530 results on '"Kler, A"'
Search Results
2. Impact of ABO blood group antigens on residual factor VIII levels and risk of inhibitor development in hemophilia A
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Debadrita Ray, Narender Kumar, Chander Hans, Anita Kler, Richa Jain, Deepak Bansal, Amita Trehan, Arihant Jain, Pankaj Malhotra, and Jasmina Ahluwalia
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Hematology - Published
- 2023
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3. Meta-analysis of avian behavioural responses to aircraft noise
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T. K Kler, null P. Sharma, G.S Sekhon, and R.K Aulakh
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Natural environments are now seriously affected by human-made noise, creating complex acoustic circumstances that are unheard of in most locations. Expansion of aero industry and increase in air traffic whether civilian or military is accompanied by large scale noise pollution and habitat disturbances. The present communication is based on meta-analysis of 47 research papers highlighting impact of aircraft noise on avian behavior and communication related to both routine and breeding activities. Aircraft acoustics have been reported to modify behavior of 22 species of birds by changing their specific song structure, communication, population abundance, territorial defence behavior, modifications to reproductive success, impaired vocalization and predator-prey interactions. Recent studies have also uncovered additional negative effects of aeroplane noise on avian behavioral responses by modifying their stress reactions, foraging activity, flight or flushing reactions and avoidance of noisy environments. The ability of bird species to counteract the masking effect of noise through changes in vocal amplitude, song and call frequency, song component redundancy, as well as temporal shifts to avoid noise have been revealed by comparative avian studies conducted in noise free environment. There seems to be a big lacuna in our understanding of influence of aircraft noise on avian community structure, intra/inter species relationships and their prey populations having possibilities of destabilizing effect on intertwined food webs. Detailed studies are required on aircraft noise versus avian population interactions so as to come up with interventions to mitigate their impacts on avian habitats, breeding potential and population abundance; in addition to reduction in noise levels in aviation, maneuvers to reduce noise during landings and take-offs, and to safeguard wildlife in airport influenced areas.
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- 2023
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4. Molecular spectrum of inherited FVII deficiency in North India revealed a recurrent variant with a founder effect
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Ritika Sharma, Manu Jamwal, Hari Kishan Senee, Namrata Singh, Narender Kumar, Chander Hans, Anita Kler, Deepak Bansal, Amita Trehan, Pankaj Malhotra, Jasmina Ahluwalia, and Reena Das
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Hematology ,General Medicine ,Genetics (clinical) - Abstract
Inherited Factor VII (FVII) deficiency is commonest among the rare bleeding disorders. A small number of patients present in infancy with severe bleeding, and many may remain asymptomatic but detected before surgery/invasive procedures. Genetic testing may be helpful in predictive testing/prenatal diagnosis in severe cases.Characterisation of clinical and genotypic spectrum of patients with inherited FVII deficiency.Retro-prospectively, 35 cases with prolonged prothrombin time and FVII activity (FVII:C)50 IU/dl were subjected to targeted resequencing. After in-silico analysis, variant/s were validated by Sanger sequencing in index cases and family members. Haplotype analysis was done for F7 polymorphisms.Severe FVII deficiency was found in 50% of patients (FVII:C ≤1 IU/dl), and 42.9% were asymptomatic. Clinical severity assessment revealed 17% severe, 17% moderate and 22.9% patients with mild bleeds. FVII levels ranged from .3 to 38 IU/dl. Molecular analysis revealed variants in 30/35 cases, of which 17 were homozygous, 10 were compound heterozygous and 3 were heterozygous. Twelve genetic variants were identified, one promoter variant c.-30AC; seven missense (c.215CG, c.244TC, c.253GC, c.904GA, c.961CT, c.1109GT, c.1211GA), two deletions (c.21delG, c.868_870delATC), and one each of nonsense c.634CT and splice-site variant c.316+1GA. Recurrent variants c.1109GT and c.215CG were found in 17 and 8 cases, 12 of the former cases were homozygous. They had the same haplotype, indicating the founder effect in North Indians.This is the largest cohort of FVII genotyping from India, confirming heterogeneity in terms of clinical manifestations, FVII activity and zygosity of the variants with a limited genotypic phenotypic correlation.
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- 2022
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5. The activated partial thromboplastin time‐clot waveform analysis in hemophilia: Does it help in differentiation?
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Khalid Abdul Mannan, Narender Kumar, Jasmina Ahluwalia, Chander Hans, Anita Kler, Gaurav Prakash, and Richa Jain
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Biochemistry (medical) ,Clinical Biochemistry ,Hematology ,General Medicine - Abstract
The clot waveform analysis (CWA) provide valuable information beyond clotting time. The present study was planned to assess whether the activated partial thromboplastin time (aPTT)-CWA can differentiate between hemophilia A (HA), hemophilia B (HB), or hemophilia A with inhibitors (HAWI).The aPTT-CWA was generated by an optical detection system (ACL-TOP™ 500 coagulation analyzer) and the other tests were performed as per instructions from the manufacturer in the kit.A total of 75 samples (47-HA, 16-HAWI, and 12-HB) with prolonged aPTT were recruited. On analyzing the quantitative aPTT-CWA data of HA (non-inhibitors) and HB samples, the width of acceleration 1 [+] peak was the differentiating finding. Among the significant parameters, the second derivative [+] peak was lower in both mild and moderate HA, equating to HB. The time for the height of 1/2 fibrin formation and width of velocity was significantly higher in mild, moderate and severe HA. The study did not show any significant differentiating finding while comparing HAWI and hemophilia A non-inhibitors (HANI). In the subgroups of HAWI and HANI with aPTT70 s and 70-100 s, the second derivative [+] peak (2A) was higher and the time for the height of 1/2 fibrin formation (1C) was lesser in HAWI.The aPTT-CWA parameters may be supportive for the differentiation of hemophilia including its severity and the existence of inhibitors.
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- 2022
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6. Neonatologist-Performed Ultrasound-Guided Internal Jugular Vein Cannulation
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Anup Thakur, Manoj Modi, Neelam Kler, and Pankaj Garg
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Pediatrics, Perinatology and Child Health - Published
- 2023
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7. Proposal of an alternative diet as an element of improving the safety and quality of nutrition for soldiers
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Paweł Kler, Sebastian Sobczuk, Jan Hlubik, and Jerzy Bertrandt
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W określonej społeczności, którą tworzą również żołnierze, stosowana przez nich dieta powinna zaspakajać wszystkie potrzeby pokarmowe, z wykorzystaniem fizycznie i ekonomicznie dostępnych środków spożywczych (produktów, potraw). Można nazwać ją dietą zwyczajową. Natomiast w określonych sytuacjach, do których zaliczyć można ekspansję, chorób cywilizacyjnych XXI wieku, a także możliwe trudności z pozyskaniem dotychczas dostępnych niektórych produktów spożywczych, spowodowanych kryzysem w związku z trwającą wojną za wschodnią granicą Polski należy rozważyć stosowanie w sposób rozważny diet alternatywnych. Propozycję przykładowej diety pescowegetariańskiej, którą można zaliczyć do diet alternatywnych przedstawiono w artykule. Celem publikacji jest opracowanie jadłospisu dla diety, która może stanowić alternatywę normy wyżywienia żołnierzy w kontekście poprawy bezpieczeństwa jakości ich żywienia. Problemem badawczym zawartym w pracy jest pytanie: w jaki sposób dieta alternatywna może poprawić bezpieczeństwo jakości żywienia żołnierzy? W publikacji zastosowano niezbędne badawcze metody teoretyczne: analiza, synteza i wnioskowanie oraz empiryczne: badania dokumentów oraz modelowanie komputerowe w celu opracowania jadłospisu dla diety alternatywnej. Przeprowadzone w publikacji rozważania i propozycja jadłospisu diety alternatywnej - pescowegetariańskiej dowodzą pozytywnego jej wpływu na zapobieganie rozprzestrzenianiu się chorób cywilizacyjnych o podłożu dietetycznym, co przekłada się na stan zdrowia personelu wojskowego, a w konsekwencji pozwala utrzymać wymaganą sprawność fizyczną żołnierzy oraz ich dyspozycyjność podczas pełnienia służby wojskowej i wykonywania powierzonych zadań służbowych.
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- 2022
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8. Impact of human habitation on avian diversity in Beas river conservation reserve
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Sachin Kumar, Tejdeep Kaur Kler, and Tanvi Sahni
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Ecology ,Geography, Planning and Development ,Computers in Earth Sciences ,Pollution ,Waste Management and Disposal - Published
- 2022
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9. Sense of Place: Narrating Emotional Experiences of Malaysian Borneo through Western Travel Blogs
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Siao Fui Wong, Balvinder Kaur Kler, and Bamini KPD Balakrishnan
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sense of place ,blog ,Borneo ,emotional experiences ,QCAmap - Abstract
Tourists’ sense of place or destination attachment could play an important role in destination branding. Yet, sense of place literature focuses on residents as the concept originates from a long-term residence in one place. This study explores the role of destination attachment based on tourist experience for branding based on a case study in Malaysian Borneo. A qualitative content analysis using QCAmap of 34 blogs extracted 116 blogposts with narratives containing emotional sentiments from international tourists. Findings uncovered six important attributes: namely nature, adventure, environment, culture, conservation, and education associated with destination attachment. Findings show that these attributes are interconnected as the main attribute, nature, produces other attributes. A tourists’ sense of place model for destination attachment is proposed to understand how tourists develop attachment to a place.
