Search

Additional file 3: Home Spirometry Survey. Home spirometry survey to be completed at visit 3 and visit 5 by study participants who agreed to enroll in the home spirometry substudy. PRECISIONS logo created by the PRECISIONS study team for the PRECISIONS study. Written permission obtained from the Data Coordinating Center.

Additional file 1: Baseline COVID-19 Questionnaire. COVID-19 questionnaire to be completed by all study participants at the baseline visit. PRECISIONS logo created by the PRECISIONS study team for the PRECISIONS study. Written permission obtained from the Data Coordinating Center.

Additional file 4: Home Spirometry Exit Survey. Home spirometry survey to be completed at visit 7 or early termination visit by study participants who agree to enroll in the home spirometry substudy. PRECISIONS logo created by the PRECISIONS study team for the PRECISIONS study. Written permission obtained from the Data Coordinating Center.

Additional file 2: COVID-19 Questionnaire Follow-Up. COVID-19 questionnaire to be completed by all study participants at each follow-up visit. PRECISIONS logo created by the PRECISIONS study team for the PRECISIONS study. Written permission obtained from the Data Coordinating Center.

The purpose of this study was to describe the demographics and in-hospital mortality of children (n = 5) compared to survivors (n = 0) (p = 0.006).

BackgroundObesity is associated with restrictive ventilatory defects and a faster rate of decline in FVC. This association is not exclusively mediated by mechanical factors and may reflect direct pulmonary injury by adipose-derived mediators.Research questionIs adipose tissue involved in the pathogenesis of interstitial lung disease (ILD)?Study design and methodsWe evaluated the association of CT measures of pericardial, abdominal visceral, and abdominal subcutaneous adipose tissue with high-attenuation areas (HAAs) and interstitial lung abnormalities (ILAs) in a large multicenter cohort study of community-dwelling adults, using multivariable-adjusted models. We secondarily evaluated the association of adipose depot size with FVC and biomarkers of obesity and inflammation.ResultsIn fully adjusted models, every doubling in pericardial adipose tissue volume was associated with a 63.4-unit increase in HAA (95%CI, 55.5-71.3), 20%increased odds of ILA (95%CI, -2%to 50%), and a 5.5%decrease in percent predicted FVC (95%CI, -6.8%to -4.3%). IL-6 levels accounted for 8%of the association between pericardial adipose tissue and HAA. Every doubling in visceral adipose tissue area was associated with a 41.5-unit increase in HAA (95%CI, 28.3-54.7), 30%increased odds of ILA (95%CI, -10%to 80%), and a 5.4%decrease in percent predicted FVC (95%CI, -6.6%to -4.3%). IL-6 and leptin accounted for 17%and 18%, respectively, of the association between visceral adipose tissue and HAA.InterpretationGreater amounts of pericardial and abdominal visceral adipose tissue were associated with CT measures of early lung injury and lower FVC in a cohort of community-dwelling adults. Adipose tissue may represent a modifiable risk factor for ILD.

BackgroundAdipokines have inflammatory and fibrotic properties that may be critical in interstitial lung disease (ILD). We examined associations of serum adipokine levels with CT imaging-based measures of subclinical ILD and lung function among community-dwelling adults.MethodsA subset of the original Multi-Ethnic Study of Atherosclerosis cohort (n= 1,968) had adiponectin, leptin, and resistin measured during follow-up visits (2002-2005). We used regression models to examine associations of adiponectin, leptin, and resistin levels with (1) high-attenuation areas (HAAs) from CT scans (2004-2005, n= 1,144), (2) interstitial lung abnormalities (ILAs) from CT scans (2010-2012, n= 872), and (3) FVC from spirometry (2004-2006, n= 1,446). We used -(1/HAA2), which we denoted with H, to model HAA as our outcome to meet model assumptions.ResultsHigher adiponectin was associated with lower HAA on CT imaging among adults with a BMI≥ 25kg/m2 (P for BMI interaction= .07). Leptin was more strongly associated with ILA among never smokers compared with ever smokers (P for smoking interaction= .004). For every 1-SD increment of log-transformed leptin, the percent predicted FVC was 3.8%lower (95%CI,-5.0 to-2.5). Higher serum resistin levels were associated with greater HAA on CT in a fully adjusted model. For every 1-SD increment of log-transformed resistin there was an increase in H of 14.8 (95%CI, 3.4-26.3).ConclusionsHigher adiponectin levels were associated with lower HAA on CT imaging among adults with a higher BMI. Higher leptin and resistin levels were associated with lower FVC and greater HAA, respectively.

Gastrodia Brown (1810: 330) is a holomycotrophic terrestrial orchid genus of c. 65 species with an Old World distribution and centre of diversity in Southeast Asia (Cribb et al. 2010, Huang et al . 2015, Ong 2015). In the Philippines, two species are thus far known: G. javanica (Blume, 1825: 421) Lindley (1840: 384) and G. verrucosa Blume (1856: 175). Both have a widespread distribution in northern Malesia and southern East Asia. During fieldwork for the Co’s Digital Flora of the Philippine project (Pelser et al. 2011 onwards) in early December 2012, Gastrodia plants were photographed that belong to a third Philippine species. These plants were observed in three areas on the island of Mindanao: Mt. Apo Natural Park (North Cotabato Prov.) and two sites in Mt. Kitanglad Range Natural Park (Lantapan and Baungon municipalities; Bukidnon Prov.). In December 2015, plants belonging to the same species were collected in Northern Negros Natural Park (Victorias City, Negros Occidental Prov., Negros) and in March 2016 plants were photographed in Barlig (Mountain Prov., Luzon). Morphological studies showed that this species is distinct from all Gastrodia species except G. spathulata (Carr, 1935: 180) Wood (in Wood et al. 2011: 355) in having petals that are considerably shorter than the calyx tube and separate from it about half way along the inner surface of the tube. It differs from G. spathulata in the longer adnation of the petals to the calyx tube, the shape of the petals and their lack of indumentum, and characters of the lip ridges. Assuming that these morphological differences are an indication of reproductive isolation, we name and describe these plants here as a new species under a biological species concept (Mayr 2000). This new addition brings the total number of Philippine Gastrodia species to three.