71 results on '"Katsushi Hiramatsu"'
Search Results
2. A rare case of eosinophilic gastritis induced by nivolumab therapy for metastatic melanoma
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Arisa Tsuji, Katsushi Hiramatsu, Shouichi Namikawa, Arisa Yamamoto, Yohei Midori, Yosuke Murata, Tomoko Tanaka, Takuto Nosaka, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Yoshiaki Imamura, Shiro Iino, Minoru Hasegawa, and Yasunari Nakamoto
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Skin Neoplasms ,Prednisolone ,Gastroenterology ,Nausea ,Neoplasms, Second Primary ,General Medicine ,Enteritis ,Antineoplastic Agents, Immunological ,Nivolumab ,Gastritis ,Eosinophilia ,Humans ,Female ,Immune Checkpoint Inhibitors ,Melanoma ,Aged - Abstract
Cancer immunotherapy using immune checkpoint inhibitors can cause immune reactions at various sites as a side effect called immune-related adverse events (irAEs). The gastrointestinal tract is susceptible to irAEs, however, the degree and presentation vary considerably from case to case. A 76-year-old woman was diagnosed with anal mucosal melanoma. She underwent radical surgery and received postoperative adjuvant therapy. However, because new metastases were also found in bilateral inguinal lymph nodes, immunotherapy with nivolumab was performed. Approximately 10 months after the initiation of nivolumab administration, she presented with epigastric discomfort and nausea, and her laboratory data showed severe eosinophilia (1938/mm
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- 2022
3. Gastrointestinal AA amyloidosis secondary to chronic pyelonephritis presenting with refractory diarrhea and severe hypoalbuminemia
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Yoshiaki Imamura, Tomoko Tanaka, Yohei Midori, Hidetaka Matsuda, Hironobu Naiki, Masahiro Ohtani, Takuto Nosaka, Tatsushi Naito, Yasunari Nakamoto, Osamu Yokoyama, Kazuya Ofuji, Katsushi Hiramatsu, and Kazuto Takahashi
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Diarrhea ,medicine.medical_specialty ,Ileum ,Gastroenterology ,AA amyloidosis ,Submucosa ,Internal medicine ,Biopsy ,medicine ,Humans ,Hypoalbuminemia ,Aged ,Gastrointestinal tract ,Pyelonephritis ,medicine.diagnostic_test ,business.industry ,Amyloidosis ,General Medicine ,medicine.disease ,Gastrointestinal Tract ,medicine.anatomical_structure ,Female ,medicine.symptom ,Complication ,business - Abstract
Secondary amyloidosis is a rare complication of chronic inflammatory diseases, such as collagen diseases, and is often difficult to treat. In addition, the gastrointestinal tract is frequently involved in amyloid deposition that often results in various disorders and symptoms. A 70-year-old woman was admitted to our hospital with refractory diarrhea and hypoalbuminemia. Abdominal computed tomography demonstrated extensive edematous wall thickening of the small intestine and colon. Video capsule endoscopy revealed multiple ulcerations with a white mossy appearance of the ileum. Double-balloon endoscopy showed severe circumferential ulcers in the entire ileum. Histological examination of ileum biopsy samples revealed severe amyloid deposition in the lamina propria and perivascular areas of the submucosa. The patient was diagnosed with gastrointestinal AA amyloidosis. The cause of AA amyloid deposition was presumed to be chronic pyelonephritis due to ureteral stones that had been left untreated for 35 years. After treatment with ureteral drainage and antibiotics, the patient's symptoms and serological abnormalities improved dramatically. Here, we describe a case of severe gastrointestinal AA amyloidosis secondary to chronic pyelonephritis. Clinicians should thoroughly investigate the entire gastrointestinal tract in patients with refractory diarrhea and severe hypoalbuminemia considering the possibility of gastrointestinal amyloidosis.
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- 2021
4. Severe necrotizing pancreatitis immediately after non-abdominal surgery under general anesthesia with propofol
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Shoichi Namikawa, Tatsushi Naito, Takuto Nosaka, Kazuto Takahashi, Yu Akazawa, Yasunari Nakamoto, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, and Kazuya Ofuji
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medicine.medical_specialty ,Pancreatitis, Acute Necrotizing ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Thyroidectomy ,General Medicine ,Anesthesia, General ,medicine.disease ,Colorectal surgery ,Anesthesia ,Acute Disease ,medicine ,Humans ,Pancreatitis ,Acute pancreatitis ,Propofol ,Adverse effect ,business ,Abdominal surgery ,medicine.drug ,Rare disease - Abstract
Postoperative pancreatitis is a relatively rare disease and is poorly recognized. Herein, we present a case of necrotizing pancreatitis that developed immediately after non-abdominal surgery under general anesthesia. In this report, 4 h after thyroidectomy under general anesthesia using propofol, the patient developed upper abdominal pain and was diagnosed with severe acute pancreatitis with extensive pancreatic necrosis. Immediately after the diagnosis, the patient received appropriate treatment, and acute pancreatitis was improved. Subsequently, the patient has the formation of non-infectious giant walled-off necrosis and remained in good condition without additional treatment for 1.5 years after pancreatitis onset. In this case report, our detailed causative search suggested that propofol administration could be the cause of this pancreatitis. Propofol-induced pancreatitis is extremely rare but develops often severely, resulting in fatality. In this case, the patient developed severe acute pancreatitis within a very short time after surgery but was able to survive by immediate intervention of treatment. We suggest that clinicians should consider acute pancreatitis as a life-threatening adverse event under general anesthesia with propofol and perform thorough postoperative management.
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- 2021
5. Hepatocellular carcinoma progression promoted by 5-lipoxygenase activity in CD163(+) tumor-associated macrophages
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Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi, and Yasunari Nakamoto
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Pharmacology ,General Medicine - Published
- 2023
6. Advanced primary adenosquamous carcinoma of the liver with a small cell carcinoma component: an autopsy case report
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Hidetaka Matsuda, Yasunari Nakamoto, Shouichi Namikawa, Takuto Nosaka, Kazuto Takahashi, Katsushi Hiramatsu, Kazuya Ofuji, Yoshiaki Imamura, Masahiro Ohtani, and Tatsushi Naito
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medicine.medical_specialty ,Pathology ,Liver tumor ,Adenosquamous carcinoma ,medicine.medical_treatment ,Small-cell carcinoma ,Carcinoma, Adenosquamous ,Internal medicine ,Biopsy ,medicine ,Humans ,Carcinoma, Small Cell ,Lymph node ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,General Medicine ,Middle Aged ,Hepatology ,medicine.disease ,Bile Ducts, Intrahepatic ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Liver ,Adenocarcinoma ,Female ,Autopsy ,business - Abstract
Primary adenosquamous carcinoma (ASC) of the liver is a rare subtype of cholangiocarcinoma that comprises both adenocarcinoma and squamous cell carcinoma components. We report a 48-year-old woman with advanced primary ASC and small cell carcinoma of the liver who had extrahepatic metastasis and received multiple chemotherapy regimens. After first presenting with upper abdominal pain, imaging revealed a 10.2 × 9.5 cm mass in the right lobe of the liver with lymph node and lung metastases. A liver tumor biopsy revealed adenocarcinoma and squamous cell carcinoma components, leading to a diagnosis of advanced primary ASC of the liver. The tumor shrank with gemcitabine/cisplatin therapy; however, neuron-specific enolase (NSE) and CYFRA levels were increased and the tumor grew. Next, hepatic arterial infusion chemotherapy using 5-fluorouracil and cisplatin decreased NSE and CYFRA levels and suppressed tumor growth. However, due to tumor growth, she died 14 months post-initial diagnosis. Post-autopsy pathology revealed a mixture of CD56- and synaptophysin-positive small cell carcinoma component in addition to ASC. We report a rare advanced primary ASC with small cell carcinoma of the liver diagnosed at autopsy.
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- 2021
7. A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis
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Hidetaka Matsuda, Takuto Nosaka, Kazuya Ofuji, Katsushi Hiramatsu, Kazuto Takahashi, Yasunari Nakamoto, Yoshiaki Imamura, Tamotsu Ishizuka, Masahiro Ohtani, and Tatsushi Naito
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Male ,medicine.medical_specialty ,Lung Neoplasms ,Rectum ,CD8-Positive T-Lymphocytes ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Atezolizumab ,Carcinoma, Non-Small-Cell Lung ,Internal medicine ,medicine ,Humans ,Colitis ,Immune Checkpoint Inhibitors ,Aged ,medicine.diagnostic_test ,business.industry ,Endoscopy ,Sigmoidoscopy ,Common Terminology Criteria for Adverse Events ,General Medicine ,medicine.disease ,Immune checkpoint ,Hematochezia ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Prednisolone ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,medicine.drug - Abstract
A man in his 70s received anticancer chemotherapy with the anti-programmed cell death protein–ligand 1 antibody atezolizumab for non-small cell lung cancer. Ten days later, he developed diarrhea and skin rash, which were suspected to be due to immune-related adverse events, and was treated with prednisolone for 2 weeks. Five weeks after atezolizumab administration, he was admitted to our hospital for Common Terminology Criteria for Adverse Events Grade 3 diarrhea and hematochezia. Sigmoidoscopy revealed a dark red color in the mucosa of the transverse colon and multiple whitish mucosal plaques extending from the transverse colon to the rectum. Biopsy specimens revealed empty vacuoles in the lamina propria with infiltration of numerous inflammatory cells, including CD8+ T cells. Based on the findings of sigmoidoscopy and histology, the diagnosis was immune checkpoint inhibitor-related colitis with colonic pseudolipomatosis. The endoscopic findings and symptoms were markedly improved by prednisolone administration. We herein report the first case of immune checkpoint inhibitor-related colitis with characteristic endoscopic findings of colonic pseudolipomatosis. It is important to perform endoscopy and histological evaluation to determine the differential diagnosis and treatment strategy for patients treated with immune checkpoint inhibitors.
