncardiac operations and ever examined by echocardiography within prior 12 months were screened. Those with moderate-severe or severe mitral regurgitation were enrolled provided they were not already trachea-intubated and the surgery was not performed under local anesthesia. The perioperative outcomes of these patients were analyzed, and related prognostic predictors were investigated by multivariate logistic regression analysis. Results A total of 84 patients (43 men, mean age of 66 years, low surgical risk in 28 and intermediate in 56) complying with the inclusion criteria were included. Their surgery was complicated by frequent (31%) yet minor intraoperative adverse events of controllable hypotension and bradycardia. In contrast, the postoperative outcomes were seriously complicated with high morbidity (27.4%, mostly pulmonary edema and prolonged tracheal intubation) and mortality (11.9%). Atrial fibrillation was identified by multivariate logistic regression analysis as the predictor of inhospital death (OD 11.579, P = .003), whereas surgical risk level (OD 5.118, P = .021), left ventricular ejection fraction (OD 0.958, P = .026), and atrial fibrillation (OD 3.058, P = .045), as independent predictors of postoperative morbidity. Conclusions Under current anesthetic management, patients with advanced mitral regurgitation could go through fairly safe intraoperative course of noncardiac surgery despite minor complications. Their postoperative outcome was, however, complicated by extraordinarily high morbidity and mortality, especially in those with preexisting atrial fibrillation, higher surgical risk level, and lower left ventricular ejection fraction.
- Published
- 2007
29. Atrial fibrillation, CHA2DS2-VASc score, antithrombotics and risk of traffic accidents: A population-based cohort study
- Author
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Wen Lieng Lee, Tsun Jui Liu, Chia Ning Liu, Kuo Yang Wang, Tsu Juey Wu, Hui Chin Lai, Wu-Chien Chien, and Chi Hsiang Chung
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Taiwan ,Poison control ,Risk Assessment ,Coronary artery disease ,Fibrinolytic Agents ,Risk Factors ,Internal medicine ,Injury prevention ,Atrial Fibrillation ,medicine ,Humans ,Cumulative incidence ,Stroke ,Aged ,Proportional Hazards Models ,Retrospective Studies ,business.industry ,Proportional hazards model ,Incidence ,Accidents, Traffic ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Hospitalization ,Treatment Outcome ,Population Surveillance ,CHA2DS2–VASc score ,Female ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background Traffic accidents account for a substantial proportion of premature disabilities and deaths. Whether atrial fibrillation (AF) provokes while antithrombotics prevent from such events remains un-investigated. Methods All patients ≥40years with newly diagnosed AF in 2005 were scrutinized from the "Longitudinal Health Insurance Database 2005" (1 million beneficiaries) of Taiwan's National Health Insurance Institute as the AF group. Four-fold number of age-, gender-, and comorbidity-matched patients but without AF served as the Non-AF controls. Patients were followed till occurrence of hospitalization-requiring traffic injury, death, withdrawal from insurance, or the end of 2010. Cumulative incidence of traffic accidents was compared between groups, and predictors and preventive role of antithrombotics for these accidents were identified by Cox regression analysis. Results Within a mean follow-up of 4.3years, traffic injury occurred significantly more often in patients with AF (N=1724) than those without it (N=6896) (5.4 vs. 4.9 per 1000 person-years, log-rank p=0.012, HR 1.110, 95% CI 1.013–1.572). Cox models identified age ≧65years, hypertension, coronary artery disease, stroke, liver cirrhosis and CHADS2VASC score≧1 as risk factors for traffic injury in AF patients, whereas oral anticoagulants (HR 0.576, 95% CI 0.285–0.791, p=0.002) used in patients with CHADS2VASC score ≧1 but not antiplatelet therapy (p=0.197) as negative predictors. Conclusion Patients with AF are more vulnerable to traffic accidents especially when with higher CHADS2VASC scores and other comorbidities. This tendency to traffic accidents, however, could be ameliorated by oral anticoagulation in specialized cases but not by antiplatelet therapy.
- Published
- 2015
30. True Lumen Stenting for a Spontaneously Dissected Superior Mesenteric Artery May Compromise Major Intestinal Branches and Aggravate Bowel Ischemia
- Author
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Kuo-Yang Wang, Yu-Tsung Cheng, Wen-Lieng Lee, Tsun-Jui Liu, Hang-Yun Yao, Chih-Feng Chang, and Hui-Chin Lai
- Subjects
Male ,medicine.medical_specialty ,Bowel ischemia ,Ischemia ,Lumen (anatomy) ,Mesenteric Artery, Superior ,Risk Factors ,Internal medicine ,medicine.artery ,medicine ,Humans ,Vascular Diseases ,Superior mesenteric artery ,business.industry ,Vascular disease ,General Medicine ,Middle Aged ,medicine.disease ,SMA ,Surgery ,Aortic Dissection ,Contrast medium ,Treatment Outcome ,medicine.anatomical_structure ,Mesenteric Ischemia ,Cardiology ,Stents ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Angioplasty, Balloon ,Artery - Abstract
Optimal endovascular therapy for isolated superior mesenteric artery (SMA) dissection remains undetermined. Here, we report a 56-year-old male with ischemic bowel syndrome caused by such a serious vascular disease. He was treated with endovascular true lumen stenting yet got aggravated in bowel ischemia from unexpected jail of major intestinal branches perfused by the false lumen, requiring subsequent complex rewiring and dilatation procedures to resolve at the cost of excessive fluoroscopic and contrast medium exposure. Thus, when treating patients with isolated SMA dissection with a functioning false lumen, true lumen stenting may inadvertently compromise crucial intestinal branches and should not be indiscriminately considered as the prime therapeutic option.
