Author: "José J. Cuenca Castillo" / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

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1. Historia y desarrollo de la cirugía coronaria en España

Author: José J. Cuenca Castillo
Subjects: Surgery, Cardiology and Cardiovascular Medicine
Published: 2023
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2. Ya nada es igual en la sustitución valvular aórtica

Author: José J. Cuenca Castillo
Subjects: Surgery, Cardiology and Cardiovascular Medicine
Published: 2023
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3. Registro Español de Trasplante Cardiaco. XXXII Informe Oficial de la Asociación de Insuficiencia Cardiaca de la Sociedad Española de Cardiología

Author: Ana Pórtoles-Ocampo, José María Arizón del Prado, Laura Morán-Fernández, Manuel Martínez-Sellés, Luis García-Guereta Silva, Juan Carlos López-Azor, Álvarez González-Rocafort, Raquel López-Viella, Leticia Jimeno-San Martín, Javier Castrodeza, Miguel Llano-Cardenal, María Ángeles Castel, Gregorio Rábago-Juan-Aracil, Ferrán Gran-Ipiña, Francisco José Hernández-Pérez, Juan Delgado-Jiménez, José J. Cuenca-Castillo, Mónica Cebrián, Eduardo Zatarain, Gonzalo Barge-Caballero, Teresa Blasco-Peiró, M. Farrero, Isabel Zegrí, José González-Costello, Carlos Ortiz, María del Val Groba-Marco, Francisco González-Vílchez, Antonio García-Quintana, Pedro Caravaca, Francisco Nistal-Herrera, Víctor Donoso, Mercedes Rivas-Lasarte, María Dolores García-Cosío, Javier Tobar-Ruiz, Luis de la Fuente-Galán, Oscar Gonzalez-Fernandez, Nuria Gil-Villanueva, Rebeca Manrique-Antón, Laura López, Beatriz Díaz-Molina, Nicolás Manito, Luz Polo-López, José Luis Lambert-Rodríguez, Zorba Blázquez, Carlos Labrandero de Lera, Luis Almenar-Bonet, Carles Díez, Iago Sousa, Luis Martínez, Manuel Gómez-Bueno, José María Herrera-Noreña, María Lasala-Alastuey, Antonio Grande-Trillo, Vicens Brossa-Loidi, Iris P. Garrido-Bravo, Mario Galván-Ruiz, Paola Dolader, Inés Ponz de Antonio, Marta de Antonio, Paula Navas, Cristina Mitroi, Ignacio Sánchez-Lázaro, Amador López-Granados, Francisco J. Pastor-Pérez, Javier Segovia-Cubero, María Jesús Valero-Masa, Cristina Fidalgo-Muñiz, David Couto-Mallón, Domingo A. Pascual-Figal, María J. Paniagua-Martín, María G. Crespo-Leiro, Eduardo Barge-Caballero, José A. Vázquez de Prada, Diego Rangel-Sousa, Sol Martínez, José Manuel Sobrino-Márquez, Manuela Camino-López, Josep Roca, Elena García-Romero, Félix Pérez-Villa, Jorge García-Carreño, Sonia Mirabet-Pérez, Manuel Cobo-Belaustegui, and Miriam Juárez
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Se presentan las caracteristicas clinicas y los resultados de los trasplantes cardiacos realizados en Espana con la actualizacion correspondiente a 2019. Metodos Se describen las caracteristicas clinicas y los resultados de los trasplantes cardiacos realizados en 2019, asi como las tendencias de estos en el periodo 2010-2018. Resultados En 2019 se realizaron 300 trasplantes (8.794 desde 1984; 2.745 entre 2010 y 2019). Respecto a anos previos, los cambios mas llamativos son el descenso hasta el 38% de los trasplantes realizados en codigo urgente, y la consolidacion en el cambio de asistencia circulatoria pretrasplante, con la practica desaparicion del balon de contrapulsacion (0,7%), la estabilizacion del uso del oxigenador extracorporeo de membrana (9,6%) y el aumento de los dispositivos de asistencia ventricular (29%). La supervivencia en el trienio 2016-2018 es similar a la del trienio 2013-2015 (p = 0,34), y ambas mejores que la del trienio 2010-2012 (p = 0,002 y p = 0,01 respectivamente). Conclusiones Se mantienen estables tanto la actividad del trasplante cardiaco en Espana como los resultados en supervivencia en los ultimos 2 trienios. Hay una tendencia a realizar menos trasplantes urgentes, la mayoria con dispositivos de asistencia ventricular.
Published: 2021
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4. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author: Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Loïc Bière, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de Pádua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, María Dolores Martínez-Ruíz, María Fernanda Canales, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall 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Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
Subjects: Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract: BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
Published: 2020
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5. Galectina-3 circulante tras el trasplante cardiaco: dinámica a largo plazo y valor pronóstico

Author: Jorge Pombo-Otero, Antoni Bayes-Genis, Lucía Moreda-Santamaría, Nieves Doménech, Francisco Estévez-Cid, Natalia Suárez-Fuentetaja, Javier Muñiz, María J. Paniagua-Martín, Miguel Solla-Buceta, María G. Crespo-Leiro, José J. Cuenca-Castillo, Eduardo Barge-Caballero, Z. Grille-Cancela, Gonzalo Barge-Caballero, David Couto-Mallón, Paula Blanco-Canosa, and José Manuel Vázquez-Rodríguez
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Los valores plasmaticos de galectina-3 (Gal-3) estan elevados y se correlacionan con la mortalidad total y cardiovascular en pacientes con insuficiencia cardiaca, pero su correlacion con el pronostico tras el trasplante cardiaco (TxC) es desconocida. El objetivo fue describir la tendencia evolutiva y el valor pronostico de este biomarcador tras el TxC. Metodos Mediante enzimoinmunoensayo, se midieron las concentraciones plasmaticas de Gal-3 en muestras de suero de 122 receptores de TxC, antes y 1, 3, 6 y 12 meses despues de este. Mediante regresion de Cox se analizo el valor pronostico del valor plasmatico de Gal-3 a los 12 meses del TxC. El objetivo primario del estudio fue la variable combinada muerte o disfuncion del injerto. Resultados Las concentraciones de Gal-3 disminuyeron progresivamente durante el primer ano tras el TxC (medianas: pretrasplante, 19,1 ng/ml; 1 ano postrasplante, 14,6 ng/ml; p Conclusiones Las concentraciones plasmaticas de Gal-3 disminuyeron progresivamente durante el primer ano tras el TxC. Un valor plasmatico elevado de Gal-3 1 ano tras el TxC se correlaciono con un pronostico adverso.
Published: 2019
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6. Galectina-3 circulante tras el trasplante cardiaco: dinámica a largo plazo y valor pronóstico

Author: Paula Blanco-Canosa, José Manuel Vázquez-Rodríguez, Javier Muñiz, Natalia Suárez-Fuentetaja, Gonzalo Barge-Caballero, David Couto-Mallón, María J. Paniagua-Martín, María G. Crespo-Leiro, Francisco Estévez-Cid, Miguel Solla-Buceta, Eduardo Barge-Caballero, Z. Grille-Cancela, José J. Cuenca-Castillo, Nieves Doménech, Jorge Pombo-Otero, Antoni Bayes-Genis, and Lucía Moreda-Santamaría
Subjects: Graft Rejection, Male, Trasplante cardiaco, medicine.medical_specialty, Time Factors, Galectin 3, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Risk Factors, Cause of Death, Internal medicine, Galectina-3, Clinical endpoint, Humans, Galectin-3, Medicine, In patient, Retrospective Studies, Cardiovascular mortality, business.industry, Proportional hazards model, Incidence, Pronóstico, General Medicine, Middle Aged, Prognosis, medicine.disease, ROC Curve, Spain, Heart failure, Heart Transplantation, Biomarker (medicine), Female, Heart transplant, business, Biomarkers, Follow-Up Studies
Abstract: [Abstract] Introduction and objectives: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between serum Gal-3 and heart transplant (HT) outcomes is unclear. The aim of this study was to describe the longitudinal trend and prognostic value of Gal-3 levels after HT. Methods: Banked serum samples were available from 122 HT recipients, collected before transplant and at 1, 3, 6, and 12 months posttransplant. Gal-3 levels in these serum samples were measured by enzyme immune assay. Multivariable Cox regression was performed to determine the prognostic value of 12-month posttransplant Gal-3 serum levels. The primary endpoint was the composite variable all-cause death or graft failure over long-term posttransplant follow-up. Results: Circulating Gal-3 concentration steadily decreased during the first year after HT (median values: pretransplant, 19.1 ng/mL; 1-year posttransplant, 14.6 ng/mL; P
Published: 2019
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7. Postoperative Plasma Mitochondrial DNA and Cytokine Profiles of Elderly Patients Undergoing Minimally Invasive Aortic Valve Replacement

