1. Spontaneous breathing during high-frequency oscillatory ventilation improves regional lung characteristics in experimental lung injury
- Author
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van Heerde, M., Roubik, K., Kopelent, V., Kneyber, M. C. J., Markhorst, D. G., Pediatric surgery, ICaR - Ischemia and repair, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
- Subjects
FUNCTIONAL EIT ,MODEL ,ELECTRICAL-IMPEDANCE TOMOGRAPHY ,SUPPORT ,RESPIRATORY-DISTRESS-SYNDROME ,AIRWAY PRESSURE RELEASE ,TIME - Abstract
Background Maintenance of spontaneous breathing is advocated in mechanical ventilation. This study evaluates the effect of spontaneous breathing on regional lung characteristics during high-frequency oscillatory (HFO) ventilation in an animal model of mild lung injury. Methods Lung injury was induced by lavage with normal saline in eight pigs (weight range 47-64 kg). HFO ventilation was applied, in runs of 30 min on paralyzed animals or on spontaneous breathing animals with a continuous fresh gas flow (CF) or a custom-made demand flow (DF) system. Electrical impedance tomography (EIT) was used to assess lung aeration and ventilation and the occurrence of hyperinflation. Results End expiratory lung volume (EELV) decreased in all different HFO modalities. HFO, with spontaneous breathing maintained, showed preservation in lung volume in the dependent lung regions compared with paralyzed conditions. Comparing DF with paralyzed conditions, the center of ventilation was located at 50% and 51% (median, left and right lung) from anterior to posterior and at 45% and 46% respectively, P
- Published
- 2010
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