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Your search keyword '"Kazanji, Mirdad"' showing total 3 results
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3 results on '"Kazanji, Mirdad"'

1. Quantifying transmission by stage of infection in the field: the example of SIV-1 and STLV-1 infecting mandrills

Author

Roussel, Marion, Pontier, Dominique, Kazanji, Mirdad, Ngoubangoye, Barthélémy, Mahieux, Renaud, Verrier, Delphine, Fouchet, David, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP), Centre International de Recherches Médicales de Franceville (CIRMF), Oncogenèse rétrovirale – Retroviral Oncogenesis (OR), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ecoépidémiologie évolutionniste, Département écologie évolutive [LBBE], Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), ANR-11-LABX-0048,ECOFECT,Dynamiques eco-évolutives des maladies infectieuses(2011), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Deltaretrovirus Infections, Models, Statistical, viruses, [SDV]Life Sciences [q-bio], Simian Acquired Immunodeficiency Syndrome, Bayes Theorem, Viral Load, Disease Transmission, Infectious, Animals, Female, Simian Immunodeficiency Virus, Mandrillus, Simian T-lymphotropic virus 1
Abstract

Affiliations ECOFECT; International audience; The early stage of viral infection is often followed by an important increase of viral load and is generally considered to be the most at risk for pathogen transmission. Most methods quantifying the relative importance of the different stages of infection were developed for studies aimed at measuring HIV transmission in Humans. However, they cannot be transposed to animal populations in which less information is available. Here we propose a general method to quantify the importance of the early and late stages of the infection on micro-organism transmission from field studies. The method is based on a state space dynamical model parameterized using Bayesian inference. It is illustrated by a 28 years dataset in mandrills infected by Simian Immunodeficiency Virus type-1 (SIV-1) and the Simian T-Cell Lymphotropic Virus type-1 (STLV-1). For both viruses we show that transmission is predominant during the early stage of the infection (transmission ratio for SIV-1: 1.16 [0.0009; 18.15] and 9.92 [0.03; 83.8] for STLV-1). However, in terms of basic reproductive number (R0 ), which quantifies the weight of both stages in the spread of the virus, the results suggest that the epidemics of SIV-1 and STLV-1 are mainly driven by late transmissions in this population. Am. J. Primatol. © 2014 Wiley Periodicals, Inc.

Published
2014

2. Tobacco use vs. helminths in Congo basin hunter-gatherers: self-medication in humans?

Author

Hagen, Edward H (Department Of Anthropology, Washington State University), Roulette, Casey J (Department Of Anthropology, Washington State University), Mann, Hayley (Department Of Anthropology, State University Of New York At Binghamton), Kemp, Brian M (Department Of Anthropology, Washington State University), Remiker, Mark (Oregon Health & Science University), Roulette, Jennifer W (Department Of Anthropology, Washington State University), Hewlett, Barry S (Department Of Anthropology, Washington State University), Kazanji, Mirdad (Institut Pasteur Bangui, CAR), Breurec, Sebastien (Institut Pasteur Bangui, CAR), and Monchy, Didier (Biomnis, Lyon, France)

Published
2014
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3. Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey

Author

Flamand, Claude, Bailly, Sarah, Fritzell, Camille, Berthelot, Léna, Vanhomwegen, Jessica, Salje, Henrik, Paireau, Juliette, Matheus, Séverine, Enfissi, Antoine, Fernandes-Pellerin, Sandrine, Djossou, Félix, Linares, Sébastien, Carod, Jean-François, Kazanji, Mirdad, Manuguerra, Jean-Claude, Cauchemez, Simon, and Rousset, Dominique

Subjects
Adult, Male, Adolescent, seroprevalence study, Zika Virus Infection, general population survey, Zika Virus, Middle Aged, Communicable Diseases, Emerging, 3. Good health, French Guiana, Young Adult, Cross-Sectional Studies, Seroepidemiologic Studies, Child, Preschool, Population Surveillance, Humans, Female, Serologic Tests, Geography, Medical, Child, Aged
Abstract

BACKGROUND: Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown. METHODS: We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests. RESULTS: The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%-25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%-31.4%) in individuals who tested positive for ZIKV. CONCLUSIONS: This study described a large-scale representative ZIKV seroprevalence study in South America from the recent 2015-2016 Zika epidemic. Our findings reveal that the majority of the population remains susceptible to ZIKV, which could potentially allow future reintroductions of the virus.

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