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3. Contributors

Author

Muhammad Aamir, K. Abhitha, Bilal Ahmad, Javeed Akhtar, Mehvish Ashiq, Sukesh Kumar Bajire, Kiran Bala, Hamed Barabadi, Ajit Behera, Madhulika Bhagat, Iman Khosravi Bigdeli, Negar Bozorgchami, Lorena Cornejo-Ponce, Vibha Devi, V. Devika, Abhishek S. Dhoble, A. Geetha, Abdul Ghaffar, Sougata Ghosh, Nellaiah Hariharan, Uzma Jabeen, Muhammad Jahangeer, Honey John, Renjith P. Johnson, Kuruvilla Joseph, Sherin Joseph, Kamyar Jounaki, Aditya Kumar, Preeti Kumari, Jeetesh Kushwaha, Meegle S. Mathew, Shalini Mohan, Hamed Morad, Ebrahim Mostafavi, Bushra Munir, Lakshmanan Muthulakshmi, Ehsan Nazarzadeh Zare, Rekha Pachaiappan, Kailash Pati Pandey, Mukesh Pasupuleti, Anmiya Peter, Elaheh Pishgahzadeh, Madhumita Priyadarsini, Sarmad Ahmad Qamar, Vincent Femilaa Rajan, Jyoti Rani, Sandhya Sadanandan, Hina Sahar, Prakash Kumar Sahoo, Fatemeh Salimi, Sandesh G. Sanjeeva, Appukuttan Saritha, Bishwarup Sarkar, M. Rehan H. Shah Gilani, Rajesh P. Shastry, Yashpal Singh, Apurba Sinhamahapatra, M.M. Sreejaya, P.J. Sreelekshmi, null Srishti, Sabu Thomas, Sirikanjana Thongmee, Hossein Vahidi, Kushal Yadav, and Mahdi Yeganeh

Published
2023

8. List of contributors

Author

Amitabha Acharya, Katya M. Aguilar-Pérez, Bhavna Alke, V. Ananthi, T. Angelin Swetha, A. Arun, Govindan Balasubramani, Monisha Banerjee, Hamed Barabadi, Maitree Bhattacharyya, Thulasinathan Boobalan, Abhispa Bora, Ariel P. Brown, Abdullah Çağlar, Zafer Ceylan, David Medina Cruz, G.H. Dinesh, Debjani Dutta, Ramakrishnan Geethalakshmi, Muthusamy Govarthanan, R. Guru Raj Rao, Habsah Hasan, Selcuk Hazir, Omid Hosseini, Chaudhery Mustansar Hussain, Hafiz M.N. Iqbal, J. Jeyakanthan, Kamyar Jounaki, Stefan Jurga, N.S. Kumar, P. Kumar, Nazan Kutlu, Ali Kılıçer, Lalita Ledwani, GS Lekshmi, Barbara M. Maciejewska, Mohammad Ali Mahjoub, Jennifer R. McCall, Samuel H. McCall, Dora I. Medina, Raciye Meral, Dasmawati Mohamad, K. Mohanrasu, Hamed Morad, Ebrahim Mostafavi, Sudip Nag, Anamika Nayak, J. Nirgund, SR Nivaz, Ebenezer Samuel James Obeth, Roberto Parra-Saldivar, Shama Parveen, Elahe Pishgahzadeh, Arnab Pramanik, Arivalagan Pugazhendhi, K.N. Purana, R Hari Krishna Raj, R. Karthik Raja, Shiwani Randhawa, Gustavo Ruiz-Pulido, Salar Sadeghian-Abadi, Himanshi Saini, Muthupandian Saravanan, Kathryn T. Sausman, D. Selvakumar, Chandni Sharma, S. Sil, N.B. Singh, Abdul Razack Sirajunnisa, G. Sivaprakash, Duraiarasan Surendhiran, Usman Taqui Syed, Syed Noeman Taqui, Oktay Tomar, Linh B. Truong, Shareefraza J. Ukkund, Hossein Vahidi, Mohini Verma, Karolina Wieszczycka, and Marta Woźniak-Budych