- Published
- 2013
31. Efficacy of different statins for primary prevention of atrial fibrillation in male and female patients: A nationwide population-based cohort study
- Author
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Tsu Juey Wu, El Wui Loh, Jin Long Huang, Yu Cheng Hsieh, Kuo Yang Wang, Ching-Heng Lin, and Chen Ying Hung
- Subjects
Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,business.industry ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Cohort Studies ,Primary Prevention ,Population based cohort ,Treatment Outcome ,Internal medicine ,Primary prevention ,Atrial Fibrillation ,Female patient ,medicine ,Physical therapy ,Humans ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business - Published
- 2013
32. Statin therapy reduces the risk of ventricular arrhythmias, sudden cardiac death, and mortality in heart failure patients: A nationwide population-based cohort study
- Author
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Kuo-Yang Wang, Jing-Long Huang, Chen-Ying Hung, Ching-Heng Lin, Ying-Chieh Liao, Tsu-Juey Wu, and Yu-Cheng Hsieh
- Subjects
Adult ,Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,education ,Taiwan ,Kounis syndrome ,Monoclonal antibody ,Sudden death ,Sudden cardiac death ,Risk Factors ,Internal medicine ,Humans ,Medicine ,Myocardial infarction ,Aged ,Retrospective Studies ,Heart Failure ,business.industry ,Middle Aged ,medicine.disease ,Survival Rate ,Death, Sudden, Cardiac ,Treatment Outcome ,Population Surveillance ,Heart failure ,Tachycardia, Ventricular ,Cardiology ,Female ,Statin therapy ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
the drug. Therefore, one should always have in mind that during treatment of systemic inflammatory, neoplastic or hematological diseases with monoclonal antibodies the production of anti-drug antibodies is a reality. These antibodies can cause hypersensitivity reactions, worsen overt or incipient heart failure [11] and induce myocardial infarction manifesting as Kounis syndrome [3]. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology.
- Published
- 2013
33. Shortest door-to-balloon time in primary percutaneous coronary intervention for a young resident physician suffering from in-hospital inferior ST-segment elevation myocardial infarction
- Author
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Hung Taw Yi, Hui Chin Lai, Chieh Shou Su, Yu Tsung Cheng, Tsun Jui Liu, Wen Lieng Lee, and Kuo Yang Wang
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Resident physician ,medicine.disease ,Internal medicine ,Emergency medicine ,Door-to-balloon ,Cardiology ,Medicine ,Myocardial infarction ,Inferior ST segment elevation ,Cardiology and Cardiovascular Medicine ,business - Published
- 2013
34. Axillofemoral Bypass Relieves Visceral Malperfusion in Type B Aortic Dissection
- Author
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Chung Chi Wang, Chih Tai Ting, Si Wa Chan, Tsun Jui Liu, Yi Wen Chang, Kuo Yang Wang, Hui Chin Lai, Hsun Nan Kuo, and Wen Lieng Lee
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Ischemia ,Anastomosis ,Aortic aneurysm ,Aneurysm ,Internal medicine ,medicine ,Humans ,Aortic dissection ,Aortic Aneurysm, Thoracic ,business.industry ,Anastomosis, Surgical ,Middle Aged ,medicine.disease ,Surgery ,Femoral Artery ,Aortic Dissection ,Mesenteric ischemia ,Cardiothoracic surgery ,Cardiology ,Axillary Artery ,Cardiology and Cardiovascular Medicine ,business ,Vascular Surgical Procedures ,Perfusion - Abstract
A 58-year-old man with acute type B aortic dissection presented with right lower limb cyanosis, mesenteric ischemia, and acute renal failure. He was treated with extraanatomic right axillofemoral bypass surgery alone, recovered completely from renal, mesenteric, and lower extremity malperfusion shortly thereafter, and lived free of symptoms for the following year. Follow-up computed tomography angiograms documented adequate expansion of the true aortic lumen and good perfusion of visceral organs. Thus, managing such patients with coexisting visceral and extremity malperfusion may be accomplished with axillofemoral bypass exclusively, which can relieve ischemia of upstream abdominal organs and downstream lower extremities effectively and durably.