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- 2021
8. A case of idiopathic portal hypertension accompanying multiple hepatic nodular regenerative hyperplasia in a patient with systemic sclerosis
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Arisa Yamamoto, Kazuto Takahashi, Takuto Nosaka, Arisa Tsuji, Yoshiaki Imamura, Tomoko Tanaka, Katsushi Hiramatsu, Masahiro Ohtani, Tatsushi Naito, Gen Tohda, Yosuke Murata, Yohei Midori, Kazuya Ofuji, Yasunari Nakamoto, and Hidetaka Matsuda
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Liver Cirrhosis ,medicine.medical_specialty ,Pathology ,Pancytopenia ,Scleroderma ,Fibrosis ,Internal medicine ,Hypertension, Portal ,Ascites ,medicine ,Humans ,skin and connective tissue diseases ,Aged ,Hyperplasia ,Scleroderma, Systemic ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Magnetic resonance imaging ,Nodule (medicine) ,Idiopathic Noncirrhotic Portal Hypertension ,General Medicine ,Hepatology ,medicine.disease ,Liver ,Liver biopsy ,Splenomegaly ,Female ,medicine.symptom ,business ,Nodular regenerative hyperplasia - Abstract
Idiopathic portal hypertension (IPH) is one of the background diseases causing nodular regenerative hyperplasia (NRH). Furthermore, IPH patients accompanied with autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are more likely to form NRH in the liver. A 76-year-old woman had been aware of the Raynaud's phenomenon and scleroderma for the past 30 years. In this case, she presented with abdominal fullness, and her imaging analysis revealed ascites and multiple liver nodules. On Gd-EOB-DTPA enhanced magnetic resonance imaging (EOB-MRI), donut-like uptake was observed in the nodules in the hepatobiliary phase. Liver biopsy of a nodule demonstrated that it was composed of hyperplastic hepatocytes without fibrous septa, and dilated sinusoids were observed beside the nodule. Conversely, background liver showed that peripheral portal veins appeared stenotic with dense fibrosis in the portal area. The final diagnosis was that multiple NRH of the liver developed in SSc patient accompanying IPH. This case suggests that NRH may be unexpectedly diagnosed in patients with autoimmune diseases accompanying IPH.
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- 2021
9. Circulating tumor cells detected with a microcavity array predict clinical outcome in hepatocellular carcinoma
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Katsuya Endo, Tomoyuki Nemoto, Kazuto Takahashi, Kazuya Ofuji, Katsushi Hiramatsu, Masayuki Higuchi, Takuto Nosaka, Tatsushi Naito, Yasunari Nakamoto, Hidetaka Matsuda, and Masahiro Ohtani
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Liver Cirrhosis ,Male ,0301 basic medicine ,Cancer Research ,Cirrhosis ,Cell Count ,Cell Separation ,0302 clinical medicine ,Circulating tumor cell ,HCC ,Original Research ,Whole blood ,Reverse Transcriptase Polymerase Chain Reaction ,Liver Neoplasms ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Epithelial Cell Adhesion Molecule ,Neoplastic Cells, Circulating ,Oncology ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Biomarker (medicine) ,Female ,alpha-Fetoproteins ,Adult ,Carcinoma, Hepatocellular ,Serum Albumin, Human ,lcsh:RC254-282 ,Sensitivity and Specificity ,03 medical and health sciences ,Glypicans ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Clinical significance ,In patient ,RNA, Messenger ,neoplasms ,albumin ,Aged ,business.industry ,microcavity array ,Albumin ,Clinical Cancer Research ,medicine.disease ,CTC ,digestive system diseases ,030104 developmental biology ,EpCAM ,Cancer research ,business - Abstract
The present study aimed to establish a novel isolation strategy for circulating tumor cells (CTCs) using a microcavity array (MCA) system and to evaluate the clinical significance of CTCs in hepatocellular carcinoma (HCC). We examined recovery rates of HCC cell lines spiked into whole blood in MCA assay. Circulating tumor cells were isolated from peripheral blood samples (3 mL) of 7 healthy donors (HD), 14 patients with liver cirrhosis (LC), and 31 patients with HCC using the MCA system. Additionally, we investigated the mRNA expression of liver‐specific genes in isolated CTCs using qPCR. The recovery rates were 65.1% (HepG2), 76.7% (HuH7), and 99.0% (PLC/PRF/5). In HD and patients with LC and HCC, the CTC positivity rate (CTCs ≥10) and average CTC number were as follows: HD 0% and 0.1, LC 14.3% and 5.3, HCC 54.8% and 47.6, respectively. The CTC positivity rate in HCC was significantly higher than that in LC (p, This study describes the detection of circulating tumor cells (CTCs) in the peripheral blood of hepatocellular carcinoma (HCC) patients using a newly developed microcavity array. Our results show that a large number of CTCs was detected in metastatic HCC patients, and mRNA expression of AFP, glypican‐3, EpCAM and albumin was detected in detected CTCs. Identification of positive CTCs or ALB mRNA expression can help predict poor prognosis of HCC patients.
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- 2021
10. Bipolar-current needle-knife with a water jet function (Jet B-knife) shortens the procedure time of endoscopic submucosal dissection for colorectal tumors
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Kazuto Takahashi, Hidetaka Matsuda, Kazuya Ofuji, Masahiro Ohtani, Takuto Nosaka, Yu Akazawa, Akito Sakai, Katsushi Hiramatsu, Yasushi Saito, Mitsuru Matsuda, Yasunari Nakamoto, and Tatsushi Naito
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medicine.medical_specialty ,Endoscopic Mucosal Resection ,education ,Perforation (oil well) ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Intestinal Mucosa ,Retrospective Studies ,Jet (fluid) ,business.industry ,Dissection ,Incidence (epidemiology) ,Water ,Cancer ,Retrospective cohort study ,Endoscopic submucosal dissection ,Hepatology ,medicine.disease ,Treatment Outcome ,surgical procedures, operative ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,sense organs ,Radiology ,Colorectal Neoplasms ,business ,Abdominal surgery - Abstract
Endoscopic submucosal dissection (ESD) is a technically difficult and time-consuming procedure for the treatment of large colorectal tumors. In Japan, the ball-tip bipolar-current needle-knife (BB-knife) has been used in ESD as a safe device that minimizes the damage to deeper tissues of colorectal neoplasms. In May 2012, a BB-knife combined with a water jet function (Jet B-knife) was newly developed. This retrospective study was aimed at examining the effectiveness and safety of the Jet B-knife. The BB-knife was used in 276 lesions (BB-knife group), while the Jet B-knife was used in 245 lesions (Jet B-knife group). We evaluated tumor characteristics and the results of the ESD procedures, including the size of the resected tumor, histological diagnosis, time required for resection, frequency of using other electrical devices, en bloc resection rate, and incidence rate of associated complications. Then, the data obtained were compared between the two groups. The histological evaluation of the resected tumors revealed that the incidence of cancer was not significantly different between the two groups. The median time required for resection was 103 min (45–255) in the BB-knife group and 51 min (28–210) in the Jet B-knife group. The difference was statistically significant (p
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- 2020
11. Molecular signature of hepatitis B virus regulation by interferon‐γ in primary human hepatocytes
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Masahiro Ohtani, Yasunari Nakamoto, Takuto Nosaka, Hiroaki Okamoto, Tatsushi Naito, Tomoyuki Nemoto, Tsutomu Nishizawa, Hidetaka Matsuda, and Katsushi Hiramatsu
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Hepatitis B virus ,Hepatology ,Microarray analysis techniques ,Chemistry ,virus diseases ,medicine.disease_cause ,Molecular biology ,digestive system diseases ,Virus ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Interferon ,030220 oncology & carcinogenesis ,medicine ,STAT protein ,030211 gastroenterology & hepatology ,Interferon gamma ,Signal transduction ,Janus kinase ,medicine.drug - Abstract
Aim A complete cure for chronic hepatitis B virus (HBV) infection requires elimination of covalently closed circular DNA; however, this remains to be clinically achieved. Interferon (IFN)-γ, a type II IFN, is produced by intrahepatic cytotoxic T lymphocytes and has non-cytolytic antiviral potential. However, the mechanism by which IFN-γ regulates HBV infection has not been fully elucidated. Thus, we developed an in vitro HBV infection assay system and analyzed the molecular signature of HBV regulation by IFN-γ. Methods The in vitro HBV infection assay system was established in primary human hepatocytes infected with HBV derived from the plasmid containing 1.3-mer HBV genome, and treated with IFN-γ. The antiviral effects and signaling pathways of IFN-γ were examined using microarray, and assessed by siRNA knockdown experiments of the related genes. Results IFN-γ treatment suppressed both HBV propagation and transcription as efficiently as IFN-α. Microarray analysis showed that IFN-γ stimulation induced the activation of both IFN-γ and IFN-α signaling, regulating HBV covalently closed circular DNA. HBV production was decreased by IFN-γ through Janus kinase/signal transducer and activator of transcription signaling and interferon-stimulated genes, such as 2'-5'-oligoadenylate synthase 2 and apolipoprotein B mRNA editing enzyme catalytic subunit 3G. Conclusions IFN-γ can suppress HBV propagation and transcription in hepatocytes by activating specific intracellular signaling pathways in hepatocytes, and suggests the future application of these particular signaling pathways or genes for the complete elimination of HBV.
