1. No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020
- Author
-
Panning, Marcus, Wiener, Julius, Dreher, M., Cornelissen, Christian, Knüppel, W., Stolz, D., Suttorp, N., Bauer, W., Mikolajewska, A., Witzenrath, M., Pankow, W., Gläser, S., Rothe, Kathrin, Thiemig, D., Prediger, M., Schmager, S., Kolditz, M., Schulte-Hubbert, B., Langner, S., Rohde, G., Bellinghausen, C., Panning, M., Hoffmann, C., Schneider, Jochen, Welte, T., Freise, J., Barten, G., Kröner, W., Nawrocki, M., Naim, J., Illig, T., Klopp, N., Pletz, M., Kroegel, C., Pletz, Mathias W., Schleenvoigt, B., Forstner, C., Moeser, A., Drömann, D., Parschke, P., Franzen, K., Rupp, J., Käding, N., Wouters, M., Walraven, K., Rohde, Gernot, Braeken, D., Spinner, C., Zaruchas, A., Schaberg, D, Heigener, D., Hering, I., Albrich, W., Waldeck, F., Rassouli, F., Baldesberger, S., Rupp, Jan, Stenger, S., Wallner, M., Burgmann, H., Traby, L., Witzenrath, Martin, Spinner, Christoph D., and Members of the CAPNETZ study group
- Subjects
0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Respiratory pathogens ,Epidemiology ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Community-acquired pneumonia ,Internal medicine ,Correspondence ,Pandemic ,Medicine ,030212 general & internal medicine ,skin and connective tissue diseases ,Multiplex RT-PCR ,SARS-CoV-2 ,business.industry ,fungi ,General Medicine ,medicine.disease ,respiratory tract diseases ,Community acquired pneumonia ,ddc ,body regions ,Pneumonia ,Infectious Diseases ,Cohort ,Rhinovirus ,business ,Cohort study - Abstract
Purpose The first SARS-CoV-2 cases in Europe were reported in January 2020. Recently, concern arose on unrecognized infections before this date. For a better understanding of the pandemic, we retrospectively analyzed patient samples for SARS-CoV-2 from the prospective CAPNETZ study cohort. Methods We used nasopharyngeal swab samples from a cohort of well characterized patients with community acquired pneumonia of the CAPNETZ study group, recruited from different geographic regions across Germany, Austria, the Netherlands, and Switzerland between 02nd December 2019 and 28th April 2020. Multiplex real-time RT-PCR for a broad range of respiratory pathogens and SARS-CoV-2 real-time RT-PCR were performed on all samples. Results In our cohort, respiratory pathogens other than SARS-CoV-2 were detected in 21.5% (42/195) of patients with rhinovirus as the most frequently detected pathogen. The detection rate increased to 29.7% (58/195) when SARS-CoV-2 was included. No SARS-CoV-2 positive sample was detected before end of March 2020. Conclusions Respiratory viral pathogens accounted for a considerable number of positive results but no SARS-CoV-2 case was identified before the end of March 2020.
- Published
- 2020
- Full Text
- View/download PDF