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- 2022
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10. Exploring cattle sheds as complementary avifaunal habitat niches in rice dominated agricultural areas in Punjab, India
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Harnoor Kaur Grewal, Tejdeep Kaur Kler, and Sukhpreet Kaur Sidhu
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Animal Science and Zoology ,Agronomy and Crop Science ,Applied Microbiology and Biotechnology ,Food Science - Abstract
Avian diversity has often been studied in agricultural habitats, but ornithological aspect of cattle sheds has never been studied. This exploratory study was conducted with the objective of studying the potential of cattle sheds for sustaining avian abundance and diversity in rice dominated agricultural areas. The study was done in Rice Field Ecosystem (System I) and Cattle Shed Ecosystem (System II) during 2019 and 2020 monsoon crop season from selected villages, namely, Dangon, Pakhowal and Sarabha (district Ludhiana), Punjab. It was recorded that 26 avian species (mainly of grassland habitat) were present in cattle sheds from a total 34 avian species (wetland, grassland and open countryside inhabiting species) observed in rice fields, which reflected that cattle sheds support a wide proportion of avian fauna and complement rice fields in supporting and preserving avian abundance and diversity. There is immense need to explore and accordingly lay emphasis on boosting dairy as allied sector so that cattle sheds can be exploited in preservation of diverse avian populations and thereby reinforcing approach of sustainable agriculture. Keywords: Avian diversity, Avian feeding guilds, Cattle Shed, Grassland birds, Rice crop
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- 2023
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11. Association Between CYP2C19 Genotypes With Clinical Phenotypes and Adipokine Levels Among Ischemic Stroke Patients: A Prospective Observational Study
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Jitender Gairolla, Dheeraj Khurana, Phulen Sarma, Rupinder Kler, Bikash Medhi, Madhu Khullar, Manish Modi, Priyanka Naithani, and Ashok Kumar
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General Engineering - Published
- 2023
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12. OC-041 TOTALLY EXTRA-PERITONEAL REPAIR VERSUS TRANS-ABDOMINAL PRE-PERITONEAL REPAIR FOR THE LAPAROSCOPIC SURGICAL MANAGEMENT OF SPORTSMAN'S HERNIA: A SYSTEMATIC REVIEW AND META-ANALYSIS
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A Kler, N Sekhon, G Antoniou, and T Satyadas
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Surgery - Abstract
Aim Open and laparoscopic modalities are employed for treatment of sportsman's hernia, with totally extra-peritoneal (TEP) and trans-abdominal pre-peritoneal (TAPP) laparoscopic approaches both currently being utilised. At present, neither subtype has demonstrated superiority for sportsman's hernia repair. The aim of this review was to evaluate current evidence to ascertain whether there was a difference in laparoscopic techniques following sportsman's hernia repair. Material & Methods A systematic literature search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards. Databases searched included PubMed, Scopus and Web of Science to identify all randomised controlled trials (RCTs) and observational studies. Risk of bias was assessed using the Cochrane risk of bias tool and Newcastle-Ottawa scale for RCTs and observational studies, respectively. The assessed outcomes included median time to return to sporting activity, complications and the degree of postoperative pain reduction within three months. Random effects model was used to calculate pooled proportion data where feasible. Subgroup analyses were also performed. Results 28 studies were identified including 2 RCTs and 26 observational studies. No significant differences were observed between techniques in the primary or secondary outcomes. Significant heterogeneity was observed in all outcomes. This was signficant for return to sporting activity; thus meta-analysis was not feasible in this domain. Median time to return to sporting activity was 28 days for both techniques. Conclusions There is no difference in the primary and secondary outcomes in either technique. An RCT comparing TEP and TAPP repair is needed to provide definitive data.
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- 2023
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13. O122 The use of directly injectable cancer therapies: a systematic review
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A Kler, M Fok, and D Vimalachandran
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Surgery - Abstract
Introduction DIT allows for targeted delivery to a cancer. This could deescalate treatments through reduced use of systemic chemotherapy, radiotherapy dosage, and avoidance of major surgery. Palliative cancers can benefit through similar means to maintain quality of life and avoid permanent interventions (such as stomas). There is no mainstream use of DIT. Therefore, the aim of this review was to assess the role of DIT in all cancers. Methods A systematic search was performed in the Pubmed, Web of Science, Embase and Google databases. Two authors independently searched the literature and extracted data onto a dedicated proforma. Human and animal studies were included. Results 8,380 papers were identified, 49 studies were included; comprising of 1,087 patients for lung, H+N, brain, oesophagogastric and colorectal cancer. Four studies performed neoadjuvant DIT, where one showed all lung tumours down staged to an operative state. The remainder showed no advantage in survival or response. Palliative intra-tumoural cisplatin (in three studies) showed promise for malignant airway obstruction, where good responses were shown in > 50% of patients (single report). Cisplatin was also favourable in palliative H+N cancers (ORR=66% in one report). A minority of studies (4/49) exhibited grade 3 toxicity or higher. Conclusion DIT is safe to administer and demonstrated promise in the palliation of malignant airway obstruction and advanced/recurrent H+N cancer. Further studies are required to verify these results. Additionally, more reports are required to determine its role in neoadjuvant treatment. DIT:Direct injection of chemotherapy ORR:objective response rate H+N:head and neck
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- 2023
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14. P10 Do chloroquine and hydroxychloroquine have a role as radiosensitisers in the treatment of cancer? A systematic review
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M S Chohan, K Goyal, M Fok, R Hill, A Kler, and D Vimalachandran
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Surgery - Abstract
Introduction Radiotherapy remains a mainstay treatment for many cancers often prior to surgery. Radiosensitisers are chemical or pharmaceutical agents that can enhance the effect of radiotherapy on tumour cells and can potentially de-escalate treatments including the need for surgery. Chloroquine (CQ) and Hydroxychloroquine (HCQ) are used as anti-inflammatory and anti-malarial agents but have shown to be promising radio sensitising agents. This systematic review assesses their role as radiosensitisers for the treatment of cancer and explored both pre-clinical and clinical trial evidence. Methods Studies that reported the use of CQ or HCQ as a radiosensitiser as either neoadjuvant or adjuvant therapy were identified via systematic review. It was conducted in accordance with PRISMA guidelines (PROSPERO: CRD42022329779). Five databases were searched for articles. Results 30 papers were selected for review following our screening process. In 6 of the 8 clinical studies, CQ showed disease regression or increased overall survival for patients who were treated with a combination of radiotherapy and CQ. One study did not show any improvement in patient outcomes for HCQ. Most studies were performed for glioblastoma multiforme. 2 of the 3 in vitro/in vivo studies illustrated CQ as a viable radiosensitiser showing reduced tumour growth. However, multiple clinical trials were terminated due to poor patient accrual. Conclusion There are a limited number of preclinical and clinical trials investigating CQ and HCQ as radiosensitisers. There is evidence to suggest CQ may have a role as a radiosensitiser but there needs to be a call for more preclinical and clinical evidence.
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- 2023
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15. O097 A drug screen to identify novel radiosensitisers in colorectal cancer cells
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A Kler, M Fok, G Grundy, J Parsons, and D Vimalachandran
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Surgery - Abstract
Introduction Locally advanced rectal cancer is typically treated with neoadjuvant chemoradiotherapy, where chemotherapy acts synergistically to radiosensitise cancer cells. Response to chemoradiotherapy is variable, with 8-20% of cases having a complete pathological response, but 20-30% demonstrate no response or progression. Novel radiosensitisers can potentially improve response, tolerability of radiotherapy and de-escalate treatments, including the need for major surgery. This study aims to perform a screen of available FDA-approved drugs to identify novel radiosensitisers in rectal cancer. Methods A drug screen of forty FDA-approved drugs was performed. HCT-116 cells were cultured and treated as a monolayer with 0.3 μM and 1.0 μM of a specific drug for 16 hours. Clonogenic assays were performed in 24 well plates after photon irradiation at 0 and 1 Gy. Relative colony formation (survival fraction) was employed to measure drug efficacy and radiosensitisation. Following the screen, two drugs were selected for dose optimisation and further mechanistic evaluation with DNA repair kinetics and DNA damage using immunofluorescence of γH2Ax foci. Results Abexinostat and fomepizole were selected from the screen for dose optimisation based on their radiosensitising capabilities. Dose optimisations determined that both drugs had an optimal concentration of 1.0 μM and required an optimum of 6 hours of treatment and showed significant radiosensitisation. There were significantly more γH2Ax foci after 24 hours in cells treated with Abexinostat than control, demonstrating persistent DNA damage. Conclusion Abexinostat and fomepizole show promise as radiosensitizers. Further experimentation is ongoing to determine the mechanisms for these drugs and translational benefit.