Author: Maria E. Serrano-Teruel, José J. Cuenca-Castillo, Victor Bautista-Hernandez, Francisco Estévez-Cid, Alberto Bouzas-Mosquera, Paula Dieguez-Garcia, Fernando Fernandez-Rodriguez, and Mercedes Fernandez-Moreno
Subjects: Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Operative Time, Inflammation, Context (language use), DNA, Mitochondrial, Severity of Illness Index, law.invention, Aortic valve replacement, law, Internal medicine, Severity of illness, Cardiopulmonary bypass, Humans, Medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, Bioprosthesis, Heart Valve Prosthesis Implantation, business.industry, Age Factors, Aortic Valve Stenosis, medicine.disease, Sternotomy, Sutureless Surgical Procedures, Stenosis, Treatment Outcome, Cytokine, Aortic Valve, Heart Valve Prosthesis, Cardiology, Cytokines, Female, Surgery, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Cell-Free Nucleic Acids, Biomarkers
Abstract: Introduction Mitochondrial DNA (mtDNA) is gaining increasing interest as a marker of cellular damage and could also act as an inflammatory mediator in cardiopulmonary bypass induced postoperative inflammatory response. Although minimally invasive heart valve surgery reportedly reduces inflammation, the mtDNA and cytokine profile in this context remains unclear.Materials and Methods Here, we report a prospective series of 40 elderly patients with aortic stenosis who underwent bioprosthetic aortic valve replacement (AVR) through upper ministernotomy with either a sutureless (n = 20) or a conventional (n = 20) valve. Primary end points included serial plasma levels of mtDNA (T1: at baseline; T2: 4 hours after surgery; and T3: 24s hour after surgery), cytokines (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α]), and myocardial necrosis biomarkers (MNBs), whereas secondary end points included clinical and echocardiographic data.Results Significant increases in the postoperative plasma levels (T2) of mtDNA, cytokines, and MNBs were observed in all patients. The postoperative plasma levels of mtDNA, TNF-α, and MNBs showed no significant differences between the treatment groups, although there was a trend toward lower levels in the sutureless group. The decreases in aortic cross-clamp and cardiopulmonary bypass times seen in the sutureless group were associated with significant lower postoperative levels (T2 and T3) of IL-6.Conclusion AVR through upper ministernotomy was associated with a significant increase in postoperative plasma levels of mtDNA and cytokines. There was no difference in the mtDNA levels between the sutureless and conventional valve groups, suggesting a similar level of inflammation in both groups. However, the shorter operation time observed in the sutureless valve group was associated with significantly lower postoperative levels of IL-6, indicating potential clinical benefits.
Published: 2019
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8. Valve-Sparing Tetralogy of Fallot Repair With Intraoperative Dilation of the Pulmonary Valve. Mid-Term Results

Author: Fernando Rueda-Núñez, José J. Cuenca-Castillo, Irene García-Hernández, Maria Garcia-Vieites, Isaac Martinez-Bendayan, Victor Bautista-Hernandez, and María Lozano-Balseiro
Subjects: Balloon Valvuloplasty, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, Mid term results, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Pulmonary regurgitation, Humans, Medicine, Cardiac Surgical Procedures, Retrospective Studies, Tetralogy of Fallot, Pulmonary Valve, business.industry, Infant, General Medicine, Left pulmonary artery, medicine.disease, Right pulmonary artery, Pulmonary Valve Insufficiency, Cardiac surgery, Surgery, Pulmonary valve function, Treatment Outcome, medicine.anatomical_structure, 030228 respiratory system, Echocardiography, Pulmonary valve, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Deleterious long-term effects of chronic pulmonary regurgitation after repair of tetralogy of Fallot have become evident during the last decades. Subsequently, some groups have developed strategies to spare the pulmonary valve function at the time of repair with good early results. However, mid-term outcomes are scarce in the literature and in some cases controversial. The aim of our study is to report our results mid-term with valve-sparing repair of tetralogy of Fallot. We retrospectively reviewed patients undergoing tetralogy of Fallot repair and having preservation of the pulmonary valve with intraoperative dilation at our institution. From June 2009 through June 2017, 42 patients underwent valve-sparing tetralogy of Fallot repair. Median age and weight at surgery were 5.2 months and 7.2 kg. Median preoperative pulmonary valve diameters and Z scores by echocardiography were 6.4 mm (range 4.5-11 mm) and -2.3 (range -1.3 to -4.5). No patient died in our series. For a median follow-up of 45 months, the pulmonary valve has grown by Z score (P0.0001) as well as the pulmonary trunk (P= 0.00216). Significant pulmonary regurgitation has developed in 9 patients (21.4%). No patient has required reintervention/reoperation for recurrent right ventricular outflow tract obstruction. Patients with tetralogy of Fallot who had valve-sparing repair with intraoperative dilation of the pulmonary valve show good early and mid-term results with respect to right ventricular outflow tract obstruction. The pulmonary valve annulus and the pulmonary trunk grow through follow-up. Progressive development of significant pulmonary regurgitation is seen in more than 20% of patients. Long-term data with this approach and comparison with a population of patients undergoing a transannular patch repair are required to establish the real utility of this approach.
Published: 2019
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9. Eficacia, seguridad y factores predictores de complicaciones de la extracción de electrodos cardiacos con láser de excímeros

Author: Yago Vilela-González, Carlos Velasco-García, Ignacio Mosquera-Pérez, José J. Cuenca-Castillo, Luisa Pérez-Álvarez, Jorge Rodríguez-Garrido, Víctor Mosquera, and Enrique Ricoy-Martínez
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Resumen Introduccion y objetivos En la ultima decada se ha incrementado la necesidad de extraccion de electrodos transvenosos (EET) de dispositivos electronicos implantables cardiacos (DEIC), frecuentemente en pacientes de alto riesgo. El objetivo del estudio es evaluar las tasas de exito de procedimiento y de exito clinico de la EET con laser de excimeros, asi como la incidencia de complicaciones cardiovasculares, su tratamiento y resultado. Metodos Se analizo a 94 pacientes consecutivos portadores de DEIC tratados mediante EET mediante laser entre junio del 2008 y julio del 2018. Resultados Se extrajeron 170 cables (69 cables auriculares y 101 ventriculares) con una mediana de antiguedad de 81 meses (rango 16-246 meses). Un 69,1% de los pacientes tenian cables de antiguedad > 5 anos y un 36,2% anomalias en la permeabilidad de los ejes venosos. La tasa de exito completo del procedimiento y la tasa de exito clinico fueron del 96,8 y el 97,9%, respectivamente. Se registraron un 6,4% de complicaciones cardiovasculares mayores y un fallecimiento. El analisis bivariante mostro como predictores de complicacion cardiovascular la antiguedad de los cables, los cables bibobina del desfibrilador automatico implantable y la oclusion completa del eje venoso ipsolateral. La mortalidad en pacientes que requirieron intervencion quirurgica o endovascular emergente por complicacion cardiovascular mayor fue del 16,7%. Conclusiones La EET de DEIC mediante laser presenta una notable eficacia y seguridad incluso en pacientes de alto riesgo. Las complicaciones cardiovasculares mayores son infrecuentes, pero potencialmente letales. Su identificacion y tratamiento precoz es fundamental para la supervivencia del paciente.
Published: 2019
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10. Non-contrast transoesophageal echo-guided transapical transcatheter aortic valve replacement: 10-year experience of a renoprotective strategy

Author: José J. Cuenca-Castillo, Alberto Bouzas-Mosquera, José M. Herrera-Noreña, Bárbara Oujo-González, Yago Vilela-González, Carlos Velasco-García, and Víctor Mosquera
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Renal function, 030204 cardiovascular system & hematology, Prosthesis, Preoperative care, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Valve replacement, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Stroke, Heart Valve Prosthesis Implantation, Adult Cardiac, business.industry, Acute kidney injury, Odds ratio, Aortic Valve Stenosis, medicine.disease, Treatment Outcome, Aortic Valve, Heart Valve Prosthesis, Cardiology, Surgery, Cardiology and Cardiovascular Medicine, business, Kidney disease
Abstract: OBJECTIVES This study aims to evaluate the efficacy, safety and long-term outcomes of a renoprotective non-contrast, transoesophageal echocardiography-guided transapical (TA) transcatheter aortic valve replacement (TAVR) strategy with a balloon-expandable prosthesis, as well as to determine its impact on renal function. METHODS Between 2009 and 2019, 200 consecutive patients underwent a non-contrast, transoesophageal echocardiography-guided TA TAVR with a balloon-expandable prosthesis. RESULTS The device success rate was 95.5%. Transoesophageal echocardiography-guided deployment demonstrated a low rate of procedure-related complications: 9.5% of acute kidney injury, 8% postoperative bleeding, 6% low-cardiac output, 4.5% postprocedural aortic regurgitation ≥+2, 4% implantation of permanent pacemaker and 2% stroke. There were no significant differences between preoperative and on discharge estimated glomerular filtration rate (53.9 ± 22.2 vs 54.3 ± 22.9 ml/min/1.73 m2, P = 0.60). Logistic regression analysis confirmed postoperative bleeding as an independent predictor for acute kidney injury (odds ratio (OR) 11.148, 95% confidence interval 3.537–35.140, P CONCLUSIONS Non-contrast, transoesophageal echocardiography-guided TA TAVR is a safe and reproducible technique with a low incidence of periprocedural complications that avoids the use of contrast and mitigates the incidence of acute kidney injury.
Published: 2020

