Search

Supplemental material, sj-pdf-2-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Supplemental material, sj-pdf-1-ajr-10.1177_19458924211009429 for A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis by Tetsuji Takabayashi MD, Daiya Asaka MD, Yoshitaka Okamoto MD, Tetsuo Himi MD, Shinichi Haruna MD, Naohiro Yoshida MD, Kenji Kondo MD, Mamoru Yoshikawa MD, Yasunori Sakuma MD, Kunihiko Shibata MD, Motohiko Suzuki MD, Masayoshi Kobayashi MD, Ryo Kawata MD, Kenzo Tsuzuki MD, Mitsuhiro Okano MD, Takaya Higaki MD, Sachio Takeno MD, Satoru Kodama MD, Syuji Yonekura MD, Hiromi Saito MS, Akiyo Nozaki BS, Nobuyoshi Otori MD, Shigeharu Fujieda MD in American Journal of Rhinology & Allergy

Purpose Mid- to long-term outcome in glioblastoma (GBM) patients following supratotal resection (SupTR), involving complete resection both of contrast-enhancing enhanced (CE) tumors and areas of methionine (Met) uptake on 11C-Met positron emission tomography (Met-PET), are not clarified. Methods A retrospective, single-center review was performed in newly diagnosed, IDH1 wild-type GBM patients, comparing SupTR with gross total resection (GTR), in which only CE tumor tissue was completely resected. Only patients who were operated on until November 2019 were included for evaluation of mid- to long-term outcome. Following resection, all patients underwent standard radiotherapy and temozolomide treatment, and were followed for progression-free survival (PFS) and overall survival (OS). Results Among the 30 patients included in this study, 7 underwent SupTR and 23 underwent GTR. Awake craniotomy with cortical and subcortical mapping was more frequently performed in the SupTR group than in the GTR group. During the follow-up period, significantly different patterns of disease progression were observed between groups. Although more than 80% of recurrences were local in the GTR group, all recurrences in the SupTR group were distant. Median PFS in the GTR and SupTR groups was 8.8 months (95% confidence interval [CI], 5.2–14.9) and 27.8 months (95% CI, 6.0-not estimable) respectively (p=0.08 by log-rank test). Median OS was 17.7 months (95% CI, 14.2–35.1) in GTR and not reached (95% CI, 30.5-not estimable) in SupTR, respectively; this difference was statistically significant (p=0.03 by log-rank test). No postoperative neurocognitive impairment was observed in SupTR patients. Conclusion Compared to GTR alone, SupTR strategy with aggressive resection of both CE tumors and Met uptake area in GBM patients under awake craniotomy with functional preservation results in a survival benefit associated with better local control.

Fine B4C powder was synthesized by the TEA-CO2 laser-induced dielectric gas breakdown of a BBr3 + CH4 + H2 gas mixture. The product was characterized by SEM, ICP atomic emission spectroscopy, and electron and X-ray diffractions. The particles show a narrow size distribution with a mean particle size of 0.18 μm. The yield of particles was increased linearly with increasing laser pulse energy. About 90% of incident pulse energy was absorbed by plasma in the reactant gas.

A TEA-CO2 laser-induced breakdown technique was applied to synthesize fine powders of Band TiB2 by irradiating gas mixtures of BCl3+H2 and BCl3+TiCl4+H2 of 10-500 Torr. The products were characterized by SEM, ICP atomic emission spectroscopy and electron and X-ray diffraction. The particle sizes of the powders were controllable from 0.08 to 0.3μm by varying the total pressure of the mixed gas. The gas breakdown threshold energy of the laser pulse was found to be inversely proportional to the total pressure of the gas mixtures in a logarithmic scale, and the proportional constant was -0.52 for BCl3+H2. The yields of particles were increased with increasing laser pulse energy, whereas average particle size was constant.