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- 2023
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16. O130 Transarterial chemoembolization in rectal cancer: a systematic review
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A Kler, A Najran, M S Choan, M Fok, and D Vimalachandran
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Surgery - Abstract
Background Locally advanced rectal cancer (LARC) is typically treated with neoadjuvant chemoradiotherapy. Response can be unpredictable, with 8-20% of patients achieving complete pathological response, whilst 20-30% have no response or progression. Transarterial chemoembolisation (TACE) is established as a non-surgical option to treat colorectal liver metastases by delivering chemotherapy and an embolic agent via its primary arterial supply. This allows for reduction in systemic toxicity whilst delivering higher doses to tumours. There have been trials of TACE in LARC, but its role as a therapeutic modality is still unknown. Therefore, this review aims to assess existing evidence of TACE in LARC and whether it warrants further investigation as a treatment. Methods A systematic literature search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Databases searched included PubMed, Scopus and Web of Science. Risk of bias was assessed using the Newcastle-Ottawa scale. The assessed outcomes included complete pathological response, objective response rate, complications, recurrence, disease-free and overall survival. Results Five reports were considered for inclusion. Minimal complications and adverse events were noted. Improved pathological complete response or objective response rates were noted in four out of five studies when compared to systemic neoadjuvant regimes. One study showed TACE reduced the risk of distant recurrence. Significant heterogeneity and bias were noted in all studies. Conclusion TACE is a safe modality, but its superiority over conventional treatment has yet to be demonstrated. Current literature is of inadequate quality but warrants further investigation in preclinical and clinical settings.
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- 2023
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17. O133 Network meta-analysis of neoadjuvant therapy in rectal cancer
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M Fok, H Fowler, R Clifford, A Kler, J Gittens, S Toh, R Wade, and D Vimalachandran
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Surgery - Abstract
Introduction Locally advanced rectal cancer can be treated with neoadjuvant chemoradiotherapy prior to surgical resection. This treatment can significantly downstage rectal tumours and consequently lead to improved long term survival and reduced risk of local reoccurrence. Controversy exists regarding the optimal regime for neoadjuvant therapy. A network meta-analysis allows the integration of multiple treatments to be compared simultaneously in a single analysis. This network meta-analysis aims to assess which neoadjuvant regime gives the highest rate of pathological complete response (pCR). Methods An extensive literature search for randomised controlled trials of neoadjuvant therapy in rectal cancer was performed. The primary outcome was pCR at surgical resection. Direct and indirect comparisons were performed with a frequentist Network Meta-Analysis and results tested for consistency. Results Following critical appraisal of 3720 studies, 16 randomised control trials were included in the study. Regimes of neoadjuvant therapy included short course radiotherapy with concurrent chemotherapy or without, long course chemoradiotherapy, long course chemoradiotherapy with either induction of consolidation chemotherapy, and radiotherapy alone (45gy). Short course radiotherapy combined with chemotherapy was shown to produce significantly higher pCR in patients with rectal cancer. Short course radiotherapy without chemotherapy was shown to have the lowest rate of pCR. Conclusion There is strong evidence to suggest that short course chemoradiotherapy is the best regime to produce the highest pCR in patients with rectal cancer.
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- 2023
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18. Comparison of Three Modalities of Feeding in Preterm Infants ≤32 Weeks and ≤1,250 G: A Randomized Controlled Trial
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Vijay Kumar, Anup Thakur, Pankaj Garg, and Neelam Kler
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Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Abstract
Objective Early establishment of enteral feeds is desirable in very preterm infants, but it may be associated with feeding intolerance. Several feeding methods have been studied with no strong evidence to suggest the preferred feeding method to establish early full enteral feeds. We studied three modalities of feeding in preterm infants ≤32 weeks and ≤1,250 g: continuous infusion (CI), intermittent bolus by infusion (IBI), and intermittent bolus by gravity (IBG) for their effect on time to reach full enteral feeds of 180 mL/kg/d. Study Design We randomized 146 infants, 49 infants in each CI and IBI group and 48 infants in the IBG group. In the CI group, feeds were delivered by an infusion pump continuously over 24 hours. In the IBI group, feeds were given every 2 hours and infused over 15 minutes by an infusion pump. In the IBG group, feeds were delivered by gravity over 10 to 30 minutes. The intervention was continued till infants reached direct breast/cup feeds. Results The mean (standard deviation) gestation in CI, IBI, and IBG groups were 28.4 (2.2), 28.5(1.9), and 28.6 (1.8) weeks, respectively. The time to reach full feeds in CI, IBI, and IBG were not significantly different (median [interquartile range]: 13 [10–16], 11.5 [9–17], and 13 [9.5–14.2] d, respectively, p = 0.71). The proportions of infants who developed feeding intolerance in CI, IBI, and IBG were similar (n [%]: 21 [51.2%], 20 [52.6%], and 22 [64.7%], respectively, p = 0.45). There was no difference in necrotizing enterocolitis ≥2 (p = 0.80), bronchopulmonary dysplasia (p = 0.86), intraventricular hemorrhage ≥2 (p = 0.35), patent ductus arteriosus requiring treatment (p = 0.44), retinopathy of prematurity requiring treatment (p = 0.51), and growth parameters at discharge. Conclusion In preterm infants, ≤32 weeks of gestation and birth weight ≤1,250 g, there was no difference in time to reach full enteral feeds in the three modalities of feeding. This study is registered with Clinical Trials Registry India (CTRI) and the registration number is CTRI/2017/06/008792. Key Points
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- 2023
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19. Depredatory Bird Damage Assessment and Its Management Techniques in Guava
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Shilpa Arora, Tejdeep Kaur Kler, Gagandeep Kaur, and Nirmaljit Kaur
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Horticulture - Published
- 2023
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20. Figure S1 from Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites
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Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, and Zachary S. Morris
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Concomitant immune tolerance prevents an immunotherapeutic response at the distant tumor site, is observed with an 8 Gy x 3 fraction RT regimen, and requires a well-established macroscopic secondary tumor.
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- 2023
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21. Figure S2 from Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites
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Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, and Zachary S. Morris
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Cooperative effect of RT and IT-hu14.18-IL2 is observed in mice bearing a single syngeneic Panc02-GD2+ tumor.
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- 2023
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22. T-PERCHES DETERMINING AVIAN FEEDING GUILDS IN MAIZE
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Khushdeep Kaur, Tejdeep Kaur Kler, and Surinder Kaur Sandhu
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Ecology ,Insect Science ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Avian diversity is considered an environmental indicator for measuring ecosystem quality. The availability of food and its diverse types influence bird distribution and their community structure in agricultural landscapes. The current study investigated the role of T-perches as bird attractants in maize at the Punjab Agricultural University, Ludhiana. A total of 39 species were observed belonging to 12 orders and 24 families. Insectivorous birds were observed as the most dominant feeding guild constituting 47.12%. Black drongo, jungle babbler, common myna, house crow, green bee-eater, and red-vented bulbul were noted utilizing t-perches for foraging purposes. The key factor driving the increase in insectivorous bird species seemed to be the additional perching sites available by installing T-perches.
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- 2023
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23. Figure S3 from Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites
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Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, and Zachary S. Morris
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The presence of an untreated secondary tumor influences the effect of RT on the ratio of tumor infiltrating CD8+:FoxP3+ cells at a radiated tumor site.
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- 2023
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24. Data from Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites
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Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, and Zachary S. Morris
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In situ vaccination is an emerging cancer treatment strategy that uses local therapies to stimulate a systemic antitumor immune response. We previously reported an in situ vaccination effect when combining radiation (RT) with intratumor (IT) injection of tumor-specific immunocytokine (IC), a fusion of tumor-specific antibody and IL2 cytokine. In mice bearing two tumors, we initially hypothesized that delivering RT plus IT-IC to the “primary” tumor would induce a systemic antitumor response causing regression of the “secondary” tumor. To test this, mice bearing one or two syngeneic murine tumors of B78 melanoma and/or Panc02 pancreatic cancer were treated with combined external beam RT and IT-IC to the designated “primary” tumor only. Primary and secondary tumor response as well as animal survival were monitored. Immunohistochemistry and quantitative real-time PCR were used to quantify tumor infiltration with regulatory T cells (Treg). Transgenic “DEREG” mice or IgG2a anti–CTLA-4 were used to transiently deplete tumor Tregs. Contrary to our initial hypothesis, we observed that the presence of an untreated secondary tumor antagonized the therapeutic effect of RT + IT-IC delivered to the primary tumor. We observed reciprocal tumor specificity for this effect, which was circumvented if all tumors received RT or by transient depletion of Tregs. Primary tumor treatment with RT + IT-IC together with systemic administration of Treg-depleting anti–CTLA-4 resulted in a renewed in situ vaccination effect. Our findings show that untreated tumors can exert a tumor-specific, Treg-dependent, suppressive effect on the efficacy of in situ vaccination and demonstrate clinically viable approaches to overcome this effect. Untreated tumor sites antagonize the systemic and local antitumor immune response to an in situ vaccination regimen. This effect is radiation sensitive and may be mediated by tumor-specific regulatory T cells harbored in the untreated tumor sites. Cancer Immunol Res; 6(7); 825–34. ©2018 AACR.