11. Prótesis sin sutura: ¿es posible reducir la tasa de bloqueos postoperatorios modificando la técnica de implante?

Author: Víctor X. Mosquera-Rodríguez, Maria Garcia-Vieites, Patricia Pardo-Martinez, José J. Cuenca-Castillo, Laura Fernández-Arias, Carlos Velasco Garcia de Sierra, Miguel González-Barbeito, Francisco Estévez-Cid, Jose María Herrera-Norena, Yago Vilela-González, Carmen Iglesias-Gil, and Jorge Rodriguez-Garrido
Subjects: business.industry, lcsh:R, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen: Introducción: El recambio valvular aórtico con prótesis sin sutura Perceval S se asocia a un aumento en la tasa de bloqueo auriculoventricular postoperatorio que precisa implante de marcapasos definitivo, comparado con las bioprótesis convencionales. En nuestra serie hemos modificado la técnica de implante (mínimo baloneo
Published: 2018
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12. Mitral Repair as a Treatment of Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: 'Myectomy Without Myectomy'

Author: Jesús Peteiro-Vázquez, Miguel González-Barbeito, Francisco Estévez-Cid, Nicolás Manuel Maneiro-Melón, Roberto Barriales-Villa, and José J. Cuenca-Castillo
Subjects: medicine.medical_specialty, business.industry, Internal medicine, medicine, Hypertrophic cardiomyopathy, Cardiology, Outflow, General Medicine, medicine.disease, business
Published: 2019
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13. Tratamiento de la obstrucción del tracto de salida en la miocardiopatía hipertrófica mediante reparación mitral: «miectomía sin miectomía»

Author: José J. Cuenca-Castillo, Jesús Peteiro-Vázquez, Francisco Estévez-Cid, Nicolás Manuel Maneiro-Melón, Roberto Barriales-Villa, and Miguel González-Barbeito
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2019
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14. Prognostic Value of the Nutritional Risk Index in Heart Transplant Recipients

Author: Gonzalo Barge-Caballero, David Couto-Mallón, Miguel Solla-Buceta, José Manuel Vázquez-Rodríguez, José J. Cuenca-Castillo, Raquel Marzoa-Rivas, María J. Paniagua-Martín, Carlos Velasco-Sierra, María G. Crespo-Leiro, José M. Herrera-Noreña, Fernando García-López, Francisco Pita-Gutiérrez, and Eduardo Barge-Caballero
Subjects: Male, Trasplante cardiaco, Desnutrición, medicine.medical_specialty, Pediatrics, Ventricular Dysfunction, Right, medicine.medical_treatment, Nutritional Status, Nutritional risk index, Outcomes, 030204 cardiovascular system & hematology, Body weight, Logistic regression, Ventricular Dysfunction, Left, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, Nutritional risk, Retrospective Studies, Heart Failure, Heart transplantation, Proportional hazards model, business.industry, Malnutrition, Pronóstico, Nutritional status, Índice de riesgo nutricional, General Medicine, Length of Stay, Middle Aged, Prognosis, medicine.disease, Malnourishment, Nutrition Assessment, Heart Transplantation, Female, Heart transplant, Primary Graft Dysfunction, business
Abstract: [Abstract] Introduction and objectives. To study the prognostic impact of preoperative nutritional status, as assessed through the nutritional risk index (NRI), on postoperative outcomes after heart transplantation (HT). Methods. We conducted a retrospective, single-center study of 574 patients who underwent HT from 1991 to 2014. Preoperative NRI was calculated as 1.519 × serum albumin (g/L) + 41.7 × (body weight [kg] / ideal body weight [kg]). The association between preoperative NRI and postoperative outcomes was analyzed by means of multivariable logistic regression and multivariable Cox regression. Results. Mean NRI before HT was 100.9 ± 9.9. According to this parameter, the prevalence of severe nutritional risk (NRI < 83.5), moderate nutritional risk (83.5 ≤ NRI < 97.5), and mild nutritional risk (97.5 ≤ NRI < 100) was 5%, 22%, and 10%, respectively. One year post-transplant mortality rates in these 4 categories were 18.2%, 25.3%, 7.9% and 10.2% (P < .001), respectively. The NRI was independently associated with a lower risk of postoperative infection (adjusted OR, 0.97; 95%CI, 0.95-1.00; P = .027) and prolonged postoperative ventilator support (adjusted OR, 0.96; 95%CI, 0.94-0.98; P = .001). Patients at moderate or severe nutritional risk had significantly higher 1-year post-HT mortality (adjusted HR, 1.55; 95%CI, 1.22-1.97; P < .001). Conclusions. Malnourished patients have a higher risk of postoperative complications and mortality after HT. Preoperative NRI determination may help to identify HT candidates who might benefit from nutritional intervention. [Resumen] Introducción y objetivos. Analizar el impacto del estado nutricional preoperatorio, evaluado mediante el índice de riesgo nutricional (IRN), en el pronóstico tras el trasplante cardiaco (TxC). Métodos. Se realizó un estudio retrospectivo de 574 pacientes que recibieron un TxC entre 1991 y 2014 en un centro. El IRN preoperatorio se calculó como 1,519 × albúmina (g/l) + 41,7 × (peso real [kg] / peso ideal [kg]). La asociación entre IRN preoperatorio y eventos clínicos posoperatorios se analizó mediante modelos multivariables de regresión logística y regresión de Cox. Resultados. El IRN preoperatorio medio de la población del estudio era de 100,9 ± 9,9. Según este parámetro, las prevalencias de riesgo nutricional grave (IRN < 83,5), moderado (83,5 ≤ IRN < 97,5) y leve (97,5 ≤ IRN < 100) antes del TxC eran el 5, el 22 y el 10% respectivamente. Las tasas de mortalidad a 1 año tras el TxC en estas 4 categorías fueron del 18,2, el 25,3, el 7,9 y el 10,2% (p < 0,001) respectivamente. El IRN preoperatorio resultó predictor independiente de menor riesgo de infección posoperatoria (odds ratio ajustada [ORa] = 0,97; intervalo de confianza del 95% [IC95%], 0,95-1,00; p = 0,027) y ventilación mecánica prolongada posoperatoria (ORa = 0,96; IC95%, 0,94-0,98; p = 0,001). Los pacientes con riesgo nutricional moderado a grave mostraron mayor mortalidad a 1 año tras el TxC (hazard ratio ajustada = 1,55; IC95%, 1,22-1,97; p < 0,001). Conclusiones. Los pacientes desnutridos tienen mayor riesgo de complicaciones posoperatorias y muerte tras el TxC. La determinación del IRN podría facilitar la identificación de candidatos a TxC que se beneficien de intervenciones nutricionales en espera del órgano.
Published: 2017
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15. Valor pronóstico del índice de riesgo nutricional en receptores de trasplante cardiaco