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- 2019
12. Successful early diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma manifesting as chronic diarrhea and hypokalemia using video capsule endoscopy and double-balloon enteroscopy
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Tatsushi Naito, Takuto Nosaka, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takahiro Yamauchi, and Yasunari Nakamoto
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Diarrhea ,Double-Balloon Enteroscopy ,Male ,Early Diagnosis ,Enteropathy-Associated T-Cell Lymphoma ,Gastroenterology ,Humans ,Hypokalemia ,General Medicine ,Capsule Endoscopy ,Granzymes ,T-Cell Intracellular Antigen-1 - Abstract
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as enteropathy-associated T-cell lymphoma (EATL) type II, is a rare disease with a poor prognosis that is often diagnosed when patients present with intestinal perforation or obstruction. Our patient, a man in his 60 s, had a 5-month history of persistent watery diarrhea. Upper and lower gastrointestinal endoscopy, abdominal computed tomography (CT), and stool culture results were unremarkable. He was admitted to our hospital 8 months later with a weight loss of 20 kg, general fatigue, and hypokalemia. Contrast-enhanced CT of the abdomen revealed mild thickening and contrast enhancement of the small intestinal wall. Video capsule endoscopy and double-balloon enteroscopy were performed to reveal a broad ulcer in the jejunum and multiple erosions throughout the small intestine. Examination of the biopsy specimens showed infiltration of atypical lymphocytes with pale cytoplasm in the glandular epithelium. The atypical lymphocytes were positive for CD3, CD8, CD56, granzyme B, and T-cell intracellular antigen-1 by immunostaining. Early diagnosis of MEITL was made, and the patient survived for 21 months with continuous chemotherapy. Aggressive examination of the small intestine is effective for the early diagnosis of serious diseases, such as MEITL, in patients with chronic diarrhea of unknown origin.
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- 2021
13. Elderly onset congenital hepatic fibrosis with portal hypertension diagnosed after recurrent cholangitis: a case report
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Kazuto Takahashi, Kazuya Ofuji, Takuto Nosaka, Tatsushi Naito, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Kenichi Harada, Hironobu Naiki, and Yasunari Nakamoto
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Liver Cirrhosis ,Cholangitis ,Hypertension, Portal ,Gastroenterology ,Genetic Diseases, Inborn ,Ascites ,Humans ,Female ,General Medicine ,Esophageal and Gastric Varices ,Gastrointestinal Hemorrhage ,Aged - Abstract
Congenital hepatic fibrosis is a rare autosomal recessive disorder caused by ductal plate malformation that can manifest as hepatic fibrosis alone or as a component in various fibropolycystic diseases including renal involvement. It is often diagnosed early in life, presenting with ascites and esophageal variceal bleeding due to non-cirrhotic portal hypertension. Here, we report a rare case of congenital hepatic fibrosis with portal hypertension diagnosed at an advanced age. A 78-year-old woman with a 6 history of recurrent cholangitis experienced abdominal distension. Imaging revealed ascites and esophageal varices. Histopathologic analysis of the liver revealed the fibrous expansion of portal tracts accompanying increased bile ducts with irregular contours in the portal area. These characteristic findings are consistent with the diagnosis of congenital hepatic fibrosis. The present case showed an extremely unique clinical course, because she did not develop any associated renal abnormalities or any disease-related symptoms until old age. Because of the variability of this disease, the slowly progressive type may be difficult to diagnose and cause non-cirrhotic portal hypertension even in the elderly. Although an unusual clinical course may suggest the presence of the disease, timely histologic assessment is crucial for the definitive diagnosis of congenital hepatic fibrosis.
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- 2021
14. Regulatory function of interferon-inducible 44-like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes
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Takuto Nosaka, Katsushi Hiramatsu, Yosuke Murata, Hidetaka Matsuda, Hiroaki Okamoto, Yasunari Nakamoto, Tsutomu Nishizawa, Masahiro Ohtani, and Tatsushi Naito
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Hepatitis B virus ,Hepatology ,Promoter ,cccDNA ,Biology ,medicine.disease_cause ,Virology ,Infectious Diseases ,Plasmid ,Interferon ,Transcription (biology) ,medicine ,Gene ,medicine.drug ,Host factor - Abstract
AIM Curing hepatitis B virus (HBV) infection requires elimination of covalently closed circular DNA (cccDNA). Interferon (IFN)-γ has noncytolytic antiviral potential; however, elimination of cccDNA could not be achieved. To enhance the regulatory effect, we comprehensively analyzed the host factors associated with cccDNA amplification and IFN-γ and IFN-α effects using an in vitro HBV infection system showing various transcription levels. METHODS Primary human hepatocytes were infected with HBV using genomic plasmids carrying the basic core promoter mutation A1762T/G1764A and/or the precore mutation G1896A and treated with IFN-γ and IFN-α. Comprehensive and functional studies involving microarray and small interfering RNA analysis revealed the host factors related to cccDNA regulation. RESULTS The HBV infection system reproduced the HBV life cycle and showed various propagation levels. Microarray analysis revealed 53 genes correlated with the cccDNA levels. Of the 53 genes, expression of IFN-induced protein 44-like (IFI44L) was significantly upregulated by IFN-γ and IFN-α. The anti-HBV effect of IFI44L is exerted regardless of IFN-γ or IFN-α by inhibiting the activation of nuclear factor-κB and signal transducer and activator of transcription 1 pathways. CONCLUSIONS Using the in vitro HBV infection system, an IFN-inducible molecule, IFI44L, associated with cccDNA amplification, was identified. These results suggest an innovative molecular strategy for the regulation of HBV cccDNA by controlling a novel host factor, IFI44L.
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- 2021
15. Clinical Usefulness of [18F]-Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography/Computed Tomography for Distinguishing Between Autoimmune Pancreatitis and Pancreatic Cancer
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Kazuya Ofuji, Hidetaka Matsuda, Kazuto Takahashi, Masahiro Ohtani, Yoshihiko Ozaki, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yasunari Nakamoto, Tatsushi Naito, and Katsushi Hiramatsu
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Male ,Endocrinology, Diabetes and Metabolism ,Autoimmune Pancreatitis ,Standardized uptake value ,Sensitivity and Specificity ,Diagnosis, Differential ,chemistry.chemical_compound ,Endocrinology ,Fluorodeoxyglucose F18 ,Pancreatic cancer ,Positron Emission Tomography Computed Tomography ,Internal Medicine ,medicine ,Humans ,In patient ,Pancreas ,Autoimmune pancreatitis ,Positron Emission Tomography-Computed Tomography ,Aged ,Retrospective Studies ,Hepatology ,business.industry ,Fdg uptake ,Reproducibility of Results ,Middle Aged ,medicine.disease ,carbohydrates (lipids) ,Pancreatic Neoplasms ,chemistry ,Multivariate Analysis ,Female ,Tomography ,2-Deoxy-D-glucose ,business ,Nuclear medicine - Abstract
We investigated the [18F]-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) findings of pancreatic and extrapancreatic lesions in patients with autoimmune pancreatitis (AIP) and pancreatic cancer (PC) and evaluated the usefulness of 18F-FDG-PET/CT for differentiating between AIP and PC.Eighty-five patients, 19 with AIP and 66 with PC, who underwent 18F-FDG-PET/CT were studied retrospectively. We evaluated the maximum standardized uptake value (SUVmax), patterns and distributions of FDG activity in pancreatic lesions, as well as FDG uptake in extrapancreatic lesions.The levels of SUVmax of pancreatic lesions in PC patients were significantly higher than those in AIP patients (P0.05). Focal/segmental distribution of FDG activity was found in 61.1% of the AIP patients and 98.4% of the PC patients. Heterogeneous FDG activity patterns were found in 61.1% of the AIP patients and 18.7% of the PC patients. Activities of FDG in pancreatic lesions were significantly different between AIP and PC. Extrapancreatic activities of salivary glands, extraperitoneal lymph nodes, prostate, retroperitoneum, and kidneys in the AIP patients were significantly higher than those in the PC patients (P0.05). Multivariate analysis revealed that SUVmax (7.08) and focal/segmental FDG distribution were independent predictors of PC (P0.05).The 18F-FDG-PET/CT findings are useful for differentiating between AIP and PC.
- Published
- 2021
16. Pembrolizumab-induced autoimmune side effects of colon and pancreas in a patient with lung cancer
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Tatsushi Naito, Takuto Nosaka, Katsushi Hiramatsu, Tamotsu Ishizuka, Yasunari Nakamoto, Kazuya Ofuji, Masahiro Ohtani, Yoshiaki Imamura, Hidetaka Matsuda, and Kazuto Takahashi
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Aged, 80 and over ,Male ,medicine.medical_specialty ,Lung Neoplasms ,business.industry ,Colon ,Gastroenterology ,Rectum ,Sigmoid colon ,General Medicine ,Pembrolizumab ,medicine.disease ,Antibodies, Monoclonal, Humanized ,Ulcerative colitis ,medicine.anatomical_structure ,Internal medicine ,medicine ,Pancreatitis ,Humans ,Colitis ,business ,Lung cancer ,Pancreas ,Autoimmune pancreatitis - Abstract
Immune checkpoint inhibitors have been shown to be effective for treating many carcinomas. However, the activated immune response may lead to the development of multiple immune-related adverse events, including rare immune-mediated inflammation due to autoimmune mechanisms. An 82-year-old man was diagnosed with large cell lung cancer (T1aN3M1 stage IVB) and was treated with inhibitors of the programmed cell death receptor-1, pembrolizumab. Diarrhea and melena occurred after six doses of pembrolizumab, and colonoscopy revealed mucosal inflammation of the rectum and sigmoid colon in a continuous manner, resembling the typical endoscopic findings of ulcerative colitis. Subsequently, fever and hyperamylasemia appeared, and the patient was diagnosed with pancreatitis resembling type 2 autoimmune pancreatitis on imaging tests and cytological examination, which showed infiltration of inflammatory cells, mainly neutrophils. Steroid therapy was administered and both, colitis and pancreatitis markedly improved. Here, we present a patient who developed colitis and pancreatitis after ICI treatment for advanced lung cancer. Both are thought to be due to autoimmune side effects of pembrolizumab. Although pancreatitis is a rare irAE, clinicians should be aware of the development of pancreatitis, especially in the case of irAE colitis resembling ulcerative colitis.
