1. Development of ClearPEM-Sonic, a multimodal mammography system for PET and Ultrasound
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O. Mundler, D. Jun, Joao Varela, N. Di Vara, P. Siles, Benjamin Frisch, V. Juhan, G. Cucciati, Paul Lecoq, M. Pizzichemi, N. Felix, Jorge A. Neves, Philippe Lasaygues, F Farina, J. Peter, l. Tessonnier, S. Tavernier, Serge Mensah, João Carlos Silva, Etiennette Auffray, M. Paganoni, R. Bugalho, Rui F. Silva, A Ghezzi, Liji Cao, Physics, Elementary Particle Physics, Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Cucciati, G, Auffray, E, Bugalho, R, Cao, L, Vara, N, Farina, F, Felix, N, Frisch, B, Ghezzi, A, Juhan, V, Jun, D, Lasaygues, P, Lecoq, P, Mensah, S, Mundler, O, Neves, J, Paganoni, M, Peter, J, Pizzichemi, M, Siles, P, Silva, J, Silva, R, Tavernier, S, Tessonnier, L, and Varela, J
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medicine.medical_specialty ,Computer science ,PET PET/CT ,Imaging phantom ,law.invention ,law ,Tissue elasticity ,Multimodality systems ,medicine ,Mammography ,3D ultrasound ,Medical physics ,Multimodality system ,Image resolution ,Instrumentation ,Gamma camera ,coronary CT angiography (CTA) ,Mathematical Physics ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Detector ,3. Good health ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,SPECT ,business - Abstract
International audience; ClearPEM-Sonic is an innovative imaging device specifically developed for breast cancer. The possibility to work in PEM-Ultrasound multimodality allows to obtain metabolic and morphological information increasing the specificity of the exam. The ClearPEM detector is developed to maximize the sensitivity and the spatial resolution as compared to Whole-Body PET scanners. It is coupled with a 3D ultrasound system, the SuperSonic Imagine Aixplorer that improves the specificity of the exam by providing a tissue elasticity map. This work describes the ClearPEM-Sonic project focusing on the technological developments it has required, the technical merits (and limits) and the first multimodal images acquired on a dedicated phantom. It finally presents selected clinical case studies that confirm the value of PEM information.