Author: Gonzalo Barge-Caballero, José Manuel Vázquez-Rodríguez, Raquel Marzoa-Rivas, José M. Herrera-Noreña, David Couto-Mallón, Fernando García-López, Carlos Velasco-Sierra, Eduardo Barge-Caballero, Miguel Solla-Buceta, José J. Cuenca-Castillo, Francisco Pita-Gutiérrez, María J. Paniagua-Martín, and María G. Crespo-Leiro
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Analizar el impacto del estado nutricional preoperatorio, evaluado mediante el indice de riesgo nutricional (IRN), en el pronostico tras el trasplante cardiaco (TxC). Metodos Se realizo un estudio retrospectivo de 574 pacientes que recibieron un TxC entre 1991 y 2014 en un centro. El IRN preoperatorio se calculo como 1,519 × albumina (g/l) + 41,7 × (peso real [kg] / peso ideal [kg]). La asociacion entre IRN preoperatorio y eventos clinicos posoperatorios se analizo mediante modelos multivariables de regresion logistica y regresion de Cox. Resultados El IRN preoperatorio medio de la poblacion del estudio era de 100,9 ± 9,9. Segun este parametro, las prevalencias de riesgo nutricional grave (IRN Conclusiones Los pacientes desnutridos tienen mayor riesgo de complicaciones posoperatorias y muerte tras el TxC. La determinacion del IRN podria facilitar la identificacion de candidatos a TxC que se beneficien de intervenciones nutricionales en espera del organo.
Published: 2017
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16. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Author: Leticia Seoane-Quiroga, Gonzalo Barge-Caballero, Ángela López-Sainz, José J. Cuenca-Castillo, María J. Paniagua-Martín, María G. Crespo-Leiro, Eduardo Barge-Caballero, José Manuel Vázquez-Rodríguez, José M. Herrera-Noreña, David Couto-Mallón, and Carmen Iglesias-Gil
Subjects: Heart transplantation, Inotrope, medicine.medical_specialty, Ejection fraction, business.industry, medicine.medical_treatment, Incidence (epidemiology), 030204 cardiovascular system & hematology, 030230 surgery, medicine.disease, Confidence interval, Surgery, Transplantation, 03 medical and health sciences, surgical procedures, operative, 0302 clinical medicine, Diabetes mellitus, Heart failure, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Aim To analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation. Methods and results We conducted an observational, single-centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in-hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow-up of 8.4 ± 6 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient-years, 95% confidence interval (CI) 3.1-4.2]. Pre-transplant diabetes, higher pre-transplant transpulmonary pressure gradient and lower donor-recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade ≥1R, and antibody-mediated rejection grade ≥1 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was ≥50% in 60.1% of these patients. Re-transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re-hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient-years (95% CI 36.6-46.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes. Conclusions Late graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.
Published: 2017
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17. Resultados del recambio valvular pulmonar según el tipo de prótesis implantada

Author: Francisco Portela Torrón, Beatriz Bouzas Zubeldía, Isaac Martínez Bendayán, María García Vieites, Daniel Vásquez Echeverri, Laura Fernandez Arias, José J. Cuenca Castillo, and Víctor Bautista Hernández
Subjects: business.industry, lcsh:R, lcsh:Surgery, Recambio valvular pulmonar, lcsh:Medicine, Prótesis biológica, lcsh:RD1-811, 030204 cardiovascular system & hematology, Disfunción protésica, 03 medical and health sciences, Patología tracto de salida ventrículo derecho, 0302 clinical medicine, 030228 respiratory system, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Humanities, Cardiopatías congénitas
Abstract: Resumen Introduccion y objetivos El recambio valvular pulmonar (RVP) es actualmente la intervencion mas frecuente de las cardiopatias congenitas del adulto. Existen numerosas controversias sobre cuando implantar una protesis y; sobre todo, acerca de cual es el sustituto ideal. El objetivo del estudio es revisar el resultado de 3 tipos de protesis biologicas implantadas en nuestro centro. Metodos Desde 2003 se implantaron 3 tipos de protesis biologicas en diferentes momentos: grupo 1-protesis Medtronic Freestyle (n = 14); grupo 2-protesis Sorin Soprano (n = 24), y grupo 3-protesis Carpentier Edwards (n = 15). Se analizaron datos clinicos, ecocardiograficos y de seguimiento, tanto pre como postoperatorios. Resultados El RVP se asocio a una mejoria de la New York Heart Association y a un aumento de la fraccion eyeccion ventriculo izquierdo postoperatoria en nuestra serie. Las caracteristicas preoperatorias fueron similares entre grupos. El grupo 1 presento un gradiente mayor inicial (p = 0,053), aunque estable en el tiempo. El grupo 2 se asocio a una mayor tasa de disfunciones protesicas tardias (p = 0,004). La degeneracion protesica global de la serie fue de 20 pacientes con 5 reintervenciones. No hubo mortalidad precoz y durante el seguimiento fallecieron 4 pacientes, 1 por causa cardiaca. T medio ± desviacion estandar de seguimiento global: 49,98 ± 42,79 meses. Conclusiones El RVP en nuestra serie se ha asociado a una baja tasa de mortalidad perioperatoria. Cuando comparamos segun el tipo de protesis, la protesis Medtronic Freestyle presento un mayor gradiente inicial y en el grupo Sorin Soprano se observa una degeneracion protesica superior a la esperada. Sin embargo, sera necesario mas seguimiento para definir el comportamiento de la protesis Carpentier Edwards.
Published: 2017
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18. Diagnóstico y tratamiento de la obstrucción al flujo en dispositivos de asistencia ventricular de flujo continuo. Un problema infrecuente

Author: María G. Crespo Leiro, David Couto Mallón, Gonzalo Barge Caballero, José J. Cuenca Castillo, Eduardo Barge Caballero, and Jorge Salgado Fernández
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Cardiology and Cardiovascular Medicine, business
Published: 2020
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19. Diagnóstico y tratamiento de la obstrucción al flujo en dispositivos de asistencia ventricular de flujo continuo; un problema infrecuente

Author: Eduardo Barge Caballero, Gonzalo Barge Caballero, José J. Cuenca Castillo, María G. Crespo Leiro, David Couto Mallón, and Jorge Salgado Fernández
Subjects: medicine.medical_specialty, Continuous flow, business.industry, Heart failure, General Medicine, medicine.disease, Flow (mathematics), Internal medicine, medicine, Cardiology, Heart-assist devices, Heart-Assist Devices, business
Abstract: Carta científica
Published: 2020
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20. Abordaje mínimamente invasivo para la asistencia biventricular con bombas centrífugas: primera experiencia en España

Author: Eduardo Barge-Caballero, Miguel González-Barbeito, Francisco Estévez-Cid, Carmen Iglesias-Gil, and José J. Cuenca-Castillo
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Published: 2020
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21. Minimally invasive approach for biventricular assist device with centrifugal pump: first experience in Spain

Author: Miguel González-Barbeito, Eduardo Barge-Caballero, José J. Cuenca-Castillo, Francisco Estévez-Cid, and Carmen Iglesias-Gil
Subjects: medicine.medical_specialty, business.industry, Biventricular assist device, medicine, General Medicine, Centrifugal pump, business, Surgery
Published: 2020
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22. Rapid Deployment Aortic Replacement (RADAR) Registry in Spain: Initial Results

Author: Fernando Hornero, Alejandro Vázquez, Francisco Gutiérrez, Victor Bautista-Hernandez, Sergio Cánovas, Manuel Carnero, Jose M Arribas-Leal, Jose Aurelio Sarralde, José J. Cuenca-Castillo, Natalia Cal-Purriños, Luis Maroto, and Miguel González-Barbeito
Subjects: medicine.medical_specialty, Aortic valve replacement, law, business.industry, Software deployment, Incidence (epidemiology), Emergency medicine, Medicine, Radar, Cardiology and Cardiovascular Medicine, business, medicine.disease, law.invention
Abstract: Objective: The aim of our study is to report our initial results with rapid deployment aortic valve replacement within the Spanish RADAR Registry, especially focusing on the incidence of patient-pr...
Published: 2020
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23. High-Definition Video Recording: Taking Sport Technology to the Operating Room

Author: José J. Cuenca-Castillo, C. Velasco Garcia de Sierra, and Francisco Estévez-Cid
Subjects: Pulmonary and Respiratory Medicine, Operating Rooms, Video Recording, Documentation, 030204 cardiovascular system & hematology, computer.software_genre, Video sharing, 03 medical and health sciences, Upload, 0302 clinical medicine, Task Performance and Analysis, Humans, Medicine, Digital recording, Surgeons, Education, Medical, Multimedia, business.industry, Equipment Design, Surgical procedures, High-definition video, Surgical Procedures, Operative, 030220 oncology & carcinogenesis, High definition, Surgery, The Internet, Line (text file), Cardiology and Cardiovascular Medicine, business, computer
Abstract: Filming surgeries for teaching purposes, publications, and patient records has become increasingly popular as the systems for digital recording have evolved, becoming high-quality systems, both smaller and lighter. Digital recording allows long-term storage, retrieval, and database organization. In addition, sharing digital contents has also become easier since video sharing sites and social networks make it possible to upload these contents onto the Internet. We describe a simple and economical system for surgeons to record surgeries in high definition under sterile conditions without any interference with the surgeon's line of vision.
Published: 2018
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24. Long-Term Outcomes and Durability of the Mitroflow Aortic Bioprosthesis

