4 results on '"Josune Goikoetxea Aguirre"'
Search Results
2. Excretion and viability of SARS-CoV-2 in feces and its association with the clinical outcome of COVID-19
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Cristina Cerrada-Romero, Judith Berastegui-Cabrera, Pedro Camacho-Martínez, Josune Goikoetxea-Aguirre, Patricia Pérez-Palacios, Sonia Santibáñez, María José Blanco-Vidal, Adoración Valiente, Jorge Alba, Regino Rodríguez-Álvarez, Álvaro Pascual, José Antonio Oteo, José Miguel Cisneros, Jerónimo Pachón, Inmaculada Casas-Flecha, Elisa Cordero, Francisco Pozo, Javier Sánchez-Céspedes, Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), European Regional Development Fund, Ministerio de Ciencia e Innovación (España), Gobierno de Andalucía, Plan Nacional de I+D+i (España), Red de Investigación Cooperativa en Investigación en Patología Infecciosa, European Commission, Junta de Andalucía, Ministerio de Economía y Competitividad (España), and Ministerio de Ciencia, Innovación y Universidades (España)
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Adult ,Cohort Studies ,Feces ,Multidisciplinary ,SARS-CoV-2 ,viruses ,COVID-19 ,Humans ,RNA, Viral ,Prospective Studies - Abstract
The main objective was to evaluate the viability of the SARS-CoV-2 viral particles excreted in stools. In addition, we aimed to identify clinical factors associated with the detection of SARS-CoV-2 RNA in feces, and to determine if its presence is associated with an unfavorable clinical outcome, defined as intensive care unit (ICU) admission and/or death. A prospective multicenter cohort study of COVID-19 adult patients, with confirmed SARS-CoV-2 infection by RT-PCR assay in nasopharyngeal (NP) swabs admitted to four hospitals in Spain, from March 2020 to February 2021. Sixty-two adult COVID-19 patients had stool samples collected at admission and/or during the follow up, with a total of 79 stool samples. SARS-CoV-2 RNA was detected in stool samples from 27 (43.5%) out of the 62 patients. Replicative virus, measured by the generation of cytopathic effect in cell culture and subsequent RT-PCR confirmation of a decrease in the Ct values, was not found in any of these stool samples. Fecal virus excretion was not associated with the presence of gastrointestinal symptoms, or with differences in the evolution of COVID-19 patients. Our results suggest that SARS-CoV-2 replicative capacity is null or very limited in stool samples, and thus, the fecal–oral transmission of SARS-CoV-2 as an alternative infection route is highly unlikely. In our study, the detection of SARS-CoV-2 RNA in feces at the beginning of the disease is not associated with any clinical factor nor with an unfavorable clinical outcome., This work was supported by National Plan R+D+I 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministry of Economy, Industry, and Competitiveness, Spanish Network for Research in Infectious Diseases [REIPI RD16/0016/0009]; cofinanced by European Development Regional Fund “A way to achieve Europe”, Operative program Intelligent Growth 2014–2020; and supported by Grants from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Proyectos de Investigación sobre el SARS-CoV-2 y la enfermedad COVID-19 [COV20/00370; COV20/00580]. J.S.C. is a researcher belonging to the program “Nicolás Monardes” (C-0059-2018), Servicio Andaluz de Salud, Junta de Andalucía, Spain.
- Published
- 2022
3. Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)
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Carmen Herrero Rodríguez, Clara Natera Kindelán, Teresa Marrodan Ciordia, Marcos Guzmán García, Juan Sevilla Blanco, Lucía Boix-Palop, Carlos Armiñanzas Castillo, Adrian Sousa Domínguez, Luis Eduardo López-Cortés, Alfredo Jover Saenz, Alberto Bahamonde-Carrasco, María Ángeles Mantecon Vallejo, Isabel María Reche Molina, María Luisa Cantón-Bulnes, José María Reguera-Iglesias, Eva León Jiménez, Berta Becerril Carral, Inmaculada López-Hernández, Jesús Rodríguez-Baño, Alfonso Del Arco Jiménez, José Bravo-Ferrer, Joaquín Felipe Lanz-García, Esperanza Merino de Lucas, Antonio Sánchez-Porto, Josune Goikoetxea Aguirre, David Garcia, Inés Pérez Camacho, Fátima Galán-Sánchez, Jonathan Fernández Suárez, Pedro María Martínez Pérez-Crespo, Alejandro Smithson Amat, Jordi Cuquet Pedragosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, and European Commission
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Adult ,Male ,0301 basic medicine ,Microbiology (medical) ,Staphylococcus aureus ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Epidemiology ,030106 microbiology ,Bacteremia ,Bloodstream infection ,Healthcare-associated ,Logistic regression ,Severity of Illness Index ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Interquartile range ,Klebsiella ,Internal medicine ,Escherichia coli ,medicine ,Humans ,Pharmacology (medical) ,Prospective Studies ,030212 general & internal medicine ,Aetiology ,Prospective cohort study ,Aged ,Aged, 80 and over ,Cross Infection ,business.industry ,Mortality rate ,General Medicine ,Middle Aged ,Confidence interval ,Community-Acquired Infections ,Infectious Diseases ,Spain ,Etiology ,Bacteraemia ,Female ,business - Abstract
PROBAC REIPI/GEIH-SEIMC/SAEI Group., The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition., This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020.