- Published
- 2013
35. Coronary severity score and C-reactive protein predict major adverse cardiovascular events in patients with stable coronary artery disease (from the Taichung CAD study)
- Author
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Wayne Huey-Herng Sheu, Wen-Jane Lee, Kuo-Yang Wang, Kae-Woei Liang, I-Te Lee, Hung-Chih Pan, Ying-Chieh Liao, Jun-Sing Wang, and Wen-Lieng Lee
- Subjects
Male ,medicine.medical_specialty ,Multivariate analysis ,Clinical Biochemistry ,CAD ,Coronary Artery Disease ,Coronary Angiography ,Biochemistry ,Severity of Illness Index ,Coronary artery disease ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Diabetes Mellitus ,Humans ,In patient ,cardiovascular diseases ,Aged ,Aged, 80 and over ,biology ,business.industry ,Biochemistry (medical) ,C-reactive protein ,Significant difference ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,C-Reactive Protein ,Multivariate Analysis ,biology.protein ,Cardiology ,Female ,business ,Mace ,Biomarkers ,Follow-Up Studies - Abstract
Whether angiographic coronary severity really predicts future major adverse cardiovascular events (MACEs) in patients with coronary artery disease (CAD) is uncertain. Few studies have compared the efficacy of SYNTAX, Gensini and Jeopardy scores in predicting MACE in stable CAD.We collected data of MACE, including all-cause mortality, all strokes, new myocardial infarction and unplanned repeat revascularization, in subjects with stable CAD from our catheterization databank. Coronary severity was graded with SYNTAX, Gensini and Jeopardy scoring systems.During a median follow-up period of 42months, 39 out of the 181 subjects developed at least 1 MACE. Those with MACE had a significantly higher baseline high sensitivity C-reactive protein (hs-CRP) (p=0.025). Multivariate analysis showed that coronary severity score, hs-CRP and diabetes mellitus were significant predictors for MACE. Kaplan-Meier estimates showed a significant difference in MACE-free rates between SYNTAX binary scores (≥15 vs.15, p=0.043), Gensini binary scores (≥36 vs.36, p=0.048) and Jeopardy binary scores (≥4 vs.4, p=0.001).Coronary severity score, hs-CRP and diabetes mellitus independently predicted MACE in patients with stable CAD. The Jeopardy score is simple to calculate and as effective for predicting MACE in stable CAD as the complex SYNTAX score.
- Published
- 2014
36. Lower serum triglyceride level is a risk factor for in-hospital and late major adverse events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention- a cohort study
- Author
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Kuo Yang Wang, Hui Chin Lai, Wen Lieng Lee, Yu Tsung Cheng, Hung Yun Ho, Chia Ning Liu, Tsun Jui Liu, and Chieh Shou Su
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Taiwan ,Coronary ,Down-Regulation ,Kaplan-Meier Estimate ,Coronary Angiography ,Risk Assessment ,Triglyceride ,Tertiary Care Centers ,Electrocardiography ,Percutaneous Coronary Intervention ,Risk Factors ,Internal medicine ,medicine ,ST segment ,Humans ,Myocardial infarction ,Hospital Mortality ,Risk factor ,Adverse effect ,Triglycerides ,Aged ,Proportional Hazards Models ,Outcome ,Aged, 80 and over ,Chi-Square Distribution ,Restenosis ,business.industry ,Revascularization ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Logistic Models ,Treatment Outcome ,Multivariate Analysis ,Cardiology ,Female ,Myocardial infarction diagnosis ,business ,Cardiology and Cardiovascular Medicine ,Mace ,Biomarkers ,Cohort study ,Research Article - Abstract
Background Whether serum triglyceride level correlates with clinical outcomes of patients with ST segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI) remains unclear. Methods From June 2008 to February 2012, all patients with STEMI who were treated with pPCI in this tertiary referral hospital and then had fasting lipid profiles measured within 24 hours were included and dichotomized into lower- (≦150 mg/dl) and higher-triglyceridemic (>150 mg/dl) groups. Baseline characteristics, in-hospital outcomes, and late major adverse cardiovascular events (MACE) were compared in-between. Independent predictors for in-hospital death and late adverse events were identified by multivariate logistic and Cox regression analyses. Results A total of 247 patients were enrolled, including 163 lower-triglyceridemic and 84 higher-triglyceridemic subjects. The angiographic characteristics, pPCI results and in-hospital outcomes were similar between the two groups. However, multivariate logistic analysis identified triglyceride level as a negative predictor for in-hospital death (OR 0.963, 95% CI 0.931-0.995, p = 0.023). At follow-up for a mean period of 1.23 to 1.40 years, compared with the high-triglyceridemic group, low-triglyceridemic patients had fewer cumulative incidences of target vessel revascularization (TVR) (21.7% vs. 9.5%, p = 0.011) and overall MACE (26.1% vs. 11.9%, p = 0.0137). Cox regression analysis confirmed serum triglyceride as a negative predictor for TVR and overall MACE. Conclusions Serum triglyceride level inversely correlates with in-hospital death and late outcomes in patients with STEMI treated with pPCI. Thus, when managing such patients, a high serum triglyceride level can be regarded as a benign factor but not a target for aggressive therapy.