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- 2021
17. The Usefulness of Video Capsule Endoscopy in Evaluating Gastrointestinal Manifestations of Immunoglobulin A Vasculitis
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Takuto Nosaka, Yasushi Saito, Hiroyuki Suto, Yasunari Nakamoto, Tatsushi Naito, Tomoyuki Nemoto, Hidetaka Matsuda, Kazuya Ofuji, Masahiro Ohtani, Tomoko Tanaka, Katsushi Hiramatsu, and Kazuto Takahashi
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Adult ,Male ,Vasculitis ,Immunoglobulin A ,medicine.medical_specialty ,Abdominal pain ,Adolescent ,Colonoscopy ,Therapeutics ,030204 cardiovascular system & hematology ,Capsule Endoscopy ,Gastroenterology ,gastrointestinal manifestations ,Video capsule endoscopy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Internal medicine ,Internal Medicine ,medicine ,Humans ,steroid therapy ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,biology ,business.industry ,Esophagogastroduodenoscopy ,General Medicine ,Middle Aged ,medicine.disease ,immunoglobulin A vasculitis ,endoscopic findings ,Abdominal Pain ,Purpura ,video capsule endoscopy ,biology.protein ,Female ,Original Article ,030211 gastroenterology & hepatology ,medicine.symptom ,Gastrointestinal Hemorrhage ,business ,Systemic vasculitis - Abstract
Objective Immunoglobulin (Ig) A vasculitis (IgAV) is a systemic vasculitis characterized by purpura and gastrointestinal involvement showing abdominal pain that usually occurs after the emergence of purpura. Criteria for evaluating gastrointestinal manifestations of IgAV are unavailable at present, so we conducted a study to investigate the usefulness of video capsule endoscopy (VCE) for detecting gastrointestinal manifestations of IgAV. Methods The clinical data of 10 patients who underwent VCE for IgAV at our hospital from 2012 to 2017 were collected. Nine patients underwent esophagogastroduodenoscopy, and five underwent colonoscopy. We compared the endoscopic severity determined by VCE to the findings of esophagogastroduodenoscopy and colonoscopy. Results The rates of positive findings of esophagogastroduodenoscopy, VCE, and colonoscopy were 56%, 100%, and 80%, respectively. In 70% of cases, the most severe gastrointestinal findings were detected by VCE. VCE was performed on average 16.8 days after the emergence of purpura, and in 8 of 10 patients, its result triggered the initiation of steroid therapy or the control of the steroid dose. Conclusion VCE is very useful for confirming gastrointestinal involvement in IgAV and may be used to determine the timing of steroid therapy initiation. We recommend performing VCE when IgAV is suspected in patients with gastrointestinal symptoms.
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- 2019
18. Successful treatment of hepatocellular carcinoma with bile duct tumor thrombus using surgical resection with pre- and postoperative transcatheter arterial chemoembolization: a case report
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Tomoyuki Nemoto, Yohei Midori, Yoshiaki Imamura, Takuto Nosaka, Yasushi Saito, Tomoko Tanaka, Yosuke Murata, Yumi Yoshida, Yasunari Nakamoto, Masahiro Ohtani, Kazuto Takahashi, Katsushi Hiramatsu, Kazuya Ofuji, Hidetaka Matsuda, and Tatsushi Naito
- Subjects
Surgical resection ,medicine.medical_specialty ,Hepatology ,business.industry ,Hepatocellular carcinoma ,Medicine ,Radiology ,Bile Duct Tumor ,Thrombus ,business ,medicine.disease ,Transcatheter arterial chemoembolization - Published
- 2019
19. Tu1189: RISK FACTORS FOR PANCREATIC MALIGNANCIES IN PATIENTS WITH LOW-RISK BRANCH DUCT INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS AFTER 5 YEARS OF LONG-TERM FOLLOW-UP
- Author
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Masahiro Ohtani, Kazuya Ofuji, Yu Akazawa, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito, Hidetaka Matsuda, Katsushi Hiramatsu, and Yasunari Nakamoto
- Subjects
Hepatology ,Gastroenterology - Published
- 2022
20. Mo1238: CLINICAL USEFULNESS OF SKELETAL MUSCLE QUANTITY AS PROGNOSTIC FACTOR IN ELDERLY PATIENTS WITH ADVANCED PANCREATIC CANCER RECEIVING NAB-PACLITAXEL PLUS GEMCITABINE CHEMOTHERAPY
- Author
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Yu Akazawa, Masahiro Ohtani, Takuto Nosaka, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Katsushi Hiramatsu, and Yasunari Nakamoto
- Subjects
Hepatology ,Gastroenterology - Published
- 2022
21. Tuberculosis‐unrelated erythema induratum occurring after commencing tumor necrosis factor (TNF)‐α antagonist therapy in a case with ulcerative colitis: A rare comorbidity interconnected by TNF‐α blockade pathway
- Author
-
Saori Uesugi-Uchida, Noritaka Oyama, Katsushi Hiramatsu, Minoru Hasegawa, Haruka Koizumi, and Yasunari Nakamoto
- Subjects
medicine.medical_specialty ,Tuberculosis ,Erythema induratum ,Tnf α antagonist ,Tumor Necrosis Factor-alpha ,business.industry ,Comorbidity ,Erythema Induratum ,Dermatology ,General Medicine ,medicine.disease ,Ulcerative colitis ,Gastroenterology ,Blockade ,Internal medicine ,medicine ,Humans ,Colitis, Ulcerative ,Tumor necrosis factor alpha ,business ,Tuberculosis, Cutaneous - Published
- 2020
22. Long-term prognosis after biliary stenting for common bile duct stones in high-risk elderly patients
- Author
-
Tatsushi Naito, Takuto Nosaka, Yu Akazawa, Tomoyuki Nemoto, Kazuya Ofuji, Katsushi Hiramatsu, Masahiro Ohtani, Yasushi Saito, Yasunari Nakamoto, Hidetaka Matsuda, and Kazuto Takahashi
- Subjects
Univariate analysis ,medicine.medical_specialty ,Performance status ,Common bile duct ,business.industry ,Hazard ratio ,Gastroenterology ,Biliary Stenting ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Internal medicine ,Propensity score matching ,Cohort ,Medicine ,030211 gastroenterology & hepatology ,business - Abstract
OBJECTIVE To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary stenting (the biliary stenting group) between July 2006 and March 2016. To reduce selection bias, we also conducted a propensity score matching analysis and generated 30 pairs of patients. Cholangitis recurrence-free survival and overall survival were compared between the two groups and independent prognostic factors of survival were identified by univariate and multivariate analyses. RESULTS Cholangitis recurrence-free survival was significantly better in the duct clearance group than in the biliary stenting group (P < 0.001). Their overall survival did not significantly differ after propensity score matching (P = 0.388). In all cohorts, univariate analysis demonstrated that poor performance status and biliary stenting were factors of poor prognosis, and in multivariate analysis only performance status remained associated with poor prognosis for survival. Similarly, in the propensity score-matched cohort, only performance status independently predicted poorer survival (hazard ratio [HR] 2.726, 95% confidence interval [CI] 1.105-6.675, P = 0.029). The choice of endoscopic treatment was not a significant factor associated with prognosis (HR 1.354, 95% CI 0.678-2.701, P = 0.391). CONCLUSIONS Biliary stenting was similar to complete stone removal in terms of prognosis for long-term survival. Biliary stenting for CBD stones could be an effective therapeutic tool in high-risk elderly patients.
- Published
- 2018
23. Reactivation of intraabdominal tuberculous lymphadenopathy after drug-eluting beads transcatheter arterial chemoembolization in a patient with hepatocellular carcinoma
- Author
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Kazuya Ofuji, Yoshihiko Ozaki, Takuto Nosaka, Yu Akazawa, Hidetaka Matsuda, Katsushi Hiramatsu, Yumi Yoshida, Yosuke Murata, Ryoko Hayama, Tatsushi Naito, Yasushi Saito, Yasunari Nakamoto, Kazuto Takahashi, Tomoyuki Nemoto, and Masahiro Ohtani
- Subjects
Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Tuberculosis ,Cirrhosis ,Population ,Contrast Media ,Tuberculosis, Lymph Node ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Latent Tuberculosis ,Internal medicine ,medicine ,Humans ,Chemoembolization, Therapeutic ,education ,Transcatheter arterial chemoembolization ,education.field_of_study ,Latent tuberculosis ,business.industry ,Liver Neoplasms ,General Medicine ,Hepatitis C ,Middle Aged ,Hepatology ,medicine.disease ,Microspheres ,Tuberculosis, Gastrointestinal ,Positron-Emission Tomography ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Virus Activation ,030211 gastroenterology & hepatology ,Tomography, X-Ray Computed ,business - Abstract
Owing to effective treatments and sanitary improvements, the incidence of latent tuberculosis infection (LTBI) has decreased. However, approximately one-quarter of the world's population is thought to have LTBI, and the reactivation of tuberculosis (TB) sometimes occurs in immunocompromised hosts. A 54-year-old man presented with a fever. The patient had past histories of alcoholic and hepatitis C virus-related cirrhosis and hepatocellular carcinoma (HCC). He was treated with drug-eluting beads transarterial chemoembolization (DEB-TACE) for HCC three times, beginning 10 months before his current visit. A computed tomography scan showed enlarged intraabdominal lymph nodes with calcification, and the interferon-gamma release assay for TB infection was positive. The patient was diagnosed with tuberculous reactivation. Anti-TB therapy was administered to the patient, after which we restarted TACE and the TB infection remains controlled. In this case, we presumed that DEB-TACE is associated with the reactivation of TB infection and that anthracycline increases the risk of reactivating TB infection. In summary, we experienced a case of TB reactivation during the clinical course of a patient with HCC who was treated with DEB-TACE. When patients with HCC are treated with TACE, their symptoms, laboratory data, and imaging results should be monitored when latent TB infections are suspected.