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- 2021
4. Clinicoepidemiological characteristics of viral hepatitis in migrants and travellers of the +Redivi network
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Cesar Henriquez-Camacho, Núria Serre, Francesca Norman, Adrián Sánchez-Montalvá, Diego Torrús, Ane Josune Goikoetxea, Juan María Herrero-Martínez, José Manuel Ruiz-Giardín, Begoña Treviño, Begoña Monge-Maillo, Israel Molina, Azucena Rodríguez, Magdalena García, Rogelio López-Vélez, José A. Pérez-Molina, Paloma Aguilera, María Martínez Serrano, Magdalena García Rodriguez, Marta Díaz Menendez, Yolanda Meije, Joaquim Martínez-Montauti, Xavier Sanz, Isabel Pacheco Tenza, Inmaculada Gonzalez Cuello, Belén Martínez López, Jara LLenas, Mar Masiá, Sergio Padilla, Mónica Romero, Philip Wilkman-Jorgensen, José Manuel Ramos Rincón, Eduardo Malmierca, Ana Perez-Ayala, Juan María Herrero, Manuel Lizasoain, Pablo Rojo, Mariano Matarranz, Carlos Zarco, Azucena Rodriguez-Guardado, Jonathan Fernández Suárez, Jose Antonio Boga Ribeiro, Josune Goikoetxea Aguirre, Miren Zuriñe Zubero Sulibarría, José Manuel Ruiz Giardin, Juan Victor Sanmartín López, María Velasco Arribas, Eva Calabuig Muñoz, Ana Mena Ribas, María Peñaranda Vera, Adrián Sánchez Montalvá, Fernando Salvador, Ángel Dominguez, Begoña Treviño-Maruri, Nuria Serre Delcor, Antonio Soriano-Arandes, Diana Pou Ciruelo, and Cristina Bocanegra
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Adult ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Hepatitis, Viral, Human ,030231 tropical medicine ,03 medical and health sciences ,0302 clinical medicine ,Chronic hepatitis ,Communicable Diseases, Imported ,Risk Factors ,Epidemiology ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Immunosuppression Therapy ,Transients and Migrants ,Travel ,business.industry ,Transmission (medicine) ,Public Health, Environmental and Occupational Health ,Hepatitis B ,Middle Aged ,medicine.disease ,Infectious Diseases ,Spain ,Female ,business ,Viral hepatitis ,Acute hepatitis - Abstract
Background Continuous growth of mobile populations has influenced the global epidemiology of infectious diseases, including chronic and acute viral hepatitis. Method A prospective observational multicentre study was performed in a Spanish network of imported infections. Viral hepatitis cases from January 2009 to September 2017 were included. Results Of 14,546 records, 723 (4.97%) had imported viral hepatitis, including 48 (6.64%) acute cases and 675 (93.36%) chronic cases. Of the 48 acute cases, 31 were travellers and immigrants returning from visiting friends or relatives (VFR), while 19 (61%) were acute Hepatitis A or Hepatitis B. Only 18.2% of VFR immigrants and 35% of travellers received pre-travel advice. Acute hepatitis was more frequent in VFR immigrants (AOR 2.59, CI95% 1.20–5.60) and travellers (AOR 2.83, CI95% 1.46–5.50) than immigrants. Of the 675 Chronic cases, 570 were immigrants, and 439 (77%) had chronic Hepatitis B. Chronic hepatitis was more frequent in immigrants (AOR 20.22, CI95% 11.64–35.13) and VFR immigrants (AOR 11.12, CI95% 6.20–19.94) than travellers. Conclusions Chronic viral hepatitis was typical of immigrants, acute viral hepatitis was common among travellers, and VFR immigrants had mixed risk. Improving pre-travel consultation and screening of immigrants may contribute to preventing new cases of viral hepatitis and avoiding community transmission.
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- 2018
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