- Published
- 2014
37. Heart rate variability parameters and ventricular arrhythmia correlate with pulmonary arterial pressure in adult patients with idiopathic pulmonary arterial hypertension
- Author
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Chieh-Shou Su, Jin-Long Huang, Kae-Woei Liang, Hung-Tao Yi, Wan-Jane Tsai, Wei-Wen Lin, Tsu-Juey Wu, Yu-Cheng Hsieh, and Kuo-Yang Wang
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Premature atrial contraction ,Pulmonary arterial pressure ,Critical Care and Intensive Care Medicine ,QT interval ,Heart Rate ,Internal medicine ,medicine ,Heart rate variability ,Humans ,Arterial Pressure ,Familial Primary Pulmonary Hypertension ,business.industry ,Central venous pressure ,Idiopathic Pulmonary Arterial Hypertension ,Arrhythmias, Cardiac ,Middle Aged ,medicine.disease ,Autonomic nervous system ,Blood pressure ,Case-Control Studies ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
This aim of this study was to correlate heart rate variability (HRV) parameters to pulmonary arterial pressure (PAP) in patients with purely idiopathic pulmonary arterial hypertension (IPAH).HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear.HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls.Time-domain HRV parameters (SDNN, p 0.0001; SDANN, p 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP, p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAP. IPAH patients had longer QTc intervals (p 0.0001) and more premature ventricular contractions (p 0.0001) than controls.IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia.
- Published
- 2014
38. Impact of right-ventricular apical pacing on the optimal left-ventricular lead positions measured by phase analysis of SPECT myocardial perfusion imaging
- Author
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Kuo-Yang Wang, Jin-Long Huang, Michael Lloyd, Guang-Uei Hung, Shih Ann Chen, Shih-Chung Tsai, Ji Chen, and Wan-Yu Lin
- Subjects
Male ,Technetium Tc 99m Sestamibi ,Ventricular lead ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Ventricular Function, Left ,Cardiac Resynchronization Therapy ,Myocardial perfusion imaging ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Arrhythmia, Sinus ,cardiovascular diseases ,Lead (electronics) ,Aged ,Ventricular function ,medicine.diagnostic_test ,business.industry ,Extramural ,Myocardial Perfusion Imaging ,General Medicine ,Middle Aged ,Lv dyssynchrony ,cardiovascular system ,Ventricular Function, Right ,Female ,Radiopharmaceuticals ,business ,Phase analysis ,Nuclear medicine ,Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - Abstract
The use of SPECT phase analysis to optimize left-ventricular (LV) lead positions for cardiac resynchronization therapy (CRT) was performed at baseline, but CRT works as simultaneous right ventricular (RV) and LV pacing. The aim of this study was to assess the impact of RV apical (RVA) pacing on optimal LV lead positions measured by SPECT phase analysis.This study prospectively enrolled 46 patients. Two SPECT myocardial perfusion scans were acquired under sinus rhythm with complete left bundle branch block and RVA pacing, respectively, following a single injection of (99m)Tc-sestamibi. LV dyssynchrony parameters and optimal LV lead positions were measured by the phase analysis technique and then compared between the two scans.The LV dyssynchrony parameters were significantly larger with RVA pacing than with sinus rhythm (p ~0.01). In 39 of the 46 patients, the optimal LV lead positions were the same between RVA pacing and sinus rhythm (kappa = 0.861). In 6 of the remaining 7 patients, the optimal LV lead positions were along the same radial direction, but RVA pacing shifted the optimal LV lead positions toward the base.The optimal LV lead positions measured by SPECT phase analysis were consistent, no matter whether the SPECT images were acquired under sinus rhythm or RVA pacing. In some patients, RVA pacing shifted the optimal LV lead positions toward the base. This study supports the use of baseline SPECT myocardial perfusion imaging to optimize LV lead positions to increase CRT efficacy.
