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2. Toyotism modelind inside the regional network for inherited lipid disorders

Author

Mancini G., Rubba F., Gentile M., Jossa F., de Simone B., Marotta G., Cipollaro R., TRIASSI, MARIA, Giancotti E., RUBBA, PAOLO OSVALDO FEDERICO, Mancini, G., Rubba, F., Gentile, M., Jossa, F., de Simone, B., Marotta, G., Cipollaro, R., Triassi, Maria, Rubba, PAOLO OSVALDO FEDERICO, and Giancotti, E.

Published
2010

5. Apo B, Small-dense LDL and carotid atherosclerosis in menopausal women

Author

Gentile M., RUBBA, PAOLO OSVALDO FEDERICO, Pauciullo P., IANNUZZO, GABRIELLA, Faccenda F., UBALDI, STEFANIA MARIA, SODANO, MARTA, Marotta G., Jossa F., Mattiello A., PANICO, SALVATORE, Gentile, M., Rubba, PAOLO OSVALDO FEDERICO, Pauciullo, P., Iannuzzo, Gabriella, Faccenda, F., Ubaldi, STEFANIA MARIA, Sodano, Marta, Marotta, G., Jossa, F., Mattiello, A., and Panico, Salvatore

Published
2009

8. Effects of food items enriched with beta glucans additioned to lipid-lowering diet in patients with familial combined hyperlipidemia

Author

Ubaldi S., Gentile M., Jossa F., Marotta G., Viceconti R., Nunziata M., SCALFI, LUCA, Montagnese C., Naccarato M., Baiano A., Pauciullo P., RUBBA, PAOLO OSVALDO FEDERICO, Ubaldi, S., Gentile, M., Jossa, F., Marotta, G., Viceconti, R., Nunziata, M., Scalfi, Luca, Montagnese, C., Naccarato, M., Baiano, A., Rubba, PAOLO OSVALDO FEDERICO, and Pauciullo, P.

Published
2007

10. Network for managed care and pharmacoeconomy strategies in Southern Italy: First report from the network of Familiar Dyslipidemias diagnosis and therapy facilities among Campania Public Health Services

Author

Rubba F., Ubaldi S., Iannuzzi A., Pauciullo P., Gentile M., Marotta G., Jossa F., Scafarto M.V., TRIASSI, MARIA, PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, Rubba, F., Ubaldi, S., Iannuzzi, A., Pauciullo, P., Gentile, M., Marotta, G., Jossa, F., Scafarto, M. V., Triassi, Maria, Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO

Published
2006

11. Inflammatory markers in Familial Combined Hyperlipidemia

Author

Pauciullo P., Gentile M., Ubaldi S, Marotta G., Jossa F., Iannuzzo G., Faccenda F., RUBBA, PAOLO OSVALDO FEDERICO, Pauciullo, P., Gentile, M., Ubaldi, S, Marotta, G., Jossa, F., Iannuzzo, G., Faccenda, F., and Rubba, PAOLO OSVALDO FEDERICO

Published
2006

13. Central adiposity and hs-CRP in a cohort of Mediterranean women: findings from Progetto ATENA

Author

Gentile M., Rubba F., Mattiello A., PANICO, SALVATORE, Jossa F., Marotta G., Pauciullo P., Celentano E., Santucci de Magistris M., Del Pezzo M., Galasso R., Panico S., RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M., Rubba, F., Mattiello, A., Panico, Salvatore, Jossa, F., Marotta, G., Pauciullo, P., Celentano, E., Rubba, PAOLO OSVALDO FEDERICO, Santucci de Magistris, M., Del Pezzo, M., Galasso, R., and Panico, S.