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- 2023
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25. Supplemental Figure Legends from Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites
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Paul M. Sondel, Paul M. Harari, Alexander L. Rakhmilevich, Jacquelyn A. Hank, Amy K. Erbe, Alan J. Korman, Stephen D. Gillies, Hans Loibner, Lakeesha L. Carmichael, Raghava N. Sriramaneni, Abigail A. Jaquish, Sara M. Busche, Jasdeep S. Kler, Clinton M. Heinze, Peter M. Carlson, Lauryn R. Werner, Emily I. Guy, and Zachary S. Morris
- Abstract
Supplemental Figure Legends
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- 2023
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26. Predicting Avian Diversity with Geospatial Technologies
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Tejdeep Kaur Kler, Hasneet Kaur Hora, Anil Sood, and Prabha Kumari
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Ecology ,Insect Science ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Abstract
Rapid urbanization accompanied by land use changes is affecting biodiversity worldwide specifically avian diversity. In the present study, the interactions of avian diversity with vegetation area were evaluated using geospatial technologies at different locations of Ludhiana city from April 2019 to March 2020. Integration of observations was done to analyze the avian diversity in relation to habitat components. Bird surveys conducted have recorded 46 bird species. There were 44 tree and 14 shrub species recorded, with vegetation and buildup area being the key determinants of diversity. Urban locations with balanced buildup area and vegetation were observed to support bird species diversity.
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- 2022
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27. Partial altitudinal movement of Himalayan Bulbul Pycnonotus leucogenys in Himalayan Siwalik range
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Sachin Kumar, Dr. Tejdeep Kaur Kler, Garima Singh, Gurkirat Sekhon, and Tanvi Sahni
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- 2022
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28. Inhibitor; An Uncommon But Vexing Challenge In North Indian Patients With Hemophilia A
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Debadrita Ray, Narender Kumar, Chander Hans, Anita Kler, Richa Jain, Deepak Bansal, Amita Trehan, Arihant Jain, Pankaj Malhotra, and Jasmina Ahluwalia
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Hematology - Abstract
Factor VIII replacement is the mainstay of treatment in hemophilia A but may lead to the development of inhibitors. While a vexing clinical problem, some observations suggest that the presence of inhibitors may not necessarily portend a higher bleeding risk. Our aim was to assess the prevalence and clinicopathological correlates of inhibitors in a well characterized cohort of Indian patients with HA patients. We retrospectively reviewed the clinical details and laboratory findings of consecutive hemophilia A patients attending a north-Indian tertiary-care center from 2010 to 2020. Among 592 patients with HA, inhibitors were detected in 35 patients (5.9%). Prevalence of inhibitors in moderate and severe hemophilia was 4.2% and 6.7%, respectively. Most patients with inhibitors had history of transfusion with factor VIII alone (54.3%) or a combination of factor VIII concentrate and other blood-products (42.9%). Intracranial bleed was significantly more frequent in patients with inhibitors compared to those without inhibitors (20% vs. 4.1%; p-0.001). Time dependent and immediately acting inhibitors were seen in 60% and 40% patients, respectively. High-titre ( 5 BU) and low-titre inhibitors ( 5 BU) were detected in 28 (80%) and 7 (20%) patients, respectively. Prevalence of inhibitors in our cohort was 5.9% and most had high-titre, time dependent inhibitors. These patients may have a higher risk of intracranial bleeding.
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- 2022
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29. Food Safety Delivered for Polish Military Cadets during the COVID-19 Pandemic
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Paweł Kler and Anna Borucka
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Food security -- Poland ,Military cadets -- Poland ,COVID-19 Pandemic, 2020- -- Influence ,Military cadets -- Nutrition ,Operational readiness (Military science) ,General Economics, Econometrics and Finance ,General Business, Management and Accounting ,Body mass index - Abstract
PURPOSE: Nutrition of cadets during the period of biological threat caused by SARS-CoV-2 is an important element shaping their combat readiness, however, scientific research in this area is scarce. The need to analyse this specific group has become the genesis of this article. The main purpose of the study was to verify the significance of the effect of selected factors on the assessment of the quality and quantity of meals provided to soldiers., DESIGN/METHODOLOGY/APPROACH: Due to the qualitative and multi-level form of the dependent variable, multinomial logistic regression was used, which allowed the evaluation of the effect of all selected predictors on the results., FINDINGS: Research involved students of 4 years of study. The article presents a discussion of the study group and the effect of selected factors on the opinions about meals received during the SARS-CoV-2 pandemic. An interesting question was the assessment of whether and how a surveyed cadet’s year of study, BMI and gender affected their decisions regarding the qualitative and quantitative assessment of food consumed during this period., PRACTICAL IMPLICATIONS: The analysis showed that there are factors related to the characteristics of the respondents which significantly affect their assessment of nutrition, and thus it is important to select the right study sample. The answers obtained in the survey differed depending on the respondent’s gender, BMI level or year of study. The results of the study provide a basis for further research aimed at optimizing nutrition for students of military universities., ORIGINALITY/VALUE: The results of the study showed that there are factors related to the characteristics of the respondents, such as gender, year of study or the BMI, which significantly affect their final value. The ratings given by women were definitely higher than those of men. Perhaps this was due to a greater tendency to show empathy and appreciate the effort associated with preparing meals., peer-reviewed
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- 2022
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30. To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma
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Harshy Harshy, Gunveen Kaur, Tanu Bala, Swati Leekha, Shikha Kler, and Vivek Singh Dahiya
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stomatognathic diseases ,General Nursing ,Education - Abstract
To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma. After ethical clearance and informed consent, the saliva samples were collected from 20 patients of OPMD’S, 20 patients of OSCC and 10 controls. Salivary IL-6 levels were detected by enzyme linked Immunosorbent essay and appropriate statistical analysis was done. Significant differences in IL-6 concentration between OSCC, OPMD’S and controls were noted. Salivary IL-6 levels were higher in OSCC. The results of present study concluded that the level of salivary IL-6 in OSCC is significantly higher than oral potentially malignant disorders like OSMF and oral epithelial dysplasia and controls. This biomarker can be utilized as a major asset for early detection of cancer and can open a new horizon for treatment plans of targeted therapy.
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- 2022
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31. User Classification and Stock Market-Based Recommendation Engine Based on Machine Learning and Twitter Analysis
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Prasad N. Achyutha, Sushovan Chaudhury, Subhas Chandra Bose, Rajnish Kler, Jyoti Surve, and Karthikeyan Kaliyaperumal
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Article Subject ,General Mathematics ,General Engineering - Abstract
The stock market prices of the company vary in a daily fashion. The social media pattern usage of the company can be determined to find the sentiment score values. The dependency factor between the social media tweet platform and the performance of an organization can have how much effect on the stock prices is determined. The historical data from the Yahoo Finance APIs are taken for the unique company ID and then the probability of stock being good or bad is determined. Also, the tweets related to the company are scanned and analyzed to find the positive and negative scores. The concentration value connected to growth, the intensity of capital expenditure, and the volume of promotion were among the factors utilized in the stock’s modeling. This paper also takes the yearly finances of the end-user based on LIC payments, medical insurance payments, and average rent and then performs a classification of the user. Based on the user classification, companies are recommended to the end-user based on descending order of stock value. The average volume, average price, average market index, average daily turnover, and sentiment discrepancy index are based on the tweets of a company and the predicted value of its performance. For the classification of the user, we make use of the support vector machine algorithm. For the sentiment analysis of the tweets, the naïve Bayes algorithm is made use of, and then stock classification is done based on mathematical modeling, which includes the sentiment analysis index.
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- 2022
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32. Identifying Smart Strategies for Effective Agriculture Solution Using Data Mining Techniques
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Anthony Jesus Bustamante Suarez, Barjinder Singh, Firas Husham Almukhtar, Rajnish Kler, Sonali Vyas, and Karthikeyan Kaliyaperumal
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Article Subject ,Safety, Risk, Reliability and Quality ,Food Science - Abstract
Agricultural producers and enterprises face a dizzying array of decisions every day, and the many factors that influence them are incredibly complex. Agricultural planning relies heavily on accurately calculating the yields of the various crops that will be used. If you want realistic and successful solutions, data mining is an essential component. Researchers in this study are looking for ways to evaluate agricultural data and extract valuable information from the results in order to increase agricultural output. Use of the CART and random forest algorithms is a data mining technique that may be used to various datasets. It is possible to recognise the effects of various climatic and other factors on agricultural output using the MATLAB software and data mining methods, and a potential strategy is highlighted.
