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Rybachuk Ann V., Hbur Zoriana V., Zavada Oksana G., Krylova Irina I. Malignant neoplasms of the lips, oral cavity and pharynx – state of the problem. Journal of Education, Health and Sport. 2021;11(11):346-357. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.11.033 https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.11.033 https://zenodo.org/record/6412836 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.10.2021. Revised: 22.10.2021. Accepted: 30.11.2021. MALIGNANT NEOPLASMS OF THE LIPS, ORAL CAVITY AND PHARYNX – STATE OF THE PROBLEM Ann V. Rybachuk 1, Zoriana V. Hbur2, Oksana G. Zavada2, Irina I. Krylova2 1A. A. Bogomolets National Medical University, Kyiv, Ukraine; 2P. L. Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine A. Rybachuk - Candidate of Medical Sciences, Associate Professor. Department of oral and maxillofacial surgery Bogomolets National Medical University Ukraine, Kyiv, Ukraine; ORCID: 0000-0001-5306-5412 (A, D) Z. Hbur- Doctor of Sciences in Public Administration, Full Professor, Professor of the Department of Healthcare Management and Public Administration, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine; ORCID: 0000-0003-4536-2438 (B, D) O. Zavada - Head of the study room of the Department of Rocket Forces of the Faculty of Rocket Forces and Artillery, Petro Sahaidachny National Academy of Ground Forces Ukraine, Lviv, Ukraine; ORCID: 0000-0002-6296-5831 (C, E) I. Krylova – Doctor of Sciences in Public Administration, Lecturer of the Department of Healthcare Management and Public Administration, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine ORCID: 000-0003-2667-9245 (A, E, F) Abstract The aim: to consider the existing methods of diagnosis, clinical course and treatment of most common malignant tumors of soft tissues of maxillofacial area and oral cavity. Materials and methods. Method of economical analysis, method of system analysis, medical – statistical method, mathematical modeling method, information-analytical method. Results. Types and clinic of the most widespread tumors of the specified area are considered. The technique of examination at the specified pathology with use of auxiliary methods of diagnostics is described. The main methods of special treatment of cancer patients are mentioned. The clinical course of four stages of maxillofacial cancer was analyzed on the example of lip cancer. It is confirmed that morphological methods are the most informative of all currently available diagnostic tools and their brief description is given. Conclusions. Early diagnosis of malignant neoplasms, timely recognition and treatment of precancerous conditions against which cancer develops, is the main task of a general practitioner for the prevention of cancer. The dentist at the stage of planned rehabilitation of the oral cavity should pay attention to all changes in the mucous membrane. The formation of high-risk cancer groups and their in-depth examination can increase and detect precancerous diseases and malignant neoplasms in the early stages, which can serve as a real basis for the prevention of cancer of the maxillofacial region, oral mucosa, tongue and lips. Key words: clinical model and signs of oncological diseases; malignant neoplasms of the maxillofacial area; group of increased cancer risk.

Arterial pressure (in the carotid artery determined by electromanometry) and total peripheral resistance (changes in the clear space of resistive arteries of the mesenterium, skeletal muscles and mammary glands measured by biotelemicroscopy) were studied in tumor-bearing animals (random bred, BALB/c and CBA mice with Ehrlich carcinoma). With the growth of hypodermic injected tumor, it has been shown that the arterial pressure first dropped and then there was a tendency towards normalization, but the pressure never reached the initial level. At the same time arterial dilatation took place, especially at the first stage of tumor growth. This shows the dependence of changes in arterial pressure on the clear space of resistive arteries. It was also revealed that changes in the vascular tone were connected with the functional disturbances of adrenoactive structures but not with reduced myocyte contractility.