Author: Javier Muñiz, Carlos Velasco-García, José J. Cuenca-Castillo, José M. Herrera-Noreña, Francisco Portela-Torron, Francisco Estévez-Cid, Víctor Mosquera, and Alberto Bouzas-Mosquera
Subjects: Pulmonary and Respiratory Medicine, Aortic valve, medicine.medical_specialty, business.industry, Incidence (epidemiology), Hemodynamics, Retrospective cohort study, 030204 cardiovascular system & hematology, medicine.disease, Left ventricular hypertrophy, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, Aortic valve replacement, Aortic valve stenosis, medicine, Cumulative incidence, Cardiology and Cardiovascular Medicine, business
Abstract: Background This study aims to determine the incidence and causes of structural valve deterioration (SVD) among all models of Mitroflow bioprostheses (A12/LX/DL), as well as to define their long-term clinical and hemodynamic performance. Methods and Results We retrospectively reviewed a series of 1023 patients who underwent aortic valve replacement with Mitroflow bioprostheses between 2001 and 2014. A small aortic root was found in 22.4% of patients. There were two cases of severe patient-prosthesis mismatch. Only 31 patients developed SVD. The rate of incidence was 8.1 cases per 1000 patient-years. Cumulative incidence of SVD was 1.4% and 3% at five and 10 years, respectively. Freedom from SVD was 97.4% and 88.2% at five and 10 years, respectively. Anticalcification phospholipid reduction treatment (PRT) for model DL was a protective factor for SVD. Multivariable analysis confirmed age 70 years, and cases with severe left ventricular hypertrophy. PRT might contribute to improved long-term durability.
Published: 2016
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25. Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders

Author: José Manuel Vázquez-Rodríguez, Ignacio Mosquera-Pérez, David Couto-Mallón, Gonzalo Barge-Caballero, Luisa Pérez-Álvarez, José J. Cuenca-Castillo, Javier Muñiz, Emilse Martínez-Paz, Laura Álvarez-Roy, María J. Paniagua-Martín, María G. Crespo-Leiro, and Eduardo Barge-Caballero
Subjects: medicine.medical_specialty, biology, business.industry, Syncope (genus), 030204 cardiovascular system & hematology, medicine.disease, biology.organism_classification, Loop (topology), 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart failure, Cardiology, medicine, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Published: 2017
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26. Mitochondrial DNA haplogroups influence the risk of aortic stenosis

Author: Maria Garcia-Vieites, F. Blanco-García, Victor Bautista-Hernandez, Ignacio Rego-Pérez, Nieves Domenech-Garcia, Maria E. Serrano-Teruel, and José J. Cuenca-Castillo
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, DNA, Mitochondrial, Risk Assessment, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Pathological, Genetic Association Studies, Aged, Aged, 80 and over, Heart Valve Prosthesis Implantation, business.industry, Haplotype, General Medicine, Aortic Valve Stenosis, Middle Aged, medicine.disease, Pathophysiology, Stenosis, Phenotype, 030228 respiratory system, Haplotypes, Spain, Aortic valve stenosis, Aortic Valve, Case-Control Studies, Cardiology, Surgery, Female, Cardiology and Cardiovascular Medicine, business, Human mitochondrial DNA haplogroup
Abstract: Aim The underlying pathophysiologic mechanisms of aortic stenosis are not clear. Mitochondrial dysfunction plays a role in many pathological conditions including cardiac diseases. We aimed to analyze the mitochondrial DNA haplogroups in a group of patients undergoing valve replacement surgery due to severe aortic stenosis. Methods Mitochondrial DNA haplogroups were assessed in 176 patients with severe aortic stenosis and 308 control subjects. Cardiovascular risk factors and demographics were similar in both groups. Results Patients carrying haplogroup Uk had a lower risk of developing aortic stenosis, especially compared to patients carrying haplogroup H (odds ratio = 0.507; 95% confidence interval: 0.270–0.952, p = 0.035). Conclusions Mitochondrial DNA haplogroups could be involved in the development of severe aortic stenosis. Specifically, haplogroup H could be a risk factor and Uk a protective factor for severe aortic stenosis in a population from Spain.
Published: 2018

27. Efficacy and safety of transcatheter valve-in-valve replacement for Mitroflow bioprosthetic valve dysfunction

Author: José M. Herrera-Noreña, José J. Cuenca-Castillo, Alberto Bouzas-Mosquera, José Manuel Vázquez-Rodríguez, Víctor Mosquera, Carlos Velasco, Jorge Salgado-Fernández, Nicolás Vázquez-González, Miguel González-Barbeito, and Ramón Calviño-Santos
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, medicine.medical_treatment, Heart Valve Diseases, Hemodynamics, Regurgitation (circulation), 030204 cardiovascular system & hematology, Bioprosthetic valve, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Bioprosthesis, business.industry, Stent, EuroSCORE, Valve in valve, Prosthesis Failure, Treatment Outcome, 030228 respiratory system, Coronary occlusion, Aortic Valve, Heart Valve Prosthesis, Cardiology, Surgery, Female, Stents, Safety, Cardiology and Cardiovascular Medicine, Complication, business, Follow-Up Studies
Abstract: Objectives Bioprostheses with pericardial leaflets mounted externally on the stent pose a high risk for valve-in-valve (ViV) procedures. This study analyzed the efficacy and safety of ViV procedures for treating structural valve deterioration (SVD) in Mitroflow bioprostheses. Methods Between January 2012 and August 2017, 11 patients (mean age 80.3 ± 5.6 years) were treated for SVD of Mitroflow bioprostheses with transcatheter ViV procedures (six transapical [TA] and five transfemoral [TF]) using balloon expandable bioprostheses. Results All patients but one were in NYHA class III-IV. Mean STS PROM, euroSCORE I, and euroSCORE II were 8 ± 6.5%, 27.8 ± 11.5%, and 12 ± 5.9%, respectively. Two patients had a "porcelain aorta." The size of implanted valves were 23 mm in 10 cases and 26 mm in one case. One patient suffered a coronary occlusion during a TF approach. The mean volume of contrast used in TF implants was 163 ± 69.8 mL. No contrast media were used in TA procedures. There was one in-hospital death (10%). At 1 year of follow-up, peak and mean aortic gradients were 25.5 ± 5.8 mmHg and 15.5 ± 5.7 mmHg, respectively. One patient had mild paravalvular regurgitation. Cumulative survival was 90.9% at 1 year, 70.7% at 2 years, and 53% at 3 years. Conclusions ViV procedures with balloon-expandable aortic valves provide good hemodynamic and clinical mid-term results for treating patients with a degenerated Mitroflow aortic bioprosthesis. Special care must be taken in small aortic roots, when the stented valve is in the supra-annular position to avoid coronary ostial obstruction.
Published: 2018

28. Transaxillary Implantation of the Impella CP Mechanical Circulatory Support Device as a Bridge to Heart Transplant. First Experience in Spain

Author: Francisco Estévez-Cid, Carlos García-Velasco, María G. Crespo-Leiro, Miguel Solla-Buceta, José J. Cuenca-Castillo, and David Couto-Mallón
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Forensic engineering, Medicine, General Medicine, 030204 cardiovascular system & hematology, business, Bridge (interpersonal), Impella
Published: 2019
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29. Quality markers in cardiology: measures of outcomes and clinical practice —a perspective of the Spanish Society of Cardiology and of Thoracic and Cardiovascular Surgery1

Author: Fausto J. Pinto, José Ramón López Mínguez, Regina Dalmau, José-Luis López-Sendón, José Luis Pomar Moya-Prats, Alessandro Sionis, Domingo A. Pascual-Figal, José Luis Zamorano, Alicia M. Maceira, Lina Badimon, José J. Cuenca Castillo, Esteban González Torrecilla, and José Ramón González-Juanatey
Subjects: medicine.medical_specialty, business.industry, media_common.quotation_subject, Perspective (graphical), lcsh:R, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, Clinical Practice, Internal medicine, Cardiology, Medicine, Surgery, Quality (business), Cardiology and Cardiovascular Medicine, business, media_common
Published: 2015
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30. Comentarios al documento INCARDIO: Indicadores de Calidad en Unidades Asistenciales del Área del Corazón

Author: Tomasa Centella Hernández, Fernando Hornero Sos, and José J. Cuenca Castillo
Subjects: business.industry, lcsh:R, lcsh:Surgery, lcsh:Medicine, Medicine, Surgery, lcsh:RD1-811, Cardiology and Cardiovascular Medicine, business, Humanities
Published: 2015
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31. Significado pronóstico y evolución a largo plazo de la frecuencia cardiaca en los pacientes con trasplante cardiaco

