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Legal crowdfunding is an emerging domain where lawyers and individuals raise funds to fight legal actions. To study how prospective donors can verify the credibility of legal campaigns, we analyzed the conversations surrounding these campaigns on Facebook. We discovered three primary themes associated with the perceptions of the contributors of legal campaigns: supporters posting admiring and appreciative comments, supporters posting critical and disapproving comments, and opponents posting critical and disapproving comments. We observed that while supporters criticized campaigns' opponents, biased media, and dishonest authorities, opponents criticized campaign owners, campaigns' objectives and opaque logistics. To understand the impact of these perspectives on donors, we followed up with an online survey study where we presented a legal campaign with its corresponding social media conversations. We found that critical comments impacted donation decisions more than appreciative comments. We concluded with design implications to better support potential donors to make more informed donation decisions.

OBJECTIVE Giant cerebral cavernous malformations (GCCMs) are rare vascular malformations. Unlike for tumors and aneurysms, there is no clear definition of a "giant" cavernous malformation (CM). As a result of variable definitions, working descriptions and outcome data of patients with GCCM are unclear. A new definition of GCCM related to surgical outcomes is needed. METHODS An institutional database was searched for all patients who underwent resection of CMs > 1 cm in diameter. Patient information, surgical technique, and clinical and radiographic outcomes were assessed. A systematic review was performed to augment an earlier published review. RESULTS In the authors’ institutional cohort of 183 patients with a large CM, 179 with preoperative and postoperative modified Rankin Scale (mRS) scores were analyzed. A maximum CM diameter of ≥ 3 cm was associated with greater risk of severe postoperative decline (≥ 2-point increase in mRS score). After adjustment for age and deep versus superficial location, size ≥ 3 cm was strongly predictive of severe postoperative decline (OR 4.5, 95% CI 1.2–16.9). A model with CM size and deep versus superficial location was developed to predict severe postoperative decline (area under the receiver operating characteristic curve 0.79). Thirteen more patients with GCCMs have been reported in the literature since the most recent systematic review, including some patients who were treated earlier and not discussed in the previous review. CONCLUSIONS The authors propose that cerebral CMs with a diameter ≥ 3 cm be defined as GCCMs on the basis of the inflection point for functional and neurological outcomes. This definition is in line with the definitions for other giant lesions. It is less exclusive than earlier definitions but captures the rarity of these lesions (approximately 1% incidence) and variation in outcomes. GCCMs remain operable with potentially favorable outcomes. The term "giant" is not meant to deter or contraindicate surgery.

Intramedullary spinal cord cavernous malformations (SCCMs) account for only 5% of overall cavernous malformations (CMs). The occurrence of recurrent or residual SCCMs has not been well discussed, nor have the technical nuances of resection.To assess the characteristics of residual SCCMs and surgical outcomes and describe the techniques to avoid leaving lesion remnants during primary resection.Demographic, radiologic, intraoperative findings and surgical outcomes data for a cohort of surgically managed intramedullary SCCMs were obtained from an institutional database and retrospectively analyzed. A systematic literature review was performed using PRISMA guidelines.Of 146 SCCM resections identified, 17 were for residual lesions (12%). Patients with residuals included 13 men and 4 women, with a mean age of 43 years (range 16-70). All patients with residual SCCMs had symptomatic presentations: sensory deficits, paraparesis, spasticity, and pain. Residuals occurred between 3 and 264 months after initial resection. Approaches for 136 cases included posterior midline myelotomy (28.7%, n = 39), pial surface entry (37.5%, n = 51), dorsal root entry zone (27.9%, n = 38), and lateral entry (5.9%, n = 8). Follow-up outcomes were similar for patients with primary and residual lesions, with the majority having no change in modified Rankin Scale score (63% [59/93] vs 75% [9/12], respectively, P = .98).SCCMs may cause significant symptoms. During primary resection, care should be taken to avoid leaving residual lesion remnants, which can lead to future hemorrhagic events and neurological morbidity. However, satisfactory results are achievable even with secondary or tertiary resections.

A sense of community is important in encouraging people to contribute to a variety of causes and the communities that support them. Researchers have identified website design features that can engender a sense of community on sites to promote contributions. However, most findings about design features are based on observational empirical research testing single features at a time or on standard practice and rarely use integrated theories to provide rationale for their design suggestions. This work investigates ways to re-design an entire website---with a simulated medical crowdfunding interface entitled Community Journey---informed by Sense of Community Theory to increase site visitors' sense of community and contributions. A between-subjects experiment revealed that the Community Journey interface increased potential supporters' sense of community and their overall willingness to contribute via monetary donations, campaign shares, personal messages, and offline support. Think-aloud interviews identified the interface features responsible for the overall increase in willingness to contribute. Finally, we suggest theory driven design implications for creating websites to build a strong support community and to encourage various contributions.