- Published
- 2018
24. Duplication cyst of the ileum presenting with severe anemia detected by double-balloon endoscopy
- Author
-
Takanori Goi, Tatsushi Naito, Katsushi Hiramatsu, Hidetaka Matsuda, Yoshihiko Ozaki, Masahiro Ohtani, Yosuke Murata, Yu Akazawa, Tomoyuki Nemoto, Yoshiaki Imamura, Kazuya Ofuji, Kazuto Takahashi, Yumi Takegawa, Yasushi Saito, Hiroyuki Suto, and Yasunari Nakamoto
- Subjects
Enteroscopy ,medicine.medical_specialty ,Abdominal pain ,medicine.diagnostic_test ,business.industry ,Colonoscopy ,Ileum ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Iron-deficiency anemia ,Melena ,030220 oncology & carcinogenesis ,Intussusception (medical disorder) ,Case report ,Medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Pharmacology (medical) ,Cyst ,Radiology ,lcsh:RC799-869 ,medicine.symptom ,business - Abstract
Background and study aims Duplication cysts of the ileum are rare and present with non-specific clinical manifestations such as abdominal pain, vomiting, melena, and intussusception. Therefore, preoperative diagnosis is difficult. Here, we report a case of duplication cyst of the small intestine that was diagnosed preoperatively using double-balloon enteroscopy. A 19-year-old man presented with severe iron deficiency anemia, abdominal pain, and exertional dyspnea. Gastroscopy and colonoscopy revealed no remarkable findings. Abdominal computed tomography revealed a cystic structure in the ileum. Therefore, we performed double-balloon enteroscopy via the anal route. The intestinal tract was bifurcated, with one segment ending in a blind sac containing normal villi and an ulceration. Tc-99 m pertechnetate scintigraphy showed no accumulation in the lesion. Accordingly, we diagnosed a duplication cyst and suspected that this was the cause of severe anemia. Following small bowel resection with cyst excision and anastomosis, the anemia and presenting symptoms resolved. This report highlights the usefulness of double-balloon enteroscopy of the small intestine for preoperative diagnosis of the obscure gastrointestinal bleeding, including duplication cysts.
- Published
- 2018
25. Genetic polymorphism and decreased expression of HLA class II DP genes are associated with HBV reactivation in patients treated with immunomodulatory agents
- Author
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Kazuto Takahashi, Ryoko Hayama, Katsushi Hiramatsu, Yukio Hida, Hideki Kimura, Yoshihiko Ozaki, Tomoyuki Nemoto, Kazuya Ofuji, Takuto Nosaka, Yu Akazawa, Yoshihiro Soya, Hidetaka Matsuda, Tatsushi Naito, Yasushi Saito, Yasunari Nakamoto, and Masahiro Ohtani
- Subjects
Male ,0301 basic medicine ,Single-nucleotide polymorphism ,HLA-DP alpha-Chains ,medicine.disease_cause ,03 medical and health sciences ,Hepatitis B, Chronic ,Virology ,Genotype ,medicine ,Humans ,SNP ,Allele ,Allele frequency ,Alleles ,HLA-DP beta-Chains ,Aged ,Retrospective Studies ,Hepatitis B virus ,Polymorphism, Genetic ,business.industry ,Odds ratio ,Middle Aged ,Genotype frequency ,030104 developmental biology ,Infectious Diseases ,Immunology ,Female ,Virus Activation ,business ,Immunosuppressive Agents - Abstract
Hepatitis B virus (HBV) reactivation can be triggered by immunosuppressive chemotherapy. HLA class II molecules may play a role in HBV reactivation. Genetic polymorphism and mRNA expression of HLA class II were examined in patients with latent HBV infection treated with immunosuppressive therapies. Subjects with resolved HBV infection who had undergone treatment with immunosuppressive chemotherapies were retrospectively enrolled (n = 42) and divided into reactivated (n = 9) and non-reactivated groups (n = 33). Patients were genotyped for 17 single nucleotide polymorphisms (SNPs) within HLA class II DPA1, and DPB1, and mRNA expression levels of HLA class II genes were assessed. The frequency of the AA genotype of rs872956, a SNP in HLA-DPB1, was significantly higher in the reactivated group than in the non-reactivated group (55.6% vs 12.1%, P < 0.05). The frequencies of the T allele and non-AA genotypes (AT/TT) of rs3116996 (located in DPB1) were significantly higher in the reactivated group (T allele frequency: 16.7% vs 0.0% [P < 0.01], non-AA genotype frequency: 22.2% vs 0.0% [P < 0.05]). Multivariate logistic regression identified the AA genotype of rs872956 as an independent protective factor against HBV reactivation (odds ratio [OR] = 18.1, 95% confidence interval [CI] = 2.6-126.7, P < 0.01). mRNA expression of HLA-DPB1 was lower in the HBV reactivated group than in the non-reactivated group (median 276.1 ± 165.6/β-actin vs 371.4 ± 407.5/β-actin [P < 0.05]). These results suggest the involvement of HLA class II molecules in HBV reactivation after treatment with immunomodulatory agents.
- Published
- 2018
26. ID: 3521747 CLINICAL USEFULNESS OF PANCREATIC VOLUME QUANTITATIVE ANALYSIS AS A PREDICTOR OF THE ONSET AND SEVERITY IN POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY PANCREATITIS
- Author
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Katsushi Hiramatsu, Takuto Nosaka, Yu Akazawa, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto, and Kazuto Takahashi
- Subjects
medicine.medical_specialty ,Endoscopic retrograde cholangiopancreatography ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Medicine ,Pancreatitis ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,medicine.disease ,Quantitative analysis (chemistry) ,Volume (compression) - Published
- 2021
27. Sa303 RAPID GROWTH RATES OF CYSTS ASSOCIATES WITH PANCREATIC MALIGNANCY IN LOW RISK BRANCH-DUCT INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS
- Author
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Kazuya Ofuji, Yasunari Nakamoto, Kazuto Takahashi, Katsushi Hiramatsu, Takuto Nosaka, Yu Akazawa, Tatsushi Naito, Hidetaka Matsuda, and Masahiro Ohtani
- Subjects
Branch Duct ,Pathology ,medicine.medical_specialty ,Pancreatic malignancy ,Hepatology ,business.industry ,Gastroenterology ,Medicine ,business - Published
- 2021
28. Su242 INFLUENCE OF ANTIPLATELET DRUGS ON GASTRIC ULCER HEALING AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION
- Author
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Katsushi Hiramatsu, Kazuya Ofuji, Kazuto Takahashi, Yasunari Nakamoto, Hidetaka Matsuda, Masahiro Ohtani, Takuto Nosaka, and Tatsushi Naito
- Subjects
Ulcer healing ,medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,Medicine ,Endoscopic submucosal dissection ,business ,Surgery - Published
- 2021
29. A case of protein-losing enteropathy caused by sclerosing mesenteritis diagnosed with capsule endoscopy and double-balloon endoscopy
- Author
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Masahiro Ohtani, Yasushi Saito, Yoshihiko Ozaki, Takuto Nosaka, Tatsushi Naito, Katsushi Hiramatsu, Yasunari Nakamoto, Yoshiaki Imamura, Kazuto Takahashi, Kazuya Ofuji, Tomoyuki Nemoto, and Hidetaka Matsuda
- Subjects
Male ,Enteroscopy ,medicine.medical_specialty ,Pathology ,Protein-Losing Enteropathies ,Lymphangiectasia ,Sclerosing mesenteritis ,Capsule Endoscopy ,Gastroenterology ,Panniculitis, Peritoneal ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Capsule endoscopy ,law ,Internal medicine ,Double-balloon enteroscopy ,medicine ,Humans ,Hypoalbuminemia ,Aged ,Double-Balloon Enteroscopy ,medicine.diagnostic_test ,business.industry ,Protein losing enteropathy ,General Medicine ,Abdominal distension ,medicine.disease ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
A 75-year-old man presented with abdominal distension, hypoproteinemia, ascites and a 35-mm mass in the small bowel mesentery. Laparotomy was performed, and he was diagnosed with sclerosing mesenteritis. His clinical condition improved, with computed tomography (CT) showing tumor shrinkage and decreasing ascites after administration of prednisolone; however, on drug withdrawal, abdominal fullness recurred and CT revealed an enlarging tumor and increasing ascites. Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) were performed to further investigate hypoalbuminemia, which revealed white villi, white nodules, white debris, and mucosal edema in the jejunum. Biopsies from the jejunal mucosa demonstrated infiltration by chronic inflammatory cells consisting mostly of lymphocytes and plasma cells, with marked lymphangiectasia of the lamina propria and submucosa. A fecal alpha-1-antitrypsin clearance test revealed abnormal leakage from the gastrointestinal tract, confirming that hypoalbuminemia was secondary to protein-losing enteropathy (PLE). The incidence of sclerosing mesenteritis accompanied by PLE is very rare. Only six cases have been reported so far. CE and DBE were helpful for diagnosing this condition, and should be performed in patients in whom the cause of hypoalbuminemia is unknown, and in those with PLE.
