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Supplemental material, Supplemental_Methods_and_Results for Effects of Exercise Intensity on Acute Circulating Molecular Responses Poststroke by Pierce Boyne, Colleen Meyrose, Jennifer Westover, Dustyn Whitesel, Kristal Hatter, Darcy S. Reisman, Daniel Carl, Jane C. Khoury, Myron Gerson, Brett Kissela and Kari Dunning in Neurorehabilitation and Neural Repair

Supplemental data from "Reference Curves and Association between PAPP-A2 and IGF-I Bioavailability throughout Childhood: A Cross-Sectional Study"

Supplemental information about PAPP-A2, Free IGF-I, and IGFBP-3 throughout childhood

Supplemental information about PAPP-A2, Free IGF-I, and IGFBP-3 throughout childhood

High quality historical control data, if incorporated, may reduce sample size, trial cost, and duration. A too optimistic use of the data, however, may result in bias under prior-data conflict. Motivated by well-publicized two-arm comparative trials in stroke, we propose a Bayesian design that both adaptively incorporates historical control data and selectively adapt the treatment allocation ratios within an ongoing trial responsively to the relative treatment effects. The proposed design differs from existing designs that borrow from historical controls. As opposed to reducing the number of subjects assigned to the control arm blindly, this design does so adaptively to the relative treatment effects only if evaluation of cumulated current trial data combined with the historical control suggests the superiority of the intervention arm. We used the effective historical sample size approach to quantify borrowed information on the control arm and modified the treatment allocation rules of the doubly adaptive biased coin design to incorporate the quantity. The modified allocation rules were then implemented under the Bayesian framework with commensurate priors addressing prior-data conflict. Trials were also more frequently concluded earlier in line with the underlying truth, reducing trial cost, and duration and yielded parameter estimates with smaller standard errors.

Supplemental material, DS_10.1177_0363546518788343 for Age-Dependent Patellofemoral Pain: Hip and Knee Risk Landing Profiles in Prepubescent and Postpubescent Female Athletes by Ryan T. Galloway, Yingying Xu, Timothy E. Hewett, Kim Barber Foss, Adam W. Kiefer, Christopher A. DiCesare, Robert A. Magnussen, Jane Khoury, Kevin R. Ford, Jed A. Diekfuss, Dustin Grooms, Gregory D. Myer and Alicia M. Montalvo in The American Journal of Sports Medicine

SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocoland related documents. (DOC 122 kb)