Published
2005

14. Integration Models of managed care in southern Italy: working for a regional network of familiar dyslipidemias diagnosis and therapy facilities amog Campania Public Health Services

Author

Rubba F., Iannuzzi A., Scafarto M. V. Pauciullo P., Gentile M., Marotta G., Jossa F., TRIASSI, MARIA, PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, Rubba, F., Iannuzzi, A., Scafarto, M. V. Pauciullo P., Gentile, M., Marotta, G., Jossa, F., Triassi, Maria, Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO

Published
2005

20. INTERSALT in Italy: Findings and community health implications

Author

Farinaro, E., Trevisan, M., Jossa, F., Panico, S., Egidio Celentano, Mancini, M., Zamboni, S., Dal Palu, C., Angelico, F., Del Ben, M., Laurenzi, M., Farinaro, Eduardo, Trevisan, M, Jossa, F, Panico, Salvatore, Celentano, E, Mancini, M, Zamboni, S, DAL PALÙ, C, Angelico, F, DEL BEN, M, and Laurenzi, M.

21. Coping and blood pressure

Author

Vittorio Krogh, Trevisan, M., Jossa, F., Bland, S., Jalowiec, A., Celentano, E., Farinaro, E., Panico, S., Fusco, G., and Mancini, M.

23. The prediction of coronary heart disease mortality as a function of major risk factors in over 30000 men in the italian RIFLE pooling project. A comparison with the MRFIT primary screenees

Author

Menotti, A., Farchi, G., Seccareccia, F., Conti, S., Giampaoli, S., Lanti, M., Mariotti, S., Scang, M., Spagnolo, A., Verdecchia, A., Di Carlo, G., Dima, F., Marenco, G., Falchero, M., Ideo, G., Caspani, B., Podda, M., Zuin, M., Ferrario, M., Cesana, G. C., Vito, G., Sega, R., Tenconi, M. T., Laddomada, M. S., Gabriele DEVOTI, Dobrilla, G., Petris, G., Angelini, G. P., Okolicsanyi, L., Toso, S., Nassuato, G., Passera, D., Ambrosio, G. B., Tasso, S., Bittolo-Bo, G., Moro, E., Alessandrini, P., Soldan, S., Feruglio, G. A., Vanuzzo, D., Pilotto, L., Carulli, N., Loria, P., Dilengite, M., Bozzoli, M., Salvioli, G. F., Lugli, R., Gadd, A., Sangiorg, Z., D’addat, S., Minard, A., Descovich, G. C., Dormi, A., Barbara, L., Festi, D., Alvisi, V., Balhous, W., Buzzelli, G. B., Giusti, A., Giacchi, M., Fatighenti, D., Giotti, M., Laurenzi, M., Ricci, G., Bucci, A., Antonini, R., Pacioni, F., Angelico, F., Del Ben, M., Lalloni, L., Azzarri, L., Ricci, P., Attili, F. A., Santis, A., Urbinati, G. C., Fazio, S., Pannozzo, F., Sotis, C. L., Righetti, G. M., Mancini, M., Farinaro, E., Panico, S., Trevisan, M., Krogh, V., Jossa, F., Celentano, E., Galasso, R., Albano, O., Palasciano, G., Misciagna, G., Guerra, V., Muntoni, S., Pintus, P., Podda, E., Stabilini, M., Frulio, T., Pulina, S., Trudu, A., Sanna, A., Baule, G. M., Avellone, G., and Di Garbo, V.

24. Prevalence and correlates of angina pectoris in the italian nine communities study

Author

Krogh, V., Trevisan, M., Panico, S., Farinaro, E., Mancini, M., Menotti, A., Ricci, G., Descovich, G. C., Lenzi, S., Benassi, M. S., Dalmonte, G., Dormi, A., Gaddi, A., Magni, G. L., Sangiorgi, Z., Muntoni, S., Pintus, F., Mascia, P., Sirigu, F., Songini, M., Mazzucato, P., Medda, G., Scalas, M. R., Usdi, N., Giumetti, D., Jossa, F., Fusco, G., Celentano, E., Ambrosio, G. B., Zamboni, S., Dal Palu, C., Vettori, P., D’este, D., Strano, A., Avellone, G., Davi, G., Novo, S., Pinto, A., Tenconi, M. T., Laddomada, M. S., Roggi, C., Sottocornola, F., Urbinati, G. C., Antonini, R., Area, M., Bava, L., Bucci, A., Cinosi, V., Massa, L., Mazzarella, B., Montali, A., Conti, S., Dima, F., Giampaoli, S., Fulvia Seccareccia, Torsello, S., Weber, G., Giacchi, M., Vannozzi, F., Cosimi, A., Salvi, M., Avogaro, P., and Alessandrini, P.