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- 2022
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33. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. E., Barai, I., Amin, H., Suresh, S., Sethi, R., Gul, W., Bolton, W., Corbridge, O., Horne, L., Attalla, M., Morley, R., Robinson, C., Hoskins, T., Mcallister, R., Lee, S., Dennis, Y., Nixon, G., Heywood, E., Wilson, H., Ng, L., Samaraweera, S., Mills, A., Doherty, C., Belchos, J., Phan, V., Lim, M., Miller, F. A., Chouari, T., Gardner, T., Goergen, N., Hayes, J. D. B., Macleod, C. S., Mccormack, R., Mckinley, A., Mckinstry, S., Milligan, W., Ooi, L., Rafiq, N. M., Sammut, T., Sinclair, E., Smith, M., Wong, J., Ablett, A. D., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Francis, A. A., Baker, C., Boulton, A. P. R., Collins, J., Copley, H. C., Fearnhead, N., Fox, H., Mah, T., Mckenna, J., Naruka, V., Nigam, N., Nourallah, B., Perera, S., Qureshi, A., Saggar, S., Sun, L., Wang, X., Yang, D. D., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Al-hadithi, A., Caroll, P., Doyle, C., Elangovan, S., Falamarzi, A., Gascon Perai, K., Greenan, E., Jain, D., Lang-Orsini, M., Lim, S., O'Byrne, L., Ridgway, P., Van der Laan, S., Arthur, J., Barclay, J., Bradley, P., Edwin, C., Finch, E., Hayashi, E., Hopkins, M., Kelly, D., Kelly, M., Mccartan, N., Ormrod, A., Pakenham, A., Christy, S., Hayward, J., Hitchen, C., Kishore, A., Martins, T., Philomen, J., Rao, R., Rickards, C., Burns, N., Copeland, M., Durand, C., Dyal, A., Ghaffar, A., Gidwani, A., Grant, M., Gribbon, C., Gruhn, A., Leer, M., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Ahmad, K., Beattie, G., Beatty, M., Campbell, G., Donaldson, G., Graham, S., Holmes, D., Kanabar, S., Liu, H., Mccann, C., Stewart, R., Vara, S., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ajibola-Taylor, O., Andah, E. J. E., Ani, C., Cabdi, N. M. O., Ito, G., Jones, M., Komoriyama, A., Titu, L., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Basra, M., Gallogly, P., Harinath, G., Leong, S. H., Pradhan, A., Siddiqui, I., Zaat, S., Ali, A., Galea, M., Looi, W. L., J. C. K., Ng, Farhan-Alanie, M. M. H., Aitken, G., Nair, M., Aly, M. H., Buari, M., Atkin, G., Azizi, A., Cargill, Z., China, Z., Elliot, J., Jebakumar, R., Lam, J., Mudalige, G., Onyerindu, C., Renju, M., Shankar Babu, V., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Hussain, M., Joji, N., Lovett, B., Mownah, H., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Ali, B., Cresswell, B., Dhillon, A. K., Dupaguntla, Y. S., Hungwe, C., Lowe-Zinola, J. D., Tsang, J. C. H., Wcislo, K., Bevan, K., Cardus, C., Duggal, A., Hossain, S., Mchugh, M., Scott, M., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Chan, F., Evans, R., Gurung, E., Haughey, B., Jacob-Ramsdale, B., Kerr, M., Lee, J., Mccann, E., O'Boyle, K., Reid, N., Kwek, I., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Lau, I. S. F., Hayat, F., Hodgson, S., Johnston, R., Jones, W., Khan, M., Linn, T., Long, S., Seetharam, P., Shaman, S., Smart, B., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anilkumar, A., Davies, J., Griffith, J., Hughes, B., Islam, Y., Kidanu, D., Mushaini, N., Qamar, I., Robinson, H., Schramm, M., Yan Tan, C., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Apperley, H., Billyard, C., Blazeby, J. M., Cannon, S. P., Carse, S., G??pfert, A., Loizidou, A., Parkin, J., Sanders, E., Sharma, S., Slade, G., Telfer, R., Whybrow Huppatz, I., Worley, E., Asif, A., Hullait, R., Quinn, P., Rylance, A., Butt, S., Leathes, J., Chandramoorthy, L., Friend, C., Harris, L., Jain, P., Karim, M. J., Killington, K., Mcgillicuddy, J., Rafferty, C., Rahunathan, N., Rayne, T., Varathan, Y., Verma, N., Zanichelli, D., Arneill, M., Brown, F., Campbell, B., Crozier, L., Henry, J., Mccusker, C., Prabakaran, P., Wilson, R., Karelia, S., Clements, J. M., Rainey, M., Asif, U., Connor, M., Dindyal, S., Math, N., Pagarkar, A., Saleem, H., Seth, I., Standfield, N., Swartbol, T., Adamson, R., Choi, J. E., El Tokhy, O., Ho, W., Javaid, N. R., Mehdi, A. S., Menon, D., Plumptre, I., Sturrock, S., Turner, J., Warren, O., Joshi, N., Rahman, A., Gallagher, M., Crane, E., Ferris, B., Gadsby, C., Smallwood, J., Vipond, M., Wilson, V., Amarnath, T., Doshi, A., Gregory, C., Kandiah, K., Powell, B., Spoor, H., Toh, C., Vizor, R., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Smith, E., Common, M., Dunleavy, K., Harris, S., Luo, C., Mesbah, Z., Prem Kumar, A., Redmond, A., Skulsky, S., Walsh, T., Daly, D., Deery, L., Epanomeritakis, E., Harty, M., Kane, D., Khan, K., Mackey, R., Mcconville, J., Mcginnity, K., Wong, H. L., Ang, A., Kee, J. Y., Leung, E., Norman, S., Palaniappan, S. V., Partha Sarathy, P., Yeoh, T., Frost, J., Hazeldine, P., Jones, L., Karbowiak, M., Macdonald, C., Mutarambirwa, A., Omotade, A., Runkel, M., Ryan, G., Sawers, N., Searle, C., Vig, S., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Mcauliffe, O., Ahmad, A., Mcgartland, R., Sim, R., Song, A., Wayman, J., Brown, R., Chang, L. H., Concannon, K., Crilly, C., Arnold, T. J., Burgin, A., Cadden, F., Choy, C. H., Coleman, M., Lim, D., Luk, J., Mahankali-Rao, P., Prudence-Taylor, A. J., Ramakrishnan, D., Russell, J., Fawole, A., Gohil, J., Green, B., Hussain, A., Mcmenamin, L., Tang, M., Azmi, F., Benchetrit, S., Cope, T., Haque, A., Harlinska, A., Holdsworth, R., Ivo, T., Martin, J., Nisar, T., Patel, A., Sasapu, K., Trevett, J., Vernet, G., Aamir, A., Bird, C., Durham-Hall, A., Gibson, W., Hartley, J., May, N., Maynard, V., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Johnson, S., McDonald Wood, C., O'Brien, M., Orbell, J., Stringfellow, T. D., Tenters, F., Tresidder, S., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Cheung, W., Grant, A., Tod, N., Yi Tew, Z., Suchdev, N., Wei Lim, S., Bews-Hair, M., Lim, Z. H., Lim, S. W., Vella-Baldacchino, M., Auckburally, S., Chopada, A., Easdon, S., Goodson, R., Mccurdie, F., Narouz, M., Radford, A., Rea, E., Taylor, O., Yu, T., Sookramanien, S. R., Chan, A., Bointas, G., Alfa-Wali, M., Amani, L., Auluck, I., Bruce, P., Emberton, J., Kumar, R., Lagzouli, N., Mehta, A., Murtaza, A., Raja, M., Dennahy, I. S., Frew, K., Given, A., Y. Y., He, Karim, M. A., Macdonald, E., Mcdonald, E., Mcvinnie, D., S. K., Ng, Pettit, A., Berthaume-Hawkins, S. D., Charnley, R., Fenton, K., Jones, D., Murphy, C., J. Q., Ng, Reehal, R., Seraj, S. S., Shang, E., Tonks, A., White, P., Yeo, A., Paul, M., Ward, K. L., Bagnall, M., Chong, P., Gabriel, R., Patel, N., Richardson, E., Symons, L., Aubrey-Jones, D., Dawood, S., Dobrzynska, M., Faulkner, S., Griffiths, H., Mahmood, F., Perry, M., Power, A., Simpson, R., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Brobbey, P., Burrows, A., Elder, P., Ganyani, R., Horseman, C., Hurst, P., Mann, H., Marimuthu, K., Mcbride, S., Pilsworth, E., Powers, N., Stanier, P., Obukofe, R., Polson, R., Mason, D., Mackenzie, E., Innes, R., Kersey, T., Kopczynska, M., Langasco, N., Rajagopal, R., Russell, C., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Imam, L., Atkins, B., Beasley, W., Cheng Lim, Z., Gill, A., Li Ang, H., Williams, H., Yogeswara, T., Drury, D. J., James, S. J., Barnett, R., Teasdale, A. B., Richardson, E. T. J., Thomas, D. A., Williams, R. L., Najabat-Lattif, H. F., Akram, B., Carter, R., Fam, M., Fong, J., Latter, J., Long, M., Mackinnon, S., Mckenzie, C., Osmanska, J., Raghuvir, V., Shafi, A., Tsang, K., Walker, L., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Bountra, K., Coldicutt, O., Fletcher, D., Hudson, S., Iqbal, S., Lopez Bernal, T., Martin, J. W. B., Moss-Lawton, F., Suchett-Kay, I., Chang, J., O'Callaghan, H., Suchett-Kaye, I., Mihailidis, T. H., Cardwell, A., Edgerton, K., Laws, J., Rai, A., Robinson, K., Waite, K., Youssef, H., Alawattegama, H., Seite, E., Barrett, A., Riordan, E., Lam, W., Dowdeswell, M., Mulvenna, C., Knight, C., Koo, P. Y., Lazarou, A., Stanger, S., Thorn, C., Triniman, M. C., Netke, T., Awokoya, O., Gurowich, L., Dhera, K., Hossaini, S., Botha, A., Boyles, L., Cumming, S., Deepak, S., Ezzat, A., Fowler, A. J., Gwozdz, A. M., Hussain, S. F., Khan, S., Li, H., Lu