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Supplemental material, sj-pdf-2-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Supplemental material, sj-pdf-2-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Supplemental material, sj-docx-3-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Supplemental material, sj-docx-4-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Supplemental material, sj-docx-4-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Supplemental material, sj-docx-3-evb-10.1177_11769343221095834 for The Prevalence of Pharmacogenomics Variants and Their Clinical Relevance Among the Pakistani Population by Abdul Rafay Khan, Sayed Hajan Shah, Sadia Ajaz, Sadaf Firasat, Aiysha Abid and Ali Raza in Evolutionary Bioinformatics

Additional file 3. Basic information and HWE analysis for SPP1 gene polymorphisms analyzed in this study.

Additional file 7. Meta-analysis of SPP1 rs11730582:T > C polymorphism with risk of urolithiasis. a) and b) Forest plots of urolithiasis association with rs11730582 polymorphism using dominant and recessive model, respectively. c) and d) Funnel plots of rs11730582 polymorphism assuming dominant and recessive inheritance, respectively, using fixed effect model.

Additional file 1. Oligonucleotide sequences, PCR conditions and restriction enzyme used for the genotyping of SPP1 gene polymorphisms.

Additional file 8. Meta-analysis of SPP1 rs11439060:delG>G polymorphism with susceptibility of urolithiasis. a) and b) Forest plots of urolithiasis association with rs11439060 polymorphism following dominant and recessive model, respectively. c) and d) Funnel plots of rs11439060 polymorphism using dominant and recessive inheritance, respectively, by random effect model.

Additional file 6. A Association of SPP1 rs2853744:G > T with different clinical characteristics of urolithiasis. B Association of SPP1 rs11730582:T > C with different clinical characteristics of urolithiasis. C Association of SPP1 rs11439060:delG>G with different clinical characteristics of urolithiasis.

Additional file 5. Pairwise linkage disequilibrium (LD) map, based on D´ values, of SPP1 polymorphic markers analyzed in the present study. No significant LD was apparent in any of the SPP1 polymorphic pairs analyzed.

Additional file 2. Basic characteristics of the study participants in the case-control part of the study.

Additional file 4. Representative electropherograms for each genotype of three SPP1 polymorphisms. (A) rs11730582:T > C, (B) rs2853744:G > T and (C) rs11439060:delG>G.