26. Small dense low-density lipoprotein in familial combined hyperlipidemia: Independent of metabolic syndrome and related to history of cardiovascular events

Author

Gabriella Iannuzzo, F. Faccenda, Stefania Ubaldi, Paolo Rubba, Fabrizio Jossa, Angela Baiano, Marco Gentile, Gennaro Marotta, Paolo Pauciullo, Salvatore Panico, Pauciullo, P, Gentile, M, Marotta, G, Baiano, A, Ubaldi, S, Jossa, F, Iannuzzo, G, Faccenda, F, Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO

Subjects
Adult, Male, Proband, medicine.medical_specialty, Apolipoprotein B, Hyperlipidemia, Familial Combined, Blood lipids, chemistry.chemical_compound, Internal medicine, Humans, Medicine, Family history, Aged, Metabolic Syndrome, biology, business.industry, Cholesterol, Cholesterol, LDL, Middle Aged, Prognosis, medicine.disease, Endocrinology, chemistry, Cardiovascular Diseases, Case-Control Studies, Low-density lipoprotein, biology.protein, Regression Analysis, Female, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, Biomarkers, Lipoprotein
Abstract

1. Atherosclerosis. 2009 Mar;203(1):320-4. Epub 2008 Jul 12. Small dense low-density lipoprotein in familial combined hyperlipidemia: Independent of metabolic syndrome and related to history of cardiovascular events. Pauciullo P, Gentile M, Marotta G, Baiano A, Ubaldi S, Jossa F, Iannuzzo G, Faccenda F, Panico S, Rubba P. Department of Clinical and Experimental Medicine, University Federico II Medical School, Nuovo Policlinico, Edificio 1, Via Pansini 5 - 80131 - Naples, Italy. pauciull@unina.it INTRODUCTION: It is unclear whether small dense low-density lipoprotein (sdLDL) are associated with familial combined hyperlipidemia (FCHL), independently of the metabolic syndrome (MS). It is also unclear whether sdLDL are related to history of cardiovascular (CVD) events in FCHL patients, independently of MS. PATIENTS AND METHODS: Serum levels of sdLDL, expressed as percentage of total LDL cholesterol (LDL score), were determined in 137 probands with FCHL and in 133 normolipidemic, normotensive, normoglycemic healthy subjects. RESULTS: In binary logistic regression age- and gender-adjusted LDL score values above the 90th and 95th percentiles of the values in the control group (10.23 and 13.11%, respectively) were found to be significant predictors of FCHL status, independently of MS diagnosis (p=0.007 and p

Published
2009
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27. Plasma creatinine levels, estimated glomerular filtration rate and carotid intima media thickness in middle-aged women: a population based cohort study

Author

Gennaro Marotta, Fabrizio Jossa, Paolo Rubba, M. De Michele, A. Mattiello, Marco Gentile, Salvatore Panico, Arcangelo Iannuzzi, Gentile, M, Panico, Salvatore, Mattiello, A, de Michele, M, Iannuzzi, A, Jossa, F, Marotta, G, and Rubba, PAOLO OSVALDO FEDERICO

Subjects
Adult, Carotid Artery Diseases, medicine.medical_specialty, Aging, Endocrinology, Diabetes and Metabolism, Population, Urology, Medicine (miscellaneous), Renal function, Kidney, Asymptomatic, Carotid Intima-Media Thickness, Severity of Illness Index, Cohort Studies, chemistry.chemical_compound, Risk Factors, Internal medicine, medicine, Prevalence, Humans, Prospective Studies, Renal Insufficiency, education, Prospective cohort study, Aged, education.field_of_study, Creatinine, Nutrition and Dietetics, business.industry, Middle Aged, Atherosclerosis, Endocrinology, Carotid Arteries, Early Diagnosis, chemistry, Intima-media thickness, Italy, Cohort, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Biomarkers, Cohort study, Glomerular Filtration Rate
Abstract