Published
2022

9. Bioengineering of green-synthesized silver nanoparticles: In vitro physicochemical, antibacterial, biofilm inhibitory, anticoagulant, and antioxidant performance

Author

Niloufar Talank, Hamed Morad, Hamed Barabadi, Faraz Mojab, Salimeh Amidi, Farzad Kobarfard, Mohammad Ali Mahjoub, Kamyar Jounaki, Neda Mohammadi, Ghazal Salehi, Milad Ashrafizadeh, and Ebrahim Mostafavi

Subjects
Staphylococcus aureus, Silver, Plant Extracts, Biofilms, Spectroscopy, Fourier Transform Infrared, Anticoagulants, Metal Nanoparticles, Bioengineering, Microbial Sensitivity Tests, Antioxidants, Anti-Bacterial Agents, Analytical Chemistry
Abstract

Green-synthesized nanobiomaterials can be engineered as smart nanomedicine platforms for diagnostic and therapeutic purposes in medicine. Herein, we investigated the bioengineering of silver nanoparticles (AgNPs) and evaluated their physicochemical, antibacterial, biofilm inhibitory, anticoagulant, and antioxidant performance. Characterization of the AgNPs was performed utilizing UV-visible, transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR). The spherical shaped AgNPs were proven by TEM and SEM techniques. Moreover, the XRD diffraction patterns demonstrated that the nanoparticles were in a crystalline state. The DLS represented the hydrodynamic particle size of the NPs at 49.62 nm at a pH of 9. The calculated minimum inhibitory concentration (MIC) of AgNPs toward Staphylococcus aureus (ATCC 25923) was 8 μg mL

Published
2022

10. Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and non-invasive alternative approach to intravitreal injection for enhanced bacterial endophthalmitis management

Author

Kamyar Jounaki, Mostafa Feghhi, Behzad Sharif Makhmalzadeh, and Asghar Heidarian

Subjects
Drug, Drug Carriers, Endophthalmitis, Chemistry, media_common.quotation_subject, Cationic polymerization, Pharmaceutical Science, Lipids, medicine.anatomical_structure, In vivo, Vancomycin, Cornea, Drug delivery, Intravitreal Injections, medicine, Distribution (pharmacology), Animals, Particle size, Rabbits, media_common, medicine.drug, Biomedical engineering
Abstract

Vancomycin (VCM) is a drug of choice for treating infections caused by Staphylococcus species, reported being the most causative agent of bacterial endophthalmitis. However, the ocular bioavailability of topically applied VCM is low due to its high molecular weight and hydrophilicity. The current study sought to explore whether the nanostructured lipid carriers (NLCs) fabricated via cold homogenization technique could improve ocular penetration and prolong the ophthalmic residence of VCM. A 23 full factorial design was adopted to evaluate the influence of different process and formulation variables on VCM-loaded NLC formulae. The optimized formula with the particle size of 96.4 ± 0.71 nm and narrow size distribution showed spherical morphology obtained by AFM and represented sustained drug release up to 67% in 48 h fitted to the Korsmeyer-Peppas model with probably non-Fickian diffusion kinetic. FTIR studies visualized the drug-carrier interactions in great detail. High encapsulation of VCM (74.8 ± 4.3% w/w) in NLC has been established in DSC and PXRD analysis. The optimal positively charged (+ 29.7 ± 0.47 mV) colloidal dispersion was also stable for 12 weeks at both 4 °C and 25 °C. According to in vivo studies, incorporation of VCM in NLC resulted in a nearly 3-fold increase in the intravitreal concentration of VCM after eye-drop instillation over control groups. Besides, microbiological evaluation admitted its therapeutic effect within five days is comparable to intravitreal injection of VCM. Further, the optimized formula was found to be nonirritant and safe for ophthalmic administration in RBC hemolytic assay. Also, fluorescent tracking of NLCs on rabbit's cornea showed an increase in corneal penetration of nanoparticles. Thus, it is possible to infer that the evolved NLCs are promising drug delivery systems with superior attainments for enhanced Vancomycin ophthalmic delivery to the eye's posterior segment and improved bacterial endophthalmitis management.

Published
2021

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