- Published
- 2013
39. Coronary artery aneurysms: A 25-patient study
- Author
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Chih-Tai Ting, Kuo-Yang Wang, Martin St. John Sutton, and Ying-Tsung Chen
- Subjects
Coronary artery aneurysm ,medicine.medical_specialty ,medicine.drug_class ,business.industry ,Incidence (epidemiology) ,Anticoagulant ,General Medicine ,medicine.disease ,Patient study ,medicine.anatomical_structure ,Internal medicine ,Cohort ,cardiovascular system ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,Vasculitis ,business ,Artery - Abstract
Coronary artery aneurysm is a rare disorder, characterized by abnormal dilatation of a localized portion or diffuse segments of the coronary artery. We studied clinical demographics, catheterization findings, and clinical outcomes in an Asian patient cohort with documented coronary artery aneurysms. Compared to a Caucasian adult population, our patient cohort had a lower incidence of coronary artery aneurysm (0.25% vs. 2.6%), and more patients with nonobstructive coronary artery aneurysms (70%); age, gender, and coronary distribution were comparable. The initial presentation of myocardial infarction occurred in five patients (5/17, 30%) with nonobstructive coronary artery aneurysms; however, none who were receiving preventive medications consisting of anticoagulant and antiplatelet agents subsequently developed myocardial infarction. We conclude that the incidence of coronary artery aneurysms with or without associated significant coronary stenosis seems to be lower in the Asian population. In contrast, the incidence of nonobstructive coronary artery aneurysms is considerably high and should not be thought of as a relatively benign disease entity if not treated with preventive medications. Rheumatoid arthritis-related vasculitis might be a cause of coronary artery aneurysm. Surgical intervention is based on the severity of coronary artery stenosis. The result of medical treatment has been compatible with long-term survival. Cathet. Cardiovasc. Intervent. 48:31-38, 1999.
- Published
- 1999
40. Surgical Ligation of Bilateral Large Coronary Artery Fistula to Pulmonary Artery
- Author
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Yu-Cheng Hsieh, Wei-Wen Lin, Kuo-Yang Wang, Yen Chang, Po-Chi Liao, Si-Wa Chan, and Shih-Rong Hsieh
- Subjects
medicine.medical_specialty ,Left atrium ,Pulmonary Artery ,Coronary Angiography ,Arterio-Arterial Fistula ,Predictive Value of Tests ,Internal medicine ,medicine.artery ,Multidetector Computed Tomography ,medicine ,continuous flow ,Humans ,cardiovascular diseases ,Cardiac Surgical Procedures ,Ligation ,business.industry ,Middle Aged ,Coronary artery fistula ,Coronary Vessels ,Systolic murmur ,Echocardiography, Doppler, Color ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,coronary pulmonary fistula ,Predictive value of tests ,Pulmonary artery ,cardiovascular system ,Cardiology ,Female ,business ,Pulmonary area ,Cardiology and Cardiovascular Medicine ,surgical ligation ,Artery - Abstract
A 63-year-old woman was admitted to our hospital due to a grade III systolic murmur over the pulmonary area. A chest x-ray ([Figure 1A][1]) showed cardiomegaly with abnormal vascular shadow over the left atrium area. Transthoracic echocardiography showed coronary artery drainage into pulmonary
- Published
- 2015
- Full Text
- View/download PDF
41. Iso-osmolar contrast medium better preserves short- and long-term renal function after cardiovascular catheterizations in patients with severe baseline renal insufficiency
- Author
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Kae Woei Liang, Yu Cheng Hsieh, Kuo Yang Wang, Tsun Jui Liu, Chih Tai Ting, Hong Yun Her, Wei Wen Lin, Ying Tsung Chen, and Wen Lieng Lee
- Subjects
medicine.medical_specialty ,Creatinine ,business.industry ,Contrast-induced nephropathy ,Iopromide ,Renal function ,medicine.disease ,Iodixanol ,Nephropathy ,Surgery ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Circulatory system ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease ,medicine.drug - Abstract
Background Iso-osmolar iodixanol was shown to least affect very-short-term renal function. However, its short- and long-term renal effects after cardiovascular catheterizations in severe renal insufficiency remain unknown. Methods Patients undergoing elective cardiovascular catheterizations and having pre-procedural serum creatinine (Scr) ≥2.5mg/dl were prospectively studied. The results were compared to those of historical controls who received iopromide. Results The iodixanol group included 27 patients, aged 73±1years, and the case-matched control group consisted of another 27 patients, aged 71±1years. The baseline Scr were 3.0±0.3 and 3.0±0.2mg/dl respectively. Although the Scr at 3months was similar, the Scr at 6months was lower in the iodixanol group (2.7±0.3 vs 4.2±0.5mg/dl, p =0.017). The absolute and percentage increments in Scr at 3months (0.0±0.2 vs 0.6±0.2mg/dl, p =0.014, and 1±4% vs 24±6%, p =0.003, respectively) and 6months (−0.3±0.2 vs 1.3±0.4mg/dl, p =0.001, and −10±5% vs 47±12%, p Conclusions Iodixanol better preserves short- and long-term renal outcomes in patients with severe baseline renal insufficiency.