- Published
- 2017
30. Identification of novel variants in HLA class II region related to HLA DPB1 expression and disease progression in patients with chronic hepatitis C
- Author
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Toshihiro Yasuda, Katsushi Hiramatsu, Kazuya Ofuji, Masahiro Ohtani, Yukio Hida, Hideki Kimura, Yoshihiro Soya, Tatsushi Naito, Yasushi Saito, Hiroyuki Suto, Yasunari Nakamoto, Takuto Nosaka, Hidetaka Matsuda, Kazuto Takahashi, and Tomoyuki Nemoto
- Subjects
Male ,0301 basic medicine ,Genotype ,Single-nucleotide polymorphism ,Biology ,Real-Time Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Gene Frequency ,Polymorphism (computer science) ,Virology ,medicine ,Humans ,Allele frequency ,Gene ,HLA-DP beta-Chains ,Aged ,HLA-DPB1 ,Gene Expression Profiling ,Sequence Analysis, DNA ,Hepatitis C, Chronic ,Middle Aged ,medicine.disease ,030104 developmental biology ,Infectious Diseases ,Case-Control Studies ,Immunology ,Disease Progression ,Leukocytes, Mononuclear ,Female ,030211 gastroenterology & hepatology ,Viral hepatitis - Abstract
Recent genome-wide studies have demonstrated that HLA class II gene may play an important role in viral hepatitis. We studied genetic polymorphism and RNA expression of HLA class II genes in HCV-related liver diseases. The study was performed in groups consisting of 24 patients with HCV-related liver disease (12 of persistent normal ALT: PNALT group and 12 of advanced liver disease: ALD group) and 26 patients without HCV infection (control group). In PBMC samples, RNA expression of HLA class II genes (HLA-DPA1, DPB1, DQA1, DQB1, and DRB1) was analyzed by real-time RT-PCR. Furthermore, 22 single nucleotide polymorphisms (SNPs) in HLA class II gene and two SNPs in IL28B gene were genotyped by genetic analyzer (GENECUBE®). In expression analysis, only DPB1 level was significantly different. Mean expression level of DPB1gene in control group was 160.0, PNALT group 233.8, and ALD group 465.0 (P
- Published
- 2017
31. Sa2053 EFFICACY AND SAFETY OF HOOKKNIFE ELECTROSURGICAL KNIFE IN ENDOSCOPIC SUBMUCOSAL DISSECTION FOR THE TREATMENT OF SUPERFICIAL NON-AMPULLARY DUODENAL EPITHELIAL TUMOR
- Author
-
Tatsushi Naito, Kazuto Takahashi, Yasunari Nakamoto, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Kazuya Ofuji, and Takuto Nosaka
- Subjects
medicine.medical_specialty ,business.industry ,Gastroenterology ,medicine ,Radiology, Nuclear Medicine and imaging ,Endoscopic submucosal dissection ,business ,Surgery - Published
- 2020
32. [The Usefulness of Strain Elastography for Determining Liver Fibrosis Stage in Chronic Viral Hepatitis: An Analysis Using Tissue Doppler Imaging with Manual Compression]
- Author
-
Fumie, Maeda, Tomoyuki, Nemoto, Kiyotaka, Saito, Norikazu, Hashimoto, Yuka, Ohtake, Yumiko, Tsuda, Hidetaka, Matsuda, Masahiro, Ohtani, Katsushi, Hiramatsu, Hiroyuki, Suto, Toshihiko, Hamada, Masayuki, Iwano, Yasunari, Nakamoto, and Hideki, Kimura
- Subjects
Liver Cirrhosis ,Male ,Hepatitis, Viral, Human ,Elasticity Imaging Techniques ,Humans ,Female ,Ultrasonography, Doppler ,Middle Aged ,Aged - Abstract
Accurate determination of the stage of liver fibrosis is an essential component in choice of treatment and assessment of cancer risk in patients with chronic viral hepatitis. The aim of this study was to evaluate the usefulness of strain elastography based on tissue Doppler imaging for liver fibrosis in chronic viral hepatitis.A total of 37 patients with chronic viral hepatitis and 8 healthy volunteers were enrolled. Strain value was measured by using a conventional ultrasound machine that included strain imaging technolo- gy. Strain elastography was performed at the right subcostal area with manual compression. Liver fibrosis stages were assessed by using liver biopsy and compared with strain values. Diagnostic performance of the strain value for fibrosis stage 4, cirrhosis, was determined by performing a receiver-operating characteristics (ROC) curve analysis.Twenty-seven patients were positive for HCV RNA, 9 were positive for HBs antigen, and 1 was positive for both (Fibrosis stage F1, n=11; F2, n=7; F3, n=15; F4, n=4). The strain value of F3 and F4 was 0.066±0.02 and 0.042±0.011, respectively. These strain Values were significantly lower compared to those of healthy volunteers (0.112 ±0.018) (P0.05). Using a cutoff value of 0.042, the area under ROC curve was 0.88 for the diagnosis of F4. The sensitivity, specificity, positive predictive value, and negative predictive value were 75%, 92%, 50%, and 94%, respectively.Strain elastography based on tissue Doppler imaging with manual compression appears to be a useful tool to diagnose cirrhosis in patients with chronic viral hepatitis. [Original].
- Published
- 2019
33. Tu1607 CLINICAL USEFULNESS OF FDG-PET/CT FOR DIFFERENTIATION OF AUTOIMMUNE PANCREATITIS FROM PANCREATIC CANCER
- Author
-
Tatsushi Naito, Masahiro Ohtani, Katsushi Hiramatsu, Takuto Nosaka, Yasunari Nakamoto, Kazuto Takahashi, Kazuya Ofuji, and Hidetaka Matsuda
- Subjects
Pathology ,medicine.medical_specialty ,Hepatology ,business.industry ,Pancreatic cancer ,Gastroenterology ,Medicine ,Fdg pet ct ,business ,medicine.disease ,Autoimmune pancreatitis - Published
- 2020
34. Long-term prognosis after biliary stenting for common bile duct stones in high-risk elderly patients
- Author
-
Yu, Akazawa, Masahiro, Ohtani, Takuto, Nosaka, Yasushi, Saito, Kazuto, Takahashi, Tatsushi, Naito, Kazuya, Ofuji, Hidetaka, Matsuda, Katsushi, Hiramatsu, Tomoyuki, Nemoto, and Yasunari, Nakamoto
- Subjects
Aged, 80 and over ,Male ,Cholangitis ,Recurrence ,Humans ,Female ,Stents ,Gallstones ,Prognosis ,Propensity Score ,Retrospective Studies - Abstract
To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones.We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary stenting (the biliary stenting group) between July 2006 and March 2016. To reduce selection bias, we also conducted a propensity score matching analysis and generated 30 pairs of patients. Cholangitis recurrence-free survival and overall survival were compared between the two groups and independent prognostic factors of survival were identified by univariate and multivariate analyses.Cholangitis recurrence-free survival was significantly better in the duct clearance group than in the biliary stenting group (P0.001). Their overall survival did not significantly differ after propensity score matching (P = 0.388). In all cohorts, univariate analysis demonstrated that poor performance status and biliary stenting were factors of poor prognosis, and in multivariate analysis only performance status remained associated with poor prognosis for survival. Similarly, in the propensity score-matched cohort, only performance status independently predicted poorer survival (hazard ratio [HR] 2.726, 95% confidence interval [CI] 1.105-6.675, P = 0.029). The choice of endoscopic treatment was not a significant factor associated with prognosis (HR 1.354, 95% CI 0.678-2.701, P = 0.391).Biliary stenting was similar to complete stone removal in terms of prognosis for long-term survival. Biliary stenting for CBD stones could be an effective therapeutic tool in high-risk elderly patients.
- Published
- 2018
35. Su1330 ENDOSCOPIC FINDINGS OF LATEST CAPSULE ENDOSCOPY PILLCAM SB3 ACCURATELY PREDICTS REBLEEDING OF OGIB
- Author
-
Takuto Nosaka, Katsushi Hiramatsu, Kazuya Ofuji, Tomoyuki Nemoto, Hidetaka Matsuda, Masahiro Ohtani, Yasunari Nakamoto, and Tatsushi Naito
- Subjects
medicine.medical_specialty ,business.industry ,Capsule endoscopy ,law ,Gastroenterology ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,law.invention - Published
- 2019
36. A case of Helicobacter pylori-negative intramucosal well-differentiated gastric adenocarcinoma with intestinal phenotype
- Author
-
Tatsushi Naito, Takuto Nosaka, Yoshihiko Ozaki, Masahiro Ohtani, Kazuya Ofuji, Hidetaka Matsuda, Tomoyuki Nemoto, Kazuto Takahashi, Yasushi Saito, Hiroyuki Suto, Yasunari Nakamoto, Yoshiaki Imamura, and Katsushi Hiramatsu
- Subjects
Adult ,medicine.medical_specialty ,Pathology ,Rapid urease test ,Adenocarcinoma ,Gastroenterology ,Stomach Neoplasms ,Internal medicine ,Gastroscopy ,medicine ,Gastric mucosa ,Humans ,CDX2 Transcription Factor ,Helicobacter ,Duodenoscopy ,Homeodomain Proteins ,Mucin-2 ,Helicobacter pylori ,biology ,medicine.diagnostic_test ,business.industry ,Esophagogastroduodenoscopy ,Dissection ,General Medicine ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,digestive system diseases ,Early Gastric Cancer ,Phenotype ,medicine.anatomical_structure ,Gastric Mucosa ,Tubular Adenocarcinoma ,Female ,Neprilysin ,Esophagoscopy ,business - Abstract
A woman in her 30s visited our hospital with stool abnormality. Esophagogastroduodenoscopy revealed a depressed lesion on the greater curvature of the gastric antrum. The tumor was diagnosed as a well-differentiated tubular adenocarcinoma based on the analysis of the biopsy specimen. The rapid urease test, histological examination, and serum anti-Helicobacter pylori antibody indicated that the patient was Helicobacter pylori negative. Gastric mucosal atrophy was not evident on esophagogastroduodenoscopy. Complete cure en bloc resection was successfully performed. The tumor was confined to the mucosa (pT1a-M). Immunohistochemistry showed positive CD10, MUC2, and CDX2 expression and negative MUC5AC and MUC6 expression. Thus, the phenotype was diagnosed as the intestinal phenotype. Helicobacter pylori-negative, well-differentiated early gastric cancer with intestinal phenotype has not been previously reported. Here, we report a rare and valuable case of Helicobacter pylori-negative early gastric cancer with intestinal phenotype treated by endoscopic submucosal dissection.
