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3. Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation

Author

Altuntas F, Cetin A, Eser B, Sk, Hacioglu, Leylagul Kaynar, Kocyigit I, Ozturk A, Saraymen R, and Sari I

Subjects
Male, antioxidant, Transplantation Conditioning, myeloablative conditioning, antioxidant activity, Graft vs Host Disease, myelofibrosis, Free radicals, acute lymphoblastic leukemia, Nitric Oxide, blood level, Antioxidants, multiple cycle treatment, statistical analysis, chronic myeloid leukemia, Malondialdehyde, Humans, Transplantation, Homologous, oxidative stress, human, busulfan, glutathione peroxidase, Adult, Antioxidants/*metabolism, Biomarkers/blood, Catalase/blood, Female, Glutathione Peroxidase/blood, Graft vs Host Disease/blood, Malondialdehyde/blood, Middle Aged, Nitric Oxide/blood, Oxidants/*blood, Oxidative Stress, Peripheral Blood Stem Cell Transplantation/*adverse effects, Superoxide Dismutase/blood, free radical, Peripheral Blood Stem Cell Transplantation, clinical article, nonhodgkin lymphoma, graft versus host reaction, adult, catalase, fludarabine, malonaldehyde, article, Oxidants, mortality, superoxide dismutase, acute granulocytic leukemia, human tissue, allogeneic peripheral blood stem cell transplantation, Allogeneic stem cell transplantation, nonmyeloablative conditioning, surgical procedures, operative, female, priority journal, hematologic malignancy, cyclophosphamide, Biological Markers
Abstract

High dose chemotherapy causes increased free radical formation and depletion of tissue antioxidants. Whether allogeneic hematopoietic stem cell transplantation (HSCT) has an effect on oxidative stress is uncertain. The aims of the study were to determine the effect of allogeneic HSCT on plasma concentrations of antioxidants and oxidative stress biomarkers, and to investigate their relationships with graft-versus-host disease (GVHD), conditioning regimens, and transplant-related mortality (TRM) in patients with hematological malignancies. Patients (n=25) undergoing allogeneic HSCT from HLA-matched sibling donors were enrolled in the study. Plasma oxidant and antioxidant status were measured at day -1 before transplantation and 30 days after HSCT. In both myeloablative (n=14) and non-myeloablative (n=11) transplant groups, the mean levels of plasma malondialdehyde (MDA) and nitric oxide (NO) increased after allogeneic HSCT (p

6. An investigation of pulse transit time as a blood pressure measurement method in patients undergoing carotid artery stenting

Author

Yusuf Can, Bilgehan Atılgan Acar, Ibrahim Kocyigit, Harun Kilic, Mehmet Bülent Vatan, Efe Edem, Murat Aksoy, Huseyin Gunduz, Nimet Uçaroğlu Can, Ramazan Akdemir, Can, Y, Kilic, H, Akdemir, R, Acar, B, Edem, E, Kocyigit, I, Vatan, MB, Aksoy, M, Can, N, Gunduz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Can, Yusuf, Kılıç, Harun, Akdemir, Ramazan, Acar, Bilgehan Atılgan, Vatan, Mehmet Bülent, Aksoy, Muhammed Necati Murat, and Gündüz, Hüseyin

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Blood Pressure, Pulse Wave Analysis, 030204 cardiovascular system & hematology, Assessment and Diagnosis, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Internal medicine, Heart rate, Internal Medicine, medicine, Humans, Carotid Stenosis, cardiovascular diseases, Aged, Advanced and Specialized Nursing, medicine.diagnostic_test, business.industry, General Medicine, Pulse Transit Time, medicine.disease, Stenosis, Mean blood pressure, Blood pressure, 030228 respiratory system, Cardiovascular System & Cardiology, Cardiology, Female, Stents, Internal carotid artery, Carotid stenting, Cardiology and Cardiovascular Medicine, business, Electrocardiography
Abstract

INTRODUCTION Pulse transit time (PTT) is the duration that a pulse wave takes to travel between two different arterial points, and it may be useful in estimating blood pressure. The aim of this study was to investigate the PTT during carotid artery stenting, as well as its value in blood pressure estimation. METHOD Thirty-four patients with critical carotid artery stenosis were enrolled in this study. The carotid PTT from the onset of the R-wave of electrocardiography to the pulse waveform at the carotid artery, obtained invasively during carotid artery catheterization, was measured. The carotid PTT was measured before and after stenting of the internal carotid artery. RESULTS The mean age was 70.4±8.0 years among the 34 patients enrolled (eight female patients, 21.9%). Measurements were obtained before and after carotid artery stenting. The heart rate (85.9±15.9 vs. 76.9±12.5 bpm, P

Published
2016
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