1. A reverse 230U/226Th radionuclide generator for targeted alpha therapy applications
- Author
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D. Scott Wilbur, Andrew C. Akin, Eva R. Birnbaum, Mark Brugh, Michael E. Fassbender, Kevin D. John, Tara Mastren, Francois M. Nortier, and Roy Copping
- Subjects
Cancer Research ,Radionuclide ,Generator (computer programming) ,Chemistry ,Elution ,Extraction (chemistry) ,Radiochemistry ,Citrate buffer ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Yield (chemistry) ,Molecular Medicine ,Radiology, Nuclear Medicine and imaging ,Radionuclide Generator ,Chromatography column - Abstract
Purpose Thorium-226 (half-life 30.6 m) is a radionuclide of interest for use in targeted alpha therapy applications. Due to its short half-life, 226Th must be provided through a radionuclide generator system from its parent 230U (20.8 d). Furthermore, as the half-life of 226Th is very short, it should be provided in a form that is directly amenable to use in biomedical applications. Methods A reverse radionuclide generator system was developed employing a DGA extraction chromatography column. A 230U/226Th parent/daughter solution in equilibrium is added to a DGA column in >6 M HCl. The parent 230U is eluted first in 0.1 M HNO3 followed by elution of 226Th in 0.1 M citrate buffer pH 5. Results Thorium-226 was recovered from the radionuclide generator column with >96% yield. Greater than 99.5% of the 230U parent was isolated for reuse in the generator. Long term evaluation over six weeks demonstrated consistent supply of 226Th with greater than 99.5% radionuclidic purity. The only contaminant found in the final product was 230U ( Conclusions The reverse radionuclide generator described herein was shown to be a feasible method for providing 226Th in high yield, purity and in a chemical form that is amenable for direct use in biomedical applications.
- Published
- 2020