Maria Rosaria Barillari, Jerome R. Lechien, Mohamad Khalife, Claire Hopkins, Christian Calvo-Henriquez, Delphine Martiny, Jan Plzak, Stéphane Hans, Pierre Cabaraux, Sven Saussez, Carlos M. Chiesa-Estomba, Lechien, J. R., Cabaraux, P., Chiesa-Estomba, C. M., Khalife, M., Plzak, J., Hans, S., Martiny, D., Calvo-Henriquez, C., Barillari, M. R., Hopkins, C., Saussez, S., Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Mons [Belgium] (UMONS), CHU Saint-Pierre, Université libre de Bruxelles, Bruxelles, Centre Hospitalier Universitaire de Charleroi, Donostia Hospital Universitario San Sebastian, University Hospital Motol [Prague], Université de Mons (UMons), Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne] (CHUS), University of Naples SUN, Guy's & St Thomas' NHS Foundation Trust, and The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Received financial support from the University of Mons (UMONS) as well as FRMH grant.
Objective: To investigate the coronavirus disease 2019 (COVID-19) status of patients with initial sudden olfactory anosmia (ISOA) through nasopharyngeal swabs for reverse transcription–polymerase chain reaction (RT-PCR) analysis and to explore their olfactory dysfunctions with psychophysical olfactory evaluation. Methods: A total of 78 ISOA patients were recruited from April 6, 2020, to April 10, 2020, through a public call of University of Mons (Mons, Belgium). Patients benefited from nasopharyngeal swabs and fulfilled the patient-reported outcome questionnaire. Among them, 46 patients performed psychophysical olfactory evaluation using olfactory identification testing. Based on the duration of the ISOA, 2 groups of patients were compared: patients with olfactory dysfunction duration ≤12 days (group 1) and those with duration >12 days (group 2). Results: In group 1, 42 patients (87.5%) had a positive viral load determined by RT-PCR and 6 patients (12.5%) were negative. In group 2, 7 patients (23%) had a positive viral load and 23 patients (77%) were negative. The psychophysical olfactory evaluation reported that anosmia and hyposmia occurred in 24 (52%) and 11 (24%) patients, respectively. Eleven patients were normosmic. The viral load was significantly higher in patients of group 1 compared with those of group 2. Conclusions: Coronavirus disease 2019 was detected in a high proportion of ISOA patients, especially over the first 12 days of olfactory dysfunction. Anosmia is an important symptom to consider in the detection of COVID-19 infection.