1. Role of extracellular rna in atherosclerotic plaque formation in mice
- Author
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Simsekyilmaz S., Cabrera-Fuentes H., Meiler S., Kostin S., Baumer Y., Liehn E., Weber C., Boisvert W., Preissner K., and Zernecke A.
- Subjects
nucleic acids ,inflammation ,vascular diseases ,atherosclerosis - Abstract
BACKGROUND -: Atherosclerosis and vascular remodeling after injury are driven by inflammation and mononuclear cell infiltration. Extracellular RNA (eRNA) has recently been implicated to become enriched at sites of tissue damage and to act as a proinflammatory mediator. Here, we addressed the role of eRNA in high-fat diet-induced atherosclerosis and neointima formation after injury in atherosclerosis-prone mice. METHODS AND RESULTS -: The presence of eRNA was revealed in atherosclerotic lesions from high-fat diet-fed low-density lipoprotein receptor-deficient (Ldlr) mice in a time-progressive fashion. RNase activity in plasma increased within the first 2 weeks (44±9 versus 70±7 mU/mg protein; P=0.0012), followed by a decrease to levels below baseline after 4 weeks of high-fat diet (44±9 versus 12±2 mU/mg protein; P
- Published
- 2014