Headlines play a critical role in how users perceive articles. But many headline publishers craft headlines in ways that either attract clicks in an attempt to earn ad revenue, or misinform users or manipulate their opinions for malicious intents. Such headlines can do harm since many users simply skim and share headlines without reading the articles in full. We present an exploratory browser extension that empowers users to suggest headlines they deem better for news articles. Users can view headlines suggested by other users that they follow as they browse websites. We conducted a study of 27 users who used the extension for one week to read news and suggest headlines. We found that users saw value in the tool and used it to change headlines that they found in need of improvement. We characterize the changes that people make to headlines if enabled. We also report on a followup study we conducted with 312 participants to evaluate headlines suggested by the tool. The purpose of the study was to examine whether headlines suggested by untrained users could be preferred over original headlines by professional editors. We found that a substantial number of the suggested headlines were indeed preferred. Our work explores the designs for, and opportunities and consequences of, empowering news consumers by giving them control over the content curation process.

Dural arteriovenous fistulas (dAVFs) located at craniocervical junction are extremely rare (1%-2% of intracranial/spinal dAVFs). Their angio-architectural complexity renders endovascular embolization to be challenging given multiple small feeders with risk of embolysate reflux into vertebral artery and limited transvenous access. The available literature discussing microsurgery for these lesions is limited to few case reports.To report a multicenter experience assessing microsurgery safety/efficacy.Prospectively maintained registries at 13 North American centers were queried to identify craniocervical junction dAVFs treated with microsurgery (2006-2021).Thirty-eight patients (median age 59.5 years, 44.7% female patients) were included. The most common presentation was subarachnoid/intracranial hemorrhage (47.4%) and myelopathy (36.8%) (92.1% of lesions Cognard type III-V). Direct meningeal branches from V3/4 vertebral artery segments supplied 84.2% of lesions. All lesions failed (n = 5, 13.2%) or were deemed inaccessible/unsafe to endovascular treatment. Far lateral craniotomy was the most used approach (94.7%). Intraoperative angiogram was performed in 39.5% of the cases, with angiographic cure in 94.7% of cases (median imaging follow-up of 9.2 months) and retreatment rate of 5.3%. Favorable last follow-up modified Rankin Scale of 0 to 2 was recorded in 81.6% of the patients with procedural complications of 2.6%.Craniocervical dAVFs represent rare entity of lesions presenting most commonly with hemorrhage or myelopathy because of venous congestion. Microsurgery using a far lateral approach provides robust exposure and visualization for these lesions and allows obliteration of the arterialized draining vein intradurally as close as possible to the fistula point. This approach was associated with a high rate of angiographic cure and favorable clinical outcomes.

OBJECTIVE Vertebrobasilar dissecting (VBD) aneurysms are rare, and patients with these aneurysms often present with thromboembolic infarcts or subarachnoid hemorrhage (SAH). The morphological nature of VBD aneurysms often precludes conventional clip reconstruction or coil placement and encourages parent artery exclusion or endovascular stenting. Treatment considerations include aneurysm location along the vertebral artery (VA), the involvement of the posterior inferior cerebellar artery (PICA), and collateral blood flow. Outcomes after endovascular treatment have been well described in the neurosurgical literature, but microsurgical outcomes have not been detailed. Patient outcomes from a large, single-surgeon, consecutive series of microsurgically managed VBD aneurysms are presented, and 3 illustrative case examples are provided. METHODS The medical records of patients with dissecting aneurysms affecting the intracranial VA (V4), basilar artery, and PICA that were treated microsurgically over a 19-year period were reviewed. Patient demographics, aneurysm characteristics, surgical procedures, and clinical outcomes (according to modified Rankin Scale [mRS] scores at last follow-up) were analyzed. RESULTS Forty-two patients with 42 VBD aneurysms were identified. Twenty-six aneurysms (62%) involved the PICA, 14 (33%) were distinct from the PICA origin on the V4 segment of the VA, and 2 (5%) were located at the vertebrobasilar junction. Thirty-four patients (81%) presented with SAH with a mean Hunt and Hess grade of 3.2 at presentation. Six (14%) of the 42 patients had been previously treated using endovascular techniques. Nineteen aneurysms (45%) underwent clip wrapping, 17 (40%) were treated with bypass trapping, and 6 (14%) underwent parent artery sacrifice. The complete aneurysm obliteration rate was 95% (n = 40), and the surgical complication rate was 7% (n = 3). The 8 patients with unruptured VBD aneurysms were significantly more likely to be discharged home (n = 6, 75%) compared with 34 patients with ruptured aneurysms (n = 9, 27%; p = 0.01). Good outcomes (mRS score ≤ 2) were observed in 20 patients (48%). Eight patients (19%) died. CONCLUSIONS These data demonstrate that patients with VBD aneurysms often present after a rupture in poor neurological condition, but favorable results can be achieved with open microsurgical repair in almost half of such cases. Microsurgery remains a viable treatment option, with the choice between bypass trapping and clip wrapping largely dictated by the specific location of the aneurysm and its relationship to the PICA.