Background and aim The relationships between high Creatinine (Cr) levels or low estimated Glomerular Filtration Rate (eGFR) and common carotid Intima Media thickness (IMT) have been evaluated in a population-based cohort study in women, aged 30–69 (Progetto ATENA). Methods and results Serum Cr and eGFR were measured in 310 women, as a part of 5.062. In this group carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. Women were classified by Cr levels >1 mg/dL or eGFR Women with Cr > 1 mg/dL (90th percentile of creatinine distribution) or eGFR less than 56 ml/min (5th percentile of eGFR distribution) had relatively more carotid plaques as compared to the rest of the cohort. Multivariate logistic analysis, after adjustment for age, demonstrated a significant association between Cr (>1 mg/dL) and IMT (≥1.2 mm): OR 4.12 (C.I 1.22–13.86), p = 0.022; or eGFR ( p = 0.019. Conclusions These findings on an independent relationship between Cr and common carotid plaques in this population of middle aged women, independently of age, suggest the value of screening for early carotid disease in asymptomatic middle aged-women with mild renal insufficiency, in order to predict those at relatively higher risk for future cardiovascular events.

Published
2013

28. ECHOCARDIOGRAFIC ANDECO-DOPPLER ABNORMALITIESIN RELATION TO LDL CHOLESTEROLIN FAMILIAL HYPERCHOLESTEROLEMIA

Author

M. G. Coppola, F. Jossa, M. Nunziata, M. Gentile, DE SIMONE, GIOVANNI, M. De Marco, G. Fortunato, M. N. D’Agostino, M. D. Di Taranto, G. Marotta, RUBBA, PAOLO OSVALDO FEDERICO, Coppola, M. G., Jossa, F., Nunziata, M., Gentile, M., DE SIMONE, Giovanni, De Marco, M., Fortunato, G., D’Agostino, M. N., Di Taranto, M. D., Marotta, G., and Rubba, PAOLO OSVALDO FEDERICO

Published
2011

29. IDENTIFICATION OF LDLR MUTATIONSIN PATIENTS WITH FAMILIAL COMBINEDHYPERLIPIDEMIA

Author

M. N. D’Agostino, M. D. Di Taranto, E. Bloise, A. D’Angelo, I. Altieri, G. Marotta, M. Gentile, F. Jossa, A. Iannuzzi, RUBBA, PAOLO OSVALDO FEDERICO, G. Fortunato, D’Agostino, M. N., Di Taranto, M. D., Bloise, E., D’Angelo, A., Altieri, I., Marotta, G., Gentile, M., Jossa, F., Iannuzzi, A., Rubba, PAOLO OSVALDO FEDERICO, and Fortunato, G.

Published
2011

30. HYPERLIPIDEMIAS HOSPITAL PATHWAYMANAGEMENT

Author

F. Rubba, G. Mancini, F. Verdesca, M. Gentile, G. Marotta, F. Jossa, G. Fortunato, G. Canfora, P. Cuccaro, E. Giancotti, RUBBA, PAOLO OSVALDO FEDERICO, Rubba, F., Mancini, G., Verdesca, F., Gentile, M., Marotta, G., Jossa, F., Fortunato, G., Canfora, G., Cuccaro, P., Rubba, PAOLO OSVALDO FEDERICO, and Giancotti, E.

Published
2011

31. Tumor necrosis factor-α is a marker of familial combined hyperlipidemia, independently of metabolic syndrome

Author

F. Faccenda, Stefania Ubaldi, Angela Baiano, Fabrizio Jossa, Paolo Rubba, Gennaro Marotta, Gabriella Iannuzzo, Marco Gentile, Paolo Pauciullo, Salvatore Panico, Pauciullo, Paolo, Gentile, M., Marotta, G., Baiano, A., Ubaldi, S., Jossa, F., Iannuzzo, G., Faccenda, F., Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO

Subjects
Adult, Male, Percentile, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Hyperlipidemia, Familial Combined, Body Mass Index, Endocrinology, Insulin resistance, Internal medicine, Humans, Medicine, Interleukin 6, Metabolic Syndrome, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, C-reactive protein, Odds ratio, Middle Aged, medicine.disease, Confidence interval, C-Reactive Protein, Logistic Models, biology.protein, Female, Insulin Resistance, Metabolic syndrome, business, Body mass index, Biomarkers
Abstract