Morrell, B., Neville, J., Nitiahpapand, R., Pickering, O., Sagoo, H., Sharma, E., Welsh, K., Williams, L., Hayat, S., Tincknell, L., Spazzapan, M., Teeling, F., Sysum, K., Denley, S., Latter, M., Agarwal, M., Al-Saadi, N., Bhambra, R., Gupta, A., Jawad, Z. A. R., Jiao, L. R., Mahir, G., Singagireson, S., Thoms, B. L., Tseu, B., Wei, R., Yang, N., Britton, N., Leinhardt, D., Mahfooz, M., Palkhi, A., Price, M., Sheikh, S., Barker, M., Bowley, D., Cant, M., Datta, U., Farooqi, M., Lee, A., Morley, G., Naushad Amin, M., Parry, A., Patel, S., Strang, S., Yoganayagam, N., Guruswamy, M., Beedham, W., Brazier, E., Elghobashy, M., Bajaj, M., Etel, E., Adlan, A., Chandramoorthy, S., Choudhary, Y., Das, K., Feldman, M., France, B., Grace, R., Puddy, H., Soor, P., Kisiel, A., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Ali, M., Dhillon, P., Faraj, A., Gerard, L., Glover, M., Imran, H., Kim, S., Patrick, Y., Peto, J., Prabhudesai, A., Tang, A., Vadgama, N., Dhaliwal, R., Ecclestone, T., Harris, A., Ong, D., Patel, D., Philp, C., Stewart, E., Wang, L., Wong, E., Xu, Y., Ashaye, T., Fozard, T., Galloway, F., Kaptanis, S., Mistry, P., Nguyen, T., Olagbaiye, F., Osman, M., Philip, Z., Rembacken, R., Tayeh, S., Theodoropoulou, K., Liu, F. Y., Arnold, A., Pedersen, A. C., Cunha, P., Ahmed, M., Al Zawawi, S., Kudva, V., Herman, A., Lau, J., Saha, A., Trotter, M., Miscampbell, M., Robinson, A. V., Johnston, J., Dharni, A., Lamb, S., Westerman, T., Adeleye, O., Cave, D., Gunwa, T., Magalh??es, J., Makwana, S., Mason, R., Parish, M., Regan, H., Renwick, P., Roberts, G., Salekin, D., Sivakumar, C., Tariq, A., Liew, I., Mcdade, A., Stewart, D., Evans, E., Campbell, L., Gillespie, M., Cheong, C. M., Hague, M., Hudson-Peacock, N., Jackson, C. E. S., James, F., Pitt, J., Walker, E. Y., Kulathevanayagam, K., Varghese, A., Ike, S. I., Aftab, R., Ang, J. J., Anwar, S., Battle, J., Budd, E., Chui, J., Crook, H., Davies, P., Easby, S., Hackney, E., Ho, B., Imam, S. Z., Rammell, J., Chu, T. S. M., Baljer, B., Mogg, J. A. W., Rai, P., Andrews, H., Perry, C., Schinle, P., Ahmed, P., Aquilina, T., Balai, E., Church, M., Cumber, E., Curtis, A., Davies, G., Dumann, E., Greenhalgh, S., Kim, P., King, S., Metcalfe, K. H. M., Passby, L., Redgrave, N., Soonawalla, Z., Waters, S., Zornoza, A., Claireaux, H., Williams, M., Smillie, R., Goetz, J., Appleby, E., Fadipe, T., Vaughan-Burleigh, S., Davies, R., Gulzar, I., Hole, J., Hull, K., Ishaq, H., Karaj, J., Kelkar, A., Love, E., Thakrar, D., Vine, M., Waterman, A., James, P., Puri, G., Hussain, P., Flather, R., Cutler, A., Pathak, S., Sheldon, J., Collicott, T., al-Ausi, M., Ko, M., Dib, N. P., Francis, N., Hanson, M., Ingleton, R., Sadanand, K. S., Sukirthan, N., Mondal, A., Jovaisaite, A., Shah, S. M., Khalid, N., Gutmann, D., Davison, S., Alame, Y. J., Syed, L., Owen, W. J., Arnell, S., Ball, M., Bassam, N., Beghal, G., Chang, A., Dawe, V., George, A., Huq, T., Ikram, B., Kanapeckaite, L., Ramjas, D., Rushd, A., Sait, S., Serry, M., Yardimci, E., Kalderon, R., Ahsan, S. D., Anthony-Uzoeto, U., Macleod Hall, C., Zheng, S., Wynter, K., Capella, S., Chenciner, L., Episkopos, C., Karam, E., Mccarthy, C., Moore-Kelly, W., Watson, N., Nadama, H. H., James, C., Sapre, D., Ghosh, R., Baird, J., Cockburn, L., Blackwood, O., Simpson, W., Ahluwalia, V., Barnfield, J., Ben-Gal, O., Bloom, I., Gharatya, A., Khodatars, K., Merchant, N., Moonan, A., Moore, M., Patel, K., Spiers, H., Sundaram, K., Jeong, S., Bishop, S., Black, J., Chadwick, H., Huisman, L., Ingram, H., Martin, L., Metcalfe, M., Sangal, P., Seehra, J., Thatcher, A., Venturini, S., Whitcroft, I., Bate, R., Hobson, C., Adam, A. H., Redclift, C., Do, J., Poli, F., Batterham, A., Brown, S., Pandya, A., Afzal, Z., Gani, A., Gomaa, A., Hussein, N., S. Y., Oh, Pazhaniappan, N., Sharkey, E., Sivagnanasithiyar, T., Williams, C., Yeung, J., Parekh, J. N., Clay, W., Pieri, K., Jackson, A., Saxena, A., Gurung, B., Oyebola, T., O'Brien, F., Reilly, S., Cruddas, L., Gurjar, S., Pau, A., Prakash, R., Randhawa, R., Djeugam, B., Gardezi, S., Ul-Hasan, S., Martin-Hernandez, M. 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V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. K., Jegathees, T., Coulter-Nile, S. M. C. J., Gosselink, M. P., Wang, Y. L., Maciaszek, M., Chrapko, P. S., White, S., Ivanov, V., Borisova, A., Kuncarov??, K., Ri??ko, J., Ludvik, M., Stercz, M., Treskon, R., Posp????il, M., Hlav??cov??, L., Tomanov??, D., Kolo??ov??, B., Sobotkov??, K., Cha, S., uta Kimle, K., Jirankova, K., Bujda, M., Pacl??k, A., Chrz, K., Antonova, T., Chodora, S., Houdek, O., Novick??, R., Skalick??, A., Farka??ov??, M., Jozaf, V., Klail, T., Prochazka, V., Harbjerg, J. L., Enevoldsen, M., H??jgaard Pedersen, J., Brandsborg, S., Amiri, S., Brinck, S., Jepsen, B. N., Hillgaard, T. K., Erichsen, S. B., Nielsen, C. V., Madsen, C. P., Bjerke, J., Skej??, C. D., Aabling, R. R., Kjaer, M. D., Unbehaun, K. P., Mark-Christensen, A., Dalsgaard, P., Trap, A., J??rgens-Lahnstein, J., Storm, M., Damgaard, I., Olawi, F., Ehlern, F., Raos, M., Ravn, S., Lycke, K. D., Kristensen, F. P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. P., Scaramuzzo, R., Larcinese, A., Fioriti, C., Picone, E., Nardi, M., Di Candido, F., Spinelli, A., Marco, M., Bevilacqua, M., Maroli, A., Colombo, F., Cigognini, M., Zaffaroni, G., Maffioli, A., Colombo, S., Bondurri, A., Sampietro, G., Foschi, D., Perrone, G., Bonati, E., Aresu, S., Saba, A., Biancafarina, A., Angelini, M., Andolfi, E., Miranda, E., Scricciolo, M., Provenza, G., Cavallina, G., Frezza, B., Fontani, A., Malatesti, R., Pellican??, G. A., Ceccarelli, G., Canonico, G., Falsetti, E., Pagnanelli, M., De Nardi, P., Rosati, R., Marcocci, G., Vignali, A., Quattromani, R., Curletti, G., Galleano, R., Malerba, M., Percivale, A., Ghazouani, O., Reggiani, L., Spirito, C., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Moretto, G., Bacchion, M., Casaril, A., Inama, M., Creciun, M., Vitali, M., Cillara, N., Mosino, L., Peddis, M., Melis, S., De Donno, G., Aru, A. C., Loche, G. A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Gr??ter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. 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E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., Psychiatry, Surgery, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Kanta-Häme Central Hospital Hämeenlinna, Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, 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J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., Ng, S. Y., Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., Pös, M., Adel, A., Sotona, O., Bartoš, M., Amjad, T., Malý, O., Berec, S., Hanušová, M., Hurný, M., Örhalmi, J., Sørensen, J. S., Chanut, F., Magnin, J., Schöning, L., CS Simon, S., Galata, C., Karampinis, I., Thäwel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Figà, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Truškovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., Müller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., 't Hart, E., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, É., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG
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renal failure ,cohort studies ,humans ,kidney ,postoperative complications ,prognosis ,prospective studies ,retrospective studies ,risk assessment ,risk factors ,acute kidney injury ,digestive system surgical procedures ,Prognosi ,Acute Kidney Injury/diagnosis ,Digestive System Surgical Procedures/adverse effects ,3121 Internal medicine ,Kidney ,Risk Assessment ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,Postoperative Complications ,Retrospective Studie ,Risk Factors ,Gastrointestinal Surgery ,Humans ,preoperative care ,Prognostic Model ,Prospective Studies ,Digestive System Surgical Procedures ,Retrospective Studies ,Science & Technology ,Risk Factor ,MORTALITY ,General Medicine ,STARSurg Collaborative and EuroSurg Collaborative ,Acute Kidney Injury ,Prognosis ,surgical procedures ,Prospective Studie ,aki ,OAKS ,Postoperative Complications/etiology ,colorectal surgery ,Surgery ,Postoperative Complication ,Cohort Studie ,Life Sciences & Biomedicine ,Human - Abstract