The benefit of antenatal corticosteroid (ACS) administration for the prevention of neonatal morbidity and mortality has been well described for preterm infants. Some studies have demonstrated a benefit for infants born by elective caesarean section (CS) at late preterm or term gestations. However, the neonatal benefits of ACS are not well described when given to pregnant women with diabetes.The aim of this study was to evaluate the neonatal outcomes following ACS administration in women with pre-gestational diabetes mellitus (PGDM) when administered prior to elective CS after 36 weeks gestation.This retrospective observational study included all women with PGDM who gave birth by elective CS between 36Of the 306 women identified, 65 (21.2%) were exposed to ACS within seven days prior to birth and 241 (78.8%) were not. Although not statistically significant, ACS-exposed infants born prior to 38This study did not demonstrate any statistically significant beneficial or harmful effects of ACS in neonates of women with PGDM who are born by elective CS. While it is plausible that ACS could reduce neonatal respiratory morbidity in this population, further prospective studies evaluating the benefits and harms are required before recommending this practice.

In specialized neurosurgical centers, open microsurgery is routinely performed for aneurysmal subarachnoid hemorrhage (aSAH).To compare the cost of endovascular vs microsurgical treatment for aSAH at a single quaternary center.All patients undergoing aSAH treatment from July 1, 2014, to July 31, 2019, were retrospectively reviewed. Patients were grouped based on primary treatment (microsurgery vs endovascular treatment). The primary outcome was the difference in total cost (including hospital, discharge facility, and all follow-up) using a propensity-adjusted analysis.Of 384 patients treated for an aSAH, 234 (61%) were microsurgically treated and 150 (39%) were endovascularly treated. The mean cost of index hospitalization for these patients was marginally higher ($9504) for endovascularly treated patients ($103 980) than for microsurgically treated patients ($94 476) ( P = .047). For the subset of patients with follow-up data available, the mean total cost was $45 040 higher for endovascularly treated patients ($159 406, n = 59) than that for microsurgically treated patients ($114 366, n = 105) ( P.001). After propensity scoring (adjusted for age, sex, comorbidities, Glasgow Coma Scale score, Hunt and Hess grade, Fisher grade, aneurysms, and type/size/location), linear regression analysis of patients with follow-up data available revealed that microsurgery was independently associated with healthcare costs that were $37 244 less than endovascular treatment costs ( P.001). An itemized cost analysis suggested that this discrepancy was due to differences in the rates of aneurysm retreatment and long-term surveillance.Microsurgical treatment for aSAH is associated with lower total healthcare costs than endovascular therapy. Aneurysm surveillance after endovascular treatments, retreatment, and device costs warrants attention in future studies.

Data visualization is the primary means by which data analysts explore patterns, trends, and insights in their data. Unfortunately, existing visual analytics tools offer limited expressiveness and scalability when it comes to searching for visualizations over large datasets, making visual data exploration labor-intensive and time-consuming. In this work, we introduce the problem of visualization search and highlight two underlying challenges of search enumeration and visualization matching. To address them, we first present our work on Zenvisage that helps enumerate large collections of visualizations and supports simple visualization matching with the help of an interactive interface and an expressive visualization query language. For more finegrained and flexible visualization matching, including search for underspecified and approximate patterns, we extend Zenvisage to develop ShapeSearch. ShapeSearch supports a novel shape querying algebra that helps express a large class of pattern queries that are hard to specify with existing systems. ShapeSearch exposes multiple specification mechanisms: sketch, natural-language, and visual regular expressions that help users easily issue shape queries, while applying query-aware and perceptually-aware optimizations to efficiently execute them within interactive response times. To conclude, we discuss a number of open research problems to further improve the usability and performance of both Zenvisage and ShapeSearch.

Interrupted Time Series (ITS) are a type of nonrandomized design commonly used to evaluate public health policy interventions, and the impact of exposures, at the population level. Meta-analysis may be used to combine results from ITS across studies (in the context of systematic reviews) or across sites within the same study. We aimed to examine the statistical approaches, methods, and completeness of reporting in reviews that meta-analyze results from ITS.Eight electronic databases were searched to identify reviews (published 2000-2019) that meta-analyzed at least two ITS. Characteristics of the included reviews, the statistical methods used to analyze the ITS and meta-analyze their results, effect measures, and risk of bias assessment tools were extracted.Of the 4213 identified records, 54 reviews were included. Nearly all reviews (94%) used two-stage meta-analysis, most commonly fitting a random effects model (69%). Among the 41 reviews that re-analyzed the ITS, linear regression (39%) and ARIMA (20%) were most commonly used; 38% adjusted for autocorrelation. The most common effect measure meta-analyzed was an immediate level-change (46/54). Reporting of the statistical methods and ITS characteristics was often incomplete.Improvement is needed in the conduct and reporting of reviews that meta-analyze results from ITS.

