1. Oxidative DNA Damage in Retinopathy of Prematurity
- Author
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Orhan Baykal, Abdulkadir Yildirim, Ayhan Tastekin, Orhan Ates, Ibrahim Kocer, Ibrahim Caner, Hamit Hakan Alp, Ates, O, Alp, HH, Caner, I, Yildirim, A, Tastekin, A, Kocer, I, Baykal, O, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Caner, İbrahim, and Yıldırım, Arzu
- Subjects
medicine.medical_specialty ,Gestational Age ,Urine ,Gastroenterology ,Oxidative dna damage ,Excretion ,Oxidative damage ,03 medical and health sciences ,chemistry.chemical_compound ,Neonatal Screening ,0302 clinical medicine ,Malondialdehyde ,Internal medicine ,Leukocytes ,Birth Weight ,Humans ,Infant, Very Low Birth Weight ,Medicine ,Retinopathy of Prematurity ,Chromatography, High Pressure Liquid ,business.industry ,Significant difference ,Infant, Newborn ,Deoxyguanosine ,Infant ,Gestational age ,Retinopathy of prematurity ,General Medicine ,medicine.disease ,Surgery ,Oxidative Stress ,Ophthalmology ,chemistry ,8-Hydroxy-2'-Deoxyguanosine ,030221 ophthalmology & optometry ,Lipid Peroxidation ,business ,Biomarkers ,030217 neurology & neurosurgery ,DNA Damage - Abstract
Purpose This study examines the levels of oxidative damage in patients with retinopathy of prematurity (ROP). Methods Fifty patients were recruited with a birthweight below 1500 g or gestational age below 32 weeks. The cases were classified into those who developed ROP (n=25) and those without ROP (n=25). The authors obtained blood and urine samples from each infant, for measuring 8-hydroxy 2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels, at the time of the first examination at 4–6 postnatal weeks. Results A significant difference was observed in leukocyte and urine 8-OHdG levels in patients with ROP compared to those without ROP (pConclusions 8-OHdG in leukocyte DNA and urine levels in premature infants can be useful as an indicator for ROP screening.
- Published
- 2009