Author: María J. Paniagua-Martín, Gonzalo Barge-Caballero, María G. Crespo-Leiro, Alfonso Castro-Beiras, Eduardo Barge-Caballero, José J. Cuenca-Castillo, Jesús Jiménez-López, S. Chávez-Leal, Raquel Marzoa Rivas, and Z. Grille-Cancela
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen Introduccion y objetivos Estudiar la evolucion y el significado pronostico de la frecuencia cardiaca tras el trasplante cardiaco. Metodos Estudio observacional de 170 pacientes que recibieron un trasplante cardiaco bicavo entre 1995 y 2005; todos estaban en ritmo sinusal. La frecuencia cardiaca en reposo se determino a partir de electrocardiogramas al final del primer ano tras el trasplante y anualmente hasta el decimo ano. Mediante analisis de Cox, se evaluo la incidencia de eventos adversos en un seguimiento medio de 8,9 ± 3,1 anos. El evento principal del estudio fue la variable combinada muerte o disfuncion del injerto. Resultados La frecuencia cardiaca en reposo, medida al final del primer ano tras el trasplante, fue un predictor independiente del evento combinado principal (hazard ratio = 1,054; intervalo de confianza del 95%, 1,028-1,080; p Conclusiones La frecuencia cardiaca elevada es un marcador pronostico adverso tras el trasplante cardiaco.
Published: 2015
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32. Evolution of conservative treatment of acute traumatic aortic injuries: lights and shadows

Author: José M. Herrera-Noreña, Miguel González-Barbeito, Daniel Gulias-Soidan, José J. Cuenca-Castillo, Carlos E. Velasco, Víctor Mosquera, Milagros Marini, and Daniel Fraga-Manteiga
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Aortography, 030204 cardiovascular system & hematology, Conservative Treatment, Wounds, Nonpenetrating, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Injury Severity Score, medicine.artery, medicine, Humans, Stage (cooking), Aorta, Retrospective Studies, medicine.diagnostic_test, Proportional hazards model, business.industry, Disease Management, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, Vascular System Injuries, Surgery, Survival Rate, Treatment Outcome, Spain, Cohort, Acute Disease, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Objectives The objective of this study is to compare early and long-term results in terms of survival and aortic complications for traumatic aortic injuries depending on the initial management strategy. Methods From January 1980 to January 2017, 101 patients with aortic injuries were divided into 3 groups according to management strategy at admission: 60 patients, conservative management; 26 patients, open surgery and 15 patients, endovascular repair. The groups were similar in terms of gender and trauma severity scores. Results All but 1 aortic-related complications and aortic-related mortality occurred in the conservative group (11.6% conservative vs 2.4% in both surgical and endovascular groups, P = 0.091). Total follow-up was 1109.27 patient-years. Survival in the conservative, surgical and endovascular group was 71.7%, 80.8% and 79.4% at 1 year, 68.2%, 80.8% and 79.4% at 5 years and 63.9%, 72.7% and 79.4% at 10 years, respectively (log-rank = 0.218). The rate of aortic-related complications was 58.3% in the conservative cohort. Cox regression identified the following risk factors for aortic-related complications: aortic injuries grade >I [odds ratio (OR), 3.05; P = 0.021], Trauma Injury Severity Score >50% (OR 1.21; P = 0.042) and the decade of treatment (OR 0.49; P = 0.011). Conclusions Minimal aortic injuries seem to be an amenable target for medical management, but patients remain at risk of developing aortic-related complications. Close, long-term imaging surveillance is mandatory to detect such complications at an early stage.
Published: 2017

33. Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders

Author: Emilse, Martínez-Paz, Eduardo, Barge-Caballero, Laura, Álvarez-Roy, Gonzalo, Barge-Caballero, David, Couto-Mallón, María J, Paniagua-Martín, Ignacio, Mosquera-Pérez, Luisa, Pérez-Álvarez, Javier, Muñiz, José J, Cuenca-Castillo, José Manuel, Vázquez-Rodríguez, and María G, Crespo-Leiro
Subjects: Heart Failure, Male, Spain, Incidence, Bradycardia, Electrocardiography, Ambulatory, Heart Transplantation, Humans, Female, Middle Aged, Transplant Recipients
Published: 2017

34. Perceval Less Invasive Aortic Replacement Register: multicentric Spanish experience with the Perceval S bioprosthesis in moderate-high-risk aortic surgery

Author: Gregorio Cuerpo Caballero, Elisabet Berastegui García, Ángel González Pinto, Fabrizio Sbraga, Eladio Sanchez Dominguez, Julio Garcia Puente, Remedios Rios Barrera, Maria Luisa Camara Rosell, Ivan García Martin, Francisco Estevez Cid, Guillermo Reyes Copa, Santiago Serrano Fiz, José J. Cuenca Castillo, Xavier Ruyra Baliarda, José A. Buendía Miñano, Marian Tena Pajuelo, Sergio Cánovas López, Juan Bustamante Munguira, and Elena Rosello Diez
Subjects: Pulmonary and Respiratory Medicine, Aortic valve, medicine.medical_specialty, medicine.medical_treatment, Periprosthetic, 030204 cardiovascular system & hematology, Prosthesis Design, Prosthesis, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Aortic valve replacement, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, Survival rate, Aged, Bioprosthesis, business.industry, Incidence, EuroSCORE, Aortic Valve Stenosis, medicine.disease, Surgery, Survival Rate, medicine.anatomical_structure, Echocardiography, Spain, Aortic valve stenosis, Aortic Valve, Heart Valve Prosthesis, Female, Cardiology and Cardiovascular Medicine, business
Abstract: OBJECTIVES: The development of new percutaneous and surgical techniques has reduced the risk associated with aortic valve replacement procedures. We present the results of a Spanish register after initiating a programme for sutureless prostheses in moderatehigh-risk patients. METHODS: This prospective multicentre study was carried out from November 2013 to November 2016. Data were obtained from 448 patients in whom a Perceval S prosthesis was implanted. RESULTS: The mean age was 79.24 (standard deviation [SD] 4.1) years, and 61.2% were women. The estimated EuroSCORE I log risk was 11.15% (SD 7.6), with an observed mortality of 4.4% (20 patients). Isolated aortic valve replacement was performed on 69.26% of patients, with 64% involving ministernotomy. The incidence of neurological events was 2%, with 2 permanent cerebrovascular accidents, and 41 (9.2%) patients were implanted with a permanent endocavitary pacemaker. At discharge, 12 (2.6%) patients presented minimal periprosthetic leakage, and 4 (0.89%) patients had moderate leakage. There were 3 reinterventions during follow-up (2 endocarditis and 1 dysfunction due to periprosthetic leak progression). The mean gradient at discharge, 6 months and 1 year was 12.94 (SD 5.3) mmHg, 12.19 (SD 4.7) mmHg and 11.77 (SD 4.7) mmHg, respectively; 59.4% of the patients were octogenarians, with a survival rate of 98% at both 6 months and 1 year at discharge. There was neither valve migration nor early structural degeneration. The mean follow-up was 12 ± 3 months. The 6-month and 1-year mortality was 1.4% and 2.1%, respectively. CONCLUSIONS: This is a prospective multicentric study on the largest cohort of patients with sutureless valves conducted in Spain to date. It is a reproducible procedure that has enabled surgery on patients with a moderatehigh risk with low morbidity and mortality, providing good haemodynamic results.
Published: 2017

35. Late graft failure in heart transplant recipients: incidence, risk factors and clinical outcomes

Author: Ángela, López-Sainz, Eduardo, Barge-Caballero, Gonzalo, Barge-Caballero, David, Couto-Mallón, María J, Paniagua-Martin, Leticia, Seoane-Quiroga, Carmen, Iglesias-Gil, José M, Herrera-Noreña, José J, Cuenca-Castillo, José M, Vázquez-Rodríguez, and María G, Crespo-Leiro
Subjects: Graft Rejection, Heart Failure, Male, Time Factors, Incidence, Middle Aged, Prognosis, Risk Assessment, Survival Rate, Risk Factors, Spain, Heart Transplantation, Humans, Female, Follow-Up Studies, Retrospective Studies
Abstract: To analyse the incidence, risk factors and clinical outcomes of late graft failure after heart transplantation.We conducted an observational, single-centre study based on 547 patients who underwent cardiac transplantation from 1991 to 2014 and who survived the in-hospital postoperative period. Late graft failure was defined as the first hospitalization due to this condition after discharge. Over a mean follow-up of 8.4 ± 6 years, 178 (32.5%) patients were hospitalized due to late graft failure [incidence rate: 3.6 cases per 100 patient-years, 95% confidence interval (CI) 3.1-4.2]. Pre-transplant diabetes, higher pre-transplant transpulmonary pressure gradient and lower donor-recipient weight ratio were independently associated with higher risk of graft failure. Cardiac allograft vasculopathy, cellular rejection grade ≥1R, and antibody-mediated rejection grade ≥1 were detected in 50.6%, 44.9% and 19.2% patients, respectively, admitted due to graft failure. Left ventricular ejection fraction was ≥50% in 60.1% of these patients. Re-transplant free survival 1, 5, 10 and 15 years after the diagnosis of late graft failure was 72.2%, 38.4%, 18.4%, and 7.5%, respectively; the incidence rate of re-hospitalization due to decompensated heart failure was 40.9 episodes per 100 patient-years (95% CI 36.6-46.1). The need for inotropes, the presence of cardiac allograft vasculopathy, higher creatinine serum levels, lower ejection fraction and lower sodium serum levels were independent predictors of worse outcomes.Late graft failure is frequent after heart transplantation, as it is associated with poor outcomes. Rejection and cardiac allograft vasculopathy are the most frequent underlying causes.
Published: 2017