How do power dynamics and value conflicts affect our ability to design and maintain socio-technical algorithmic processes? In this paper, we study the SIGCHI student volunteer (SV) selection process that uses a weighted semi-randomized algorithm to recruit a desired pool of volunteers. Our interviews with the community members showed that the process is complex and socio-technical; the algorithm's outputs are interpreted and adjusted by the conference organizers to reflect the community values while ensuring the selection of effective volunteers to help with organizing the conference. This provides a stage in which the power dynamics and value conflicts among the stakeholders play salient roles in determining how the process was perceived and envisioned. For instance, non-organizers of the conference found the algorithm used in the selection process to be a power-balancer that places a check on the organizers who oversee the process. However, even with a participatory process to elicit the algorithm's weights, the power dynamics and value conflicts between the participants made it difficult to reach a consensus on what the SV selection process should consider and prioritize. Our findings highlight the importance of value transparency -- the type of transparency that focuses on explaining why a decision was made rather than how it was made -- as a mechanism for resolving such conflicts. Based on our findings, we lay out design recommendations that can guide communities to better design and maintain algorithmic socio-technical processes over time in the face of power dynamics and value conflicts.

With the increasing adoption of smart home devices, users rely on device automation to control their homes. This automation commonly comes in the form of smart home routines, an abstraction available via major vendors. Yet, questions remain about how a system should best handle conflicts in which different routines access the same devices simultaneously. In particular---among the myriad ways a smart home system could handle conflicts, which of them are currently utilized by existing systems, and which ones result in the highest user satisfaction? We investigate the first question via a survey of existing literature and find a set of conditions, modifications, and system strategies related to handling conflicts. We answer the second question via a scenario-based Mechanical-Turk survey of users interested in owning smart home devices and current smart home device owners (N=197). We find that: (i) there is no context-agnostic strategy that always results in high user satisfaction, and (ii) users' personal values frequently form the basis for shaping their expectations of how routines should execute.

Background Operating microscopes and adjunctive technologies are continually refined to advance microneurosurgical care. How frequently these advances are used is unknown. In the present study, we assessed the international adoption of microneurosurgical technologies and discussed their value. Methods A 27-question electronic survey was distributed to cerebrovascular neurosurgeon members of U.S., European, and North American neurosurgical societies and social media networks of cerebrovascular and skull base neurosurgeons. The survey encompassed the surgeons' training background, surgical preferences, and standard microneurosurgical practices. Results Of the respondents, 56% (53 of 95) were attendings, 74% (70 of 95) were in their first 10 years of practice, and 67% (63 of 94) practiced at an academic teaching hospital. Vascular, endovascular, and skull base fellowships had been completed by 38% (36 of 95), 27% (26 of 95), and 32% (30 of 95) of the respondents, respectively. Most respondents did not use an exoscope (78%; 73 of 94), a mouthpiece (61%; 58 of 95), or foot pedals (56%; 55 of 94). All 95 respondents used a microscope, and 71 (75%) used Zeiss microscopes. Overall, 57 neurosurgeons (60%) used indocyanine green for aneurysms (n = 54), arteriovenous malformations (n = 43), and dural arteriovenous fistulas (n = 42). Most (80%; 75 of 94) did not use fluorescence. The respondents with a vascular-focused practice more commonly used indocyanine green, Yellow 560 fluorescence, and intraoperative 2-dimensional digital subtraction angiography. The respondents with a skull base–focused practice more commonly used foot pedals and an endoscope-assist device. Conclusions The results from the present survey have characterized the current adoption of operative microscopes and adjunctive technologies in microneurosurgery. Despite numerous innovations to improve the symbiosis between neurosurgeon and microscope, their adoption has been underwhelming. Future advances are essential to improve surgical outcomes.

Background The Interrupted Time Series (ITS) is a robust design for evaluating public health and policy interventions or exposures when randomisation is infeasible. Several statistical methods are available for the analysis and meta-analysis of ITS studies. We sought to empirically compare available methods when applied to real-world ITS data. Methods We sourced ITS data from published meta-analyses to create an online data repository. Each dataset was re-analysed using two ITS estimation methods. The level- and slope-change effect estimates (and standard errors) were calculated and combined using fixed-effect and four random-effects meta-analysis methods. We examined differences in meta-analytic level- and slope-change estimates, their 95% confidence intervals, p-values, and estimates of heterogeneity across the statistical methods. Results Of 40 eligible meta-analyses, data from 17 meta-analyses including 283 ITS studies were obtained and analysed. We found that on average, the meta-analytic effect estimates, their standard errors and between-study variances were not sensitive to meta-analysis method choice, irrespective of the ITS analysis method. However, confidence interval widths and p-values for the meta-analytic effect estimates varied depending on the choice of confidence interval method and ITS analysis method. Conclusions The meta-analysis effect estimates, their standard errors and between-study variance estimates were minimally impacted by ITS analysis and meta-analysis method choice. However, the confidence interval widths and p-values could vary according to the statistical method, which may impact interpretations and conclusions of a meta-analysis. This empirical study, in conjunction with evidence from numerical simulation, allows for a more complete understanding of which methods should be used in different scenarios.

