1. Synthesis of the chiral stationary phase based on functionalized ZIF-8 with amylose carbamate
- Author
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Juliana Faccin de Conto, Cláudio Dariva, Silvia Maria da Silva Egues, Cesar Costapinto Santana, Elton Franceschi, Gustavo R. Borges, Tamires dos Reis Menezes, and Kátilla Monique Costa Santos
- Subjects
Materials science ,Ligand ,Mechanical Engineering ,Intermolecular force ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,Adsorption ,chemistry ,Mechanics of Materials ,Amylose ,Surface modification ,Racemic mixture ,General Materials Science ,Enantiomer ,0210 nano-technology ,Selectivity - Abstract
Commercial chiral stationary phases (CSPs) are based mainly on polysaccharides supported on silica; however, the pharmaceutical industry shows a special interest on chiral separations, exhibiting high financial investment in the development of new CSPs. These can be structured by a new optically active compound or different support. Thus, metal–organic frameworks (MOFs) are crystalline materials that arise with great potential for support, due to its high porosity, the strong intermolecular force between the metal and the ligand selectivity, and high adsorption capacity. Interested in this, this work proposes a new CSP using the metal–organic structure ZIF-8 (Basolite Z1200) due to its high mechanical stability. To this end, it is proposed the modification of the ZIF-8 with the optically active compound, tris-3,5-dimethylphenylcarbamate amylose. Through characterization textural, structural, and physicochemical performed, it is possible to confirm the synthesis of the chiral compound (amylose carbamate), as well as the functionalization of the metal–organic structure with tris-3,5-dimethylphenylcarbamate amylose (ZIF-8-PEI-CA). In addition, as a validation technique, HPLC can detect the presence of enantiomers present in the racemic mixture of Troger bases.
- Published
- 2020
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