1. Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
- Author
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Eduard Vieta, Jose Manuel Goikolea, Joaquim Raduà, Janice M. Fullerton, Lakshmi N. Yatham, Peter R. Schofield, Carlos López-Jaramillo, Tomas Hajek, Edith Pomarol-Clotet, Henk Temmingh, Francesco Benedetti, Ulrik Fredrik Malt, Erlend Bøen, Roel A. Ophoff, Bartholomeus C M Haarman, Cristian Vargas, Kang Sim, Katharina Thiel, Ole A. Andreassen, Tim Hahn, Lisa T. Eyler, Philip B. Mitchell, Christopher R.K. Ching, Axel Krug, Jonathan Repple, Annabel Vreeker, Dara M. Cannon, Sandra Meier, Colm McDonald, Holly Van Gestel, Hannah Lemke, Maike Richter, Caterina del Mar Bonnín, Udo Dannlowski, Tilo Kircher, Martin Alda, Mikael Landén, Janik Goltermann, Torbjørn Elvsåshagen, Genevieve McPhilemy, Jonathan Savitz, Susanne Meinert, Igor Nenadic, Simon Schmitt, Bronwyn Overs, Katharina Brosch, Dan J. Stein, Raymond Salvador, Dominik Grotegerd, Nils Opel, Martin Ingvar, Sean R. McWhinney, Erick J. Canales-Rodríguez, Elena Mazza, Gloria Roberts, Paul M. Thompson, Neeltje E.M. van Haren, Tiana Borgers, Fiona M. Martyn, Frederike Stein, Julia-Katharina Pfarr, Benny Liberg, Julian A Pineda-Zapata, Christoph Abé, Lena Waltemate, Tina Meller, Kai Ringwald, Ana M. Díaz-Zuluaga, Elisa M T Melloni, Rayus Kuplicki, Leila Nabulsi, Fleur M. Howells, Psychiatry, Child and Adolescent Psychiatry / Psychology, Mcwhinney, S. R., Abe, C., Alda, M., Benedetti, F., Boen, E., del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodriguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Elvsashagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B. C. M., Hahn, T., Howells, F. M., Ingvar, M., Kircher, T. T. J., Krug, A., Kuplicki, R. T., Landen, M., Lemke, H., Liberg, B., Lopez-Jaramillo, C., Malt, U. F., Martyn, F. M., Mazza, E., Mcdonald, C., Mcphilemy, G., Meier, S., Meinert, S., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Ophoff, R. A., Overs, B. J., Pfarr, J. -K., Pineda-Zapata, J. A., Pomarol-Clotet, E., Radua, J., Repple, J., Richter, M., Ringwald, K. G., Roberts, G., Salvador, R., Savitz, J., Schmitt, S., Schofield, P. R., Sim, K., Stein, D. J., Stein, F., Temmingh, H. S., Thiel, K., van Haren, N. E. M., Gestel, H. V., Vargas, C., Vieta, E., Vreeker, A., Waltemate, L., Yatham, L. N., Ching, C. R. K., Andreassen, O., Thompson, P. M., Hajek, T., and Clinical Cognitive Neuropsychiatry Research Program (CCNP)
- Subjects
medicine.medical_specialty ,Bipolar Disorder ,Hippocampus ,Amygdala ,Article ,Body Mass Index ,Cellular and Molecular Neuroscience ,Lateral ventricles ,SDG 3 - Good Health and Well-being ,Neuroimaging ,Internal medicine ,medicine ,Humans ,Risk factor ,Molecular Biology ,business.industry ,Brain ,medicine.disease ,Magnetic Resonance Imaging ,Obesity ,Comorbidity ,Psychiatry and Mental health ,medicine.anatomical_structure ,Cardiology ,business ,Body mass index ,Neuroscience - Abstract
Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
- Published
- 2021
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