Informed consent is a core cornerstone of ethics in human subject research. Through the informed consent process, participants learn about the study procedure, benefits, risks, and more to make an informed decision. However, recent studies showed that current practices might lead to uninformed decisions and expose participants to unknown risks, especially in online studies. Without the researcher's presence and guidance, online participants must read a lengthy form on their own with no answers to their questions. In this paper, we examined the role of an AI-powered chatbot in improving informed consent online. By comparing the chatbot with form-based interaction, we found the chatbot improved consent form reading, promoted participants' feelings of agency, and closed the power gap between the participant and the researcher. Our exploratory analysis further revealed the altered power dynamic might eventually benefit study response quality. We discussed design implications for creating AI-powered chatbots to offer effective informed consent in broader settings., Comment: Accepted by CHI 2023

Content moderation systems for social media have had numerous issues of bias, in terms of race, gender, and ability among many others. One proposal for addressing such issues in automated decision making is by designing for contestability, whereby users can shape and influence how decisions are made. In this study, we conduct a series of participatory design workshops with participants from communities that have experienced problems with social media content moderation in the past. Together with participants, we explore the idea of designing for contestability in content moderation and find that users' designs suggest three fruitful, practical avenues: adding representation, improving communication, and designing with compassion. We conclude with design recommendations drawn from participants' proposals, and reflect on the challenges that remain.

BackgroundRuptured anterior communicating artery (ACoA) aneurysms can be challenging to treat via an endovascular procedure. This study analyzed retreatment rates and neurological outcomes associated with ruptured ACoA aneurysms treated via endovascular coiling.MethodsAll patients with a ruptured ACoA aneurysm treated with endovascular coiling from 2003 to 2019 were retrospectively analyzed at a single center. Two comparisons were performed: no retreatment versus retreatment and coil embolization versus balloon-assisted coil embolization. Outcomes included retreatment and neurological outcome assessed via modified Rankin Scale (mRS).ResultsDuring the study period, 186 patients with ruptured ACoA aneurysms underwent coil embolization. Treatment included standard coil embolization (68.3%, n=127), balloon-assisted coiling (28.5%, n=53), and stent-assisted embolization (2.7%, n=5). Angiographic outcomes were as follows: class I, 65.1% (n=121); class II, 28.5% (n=53); and class III, 6.5% (n=12). There were no aneurysm reruptures after the index procedure. The mean (SD) mRS score was 2.7 (2.0) at last follow-up (mortality, 19 (10%)). Retreatment occurred in 9.7% (n=18). Patients with retreatment were younger with lower-grade subarachnoid hemorrhage and more favorable functional status at discharge. Patients with aneurysms >7 mm (n=36) were significantly more likely to have recurrence (22.2% vs 6.7%, P=0.005).ConclusionsEndovascular treatment of ruptured ACoA aneurysms is safe and is associated with low mortality and retreatment rates. Younger patients with favorable functional status and larger aneurysm size are more likely to be retreated. Ruptured aneurysms

BACKGROUND Patients with intraventricular hemorrhage (IVH) are at higher risk of hydrocephalus requiring an external ventricular drain and long-term ventriculoperitoneal shunt placement. OBJECTIVE To investigate whether intraventricular tissue plasminogen activator (tPA) administration in patients with ventricular casting due to IVH reduces shunt dependence. METHODS Patients from the Post-Barrow Ruptured Aneurysm Trial (PBRAT) database treated for aneurysmal subarachnoid hemorrhage (aSAH) from August 1, 2010, to July 31, 2019, were retrospectively reviewed. Patients with and without IVH were compared. A second analysis compared IVH patients with and without ventricular casting. A third analysis compared patients with ventricular casting with and without intraventricular tPA treatment. The primary outcome was chronic hydrocephalus requiring permanent shunt placement. RESULTS Of 806 patients hospitalized with aSAH, 561 (69.6%) had IVH. IVH was associated with a higher incidence of shunt placement (25.7% vs 4.1%, P

BackgroundInterrupted time series (ITS) are often meta-analysed to inform public health and policy decisions but examination of the statistical methods for ITS analysis and meta-analysis in this context is limited.MethodsWe simulated meta-analyses of ITS studies with continuous outcome data, analysed the studies using segmented linear regression with two estimation methods [ordinary least squares (OLS) and restricted maximum likelihood (REML)], and meta-analysed the immediate level- and slope-change effect estimates using fixed-effect and (multiple) random-effects meta-analysis methods. Simulation design parameters included varying series length; magnitude of lag-1 autocorrelation; magnitude of level- and slope-changes; number of included studies; and, effect size heterogeneity.ResultsAll meta-analysis methods yielded unbiased estimates of the interruption effects. All random effects meta-analysis methods yielded coverage close to the nominal level, irrespective of the ITS analysis method used and other design parameters. However, heterogeneity was frequently overestimated in scenarios where the ITS study standard errors were underestimated, which occurred for short series or when the ITS analysis method did not appropriately account for autocorrelation.ConclusionsThe performance of meta-analysis methods depends on the design and analysis of the included ITS studies. Although all random effects methods performed well in terms of coverage, irrespective of the ITS analysis method, we recommend the use of effect estimates calculated from ITS methods that adjust for autocorrelation when possible. Doing so will likely to lead to more accurate estimates of the heterogeneity variance.