36. Rationale and design of a multicentre, prospective, randomised, controlled clinical trial to evaluate the efficacy of the adipose graft transposition procedure in patients with a myocardial scar: the AGTP II trial

Author: Pablo Avanzas, J. Alberto San Román, Ramon Brugada, Eduardo de Teresa, Jacobo Silva, Domingo A. Pascual-Figal, Pablo García-Pavia, Julio Núñez, María G. Crespo-Leiro, Josep Lupón, Ana Revilla-Orodea, Maria Luisa Camara, Francisco Fernández-Avilés, Ángel González-Pinto, José J. Cuenca-Castillo, Ángel Caballero, Nicolás Manito, Juan Bustamante-Munguira, Carolina Gálvez-Montón, Sergio Cánovas, Albert Teis, Antoni Bayes-Genis, José M. Melero, Paloma Gastelurrutia, and Carlos Martín
Subjects: 0301 basic medicine, Cardiac function curve, Adult, Male, medicine.medical_specialty, Cardiac Volume, Myocardial Infarction, Adipose tissue, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Transplantation, Autologous, Ventricular Function, Left, 03 medical and health sciences, Cicatrix, 0302 clinical medicine, pericardial adipose graft, Natriuretic Peptide, Brain, Clinical endpoint, Protocol, Medicine, Humans, Regeneration, Myocardial infarction, Prospective Studies, Coronary Artery Bypass, adipose progenitor cells, Randomized Controlled Trials as Topic, clinical trials, Ejection fraction, business.industry, Myocardium, cardiac regeneration, General Medicine, Brain natriuretic peptide, Institutional review board, medicine.disease, Peptide Fragments, Surgery, Clinical trial, 030104 developmental biology, Treatment Outcome, Adipose Tissue, Research Design, tissue engineering, chronic myocardial infarction, Female, business
Abstract: IntroductionCardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area. Following encouraging results in acute and chronic MI porcine models, we performed the clinical trial (NCT01473433, AdiFLAP trial) to evaluate safety in patients with chronic MI undergoing coronary artery bypass graft. The good safety profile and trends in efficacy warranted a larger trial.Study designThe AGTP II trial (NCT02798276) is an investigator initiated, prospective, randomised, controlled, multicentre study to assess the efficacy of the AGTP in 108 patients with non-revascularisable MI. Patients will be assigned to standard clinical practice or the AGTP. The primary endpoint is change in necrotic mass ratio by gadolinium enhancement at 91 and 365 days. Secondary endpoints include improvement in regional contractibility by MRI at 91 and 365 days; changes in functional MRI parameters (left ventricular ejection fraction, left and right ventricular geometric remodelling) at 91 and 365 days; levels of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) at 7, 91 and 365 days; appearance of arrhythmias from 24 hour Holter monitoring at 24 hours, and at 91 and 365 days; all cause death or re-hospitalisation at 365 days; and cardiovascular death or re-hospitalisation at 365 days.Ethics and disseminationThe institutional review board approved the trial which will comply with the Declaration of Helsinki. All patients will provide informed consent. It may offer a novel, effective and technically simple technique for patients with no other therapeutic options. The results will be submitted to indexed medical journals and national and international meetings.Trial registration numberClinicalTrials.gov:NCT02798276, pre-results.
Published: 2017

37. Indexed left atrial size predicts all-cause and cardiovascular mortality in patients undergoing aortic valve surgery

Author: Victor Bautista-Hernandez, Javier Muñiz, Alberto Bouzas-Mosquera, Víctor Mosquera, Nemesio Álvarez-García, José J. Cuenca-Castillo, and Miguel González-Barbeito
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Time Factors, Aortic Valve Insufficiency, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Aortic valve diseases, Left atrial, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Left atrial enlargement, Humans, In patient, 030212 general & internal medicine, Heart Atria, Cardiac Surgical Procedures, Aortic valve surgery, Stroke, Cardiovascular mortality, Aged, Retrospective Studies, Outcome, Aged, 80 and over, business.industry, Indexed left atrial diameter, Aortic Valve Stenosis, Atrial Remodeling, Middle Aged, medicine.disease, Confidence interval, Surgery, Treatment Outcome, Echocardiography, Aortic Valve, Cardiology, Atrial Function, Left, Female, Cardiology and Cardiovascular Medicine, business, All cause mortality
Abstract: [Abstract] OBJECTIVES: The enlargement of the left atrium has been identified as a marker of chronically increased left ventricular filling pressure and left ventricular diastolic dysfunction. This study aims to evaluate the association of indexed left atrial diameter with stroke, cardiovascular mortality, the combined event, and all-cause mortality in patients who underwent aortic valve surgery. METHODS: Indexed left atrial diameter was measured in 2011 adult patients (mean age, 70.9 ± 10.8 years; 58.7% were men) who underwent aortic valve surgery between January 2008 and March 2016. RESULTS: On the basis of the criteria of the American Society of Echocardiography, indexed left atrial diameter was normal in 64% of patients, mildly enlarged in 12.4% of patients, moderately enlarged in 9.2% of patients, and severely enlarged in 14.3% of patients. Over a mean follow-up period of 3.2 ± 2.1 years, there were 334 deaths and 97 strokes. Cardiovascular mortality survival at 5 years among patients with normal, mild, moderate, and severe left atrial enlargement was 91.6%, 86.8%, 77.9%, and 77.4%, respectively (P < .001). After covariable adjustment, Cox regression analysis showed indexed left atrial diameter as an independent predictor of all-cause mortality (hazard ratio per 1-cm/m2 increment, 1.545; 95% confidence interval, 1.252-1.906, P < .001), cardiovascular death (hazard ratio per 1-cm/m2 increment, 1.971; 95% confidence interval, 1.541-2.520; P < .001), and the combined event (hazard ratio per 1-cm/m2 increment, 1.673; 95% confidence interval, 1.321-2.119; P < .001). CONCLUSIONS: Indexed left atrial diameter is a strong predictor of long-term outcomes in patients with aortic valve diseases who undergo surgery.
Published: 2017

38. Impacto del tratamiento anticalcificación en la durabilidad de la bioprótesis Mitroflow y factores de riesgo para el deterioro valvular estructural

Author: Laura Fernández-Arias, Concepción Pradas-Irún, Jose María Herrera-Norena, Victor Bautista-Hernandez, Carlos Velasco-García, Carmen Iglesias-Gil, Francisco Portela-Torrón, Miguel González-Barbeito, Víctor Mosquera, José J. Cuenca-Castillo, Maria Garcia-Vieites, Francisco Estévez-Cid, Alberto Bouzas-Mosquera, and Daniel Vasquez-Echeverri
Subjects: Gynecology, medicine.medical_specialty, Deterioro valvular estructural, business.industry, Calcificación, lcsh:R, Bioprótesis, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Sustitución valvular aórtica, Medicine, Surgery, Ecocardiografía, Cardiology and Cardiovascular Medicine, business
Abstract: Objetivo: Determinar la incidencia de deterioro valvular estructural (DVE) entre todos los modelos de bioprótesis aórtica Mitroflow (A12/LX/DL), así como definir los factores de riesgo implicados y el posible papel protector del tratamiento anticalcificación phospholipid reduction treatment (PRT) del modelo DL. Métodos: Estudio retrospectivo de 1.023 pacientes consecutivos operados de recambio valvular aórtico con bioprótesis Mitroflow entre 2001 y 2014. Resultados: El seguimiento medio fue de 5,4 ± 3,1 años. La incidencia acumulada global de DVE fue 0,48% a un año, 2,1% a 5 años y 6,8% a 10 años. El grupo PRT mostró menor incidencia acumulada de DVE (0,2% vs. 1,2% a 4 años) (p = 0,04). El análisis de regresión de riesgos competitivos confirmó: edad < 70 años (HR = 2,98 [1,5-5,89], p = 0,002), tamaño valvular de 19 mm (HR = 4,7 [2,29-9,64], p 30 mmHg en postoperatorio precoz (HR = 10,3 [5,3-19,9], p
Published: 2017
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39. Post-introduction observation of transcatheter aortic valve implantation in Galicia (Spain)

