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1. Validity of platelet indices in predicting the risk of developing preeclampsia

Author

KURTOGLU, Emel, KOKCU, Arif, CELIK, Handan, BILDIRCIN, Fatma Devran, TOSUN, Migraci, ALPER, Tayfun, and MALATYALIOGLU, Erdal

Subjects
reproductive and urinary physiology, Mean platelet volume,platelet indices, preeclampsia, pregnancy
Abstract

The aim of this study was to evaluate the validity of platelet count (PC) and indices, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet crit (PCT), in identifying the pregnancies at risk for preeclampsia. Demographic data and laboratory tests for PC, MPV, PDW and PCT of 250 pregnant women (100 normotensive pregnants, 121 pregnants with severe preeclampsia and 29 pregnants with mild preeclampsia) were retrospectively analyzed. Platelet counts and indices were compared between the study groups. MPV and PDW were significantly higher in preeclamptic pregnant women when compared to the normal group (p=0.006, p=0.046) and area under ROC curve for MPV was found statistically significant. PC, MPV and PCT were found significantly increased in late-onset preeclampsia (p

Published
2015

2. Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

Author

Zehra Kurdoglu, Arif Kokcu, Taner Turan, Selen Dogan, Mustafa Cosan Terek, Bülent Özçelik, Sabit Sinan Özalp, Tolgay Tuyan Ilhan, Hasan Bozkaya, Gökhan Tosun, Yılmaz Dikmen, Muzaffer Sanci, Bulent Cakmak, Müfit Cemal Yenen, Hasan Yüksel, Mehmet Kefeli, Kunter Yuce, Derya Sakarya Kilic, Yunus Yıldız, Tayfun Gungor, Fusun Varol, Kadir Guzin, Anil Onan, Eray Caliskan, Nadire Tuncer, Volkan Ulker, Tevfik Guvenal, Fuat Demirkiran, Mehmet Dolanbay, Serdar Serin, Hakan Camuzoglu, T Simsek, Tayfun Toptas, Macit Arvas, Tugan Bese, Mehmet Gökçü, Murat Api, Ali Ozler, Elcin Telli, Aydın Özsaran, Serkan Kuruoglu, Pinar Solmaz Hasdemir, Nurettin Boran, Deniz Kulaksiz, Ali Yanık, Levent Akman, Emre Özgü, Hakan Yetimalar, Emek Doğer, Dagistan Tolga Arioz, Suleyman Guven, Gökhan Tulunay, Tufan Oge, Nedim Tokgozoglu, Gonca Ogurlu, Ege Üniversitesi, [Ozalp, Sabit Sinan -- Telli, Elcin -- Oge, Tufan] Eskisehir Osmangazi Univ, Sch Med, Dept Obstet & Gynecol, Eskisehir, Turkey -- [Tulunay, Gokhan -- Boran, Nurettin -- Turan, Taner] Etlik Zubeyde Hanim Womens Hlth Teaching & Res Ho, Ankara, Turkey -- [Yenen, Mufit] Gulhane Mil Med Acad, Ankara, Turkey -- [Yuce, Kunter] Hacettepe Univ, Sch Med, Ankara, Turkey -- [Onan, Anil] Gazi Univ, Sch Med, Ankara, Turkey -- [Gungor, Tayfun -- Ozgu, Emre -- Yildiz, Yunus] Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Ankara, Turkey -- [Kurdoglu, Zehra] Yuzuncu Yil Univ, Sch Med, Van, Turkey -- [Ozler, Ali] Dicle Univ, Sch Med, Diyarbakir, Turkey -- [Ulker, Volkan] Kanuni Sultan Suleyman Teaching & Res Hosp, Istanbul, Turkey -- [Arvas, Macit -- Demirkiran, Fuat -- Bese, Tugan -- Tokgozoglu, Nedim] Cerrahpasa Univ, Sch Med, Istanbul, Turkey -- [Api, Murat] Zeynep Kamil Matern & Pediat, Res & Training Hosp, Istanbul, Turkey -- [Guzin, Kadir] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Istanbul, Turkey -- [Sanci, Muzaffer -- Gokcu, Mehmet -- Tosun, Gokhan] Ege Gynecol & Matern Training & Res Hosp, Izmir, Turkey -- [Dikmen, Yilmaz -- Ozsaran, Aydin -- Terek, Mustafa Cosan -- Akman, Levent] Ege Univ, Sch Med, Izmir, Turkey -- [Yetimalar, Hakan -- Kilic, Derya Sakarya] Ataturk Training & Res Hosp, Izmir, Turkey -- [Kokcu, Arif -- Kefeli, Mehmet -- Kuruoglu, Serkan] Ondokuz Mayis Univ, Sch Med, Samsun, Turkey -- [Yuksel, Hasan] Adnan Menderes Univ, Sch Med, Aydin, Turkey -- [Guvenal, Tevfik -- Hasdemir, Pinar Solmaz] Celal Bayar Univ, Sch Med, Manisa, Turkey -- [Ozcelik, Bulent -- Serin, Serdar -- Dolanbay, Mehmet] Erciyes Univ, Sch Med, Kayseri, Turkey -- [Arioz, Dagistan Tolga -- Tuncer, Nadire] Afyon Kocatepe Univ, Sch Med, Afyon, Turkey -- [Bozkaya, Hasan -- Guven, Suleyman -- Kulaksiz, Deniz] Karadeniz Tech Univ, Sch Med, Trabzon, Turkey -- [Varol, Fusun] Trakya Univ, Sch Med, Edirne, Turkey -- [Yanik, Ali -- Ogurlu, Gonca] Cumhuriyet Univ, Sch Med, Sivas, Turkey -- [Simsek, Tayyup -- Toptas, Tayfun -- Dogan, Selen] Akdeniz Univ, Sch Med, TR-07058 Antalya, Turkey -- [Camuzoglu, Hakan] Harran Univ, Sch Med, Sanliurfa, Turkey -- [Caliskan, Eray -- Doger, Emek] Kocaeli Univ, Sch Med, Kocaeli, Turkey -- [Cakmak, Bulent] Gaziosmanpasa Univ, Sch Med, Tokat, Turkey -- [Ilhan, Tolgay Tuyan] Selcuk Univ, Sch Med, Konya, Turkey, gokcu, mehmet -- 0000-0002-3187-2317, Ozgu, Emre -- 0000-0002-8444-9694, Kurdoglu, Zehra -- 0000-0001-5191-1072, Gungor, Tayfun -- 0000-0002-7869-9662, Selçuk Üniversitesi, and OMÜ

Subjects
Adult, Cancer Research, medicine.medical_specialty, Gestational trophoblastic disease, Adolescent, Turkey, Epidemiology, medicine.medical_treatment, Trophoblastic Tumor, Hysterectomy, Cohort Studies, Trophoblastic Tumor, Placental Site, Young Adult, Pregnancy, Antineoplastic Combined Chemotherapy Protocols, gestational trophoblastic neoplasia, Humans, Medicine, Choriocarcinoma, Young adult, Retrospective Studies, Gynecology, Hydatidiform Mole, Invasive, business.industry, Obstetrics, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Oncology, Uterine Neoplasms, incidence, Female, business, Cohort study
Abstract

WOS: 000338633500049, PubMed: 24870768, Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

Published
2014

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