It is unclear whether an association between familial combined hyperlipidemia (FCHL) and inflammatory markers exists, independently of age, sex, body weight, insulin resistance, and metabolic syndrome. Serum concentrations of soluble vascular cell adhesion molecule-1 (sVCAM-1), monocyte chemoattractant protein 1, interleukin 6, tumor necrosis factor-alpha (TNF-alpha), and high-sensitive C-reactive protein were determined in 135 probands with FCHL and in 146 normolipidemic, normotensive, normoglycemic healthy subjects. Insulin resistance was evaluated using homeostasis model assessment (HOMA). All inflammatory parameters, except interleukin 6, were significantly higher in FCHL according to medians or mean comparisons. After adjustment for age, sex, body mass index, and HOMA, only TNF-alpha remained an independent predictor of FCHL status by binary logistic regression (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.07-1.31; P = .001). In particular, elevated levels of TNF-alpha (above the 90th and 95th percentiles of the value observed in the control group, 9.6 and 9.8 pg/mL, respectively) were independent predictors of FCHL status: for TNF-alpha above the 90th percentile, OR was 7.91 (95% CI, 3.27-19.13; P < .001), and for TNF-alpha above 95th percentile, OR was 13.08 (95% CI, 4.60-37.15; P < .0001). The independent role of TNF-alpha as predictor of FCHL status was confirmed after adjustment for components of the metabolic syndrome (P = .007 and P = .003, for TNF-alpha values above 90th and 95th percentiles, respectively). In conclusion, among the inflammatory markers most commonly measured, only TNF-alpha was associated with FCHL independently of age, sex, body mass index, and HOMA. The association of TNF-alpha with FCHL was also independent of the metabolic syndrome.

Published
2008

32. Sodium lithium countertransport and blood pressure: Longitudinal findings

Author

Fabrizio Jossa, Roberto Iacone, Francesco P. Cappuccio, I Russo, Maurizio Trevisan, Eduardo Farinaro, Pasquale Strazzullo, M., Trevisan, Strazzullo, Pasquale, F., Cappuccio, Jossa, Fabrizio, Iacone, Roberto, I., Russo, Farinaro, Eduardo, Trevisan, M, Cappuccio, Fp, Jossa, F, Iacone, R, Russo, O, and Farinaro, E.

Subjects
Adult, Male, medicine.medical_specialty, Adult, Antiporter, Blood Pressure, Lithium, metabolism, Biological Transport, Blood Pressure, metabolism, Logistic Models, Longitudinal Studies, Male, Middle Aged, Sodium, Antiporters, Internal medicine, Internal Medicine, medicine, Humans, Longitudinal Studies, business.industry, Incidence (epidemiology), Body Weight, Sodium, Sodium lithium countertransport, Biological Transport, physiology, Body Weight, Humans, Lithium, Middle Aged, Red blood cell, Logistic Models, Endocrinology, medicine.anatomical_structure, Blood pressure, Cardiology, business, Body mass index, metabolism
Abstract

A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-Li CT and blood pressure. The present study analyzes the longitudinal association between Na-Li CT and blood pressure in 124 men participants in the Olivetti Heart Study and normotensives at the baseline examination. The Na-Li CT measured at the 12 year follow-up examination was analyzed in regard to the blood pressure changes over time during the 12 year follow-up. Na-Li CT (measured at follow-up examination) was positively related to changes over time in systolic pressure (r = 0.16) and diastolic pressure (r = 0.07) and changes in body mass index (r = 0.18). When blood pressure changes over time were analyzed by tertiles of Na-Li CT, the highest tertile group exhibited on the average significantly higher increases in systolic blood pressure compared with participants of the lowest tertile of the Na-Li CT distribution. This difference remained statistically significant after adjusting for the changes in weight observed during the 12 years follow-up. These findings indicate that the Na-Li CT distribution is related to blood pressure changes over time. However, the usefulness of Na-Li CT as a predictor of incidence of hypertension remains to be established. Am J Hypertens 1996;9:1132–1135

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