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
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- 2022
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34. Optimization of Integrated Systems for Natural Gas Production, Conversion, and Transportation
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Aleksandr Kler, Elina Tyurina, and Aleksandr Mednikov
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Renewable Energy, Sustainability and the Environment ,Control and Systems Engineering ,General Chemical Engineering ,Geography, Planning and Development ,Management, Monitoring, Policy and Law ,Pollution ,Waste Management and Disposal - Published
- 2022
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35. Does a Cancer Diagnosis in Mid-to-Later Life Modify Racial Disparities in Memory Aging?
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Marisa R. Eastman, Monica Ospina-Romero, Ashly C. Westrick, Jasdeep S. Kler, Medellena Maria Glymour, Ekland Abdiwahab, and Lindsay C. Kobayashi
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Black or African American ,Aging ,Memory Disorders ,Psychiatry and Mental health ,Clinical Psychology ,Neoplasms ,Humans ,Geriatrics and Gerontology ,Gerontology ,Aged - Abstract
It is unknown whether an incident cancer diagnosis differentially impacts acute and long-term memory aging between older White and Black Americans.Incident cancer diagnoses and memory (immediate and delayed recall, combined with proxy-reported memory) were assessed at biennial study interviews in the US Health and Retirement Study (N=14,235, 1998-2016). We used multivariable segmented linear mixed-effects models to evaluate the rate of change in standardized memory score (SD/decade) in the years before, acutely at the time of, and in the years following an incident cancer diagnosis, compared to cancer-free adults, by race.Black participants experienced faster memory decline than White participants (cancer-free group: -1.211 vs. -1.077; P0.0001). An incident cancer diagnosis was associated with an acute memory drop in White, but not Black participants (-0.065 vs. 0.024; P0.0001). However, White cancer survivors experienced slower memory decline than cancer-free White adults before and after diagnosis, but this memory advantage was not observed among Black cancer survivors.Racial disparities in memory aging are not modified by an incident cancer diagnosis. The acute cancer-related memory decline and long-term memory advantage experienced by White, but not Black, cancer survivors relative to cancer-free older adults, requires further investigation.
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- 2022
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36. Avian diversity in agricultural habitats of Punjab state
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Tejdeep Kaur Kler, Manoj Kumar, Sachin Kumar, and Sukhpreet Kaur Sidhu
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Horticulture ,Agricultural and Biological Sciences (miscellaneous) ,Agronomy and Crop Science ,Food Science - Published
- 2022
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37. The method of dynamic calculations of elements of thermal power plants, which reduces the solution of systems of differential equations in partial derivatives to the solution of linear programming problems
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Alexandr M. Kler and Danil V. Apanovich
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General Medicine - Published
- 2022
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38. A method for processing the results of thermophysical experiments based on solving two types of problems of nonlinear mathematical programming
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Aleksandr M. Kler, Vitalii E. Alekseiuk, Anatolii A. Levin, and Polina V. Khan
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General Medicine - Published
- 2022
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39. Validity of Capillary Imbibition Models in Paper-Based Microfluidic Applications
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Gabriel S. Gerlero, Andrés R. Valdez, Raúl Urteaga, and Pablo A. Kler
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General Chemical Engineering ,Catalysis - Published
- 2022
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40. Corrigendum: Do environmental quality, financial inclusion and good governance ensure the FDI sustainably in belt and road countries? Evidence from an application of CS-ARDL and NARDL
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JinRu, Long, Qamruzzaman, Md., Hangyu, Wu, and Kler, Rajnish
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General Environmental Science - Published
- 2023
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41. Spontaneous haemorrhagic cholecystitis secondary to the use of novel anticoagulants (rivaroxaban)
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Merina Kurian, Chee Khong Lim, Prabhjoyt Kler, Bing Lun Chow, and Cyril Jacob Chacko
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General Medicine - Abstract
Haemorrhagic cholecystitis is a rare complication of acute cholecystitis. It carriesa high risk of morbidity and mortality. Risk factors for haemorrhagic cholecystitis include cholelithiasis, trauma, malignancy and the use of anticoagulants. There have only been a few reported cases of haemorrhagic cholecystitis secondary to the use of novel oral anticoagulants (NOACs). The demographic transition of an ageing population will potentially increase the utilisation of NOACs. Therefore the incidence ofhaemorrhagic cholecystitis secondary to NOACs will likely increase. Awareness and prompt diagnosis is paramount to avoid morbidity and mortality associated with haemorrhagiccholecystitis.
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- 2023
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42. Nappies, books and wrinkles: How children, qualifications and age affect female underemployment in Australia
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Parvinder Kler, Azhar Hussain Potia, and Sriram Shankar
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Organizational Behavior and Human Resource Management ,Management of Technology and Innovation ,Strategy and Management ,General Business, Management and Accounting - Abstract
This study examines the determinants of underemployment among part-time employed Australian females, accounting for the interaction of their age, educational qualifications and offspring presence. Females who are young, tertiary educated and without offspring are likeliest to be underemployed, and in general the presence of children lowers the probability of underemployment for those aged below 35, but this impact ameliorates significantly for those aged 35 and above. Policies to address female underemployment need to account for the fact that there is no representative ‘average female worker’, so as to ensure requisite policies better target those most at risk of underemployment. This finding holds for those working either minimum or maximum hours within the part-time spectrum, where greater uniformity of underemployment is found. Age of offspring affects the likelihood of underemployment with younger offspring reducing the incidence of a mismatch between preferred and actual hours, while the opposite holds for older offspring.
