1. Association of miR-760 with cancer: An overview
- Author
-
Pawan K. Dhar, Monika Kaushik Siddharth Manvati, Juveria Khan, and Neeraj Verma
- Subjects
0301 basic medicine ,Programmed cell death ,Angiogenesis ,Biology ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,microRNA ,Genetics ,medicine ,Humans ,Post-transcriptional regulation ,Genetic Association Studies ,Cervical cancer ,Cell growth ,Cancer ,General Medicine ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Disease Progression ,Cancer research ,Signal Transduction - Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules of around 22 nucleotides in length. They are crucially involved in the post transcriptional regulation and thus play a significant role in the modulation of different diseases. Several studies have suggested that miRNA expression is dysregulated in various cancers through different mechanisms and the dysregulated miRNA in return affects different cancer hallmarks including cell proliferation, cell death suppression, metastasis and angiogenesis. Compilation of the available miRNA data can be a stimulator for proper understanding of the correlation between the miRNA expression and cancer progression. In this review, we have focussed on the role of miR-760 in the progression of different cancer. MicroRNA-760 (miR-760) has been found to be down regulated in various cancers, thus it can be utilized as a possible prognostic marker for cancer detection. Here, we have tried to fill a gap regarding the role of miR-760 in relation to cervical cancer also. Moreover, unravelling the role of miR-760 in different cancers will enlighten the researchers with proper understanding of biology of miR-760 in regulation of different cancers.
- Published
- 2020