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The phase III study was designed to compare event-free survival (EFS) after treosulfan-based conditioning with a widely applied reduced-intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up are presented. Patients presenting HCT-specific comorbidity index >2 or aged >= 50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m(2) IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36-months-EFS rate 59.5% (95% CI, 52.2-66.1) vs. 49.7% (95% CI, 43.3-55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49-0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36-month-OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48-0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.

Wireless backhauling at millimeter-wave frequencies (mmWave) in static scenarios is a well-established practice in cellular networks. However, highly directional and adaptive beamforming in today's mmWave systems have opened new possibilities for self-backhauling. Tapping into this potential, 3GPP has standardized Integrated Access and Backhaul (IAB) allowing the same base station serve both access and backhaul traffic. Although much more cost-effective and flexible, resource allocation and path selection in IAB mmWave networks is a formidable task. To date, prior works have addressed this challenge through a plethora of classic optimization and learning methods, generally optimizing a Key Performance Indicator (KPI) such as throughput, latency, and fairness, and little attention has been paid to the reliability of the KPI. We propose Safehaul, a risk-averse learning-based solution for IAB mmWave networks. In addition to optimizing average performance, Safehaul ensures reliability by minimizing the losses in the tail of the performance distribution. We develop a novel simulator and show via extensive simulations that Safehaul not only reduces the latency by up to 43.2% compared to the benchmarks but also exhibits significantly more reliable performance (e.g., 71.4% less variance in achieved latency)., Comment: To appear in Proceedings of IEEE INFOCOM 2023

Wissen als Praxis zu begreifen, ist in der Europäischen Ethnologie heute selbstverständlich. Erkenntnisse der Wissenschafts- und Technikforschung, feministischer Kritiken und praxistheoretischer Entwicklungen haben sich produktiv mit fachlichen Problematisierungen von Rationalität, materieller und epistemischer Kultur verbunden. Im Zuge dieser Entwicklungen ist zunehmend die Performativität von Wissenspraktiken betont worden, d. h. ihre notwendigerweise immer auch gestaltende Weltwirksamkeit. Dies wiederum hat Anthropolog*innen ermutigt, verstärkt mit ethnografischen Methoden zu experimentieren, um eben jene Weltwirksamkeit besser kontrollieren bzw. entfalten zu können. Konzepte von Wissenstransfer und mode 2 Wissensproduktion sind ersetzt worden durch Interventionen, Ko-Produktion/Kreation/Design, Kollaboration, experimental entanglement und Ko-Laboration. Uns interessiert in diesem Beitrag die Frage, was diese Entwicklung praktisch für ethnografische Theorieproduktion bedeutet. Wir entwickeln unsere Argumentation an vier Forschungsfeldern, die derzeit in unserem Labor ethnografisch im Rahmen von fortgeschrittenen Dissertationsprojekten bearbeitet werden: Genesungsbegleitung in psychiatrischen Kliniken (Schmid), Praktiken des Plattformwirtschaftens in digitalen start-up Ökosystemen (Josties), Offener Dialog in der Psychiatrie als prozessuale Therapieform (Cubellis) und Skalierung in Modellen für Mensch-Umwelt Beziehungen (Klein). Wir legen besonderen Wert auf das gemeinschaftliche "Fügen" von Theorie und Reflexivität und beleuchten fallübergreifend drei Fragen genauer: Welche Konsequenzen hat die Verteilung von epistemischer Handlungsträgerschaft für ethnografische Theoriebildung? Wie müssen Differenzierungen in ko-laborativer Forschung kuratiert werden? Wo liegen Herausforderungen, Grenzen und Risiken dieser Herangehensweise? To understand knowledge as practice is taken for granted in European Ethnology today. Insights from science and technology studies, feminist critique and developments in practice theory have productively combined with disciplinary problematizations of rationality, materiality and epistemic culture. In the course of these developments, the performativity of knowledge practices has been increasingly emphasized, i. e. their worlding capacity. This, in turn, has encouraged anthropologists to experiment more with ethnographic methods in order to better understand and develop this worlding capacity. Concepts of knowledge transfer and mode 2 knowledge production have been replaced by approaches of intervention, co-production/creation/design, collaboration, experimental entanglement and co-laboration. In this contribution, we are interested in the question of what this development means in practice for ethnographic theory building. We develop our argument across four research fields that are currently being ethnographically studied in our laboratory in the context of advanced dissertation projects: Peer support in psychiatric clinics (Schmid), economic and management practices in digital start-up ecosystems (Josties), open dialogue in psychiatry (Cubellis) and scaling in models of human-environment relations (Klein). We place special emphasis on the joint "assembling" of theory and reflexivity and take a closer look at three questions across all cases: What consequences does the distribution of epistemic agency have for ethnographic theory building? How do differentiations in co-laborative research have to be curated? What are the challenges, limits and risks of this approach?

Andreas Baranowski,1 Ludwig Schlemmer,1 Katharina Förster,1 Ekaterina Slotina,1 Tim Mickan,1 Sebastian Truffel,1 Anja Klein,1 Stefan G Mattyasovszky,1 Alexander Hofmann,1,2 Ulrike Ritz,1 Pol M Rommens11Department of Orthopaedics and Traumatology, Biomatics Group, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany; 2Department of Traumatology and Orthopaedics 1, Westpfalz-Medical Centre Kaiserslautern, Kaiserslautern, GermanyBackground: After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic joint stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems.Objective: The purpose of this study was the evaluation of the influence of losartan and atorvastatin on the early development of joint contracture. In addition to joint angles, the change in myofibroblast numbers and the distribution of bone sialoprotein (BSP) were assessed.Study design and methods: In this randomized and blinded experimental study with 24 rats, losartan and atorvastatin were compared to a placebo. After an initial joint injury, rat knees were immobilized with a Kirschner wire. Rats received either losartan, atorvastatin or a placebo orally daily. After 14 days, joint angle measurements and histological assessments were performed.Results: Losartan increased the length of the inferior joint capsule. Joint angle and other capsule length measurements did not reveal significant differences between both drugs and the placebo. At cellular level both losartan and atorvastatin reduced the total number of myofibroblasts (losartan: 191±77, atorvastatin: 98±58, placebo: 319±113 per counting field, p

The increasing demand for diverse, mobile applications with various degrees of Quality of Service requirements meets the increasing elasticity of on-demand resource provisioning in virtualized cloud computing infrastructures. This paper provides a dynamic optimization approach for enhanced cloud infrastructures, based on the concept of cloudlets, which are located at hotspot areas throughout a metropolitan area. In conjunction, we consider classical remote data centers that are rigid with respect to QoS but provide nearly abundant computation resources. Given fluctuating user demands, we optimize the cloudlet placement over a finite time horizon from a cloud infrastructure provider's perspective. By the means of a custom tailed heuristic approach, we are able to reduce the computational effort compared to the exact approach by at least three orders of magnitude, while maintaining a high solution quality with a moderate cost increase of 5.8% or less.

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007