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- 2021
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43. Duration of Antibiotic Therapy in Neonatal Gram-negative Bacterial Sepsis—10 Days Versus 14 Days
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Anurag, Fursule, Anup, Thakur, Pankaj, Garg, and Neelam, Kler
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Male ,Microbiology (medical) ,Infectious Diseases ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Humans ,Bacteremia ,Female ,Treatment Failure ,Neonatal Sepsis ,Gram-Negative Bacterial Infections ,Anti-Bacterial Agents - Abstract
Optimal duration of antibiotic therapy in Gram-negative bacterial (GNB) sepsis in non-VLBW infants has not been specifically evaluated in previous studies.This was an open labeled noninferiority randomized controlled trial. Non-VLBW infants with GNB sepsis without meningitis whose blood culture were sterile after day 7 of treatment and who were in clinical remission on day 9 of appropriate antibiotic were randomized to short duration (SDR) group and long duration (LDR) group. Infants in SDR group and LDR group received antibiotic therapy for 10 days and 14 days respectively. Primary objective was to compare treatment failure. Secondary objectives were to compare duration of hospitalization, complications of intravenous (IV) therapy and its duration, episodes of new-onset sepsis and all-cause mortality.Of 222 infants with GNB sepsis, 58 eligible infants were randomized in each group and 113 of these were analyzed. There was no difference in proportion of infants with multidrug-resistant (MDR) organism in SDR versus LDR group [33(60%) versus 32(55.1%) (P = 0.84)]. There were no treatment failures in either group. Median (IQR) duration of hospital stay was higher in LDR group as compared with SDR group: 20(18, 23) versus 16(13, 20) days (P 0.001). Infants in LDR group required IV therapy for a longer duration as compared with SDR group mean (SD): 15.2(1.2) versus 10.9(0.8) days (P 0.001). Median (IQR) episodes of extravasation were higher in LDR group: 5(4.7) versus 3(2.3) (P 0.001). There was no difference in episodes of phlebitis and hematoma. No infants had died on follow up.In suitably selected non-VLBW infants with Gram-negative sepsis, 10 days therapy is noninferior to 14 days therapy.
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- 2021
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44. The ASCEND-ND trial: study design and participant characteristics
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Vlado Perkovic, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R Cobitz, Rich Davies, Tara L DiMino, Vivekanand Jha, Kirsten L Johansen, Renato D Lopes, Lata Kler, Iain C Macdougall, John J V McMurray, Amy M Meadowcroft, Gregorio T Obrador, Scott Solomon, Lin Taft, Christoph Wanner, Sushrut S Waikar, David C Wheeler, Andrzej Wiecek, and Ajay K Singh
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Male ,Transplantation ,Iron ,Anemia ,Prolyl-Hydroxylase Inhibitors ,Hemoglobins ,Renal Dialysis ,Nephrology ,hemic and lymphatic diseases ,Hematinics ,Humans ,Female ,Darbepoetin alfa ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Renal Insufficiency, Chronic ,Erythropoietin ,Aged - Abstract
Background Anaemia is common in chronic kidney disease (CKD) and assessment of the risks and benefits of new therapies is important. Methods The Anaemia Study in CKD: Erythropoiesis via a Novel prolyl hydroxylase inhibitor Daprodustat-Non-Dialysis (ASCEND-ND) trial includes adult patients with CKD Stages 3–5, not using erythropoiesis-stimulating agents (ESAs) with screening haemoglobin (Hb) 8–10 g/dL or receiving ESAs with screening Hb of 8–12 g/dL. Participants were randomized to daprodustat or darbepoetin alfa (1:1) in an open-label trial (steering committee- and sponsor-blinded), with blinded endpoint assessment. The co-primary endpoints are mean change in Hb between baseline and evaluation period (average over Weeks 28–52) and time to first adjudicated major adverse cardiovascular (CV) event. Baseline characteristics were compared with those of participants in similar anaemia trials. Results Overall, 3872 patients were randomized from 39 countries (median age 67 years, 56% female, 56% White, 27% Asian and 10% Black). The median baseline Hb was 9.9 g/dL, blood pressure was 135/74 mmHg and estimated glomerular filtration rate was 18 mL/min/1.73 m2. Among randomized patients, 53% were ESA non-users, 57% had diabetes and 37% had a history of CV disease. At baseline, 61% of participants were using renin–angiotensin system blockers, 55% were taking statins and 49% were taking oral iron. Baseline demographics were similar to those in other large non-dialysis anaemia trials. Conclusion ASCEND-ND will define the efficacy and safety of daprodustat compared with darbepoetin alfa in the treatment of patients with anaemia associated with CKD not on dialysis.
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- 2021
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45. The Role of Remittances on Financial Development through Capital Formation and FDI Channels: A Symmetric and Asymmetric Investigation for Selected South Asian Countries
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Md. Qamruzzaman and Rajnish Kler
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Accounting ,Finance - Published
- 2021
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46. Non-pulmonary complications after lung transplantation: part II
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Rohan Kanade, Aditya Kler, and Amit Banga
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Pulmonary and Respiratory Medicine ,Surgery ,Review Article ,Cardiology and Cardiovascular Medicine - Abstract
Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. These complications are, therefore, becoming increasingly relevant as patients with LT are living longer. These complications encompass almost all organ systems and are driven by a combination of the pre-existing comorbidities, events, and complications around the operative procedure and recovery, and perhaps most importantly, medication side effects of the post-LT regimen. In the first of the two-part review, we covered the general approach to management of extrapulmonary complications and covered specific complications pertaining to cardiovascular, renal, neuropsychiatric, and ophthalmologic organ systems. In the current article, we discuss most relevant complications pertaining to the hematologic, endocrine, and gastrointestinal organ systems. In addition, we discuss two of the most common and consequential complications under the miscellaneous category, namely malignancy and venous thrombo-embolism after LT. These two complications have gained increasing significance in the lung allocation score era where progressively sicker and older patients are being transplanted.
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- 2021
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47. Stock Market Volatility Transmission and Interlinkage: Evidence from BRICS
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Salma Karim, Md. Qamruzzaman, Rajnish Kler, and M. Theivanayaki
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Cointegration ,Order (exchange) ,Accounting ,Financial market ,Financial integration ,Economics ,Unit root ,Monetary economics ,Foreign direct investment ,Causality ,Finance ,Stock (geology) - Abstract
No isolated financial markets are available due to global financial integration through trade liberation and FDI presence. Therefore, financial markets are subject to response to home economy events and pair economy movements. The study's motivation is to investigate the volatility transmission and interlinkage between financial markets in BRICS nations from January 01, 2001 to December 31, 2019. The study applies unit root tests, the test of cointegration, ARCH-GARCH effects, and the Non-granger causality test to expose interlinkages. Results of unit root tests expose variables are integrated in mixed order, i.e., few variables are stationary at a level I (0), and few variables are after first difference I (0). The cointegration test reveals the long-run association available in the empirical model, implying that the long-run BRICS stock markets act in the same direction. Results of ARCH-GARCH (1.1) disclose the presence of volatility persistence in the financial markets. Furthermore, the directional causality under the error correction term discloses that the feedback hypothesis explains the causality among financial markets in BRICS nations in the long run. On the other hand, a similar conclusion also derives from the Non-granger causality test.
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- 2021
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48. Do environmental quality, financial inclusion, and good governance ensure the FDI sustainably in Belt and Road countries? Evidence from an application of CS-ARDL and NARDL
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Long JinRu, Md. Qamruzzaman, Wu Hangyu, and Rajnish Kler
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General Environmental Science - Abstract
Domestic capital adequacy and sustainable economic growth are heavily reliant on technological advancement, managerial know-how, and money supply in the economy. In this context, FDI has emerged and is placed at an apex position due to its unprecedented impact on achieving sustainability across the world. The motivation of this study is to scale the effects of good governance, financial inclusion, and environmental quality on inflows of FDI in BRI nations for the period from 1990 to 2020. Several panel econometrical tools have been applied, for example, CDS, CADF, CIPS, CS-ARDL, and NARDL, to investigate the association and explanatory variables elasticity on inflows of FDI in BRI nations. CDS results revealed that research units share common dynamism and second-generation panel unit root test-documented variables are stationary after the first difference. The results of the panel co-integration with an error-correction term confirmed the empirical equation’s long-run association. According to the CS-ARDL assessment, positive and statistically significant impacts have been documented, from financial inclusion, good governance, and environmental quality to FDI inflows. Study findings suggest that governmental effectiveness, easy access to financial services and benefits, and a less-regulated environmental concern economy motivate capital transfer decisions. The asymmetric assessment documented a long-run asymmetric association between FI, GG, EQ, and FDI. Referring to asymmetric shock elasticity, the study disclosed a positive and statistically significant relation to FDI inflows, especially in the long run. The directional causality test documented bidirectional causality running between FI, EQ, GG, and FDI [FI←→FDI; GG←→FDI; and EQ←→FDI] in the short-run.
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- 2022
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49. Community Connectedness as a Moderator of the Association between Intersectional Microaggressions and Alcohol Use among Sexual and Gender Minoritized People of Color
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Satveer Kler, Benjamin F. Shepherd, and Roberto Renteria
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Psychiatry and Mental health ,Health (social science) ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) - Published
- 2022
50. Surface Space‐Charge Potential and Oxygen Surface Exchange Coefficient of SrTiO 3 : The Effect of Surface Orientation
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Joe Kler, Jacqueline M. Börgers, and Roger A. De Souza
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Mechanics of Materials ,Mechanical Engineering - Published
- 2022
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