- Published
- 2006
42. The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan
- Author
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Wei-Hsian Yin, Shao Yuan Chuang, Chun-Yuan Chu, Kuo-Yang Wang, Tsung-Hsien Lin, Lien-Chi Huang, Ching-Chang Fang, Ai-Hsien Li, Jaw Wen Chen, Yi-Heng Li, Po-Chao Hsu, Wen-Hsien Lee, Chiun-Hsiung Wang, Ho-Ming Su, Hung-I Yeh, Wei-Kung Tseng, Wen-Harn Pan, Kwo-Chang Ueng, I-Chang Hsieh, and Chau-Chung Wu
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Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Population ,Taiwan ,Disease ,urologic and male genital diseases ,chemistry.chemical_compound ,lipid ,Internal medicine ,atherosclerosis ,medicine ,Humans ,Renal Insufficiency, Chronic ,education ,Stroke ,Triglycerides ,goal ,education.field_of_study ,Triglyceride ,Cholesterol ,business.industry ,General Medicine ,medicine.disease ,Atherosclerosis ,female genital diseases and pregnancy complications ,Lipoproteins, LDL ,Endocrinology ,Cross-Sectional Studies ,chemistry ,Heart failure ,Multivariate Analysis ,lipids (amino acids, peptides, and proteins) ,Female ,business ,Lipoproteins, HDL ,chronic kidney disease ,Kidney disease ,Research Paper - Abstract
Background: Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan. Methods: 3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl. Results: Compared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019). Conclusion: Although presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects.
- Published
- 2013
43. Hypoxemia during one-lung ventilation for robot-assisted coronary artery bypass graft surgery
- Author
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Kuo Yang Wang, Meng Shen Shih, Wen Lieng Lee, Hui Chin Lai, Chih Jen Hung, Tsun Jui Liu, and Chia Ning Liu
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Taiwan ,Coronary Artery Disease ,Hypoxemia ,Coronary artery bypass surgery ,Risk Factors ,Fraction of inspired oxygen ,Internal medicine ,medicine ,Extracorporeal membrane oxygenation ,Humans ,Coronary Artery Bypass ,Hypoxia ,Intraoperative Complications ,Aged ,Retrospective Studies ,Aged, 80 and over ,Ejection fraction ,business.industry ,Incidence ,Robotics ,Middle Aged ,medicine.disease ,Surgery ,One-Lung Ventilation ,Oxygen ,medicine.anatomical_structure ,Treatment Outcome ,Pneumothorax ,Anesthesia ,Vascular resistance ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Artery ,Follow-Up Studies - Abstract
Robot-assisted coronary artery bypass grafting requires continuous one-lung ventilation (OLV) to evacuate the thoracic cavity. Whether this ventilatory mode subjects patients to serious hypoxemia remains underinvestigated.From 2005 to 2010, all patients receiving robot-assisted coronary artery bypass graft surgery using OLV with active capnothorax for internal mammary artery harvesting and then passive pneumothorax for minithoracotomy direct-vision coronary bypass graft surgery were included. Patients' variables of oxygenation were monitored and compared throughout the whole surgical period. Persistent oxygen desaturation (arterial oxygen pressure70 mm Hg) refractory to primary managements was defined as a hypoxemic event, and predictors of such events were identified by multivariate regression analysis.A total of 255 consecutive patients were enrolled. Average oxygen saturation decreased modestly during the first stage of OLV with active capnothorax, causing hypoxemic events in 9 patients (4.3%) leading to death in 2 (0.8%), whereas it dropped drastically in the second stage of OLV with passive pneumothorax, resulting in hypoxemic events in 32 patients (12.6%) and death in 1 (0.4%). Multivariate regression analysis identified high pulmonary vascular resistance and low left ventricular ejection fraction as predictors of hypoxemia during internal mammary artery takedown, whereas prolonged procedure and chronic obstructive pulmonary disease were identified as predictors during minithoracotomy bypass grafting.Robot-assisted two-stage coronary artery bypass surgery employing OLV could be complicated by serious hypoxemia especially at the minithoracotomy grafting stage and in patients with specific risk factors. Thus, when managing such patients, invasive monitoring and aggressive treatment of arterial desaturation are mandatory to ensure the patient's safety and procedural smoothness.
