1. Renal distribution of Vasohibin-1 in patients with chronic kidney disease
- Author
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Hinamoto, Norikazu, Maeshima, Yohei, Saito, Daisuke, Yamasaki, Hiroko, Tanabe, Katsuyuki, Nasu, Tatsuyo, Watatani, Hiroyuki, Ujike, Haruyo, Kinomura, Masaru, Sugiyama, Hitoshi, Sonoda, Hikaru, Kanomata, Naoki, Sato, Yasufumi, and Makino, Hirofumi
- Subjects
Adult ,Male ,Cell Cycle Proteins ,Middle Aged ,urologic and male genital diseases ,Kidney ,VEGF-A ,VEGFR-2 ,Vasohibin-1 ,Gene Expression Regulation ,inflammation ,Humans ,Female ,Renal Insufficiency, Chronic ,chronic kidney disease - Abstract
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
- Published
- 2014