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4. Highlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group

Author

Elisa Fontana, Maria Alsina, Manfred P Lutz, Anna Dorothea Wagner, Lucjan Wyrwicz, Francesco Sclafani, Elizabeth C Smyth, Thibaud Koessler, Irit Ben-Aharon, Radka Obermannova, Mark Peeters, Markus Moehler, Dirk Arnold, Juan W. Valle, Koessler, Thibaud [0000-0001-9196-9076], Smyth, Elizabeth [0000-0001-6427-229X], Valle, Juan W [0000-0002-1999-0863], Apollo - University of Cambridge Repository, Institut Català de la Salut, [Koessler T] Department of Oncology, Geneva University Hospital, Geneva, Switzerland. Swiss Cancer Center Leman (SCCL), University of Geneva, Lausanne, Switzerland. European Organisation for Research and Treatment of Cancer, Brussel, Belgium. [Alsina M] European Organisation for Research and Treatment of Cancer, Brussel, Belgium. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Arnold D] European Organisation for Research and Treatment of Cancer, Brussel, Belgium. Department of Oncology, Haematology and Palliative Care, Asklepios Klinik Altona, Asklepios Tumorzentrum Hamburg, Hamburg, Germany. [Ben-Aharon I] European Organisation for Research and Treatment of Cancer, Brussel, Belgium. Division of Oncology, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel. [Lutz MP] European Organisation for Research and Treatment of Cancer, Brussel, Belgium. Caritasklinikum, Saarbrucken, Germany. [Obermannova R] European Organisation for Research and Treatment of Cancer, Brussel, Belgium. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Immunoteràpia, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Cancer immunotherapy, Drug development, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms [DISEASES], Internal medicine, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales [ENFERMEDADES], medicine, Humans, Routine clinical practice, Molecular Targeted Therapy, Aparell digestiu - Càncer - Tractament, Gastrointestinal Neoplasms, Gastrointestinal tract, Clinical Trials as Topic, business.industry, Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], terapéutica::terapia biológica::inmunomodulación::inmunoterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Cancer, diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Congresses as Topic, medicine.disease, Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Colorectal cancer, Survival Analysis, Clinical Practice, Treatment Outcome, Hepatocellular carcinoma, Perspective, Avaluació de resultats (Assistència sanitària), Biliary tract cancer, Human medicine, Immunotherapy, Gastric cancer, business, Early phase
Abstract

Biliary tract cancer; Colorectal cancer; Drug development Cáncer del tracto biliar; Cáncer colorrectal; Desarrollo de fármacos Càncer del tracte biliar; Càncer colorectal; Desenvolupament de fàrmacs Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual ASCO-GI symposium 2021, several large trial results have been reported, some leading to a change of practice. Furthermore, during ASCO-GI 2021, results from early phase trials have been presented, some with potential important implications for future treatments. We provide here an overview of these important results and their integration into routine clinical practice. Open Access funding provided by Université de Genève.

Published
2021
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5. ESMO Congress 2021: highlights from the EORTC gastrointestinal tract cancer group’s perspective

Author

T, Koessler, M, Alsina, D, Arnold, I, Ben-Aharon, M, Collienne, M P, Lutz, C, Neuzillet, R, Obermannova, M, Peeters, F, Sclafani, E, Smyth, J W, Valle, A D, Wagner, L, Wyrwicz, E, Fontana, M, Moehler, Institut Català de la Salut, [Koessler T] Department of Oncology, Geneva University Hospital, Geneva, Switzerland. Swiss Cancer Center Leman (SCCL), University of Geneva, Lausanne, Switzerland. [Alsina M] Hospital Universitario de Navarra (HUN), Medical Oncology Department, Pamplona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Arnold D] Department of Oncology, Haematology and Palliative Care, Asklepios Klinik Altona, Asklepios Tumorzentrum Hamburg, Hamburg, Germany. [Ben-Aharon I] Division of Oncology, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel. [Collienne M] Department of Oncology, Haematology and Palliative Care, Asklepios Klinik Altona, Asklepios Tumorzentrum Hamburg, Hamburg, Germany. European Organisation for Research and Treatment of Cancer, Brussels, Belgium. [Lutz MP] Caritasklinikum, Saarbrucken, Germany, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Cancer Research, Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], terapéutica::terapia biológica::inmunomodulación::inmunoterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Immunoteràpia, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Medical Oncology, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Estómac - Càncer - Tractament, Oncology, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms [DISEASES], neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales [ENFERMEDADES], Humans, Immunotherapy, Human medicine, Gastrointestinal Neoplasms, Aparell digestiu - Càncer - Tractament
Abstract

Neuroendocrine tumours; Pancreatic cancer; Stomach cancer Tumores neuroendocrinos; Cáncer de páncreas; Cáncer de estómago Tumors neuroendocrins; Càncer de pàncrees; Càncer d'estómac There has been no major change of practice in gastrointestinal oncology at the European Society for Medical Oncology (ESMO) symposium 2021, but confirmation that immunotherapy in combination with chemotherapy has become standard of care in several indications. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Track Cancer Group has selected important phase II and III trials presented during the symposium across all gastrointestinal cancers as well as early reports on new drugs or new combinations that may change practice in the future. This work was supported by a donation from the Swiss Cancer Research Foundation from Switzerland. MC was supported by a grant by EORTC Cancer Research Fund (ECRF) and the Gastrointestinal Tract Cancer Group.

Published
2022

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