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Ascending aortic pseudoaneurysm (PSA) is a rare but serious complication of cardiothoracic surgery, infection or trauma1-2. If left untreated can develop complications including rupture, fistula and thrombus which have mortality up to 61%3. Conventional therapy for ascending PSA is cardiac surgery where mortality can reach up to 46%4. Recently percutaneous closure of ascending PSA has shown promise, especially in those with prohibitive risk for cardiothoracic surgery. The first percutaneous closure of ascending aortic PSA was published in 2005 by Bashir et al where an Amplatzer ASD occluder device was successfully used for exclusion of a large ascending aortic PSA1. Following this many case reports and case series have been published describing a variety of devices including ASD occluders, VSD occluders, plugs, coiling, stents/TEVAR. This systematic review is being undertaken to update the body of literature pertaining specifically to percutaneous repair of ascending aortic PSA.