- Published
- 2015
37. Sa1956 EFFECTIVENESS AND SAFETY OF ENDOSCOPIC SUBMUCOSAL DISSECTION USING THE BALL-TIP BIPOLARCURRENT NEEDLE KNIFE WITH WATER-JET FUNCTION (JET B-KNIFE) FOR THE TREATMENT OF COLORECTAL TUMORS
- Author
-
Katsushi Hiramatsu, Hidetaka Matsuda, Tatsushi Naito, Takuto Nosaka, Tomoyuki Nemoto, Yasushi Saito, Yasunari Nakamoto, Tomoko Tanaka, Kazuto Takahashi, Kazuya Ofuji, and Masahiro Ohtani
- Subjects
business.industry ,Gastroenterology ,Water jet ,Medicine ,Radiology, Nuclear Medicine and imaging ,Endoscopic submucosal dissection ,Needle knife ,business ,Nuclear medicine ,Colorectal Tumors - Published
- 2018
38. Su1235 THE EFFECT OF LIQUID-BASED CYTOLOGY ON EUS-GUIDED SAMPLING OF SOLID MASSES AND LYMPH NODES
- Author
-
Yasunari Nakamoto, Hidetaka Matsuda, Takuto Nosaka, Tatsushi Naito, Masahiro Ohtani, Kazuya Ofuji, and Katsushi Hiramatsu
- Subjects
medicine.medical_specialty ,business.industry ,Liquid-based cytology ,Gastroenterology ,medicine ,Sampling (statistics) ,Radiology, Nuclear Medicine and imaging ,Radiology ,Lymph ,business - Published
- 2019
39. Sa1338 – Development of a Novel Circulating Tumor Cells Isolation System in Patients with Pancreatic Cancer Using a Microcavity Array
- Author
-
Takuto Nosaka, Tatsushi Naito, Kazuya Ofuji, Masahiro Ohtani, Yasunari Nakamoto, Katsushi Hiramatsu, Hidetaka Matsuda, Kazuto Takahashi, and Tomoyuki Nemoto
- Subjects
Circulating tumor cell ,Hepatology ,business.industry ,Isolation system ,Pancreatic cancer ,Gastroenterology ,medicine ,Cancer research ,In patient ,medicine.disease ,business - Published
- 2019
40. [Rapid automated genotyping of HLA class II gene in patients with hepatitis C virus-related liver disease]
- Author
-
Katsushi, Hiramatsu and Yasunari, Nakamoto
- Subjects
Gene Expression Regulation ,Liver Diseases ,Histocompatibility Antigens Class II ,Humans ,Hepatitis C ,Polymorphism, Single Nucleotide ,Genome-Wide Association Study - Published
- 2016
41. Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice
- Author
-
Tomoyuki Nemoto, Takashi Ohno, Yoshiaki Imamura, Masahiro Ohtani, Hiroyuki Suto, Makoto Ohta, Yasunari Nakamoto, Hidetaka Matsuda, and Katsushi Hiramatsu
- Subjects
0301 basic medicine ,Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Drug Evaluation, Preclinical ,Inflammation ,Biology ,Camellia sinensis ,Catechin ,03 medical and health sciences ,Interferon-gamma ,Mice ,0302 clinical medicine ,Stomach Neoplasms ,Internal medicine ,Gastrins ,medicine ,Animals ,Anticarcinogenic Agents ,Gastrin ,Cell Proliferation ,Insulin ,Body Weight ,Epithelial Cells ,General Medicine ,medicine.disease ,030104 developmental biology ,Cytokine ,Endocrinology ,Oncology ,Apoptosis ,Dysplasia ,Gastric Mucosa ,030220 oncology & carcinogenesis ,Gastritis ,Immunology ,Histopathology ,medicine.symptom - Abstract
Green tea catechins (GTCs) have been implicated in various physiological effects, including anti-carcinogenic activities. In the present study, we evaluated the effects of GTCs specifically on the development of gastritis and pre-malignant lesions in insulin-gastrin mice. Nine-week-old male INS-GAS mice (n=38) were supplemented with GTCs for 4 and 28 weeks, and their body weights, serum gastrin levels, histopathology and pro-inflammatory cytokine levels in gastric tissue and mucosal cell proliferation were monitored. Body weights of the GTC-treated mice were significantly lower than those of the untreated controls (P≤0.05). Serum gastrin levels were suppressed at the age of 37-weeks (P≤0.05). The histopathological scores indicated that the extent of dysplasia was significantly diminished (P≤0.05), although GTC supplementation did not affect the inflammation scores. The messenger RNA levels of interferon (IFN)-γ were significantly reduced at the age of 13 weeks (P≤0.05), although the changes did not reach statistical significance at the age of 37 weeks (P=0.056). The labeling index of Ki-67 immunohistochemistry was significantly decreased (P≤0.05). These results demonstrated that GTCs may play a protective role in the development of gastritis and pre-malignant lesions via an IFN-γ, gastrin, and mucosal cell proliferation-dependent mechanism in this rodent model and potentially in humans.
- Published
- 2015
42. Su1399 DIAGNOSTIC UTILITY OF LIQUID-BASED CYTOLOGY IN EUS-FNA FOR PANCREATIC LESION AND SUBEPITHELIAL TUMOR
- Author
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Yasunari Nakamoto, Takuto Nosaka, Masahiro Ohtani, Hidetaka Matsuda, Kazuya Ofuji, Tatsushi Naito, Katsushi Hiramatsu, and Tomoyuki Nemoto
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Liquid-based cytology ,Gastroenterology ,medicine ,030211 gastroenterology & hepatology ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Pancreatic lesion - Published
- 2018
43. Clinicopathological characteristics of surgically treated patients with non-B non-C type hepatocellular carcinoma
- Author
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Satoshi Hirai, Shintaro Terahata, Akiyoshi Shimatani, Katsushi Hiramatsu, Yatsugi Noda, Hidero Ogino, Koichiro Matsuda, Kouichi Shimizu, Tomoyuki Hayashi, Yosuke Horita, Akio Uchiyama, and Mitsuru Matsuda
- Subjects
medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,Hepatocellular carcinoma ,medicine ,business ,medicine.disease ,Gastroenterology - Abstract
非B非C(NBNC)型肝細胞癌(HCC)手術例の臨床病理学的特徴についてB型およびC型HCC手術例と比較しつつ検討した.当院で過去11年間に手術されたHCC 108例中NBNC型は43例(39.8%)と多くを占め,これら43例中35例でHBc抗体は測定されており18例(51.4%)でHBc抗体陽性であった.B型は108例中18例(16.7%),C型は47例(43.5%)であった.NBNC型では,B型およびC型に比し肥満と糖尿病の合併頻度は有意に高かった.背景肝の組織学的所見は,NBNC型ではB型と同様C型に比し軽度であった.NASH/NAFLDの頻度は,burned-out NASHも含めNBNC型非飲酒者18例中6例(33.3%)であった.平均無再発生存期間はNBNC型74.6カ月,B型62.6カ月,C型38.2カ月と3群間比較ではNBNC型が有意に長く,平均生存期間においても同様な傾向であった.
- Published
- 2010
44. Pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism: a case report
- Author
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Takuto Nosaka, Hirohiko Kimura, Tatsushi Naito, Hidetaka Matsuda, Tatsuya Yamamoto, Masahiro Ohtani, Yasushi Saito, Hiroyuki Suto, Yasunari Nakamoto, Tomoyuki Nemoto, Kazuto Takahashi, Katsushi Hiramatsu, Tomoko Tanaka, and Kazuya Ofuji
- Subjects
Oncology ,Cancer Research ,Pituitary gland ,medicine.medical_specialty ,Pathology ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,Biopsy ,Case Report ,Hypopituitarism ,Pituitary neoplasm ,Metastasis ,Diagnosis, Differential ,Fatal Outcome ,Internal medicine ,Metastasis to pituitary gland ,Genetics ,medicine ,Carcinoma ,Humans ,Pituitary Neoplasms ,Lung cancer ,Aged, 80 and over ,business.industry ,Liver Neoplasms ,medicine.disease ,Immunohistochemistry ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Female ,Differential diagnosis ,business - Abstract
Background Metastasis to the pituitary gland is extremely rare and is often detected incidentally by symptoms associated with endocrine dysfunction. Breast and lung cancer are the most common primary metastasizing to pituitary gland. Metastasis from hepatocellular carcinoma to the pituitary gland is extremely rare, with only 10 cases having been previously reported. We present here the first case of pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism diagnosed by magnetic resonance imaging. Case presentation We report the case of an 80-year-old Japanese woman who presented with the sudden onset of hypotension and bradycardia after having previously been diagnosed with hepatocellular carcinoma. Based on low levels of pituitary hormones, she was diagnosed with panhypopituitarism caused by metastasis of the hepatocellular carcinoma to the pituitary gland. Magnetic resonance imaging with arterial spin-labeling was effective in the differential diagnosis of the intrasellar tumor. The patient died despite hormone replacement therapy because of hypovolemic shock. Conclusion Metastasis to the pituitary gland causes various non-specific symptoms, so it is difficult to diagnose. The present case emphasizes the importance of diagnostic imaging in identifying these metastases. Clinicians should consider the possibility of pituitary metastasis in patients with malignant tumors who demonstrate hypopituitarism.