Many factors influence an author's choice for journal submission, including journal impact factor and publication speed. These and other bibliometric data points have not been assessed in journals dedicated to neurosurgery.Eight leading neurosurgery journals were analyzed to identify original articles and reviews, collected via randomized, stratified sampling per published issue per year from 2016 to 2020. Bibliometric data on publication speed were gathered for each article. Journal impact factor, article processing fees, and open access availability were determined using Clarivate Journal Citation Reports. Correlation analysis and a linear regression model were used to estimate the effect of impact factor and publication year on publication speed.Across 8 neurosurgery journals, 1617 published articles were reviewed. The mean (standard deviation) time from submission to acceptance was 131 (101) days, from acceptance to online publication was 77 (61) days, and from submission to online publication was 207 (123) days. Higher impact factors correlated with longer publication times for all metrics. Later years of publication correlated with longer times from submission to acceptance and submission to online publication. For each point increase in a journal's impact factor, multivariate regression modeling estimated a 19.2-day increase in time from submission to acceptance, a 19.7-day increase in time from acceptance to online publication, and a 38.9-day increase in time from submission to online publication (p0.001 for all).Publication speeds vary widely among neurosurgery journals and appear to be associated with the journal impact factor. Time to publication increased over the study period.

Previously, we reviewed 1052 randomized-controlled trial abstracts presented at the American Society of Anesthesiologists annual meetings from 2001–2004. We found significant positive publication bias in the period examined, with the odds ratio for abstracts with positive results proceeding to journal publication over those with null results being 2.01 [95% confidence interval: 1.52, 2.66; P < 0.001]. Mandatory trial registration was introduced in 2005 as a required standard for publication. We sought to examine whether mandatory trial registration has decreased publication bias in the anesthesia and perioperative medicine literature. We reviewed all abstracts from the 2010–2016 American Society of Anesthesiologists meetings that reported on randomized-controlled trials in humans. We scored the result of each abstract as positive or null according to a priori definitions. We systematically searched for any subsequent publication of the studies and calculated the odds ratio for journal publication, comparing positive vs null studies. We compared the odds ratio from the 2010–2016 abstracts (post-mandatory trial registration) with the odds ratio from the 2001–2004 abstracts (pre-mandatory trial registration) as a ratio of odds ratios. We defined a 33% decrease in the odds ratio as significant, corresponding to a new odds ratio of 1.33. We reviewed 9789 abstracts; 1049 met inclusion criteria as randomized-controlled trials, with 542 (51.7%) of the abstracts going on to publication. The odds ratio for abstracts with positive results proceeding to journal publication was 1.28 [95% CI: 0.97, 1.67; P = 0.076]. With adjustment for sample size and abstract quality, the difference in publication rate between positive and null abstracts was statistically significant (odds ratio 1.34; 95% CI: 1.02, 1.76; P = 0.037). The ratio of odds ratios, comparing the odds ratio from the 2010–2016 abstracts (post-mandatory trial registration) to the odds ratio from the 2001–2004 abstracts (pre-mandatory trial registration), was 0.63 (95% CI: 0.43, 0.93); P = 0.021). We present the first study in the anesthesia and perioperative medicine literature that examines and compares publication bias over two discrete periods of time, prior to and after the implementation of mandatory trial registration. Our results suggest that the amount of publication bias has decreased markedly following implementation of mandatory trial registration. However, some positive publication bias in the anesthesia and perioperative medicine literature remains.

Data visualization is the primary means by which data analysts explore patterns, trends, and insights in their data. Unfortunately, existing visual analytics tools offer limited expressiveness and scalability when it comes to searching for visualizations over large datasets, making visual data exploration labor-intensive and timeconsuming. We first discuss our prior work on Zenvisage that helps accelerate exploratory data analysis via an interactive interface and an expressive visualization query language, but offers limited flexibility when the pattern of interest is under-specified and approximate. Motivated from our findings from Zenvisage, we develop ShapeSearch, an efficient and flexible pattern-searching tool that enables the search for desired patterns via multiple mechanisms: sketch, natural-language, and visual regular expressions. ShapeSearch leverages a novel shape querying algebra that can express a large class of shape queries and supports query-aware and perceptually-aware optimizations to execute shape queries within interactive response times. To further improve the usability and performance of both Zenvisage and ShapeSearch, we discuss a number of open research problems.