- Published
- 2012
44. Combination With Low-dose Dextromethorphan Improves the Effect of Amlodipine Monotherapy in Clinical Hypertension
- Author
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Ming Shien Wen, Chau Chung Wu, Jaw Wen Chen, Wei Kung Tseng, Kuo Yang Wang, Hung I. Yeh, Yi Jen Hung, Wei Hsian Yin, Pei Chen, Shu Meng Cheng, and Tao Cheng Wu
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Urology ,Observational Study ,030204 cardiovascular system & hematology ,Dextromethorphan ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,medicine ,Humans ,Single-Blind Method ,Prospective Studies ,Amlodipine ,Prospective cohort study ,Antihypertensive Agents ,business.industry ,Low dose ,General Medicine ,Middle Aged ,Surgery ,Clinical trial ,030104 developmental biology ,Blood pressure ,Multicenter study ,Hypertension ,Drug Therapy, Combination ,Female ,business ,Research Article ,medicine.drug - Abstract
The combination of low rather than high dose of dextromethorphan (DXM) with amlodipine (AM) could improve blood pressure (BP) reduction in hypertensive animals. The study aimed to evaluate the feasibility of different doses of DXM combined with standard AM treatment in clinical hypertension. This was a prospective, 14-week, dose-escalation, multicenter study. After 2-week run-in period with AM 5 mg/day, hypertensive patients who got the BP goal of 140/90 mmHg kept receiving AM monotherapy for another 12 weeks. The nonresponders, while kept on AM 5 mg/day, received additional DXM treatment for 3 sequential dose-titrated periods with initially 2.5 mg/day, followed by 7.5 mg/day, and finally 30 mg/day. Each period was for 4 weeks. The patients at BP goal after each treatment period were defined as the responders and kept on the same combination till the end of the study. The responder rate of each treatment period was recorded. The changes of BP and serum antioxidant/endothelial markers between week 14 and week 2 were evaluated. Of the 103 patients initially enrolled, 89 entered the treatment period. In the 78 patients completing the study, 31 (40%) at BP goal after 2-week AM run-in kept on AM monotherapy (DXM0). The addition of 2.5 (DXM2.5) and 7.5 mg/day (DXM7.5) of DXM enabled BP goal achievement in 22 (47%) nonresponders to AM monotherapy including 16 (29%) with DXM2.5 and 6 (18%) with DXM7.5. Only 4 patients (16%) reached BP goal with the combination of DXM 30 mg/day (DXM30). Overall, 73% of the 78 patients reached BP goal at the end of the 14-week study. Mean systolic BP was reduced by 7.9% ± 7.0% with DXM2.5 (P
- Published
- 2016
45. Dosage of statin, cardiovascular comorbidities, and risk of atrial fibrillation: a nationwide population-based cohort study
- Author
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Chen Ying Hung, Yu Cheng Hsieh, Kuo Yang Wang, Pesus Chou, Tsu Juey Wu, Jin Long Huang, El Wui Loh, Chih Tai Ting, Ching-Heng Lin, and Tsuo Hung Lan
- Subjects
Male ,medicine.medical_specialty ,Statin ,Databases, Factual ,medicine.drug_class ,Taiwan ,Subgroup analysis ,Cohort Studies ,Population based cohort ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,In patient ,cardiovascular diseases ,Longitudinal Studies ,Aged ,Dose-Response Relationship, Drug ,business.industry ,Medical record ,Hazard ratio ,Atrial fibrillation ,Statin treatment ,Middle Aged ,medicine.disease ,Cardiovascular Diseases ,Population Surveillance ,Cardiology ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Statin has potential protective effects against atrial fibrillation. Clinically, there is a need to predict the atrial fibrillation protective effects in statin-treated patients. The purpose of this study was to investigate if cardiovascular co-morbidities or cumulative defined daily doses (cDDDs) of statin use could predict statin efficacy in atrial fibrillation prevention.Patients aged ≥ 50 years were identified from the Taiwan National Health Insurance Research Database. Medical records of 171,885 patients were used in this study, and 40,001 (23.3%) of the patients received statin therapy (≥ 28 cDDDs). Risk of new-onset atrial fibrillation in statin users and non-users (28 cDDDs) was estimated.During the 9-year follow-up period, 6049 patients experienced new-onset atrial fibrillation. Overall, statin therapy reduced the risk of atrial fibrillation by 28% (adjusted hazard ratio [HR] 0.72; 95% CI 0.68 to 0.77). There was a dose-response relationship between statin use and the risk of atrial fibrillation. The adjusted HRs for atrial fibrillation were 1.04, 0.85, and 0.50 when cDDDs ranged from 28 to 90, 91 to 365, and more than 365, respectively. Subgroup analysis showed that statin use was more beneficial in patients with higher CHADS2 and CHA2DS2VASc scores than those with a score of 0 (P value for interaction0.001). The therapy provided no obvious beneficial effect in those with a CHADS2 score of 0, a CHA2DS2VASc score of 0, or cDDDs less than 91.Statin therapy reduces the risk of new-onset atrial fibrillation in a dose-dependent manner, and is beneficial in patients with cardiovascular co-morbidities.
- Published
- 2012
46. Left circumflex coronary-to-pulmonary artery fistula as the exclusive collateral to the occluded left anterior descending artery
- Author
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Tsun-Jui Liu, Wen-Lieng Lee, H. Hsu, Hui-Chin Lai, Kuo-Yang Wang, H.-T. Yi, and M.-S. Chiang
- Subjects
Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Percutaneous ,Fistula ,Anterior wall ,Coronary Artery Disease ,Anterior Descending Coronary Artery ,Pulmonary Artery ,Coronary Angiography ,Ventricular Function, Left ,Percutaneous Coronary Intervention ,Arterio-Arterial Fistula ,Internal medicine ,medicine.artery ,Occlusion ,medicine ,Humans ,Circumflex ,business.industry ,Middle Aged ,medicine.disease ,Coronary Vessels ,Surgery ,medicine.anatomical_structure ,Pulmonary artery ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
A 64 year-old male presented with a five month history of effort angina. Non-invasive studies demonstrated preserved left ventricular function and a modest stress-induced myocardial perfusion defect at the anterior wall. Coronary angiography revealed occlusion of the proximal left anterior descending coronary artery with its distal segment well supplied by collaterals branching from a left circumflex-to-main pulmonary artery fistula. The occluded left anterior descending coronary artery was recanalised by percutaneous interventions, the collaterals vanished immediately, and the patient lived free of symptoms for the following five months.