- Published
- 2015
45. Efficacy of radiation therapy for advanced hepatocellular carcinoma with vascular and/or bile duct involvement
- Author
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Katsushi Hiramatsu, Yoshitake Satomura, Yatsugi Noda, Yosuke Horita, Samon Miyata, Hiroshi Demachi, Mitsuru Matsuda, and Hidero Ogino
- Subjects
Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Bile duct ,medicine.medical_treatment ,Urology ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Hepatocellular carcinoma ,Internal medicine ,medicine ,business - Abstract
1996年4月∼2002年3月に当科において放射線療法を施行した肝細胞癌患者21例を対象とし,脈管侵襲を伴う肝細胞癌に対する放射線療法の治療効果と予後について検討を行った.また,治療前後での食道胃静脈瘤・腹水等随伴所見の変化についても検討した.結果はMinor Response以上の奏効例が全体の21例中5例(23.8%)であった.また,門脈侵襲症例では15例中3例(20.0%)に奏効を得た.食道胃静脈瘤は10例中1例(10.0%)で改善,5例(50.0%)で悪化が見られた.また,治療前に腹水を認めた13例は全例で改善は見られなかった.放射線療法開始から死亡までの平均生存期間は242日(25∼949日)であった.放射線療法は肝細胞癌に対しての集学的治療の一つとして一部症例では効果の期待しうる治療法と考えられた.
- Published
- 2006
46. A case of chronic hepatitis C with malignant lymphoma arising from porta hepatical lymph node in follow up period
- Author
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Hidenobu Ohsaka, Shunji Tomita, Katsushi Hiramatsu, Satoshi Hirai, Hidero Ogino, Atsuo Miwa, Yatsugi Noda, Mitsuru Matsuda, Yoshitake Satomura, and Akio Uchiyama
- Subjects
Malignant lymphoma ,Oncology ,medicine.medical_specialty ,medicine.anatomical_structure ,Hepatology ,Chronic hepatitis ,business.industry ,Internal medicine ,medicine ,business ,Lymph node - Abstract
症例は44歳男性.1992年12月よりC型慢性肝炎にて当科に通院していた.1993年,肝生検にて慢性活動性肝炎と診断し,Interferonα-2a 600万単位を6カ月間投与したが無効であった.腹部超音波検査にて経過を見ていたが,2003年1月に直径約35mm大の低エコー腫瘤を門脈・下大静脈間に認めた.悪性リンパ腫を疑い開腹術を勧めたが拒否されたため経過観察をしていたところ,1年後の2004年1月には直径14×26mmまで自然縮小していた.しかし,同年12月には最大径78mmまで増大し体表から触知可能となったため,超音波ガイド下腫瘍生検施行した.病理結果よりdiffuse large B cell lymphomaと診断した.2005年3月10日よりRituximab併用CHOP療法を開始し,腫瘍縮小を認めた.C型慢性肝炎では,肝門部リンパ節腫大は比較的高頻度に認められるが,悪性リンパ腫の発生も念頭に経過観察すべきと思われた.
- Published
- 2006
47. Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B
- Author
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Katsushi Hiramatsu, Yusuke Hiraku, Yasunari Nakamoto, Hiroyuki Marusawa, Shosuke Kawanishi, Tatsushi Naito, Shuichi Kaneko, Ning Ma, Takuto Nosaka, Masahiro Ohtani, Taro Yamashita, and Tomoyuki Nemoto
- Subjects
Male ,0301 basic medicine ,Cell signaling ,Chronic Hepatitis ,HBsAg ,Carcinogenesis ,lcsh:Medicine ,Gene Expression ,Signal transduction ,medicine.disease_cause ,Chronic liver disease ,Chronic Liver Disease ,Mice ,Animal Cells ,Medicine and Health Sciences ,Membrane Receptor Signaling ,lcsh:Science ,Oligonucleotide Array Sequence Analysis ,Multidisciplinary ,Liver Diseases ,Liver cell ,Liver Neoplasms ,Animal Models ,Hepatitis B ,Immune Receptor Signaling ,STAT signaling ,Liver ,Experimental Organism Systems ,Oncology ,Hepatocellular carcinoma ,Cellular Types ,Anatomy ,Viral hepatitis ,EGFR signaling ,Research Article ,STAT3 Transcription Factor ,Cell biology ,Carcinoma, Hepatocellular ,DNA, Complementary ,Mice, Transgenic ,Mouse Models ,Gastroenterology and Hepatology ,Biology ,Research and Analysis Methods ,Carcinomas ,03 medical and health sciences ,Hepatitis B, Chronic ,Model Organisms ,Gastrointestinal Tumors ,Genetics ,medicine ,Animals ,Hepatitis B virus ,Hepatitis ,Biology and life sciences ,Gene Expression Profiling ,lcsh:R ,Cancers and Neoplasms ,Hepatocellular Carcinoma ,Genes, p53 ,medicine.disease ,Disease Models, Animal ,030104 developmental biology ,Hepatocytes ,Cancer research ,lcsh:Q - Abstract
Background Hepatocellular carcinoma (HCC) is a common complication of chronic viral hepatitis. In support of this notion, we have reported that hepatitis B surface antigen (HBsAg)-specific CD8+ T lymphocytes critically contribute to inducing chronic liver cell injury that exerts high carcinogenic potential in a hepatitis B virus (HBV) transgenic mouse model. The dynamics of the molecular signatures responsible for hepatocellular carcinogenesis are not fully understood. The current study was designed to determine the serial changes in gene expression profiles in a model of chronic immune-mediated hepatitis. Methods Three-month-old HBV transgenic mice were immunologically reconstituted with bone marrow cells and splenocytes from syngeneic nontransgenic donors. Liver tissues were obtained every three months until 18 months at which time all mice developed multiple liver tumors. Nitrative DNA lesions and hepatocyte turnover were assessed immunohistochemically. Gene expression profiles were generated by extracting total RNA from the tissues and analyzing by microarray. Results The nitrative DNA lesions and the regenerative proliferation of hepatocytes were increased during the progression of chronic liver disease. In a gene expression profile analysis of liver samples, the chemokine- and T cell receptor (TCR)-mediated pathways were enhanced during chronic hepatitis, and the EGF- and VEGF-mediated pathways were induced in HCC. Among these molecules, the protein levels of STAT3 were greatly enhanced in all hepatocyte nuclei and further elevated in the cytoplasm in HCC tissue samples at 18 months, and the levels of phosphorylated TP53 (p-p53-Ser 6 and -Ser 15) were increased in liver tissues. Conclusions HBV-specific immune responses caused unique molecular signatures in the liver tissues of chronic hepatitis and triggered subsequent carcinogenic gene expression profiles in a mouse model. The results suggest a plausible molecular basis responsible for HBV-induced immune pathogenesis of HCC.
- Published
- 2017
48. Mo1177 Influence of Antithrombotic Drugs on Gastric Ulcer Healing After Endoscopic Submucosal Dissection
- Author
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Kazuya Ofuji, Tatsushi Naito, Takuto Nosaka, Masahiro Ohtani, Katsushi Hiramatsu, Kazuto Takahashi, Yasushi Saito, Hiroyuki Suto, Yasunari Nakamoto, Hidetaka Matsuda, and Tomoyuki Nemoto
- Subjects
Ulcer healing ,medicine.medical_specialty ,business.industry ,Internal medicine ,Antithrombotic ,Gastroenterology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Endoscopic submucosal dissection ,business - Published
- 2017
49. Tu1414 Long-Term Prognosis After Biliary Stenting for Common Bile Duct Stones in Elderly High-Risk Patients
- Author
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Masahiro Ohtani, Tatsushi Naito, Takuto Nosaka, Yu Akazawa, Yasushi Saito, Yasunari Nakamoto, Hidetaka Matsuda, Tomoyuki Nemoto, Kazuto Takahashi, Katsushi Hiramatsu, and Kazuya Ofuji
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,High risk patients ,Common bile duct ,business.industry ,Gastroenterology ,medicine ,Radiology, Nuclear Medicine and imaging ,Biliary Stenting ,business ,Term (time) ,Surgery - Published
- 2017
50. [A case of superficial esophageal basaloid squamous cell carcinoma resected by endoscopic submucosal dissection]
- Author
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Takuto, Nosaka, Hiroyuki, Suto, Hidetaka, Matsuda, Kazuto, Takahashi, Masahiro, Ohtani, Katsushi, Hiramatsu, Tomoyuki, Nemoto, Yoshiaki, Imamura, and Yasunari, Nakamoto
- Subjects
Esophagus ,Esophageal Neoplasms ,Carcinoma, Squamous Cell ,Humans ,Female ,Esophageal Squamous Cell Carcinoma ,Esophagoscopy ,Aged - Abstract
A woman in her 70s visited our hospital to undergo endoscopy. Esophagogastroduodenoscopy showed a white submucosal tumor-like lesion in the upper esophagus. Analysis of a biopsy specimen revealed that the tumor was a basaloid squamous cell carcinoma. A superficial squamous cell carcinoma was also revealed near the basaloid squamous cell carcinoma before endoscopic submucosal dissection. Curative en bloc resection was successfully performed. Histopathological examination revealed that the basaloid and superficial squamous cell carcinomas had invaded the lamina propria (pT1a-LPM) and epithelium (pT1a-EP), respectively. In addition, the basaloid squamous cell carcinoma had two different components in terms of malignancy and differentiation. Here we report a rare case of esophageal basaloid squamous cell carcinoma resected by endoscopic submucosal dissection.
- Published
- 2014
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