BackgroundComorbid depression is prevalent in people with multiple sclerosis (MS). Depression is commonly untreated or undertreated, thus, there is a need for effective and safe interventions and current guidelines recommend psychological and pharmaceutical interventions for people with MS. However, research suggests that other interventions, such as exercise, could also be effective. The comparative efficacy and safety of intervention modalities have not been quantified.We plan to conduct a systematic review and network meta-analysis to compare efficacy and safety of psychological, pharmaceutical, physical and magnetic stimulation interventions for depression in people with MS.Methods and analysisWe will search EMBASE, Medline, Cochrane CENTRAL, APA PsycINFO, Web of Science, CINAHL and PEDro from inception to 31 December 2021. Search terms will stem from three concepts: MS, depression and randomised controlled trials. Included studies will be randomised controlled trials, where participants are people with MS randomised to receive one of the aforementioned intervention types, and depression or depressive symptoms is the primary outcome, only outcome or secondary outcome with an a priori power calculation. Screening, data extraction and risk of bias assessment (using the Risk of Bias 2 tool) will be conducted independently by two reviewers. If possible, we will synthesise the evidence by fitting a frequentist network meta-analysis model with multivariate random effects, or a pairwise random-effects meta-analysis model. For each model, efficacy will be measured using a standardised mean difference, and safety using an OR. We plan to provide summary measures including forest plots, a geometry of the network, surface under the cumulative ranking curve, and a league table, and perform subgroup analyses. Otherwise, a narrative review will be provided.Ethics and disseminationEthics is not required for a systematic review and network meta-analysis. Results will be published in a peer reviewed journal.PROSPERO registration numberCRD42020209803.

Surveys are a common instrument to gauge self-reported opinions from the crowd for scholars in the CSCW community, the social sciences, and many other research areas. Researchers often use surveys to prioritize a subset of given options when there are resource constraints. Over the past century, researchers have developed a wide range of surveying techniques, including one of the most popular instruments, the Likert ordinal scale, to elicit individual preferences. However, the challenge to elicit accurate and rich self-reported responses with surveys in a resource-constrained context still persists today. In this study, we examine Quadratic Voting (QV), a voting mechanism powered by the affordances of a modern computer and straddles ratings and rankings approaches, as an alternative online survey technique. We argue that QV could elicit more accurate self-reported responses compared to the Likert scale when the goal is to understand relative preferences under resource constraints. We conducted two randomized controlled experiments on Amazon Mechanical Turk, one in the context of public opinion polling and the other in a human-computer interaction user study. Based on our Bayesian analysis results, a QV survey with a sufficient amount of voice credits, aligned significantly closer to participants' incentive-compatible behaviors than a Likert scale survey, with a medium to high effect size. In addition, we extended QV's application scenario from typical public policy and education research to a problem setting familiar to the CSCW community: a prototypical HCI user study. Our experiment results, QV survey design, and QV interface serve as a stepping stone for CSCW researchers to further explore this surveying methodology in their studies and encourage decision-makers from other communities to consider QV as a promising alternative.

Spreadsheet systems are by far the most popular platform for data exploration on the planet, supporting millions of rows of data. However, exploring spreadsheets that are this large via operations such as scrolling or issuing formulae can be overwhelming and error-prone. Users easily lose context and suffer from cognitive and mechanical burdens while issuing formulae on data spanning multiple screens. To address these challenges, we introduce dynamic hierarchical overviews that are embedded alongside spreadsheets. Users can employ this overview to explore the data at various granularities, zooming in and out of the spreadsheet. They can issue formulae over data subsets without cumbersome scrolling or range selection, enabling users to gain a high or low-level perspective of the spreadsheet. An implementation of our dynamic hierarchical overview, NOAH, integrated within DataSpread, preserves spreadsheet semantics and look and feel, while introducing such enhancements. Our user studies demonstrate that NOAH makes it more intuitive, easier, and faster to navigate spreadsheet data compared to traditional spreadsheets like Microsoft Excel and spreadsheet plug-ins like Pivot Table, for a variety of exploration tasks; participants made fewer mistakes in NOAH while being faster in completing the tasks.

Background: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens. We aimed to quantify the mediating effects of adiponectin (anti-inflammatory adipocytokine); IL6, IL1-receptor antagonist, TNF receptor 1 and 2, and C-reactive protein (inflammatory status biomarkers); C-peptide (hyperinsulinemia biomarker); and free estradiol and estrone (estrogen biomarkers) in the adiposity–endometrial cancer link in postmenopausal women. Methods: We used data from a case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). Eligible women did not have cancer, hysterectomy, and diabetes; did not use oral contraceptives or hormone therapy; and were postmenopausal at recruitment. Mediating pathways from adiposity to endometrial cancer were investigated by estimating natural indirect (NIE) and direct (NDE) effects using sequential mediation analysis. Results: The study included 163 cases and 306 controls. The adjusted OR for endometrial cancer for body mass index (BMI) ≥30 versus ≥18.5− Conclusions: Reduced adiponectin and increased inflammatory biomarkers, C-peptide, and estrogens mediated approximately 70% of increased odds of endometrial cancer in women with obesity versus normal weight. Impact: If replicated, these results could have implications for identifying targets for intervention to reduce endometrial cancer risk in women with obesity.