- Published
- 2012
47. Comprehensive MDCT evaluation of patients with pulmonary hypertension: diagnosing underlying causes with the updated Dana Point 2008 classification
- Author
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Wan-Chun Liao, I-Chen Tsai, Hsin-Yu Tsai, Kuo-Yang Wang, Min-Chi Chen, Kae-Woei Liang, and Wei-Lin Tsai
- Subjects
Adult ,Male ,medicine.medical_specialty ,business.industry ,Hypertension, Pulmonary ,Cardiac-Gated Imaging Techniques ,General Medicine ,Middle Aged ,medicine.disease ,Pulmonary hypertension ,Tomography x ray computed ,medicine ,Humans ,Radiographic Image Interpretation, Computer-Assisted ,Radiology, Nuclear Medicine and imaging ,Female ,Radiology ,business ,Intensive care medicine ,Tomography, X-Ray Computed ,Aged - Abstract
OBJECTIVE. Pulmonary hypertension is a challenge for imagers and clinicians, with a variety of possible underlying causes, each with its own specific treatment. Although the diagnosis is based on physiologic measurements, ECG-gated MDCT can play a vital role in elucidating underlying cardiac, vascular, and pulmonary causes. CONCLUSION. A revised system for pulmonary hypertension, the Dana Point classification, can provide a template for review of the myriad causes of this complex condition.
- Published
- 2011
48. Educational program for myofascial pain syndrome
- Author
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Hon-Yi Shi, Kuo-Yang Wang, Yuan-Ting Huang, Shun-Yuan Lin, Choo-Aun Neoh, and Ho-Fu Ng
- Subjects
Adult ,Male ,medicine.medical_specialty ,Shoulder ,Psychological intervention ,Acupuncture Therapy ,Taiwan ,Myofascial pain syndrome ,Severity of Illness Index ,law.invention ,Physical medicine and rehabilitation ,Randomized controlled trial ,law ,Muscle Stretching Exercises ,Severity of illness ,medicine ,Humans ,Muscle, Skeletal ,Health Education ,Myofascial Pain Syndromes ,Dry needling ,business.industry ,Videotape Recording ,Middle Aged ,medicine.disease ,Regimen ,Pain Clinics ,Treatment Outcome ,Complementary and alternative medicine ,Needles ,Physical therapy ,Regression Analysis ,Female ,business ,Educational program - Abstract
The objective of this study was to evaluate a program for managing myofascial pain syndrome (MPS).The study design was a randomized controlled trial.The setting was the pain clinic of an academic hospital in Taiwan.Sixty-two (62) patients with a 3-month or longer history of MPS who were treated at this institution from July to November 2007 were included in the study.The participants were randomized to an experimental group (n = 32) or a control group (n = 30). Both groups underwent trigger-point dry needling and muscle-stretch exercise regimen for passively stretching the affected muscles to their normal lengths; the experimental group then watched an 8-minute multimedia instructional video about MPS with supplemental handouts.The Brief Pain Inventory-Taiwan was administered at baseline and 1 month thereafter. The effect size model was used to measure the effects of Brief Pain Inventory-Taiwan. Bootstrap estimation was used to derive 95% confidence intervals for group differences.Compared to the control group, the experimental group had significantly less interference of pain, lower intensity of present pain, and least pain (p0.05). Multiple regression analysis of patients with shoulder pain revealed significantly improved pain intensity and interference of pain (p0.05).The findings emphasize the importance of including patient education programs in MPS intervention.
- Published
- 2010
49. Hybrid Algorithm of FLC Design for Robot Soccer
- Author
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Kuo-Yang Wang, Chi-Jo Wang, Chun-Hsu Chen, Juing-Shian Chiou, Yu-Chia Hu, and Shih-Wen Cheng
- Subjects
Mechanics of Materials ,Computer science ,Control theory ,Applied Mathematics ,Modeling and Simulation ,Computational Mechanics ,General Physics and Astronomy ,Robot ,Statistical and Nonlinear Physics ,Engineering (miscellaneous) ,Hybrid algorithm - Published
- 2010
50. Design of Hybrid Based Image Recognition System for Intelligent Interactive Robots
- Author
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Kuo-Yang Wang, Juing-Shian Chiou, Ming-Yuan Shieh, Shih-Wen Cheng, Yu-Chia Hu, and Chung-Chieh Lien
- Subjects
Mechanics of Materials ,Computer science ,business.industry ,Applied Mathematics ,Modeling and Simulation ,Computational Mechanics ,General Physics and Astronomy ,Robot ,Statistical and Nonlinear Physics ,Computer vision ,Artificial intelligence ,business ,Engineering (miscellaneous) - Published
- 2010
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