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2. Overview of mitral regurgitation in Europe: results from the European Registry of mitral regurgitation (EuMiClip)

Author

Noah Liel-Cohen, Juan Manuel Monteagudo Ruiz, David Alonso-Rodriguez, Javier Matabuena, Gerasimos Filippatos, Chi Hion Li, Laura Sanchis, Mark J. Monaghan, Felix C. Tanner, Antti Saraste, Antonio Grande-Trillo, Laura Anna Leo, M. J. Swaans, Patrizia Aruta, Konstantinos C. Theodoropoulos, B Berlot, Covadonga Fernández-Golfín, Michael Papitsas, Teresa González-Alujas, Dolores Mesa, Marta Sitges, Mojca Bervar, Amparo Martinez, Maurizio Galderisi, Spyridon Katsanos, Luigi P. Badano, D Cassani, Agostino Buonauro, Francesco Faletra, José Luis Zamorano, Sergio L. Kobal, Fernando Carrasco-Chinchilla, Ignatios Ikonomidis, Ruiz, J, Galderisi, M, Buonauro, A, Badano, L, Aruta, P, Swaans, M, Sanchis, L, Saraste, A, Monaghan, M, Theodoropoulos, K, Papitsas, M, Liel-Cohen, N, Kobal, S, Bervar, M, Berlot, B, Filippatos, G, Ikonomidis, I, Katsanos, S, Tanner, F, Cassani, D, Faletra, F, Leo, L, Martinez, A, Matabuena, J, Grande-Trillo, A, Alonso-Rodriguez, D, Mesa, D, Gonzalez-Alujas, T, Sitges, M, Carrasco-Chinchilla, F, Li, C, Fernandez-Golfin, C, Zamorano, J, Monteagudo Ruiz, Juan Manuel, Galderisi, Maurizio, Buonauro, Agostino, Badano, Luigi, Aruta, Patrizia, Swaans, Martin J, Sanchis, Laura, Saraste, Antti, Monaghan, Mark, Theodoropoulos, Konstantinos C, Papitsas, Michael, Liel-Cohen, Noah, Kobal, Sergio, Bervar, Mojca, Berlot, Boštjan, Filippatos, Gerasimo, Ikonomidis, Ignatio, Katsanos, Spyridon, Tanner, Felix C, Cassani, Daniela, Faletra, Francesco F, Leo, Laura A, Martinez, Amparo, Matabuena, Javier, Grande-Trillo, Antonio, Alonso-Rodriguez, David, Mesa, Dolore, Gonzalez-Alujas, Teresa, Sitges, Marta, Carrasco-Chinchilla, Fernando, Li, Chi Hion, Fernandez-Golfin, Covadonga, and Zamorano, José Luis

Subjects
Male, Internationality, Echocardiography, Three-Dimensional, Comorbidity, 030204 cardiovascular system & hematology, Severity of Illness Index, Cohort Studies, 0302 clinical medicine, Degenerative disease, Prevalence, echocardiography, 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, Aged, 80 and over, Mitral Valve Insufficiency, General Medicine, Middle Aged, Prognosis, Europe, Echocardiography, Female, Radiology, Cardiology and Cardiovascular Medicine, Cohort study, Human, medicine.medical_specialty, Prognosi, Risk Assessment, 03 medical and health sciences, Age Distribution, Severity of illness, medicine, Humans, Radiology, Nuclear Medicine and imaging, Sex Distribution, Aged, Mitral regurgitation, business.industry, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, ta3121, medicine.disease, Prospective Studie, Concomitant, Etiology, mitral regurgitation, Cohort Studie, business
Abstract

Aims To determine the prevalence of mitral regurgitation (MR) in a large cohort of consecutive patients undergoing clinically indicated echocardiography and to examine the distribution of primary and secondary MR Methods and results All patients undergoing an echocardiographic study in 19 European centres within a 3-month period were prospectively included. MR assessment was performed as recommended by the European Association of Cardiovascular Imaging (EACVI). MR was classified according to mechanism as primary or secondary and aetiologies were reported. A total of 63 463 consecutive echocardiographic studies were reviewed. Any degree of MR was described in 15 501 patients. Concomitant valve disease of at least moderate grade was present in 28.5% of patients, being tricuspid regurgitation the most prevalent. In the subgroup of moderate and severe MR (n = 3309), 55% of patients had primary MR and 30% secondary MR. Both mechanisms were described in 14% of the studies. According to Carpentier's classification, 26.7% of MR were classified as I, 19.9% of MR as II, 22.4% of MR as IIIa, and 31.1% of MR as IIIb Conclusion To date, this is the largest echocardiography-based study to analyse the prevalence and aetiology distribution of MR in Europe. The burden of secondary MR was higher than previously described, representing 30% of patients with significant MR. In our environment, degenerative disease is the most common aetiology of primary MR (60%), whereas ischaemic is the most common aetiology of secondary MR (51%). Up to 70% of patients with severe primary MR may have a Class I indication for surgery. However, the optimal therapeutic approach for secondary MR remains uncertain.

Published
2018

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