Current teacher preparation programs have received scrutiny for failing to sufficiently support teachers in valuing and developing their knowledge of data literacy. The current study explores a col...

Background Plasmodium vivax forms dormant liver stages that can reactivate weeks or months following an acute infection. Recurrent infections are often associated with a febrile illness and can cause a cumulative risk of severe anaemia, direct and indirect mortality, and onward transmission of the parasite. There is an increased risk of P. vivax parasitaemia following falciparum malaria suggesting a rationale for universal use of radically curative treatment in patients with P. falciparum malaria even in the absence of detectable P. vivax parasitaemia in areas that are co-endemic for both species. Methods This is a multicentre, health care facility-based, randomized, controlled, open-label trial in Bangladesh, Indonesia and Ethiopia. Patients with uncomplicated falciparum malaria, G6PD activity of ≥70% of the adjusted male median (AMM) and haemoglobin levels ≥8g/dl are recruited into the study and randomized to either receive standard schizonticidal treatment plus 7-day high dose primaquine (total dose 7mg/kg) or standard care in a 1:1 ratio. Patients are followed up weekly until day 63. The primary endpoint is the incidence risk of any P. vivax parasitemia on day 63. Secondary endpoints include incidence risk on day 63 of symptomatic P. vivax malaria and the risk of any P. falciparum parasitaemia. Secondary safety outcomes include the proportion of adverse events and serious adverse events, the incidence risk of severe anaemia (Hb Discussion This study evaluates the potential benefit of a universal radical cure for both P. vivax and P. falciparum in different endemic locations. If found safe and effective universal radical cure could represent a cost-effective approach to clear otherwise unrecognised P. vivax infections and hence accelerate P. vivax elimination. Trial registration NCT03916003. Registered on 12 April 2019.

Aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to primary stroke centers are often transferred to neurosurgical and endovascular services at tertiary centers. The effect on microsurgical outcomes of the resultant delay in treatment is unknown. We evaluated microsurgical aSAH treatment 72 h after the ictus.All aSAH patients treated at a single tertiary center between August 1, 2007, and July 31, 2019, were retrospectively reviewed. The additional inclusion criterion was the availability of treatment data relative to time of bleed. Patients were grouped based on bleed-to-treatment time as having acute treatment (on or before postbleed day [PBD] 3) or delayed treatment (on or after PBD 4). Propensity adjustments were used to correct for statistically significant confounding covariables.Among 956 aSAH patients, 92 (10%) received delayed surgical treatment (delayed group), and 864 (90%) received acute endovascular or surgical treatment (acute group). Reruptures occurred in 3% (26/864) of the acute group and 1% (1/92) of the delayed group (p = 0.51). After propensity adjustments, the odds of residual aneurysm (OR = 0.09; 95% CI = 0.04-0.17; p 0.001) or retreatment (OR = 0.14; 95% CI = 0.06-0.29; p 0.001) was significantly lower among the delayed group. The OR was 0.50 for rerupture, after propensity adjustments, in the delayed setting (p = 0.03). Mean Glasgow Coma Scale scores at admission in the acute and delayed groups were 11.5 and 13.2, respectively (p 0.001).Delayed microsurgical management of aSAH, if required for definitive treatment, appeared to be noninferior with respect to retreatment, residual, and rerupture events in our cohort after adjusting for initial disease severity and significant confounding variables.

OBJECTIVE The objective of this paper was to assess applications of the supratentorial-infraoccipital (STIO) approach for cerebrovascular neurosurgery. METHODS The authors conducted a cohort study of all consecutive cases in which the STIO approach was used during the study period, December 1995 to January 2021, as well as a systematic review of the literature. RESULTS Twenty-five cerebrovascular cases were identified in which the STIO approach was used. Diagnoses included arteriovenous malformation (n = 15), cerebral cavernous malformation (n = 5), arteriovenous fistula (n = 4), and aneurysm (n = 1). The arteriovenous malformations consisted of Spetzler-Martin grade II (n = 3), grade III (n = 8), and grade IV (n = 4) lesions. Lesion locations included the occipital lobe (n = 15), followed by the tentorial dural (n = 4), temporal-occipital (n = 3), temporal (n = 1), thalamic (n = 1), and quadrigeminal cistern (n = 1) regions. Many patients (75%) experienced transient visual deficits attributable to retraction of the occipital lobe, all of which resolved. As of last follow-up (n = 12), modified Rankin Scale scores had improved for 6 patients and were unchanged for 6 patients compared with the preoperative baseline. CONCLUSIONS The STIO approach is a safe and effective skull base approach that provides a specialized access corridor for appropriately selected cerebrovascular lesions.