Author: Marisa López-García, Teresa Queiro-Verdes, José Ramón González-Juanatey, Ramiro Trillo Nouche, José Antonio Baz-Alonso, Nicolás Vázquez-González, Leonor Varela-Lema, Gonzalo Pradas-Montilla, Andrés Íñiguez-Romo, Diego López-Otero, José Rubio-Álvarez, Darío Durán-Muñoz, José J. Cuenca-Castillo, José M. Herrera Noreña, and Jorge Salgado-Fernández
Subjects: medicine.medical_specialty, Percutaneous aortic valve replacement, business.industry, Health Policy, medicine.medical_treatment, Public Health, Environmental and Occupational Health, Health services research, Psychological intervention, Context (language use), medicine.disease, Prosthesis, Surgery, Aortic valve stenosis, Health care, Emergency medicine, medicine, Observational study, business
Abstract: Rationale, aims and objectives Transcatheter aortic valve implantation constitutes an example of a technology introduced into the Galician Health Care System basket and subjected to a post-introduction observational study after coverage. This paper aims to describe the process and results of this experience, illustrating the main challenges and opportunities in using these studies for supporting decision making. Methods The study protocol was developed by a multidisciplinary team consisting of experts from the Galician HTA Agency (avalia-t), interventional cardiologists and cardiac surgeons. Together they agreed on the information that was relevant and feasible for collection, and planned the study design, data collection and analysis of results. Results During the 1-year recruitment period, 94 patients underwent percutaneous aortic valve replacement in the three authorized centres. Implantation rate and prosthesis models differed substantially across the centres. Overall, procedural success rate was 96.8% and hospital mortality was 7.4%. Complications during post-surgical admission were recorded in 40.4% of patients. Moderate residual aortic regurgitation was observed in 10% of patients, and the procedure was associated with a stroke rate of 3.3% at 30 days and 5.3% at 1 year. Conclusions Post-introduction observation has made it feasible to determine the use of this procedure within the SERGAS context and has enabled the assessment of performance in real-life conditions. The proposed strategic actions and interventions have been drawn up based upon the collective judgement of a group of experienced professionals, and have served to establish recommendations on further research that would be required to optimize health benefits.
Published: 2014
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40. Evolución y distribución de la formación MIR en cirugía cardiovascular en España. Implicaciones en la relación oferta-demanda en nuestra especialidad

Author: José J. Cuenca Castillo
Subjects: business.industry, lcsh:R, lcsh:Surgery, Medicine, lcsh:Medicine, Surgery, lcsh:RD1-811, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Desde muchas Sociedades Cientificas y Comisiones Nacionales e especialidad, hemos contemplado con sorpresa las convocatoias MIR de cada ano. En diversas especialidades, pero sobre todo en a nuestra, Cirugia Cardiovascular (CCV), el numero de plazas MIR fertadas han, cuanto menos, duplicado sistematicamente las recoendaciones de nuestra Comision Nacional. Se pueden argumentar iferentes razones para justificarlo, pero parece evidente que, como n otras especialidades, la obligada necesidad de adecuar la oferta e plazas para formacion especializada, a la de estudiantes de Mediina que acaban sus estudios cada ano en nuestras universidades, s el factor clave. Hasta hace unos 5 anos, encontrar un especialista en CCV en aro, en nuestro pais, era francamente complicado, tan solo, casos xcepcionales e incluso temporales. El progresivo recambio generaional fue absorbiendo el inicial incremento de plazas de formacion. n estos ultimos anos, la ralentizacion en las jubilaciones por la rolongacion de la edad laboral o su mantenimiento en 70 anos, en lgunas CC. AA., la amortizacion de algunas plazas y las dificultaes economicas en el sector sanitario publico, han provocado una norme precariedad del mercado laboral para CCV, contratos de uardias, acumulos de tareas temporales y, sobre todo, necesidad e realizar nuevas especialidades dentro del programa MIR, o marhar a continuar su formacion en centros de fuera de Espana. En una ublicacion reciente (8 de septiembre del 2014) de Diario Medico, citando una encuesta telefonica realizada a los MIR finalizados ntre 2009 y 2012, auspiciada por la Subdireccion General de Ordeacion Profesional del Ministerio de Sanidad, se refleja que nuestra specialidad, con un 23% de paro entre ellos, es la especialidad uirurgica con mas paro y la segunda global, tras la Microbiologia.
Published: 2015
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41. Comments on the ESC Guidelines on the Management of Valvular Heart Disease (Version 2012). A Report of the Task Force of the Clinical Practice Guidelines Committee of the Spanish Society of Cardiology

Author: Javier Lopez, Josep Comín, Manuel Pan, Isidre Vilacosta, Rafael García Fuster, José Eduardo López Haldón, Pilar Tornos, Antonio Fernández-Ortiz, Ángel M. Alonso Gómez, Alberto San Román, Miguel Angel García Fernández, Isabel Diaz-Buschmann, José Luis Zamorano, Arturo Evangelista, Manuel Anguita, Marta Sitges, José Ignacio Sáez de Ibarra, Rosana Hernández Antolín, Patricia Mahía, Javier Bermejo, Joaquín Barba, Ángel Luis Fernández González, Juan José Gómez Doblas, José María Hernández García, Xavier Borrás, Rocío García Orta, Gonzalo Barón, José Juan Gómez de Diego, Fernando Wornerm, Ignacio Fernández Lozano, Angel Cequier, and José J. Cuenca Castillo
Subjects: medicine.medical_specialty, business.industry, Task force, valvular heart disease, Heart Valve Diseases, MEDLINE, General Medicine, medicine.disease, Clinical Practice, Spain, Internal medicine, Practice Guidelines as Topic, Physical therapy, Cardiology, Humans, Medicine, Cardiac Surgical Procedures, business
Published: 2013
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42. Estudio de casos y controles de los factores de riesgo de mediastinitis en cirugía de revascularización miocárdica

Author: José María Gutiérrez-Urbón, José J. Cuenca-Castillo, and María J. Pereira-Rodríguez
Subjects: Gynecology, medicine.medical_specialty, business.industry, lcsh:R, lcsh:Surgery, lcsh:Medicine, Case-control study, lcsh:RD1-811, Cirugía de revascularización miocárdica, Mediastinitis, Risk factors, Coronary artery bypass graft, medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Factores de riesgo, Estudio de casos y controles
Abstract: ResumenIntroducción y objetivosLa mediastinitis es una complicación de la cirugía de revascularización miocárdica (CRM) que causa elevada morbimortalidad. El objetivo del estudio es identificar los factores de riesgo de mediastinitis en CRM, con o sin cirugía cardíaca adicional, y los microorganismos implicados en esta infección.MétodoEstudio de casos y controles retrospectivo en pacientes sometidos a CRM durante los años 2004 a 2008 en un hospital general de nivel terciario. Los casos fueron todos los pacientes con mediastinitis posquirúrgica. Se seleccionaron al azar y por proximidad temporal 2 controles por cada caso. Se registró la información de las variables a estudio mediante la revisión de historias clínicas, y se realizaron análisis univariables y multivariables.ResultadosSe registraron 73 mediastinitis en un total de 1.353 CRM (incidencia: 5,39%). En el modelo final de regresión logística, los factores de riesgo de mediastinitis identificados fueron: obesidad ≥ grado II (p=0,004), cirujano (p=0,004), insuficiencia renal (p=0,006), estancia posquirúrgica en unidad de cuidados intensivos > 3 días (p=0,019) y cirugía cardíaca adicional (p=0,020). Los microorganismos aislados con más frecuencia fueron estafilococos, mayoritariamente Staphylococcus epidermidis (30,7%).ConclusionesEl cirujano que practica la intervención, la obesidad ≥ grado II, la insuficiencia renal, la cirugía cardíaca adicional y la estancia posquirúrgica en unidad de cuidados intensivos > 3 días fueron los factores de riesgo asociados a mediastinitis en pacientes sometidos a CRM.AbstractIntroduction and objectivesMediastinitis is a complication of coronary artery bypass graft surgery (CABG) causing high morbidity and mortality. The aim of this study was to identify risk factors for suffering from mediastinitis in patients undergoing CABG with or without additional cardiac surgery, and the microorganisms involved in this infection.MethodA retrospective case-control study was conducted on patients who underwent a CABG during the years 2004-2008 in a third level hospital. The cases were all patients with postoperative mediastinitis. Two controls of similar age were randomly selected for each case. The study variables were collected by reviewing medical records, and univariate and multivariate analyses were performed on these.ResultsThere were 73 mediastinitis in a total of 1353 surgeries (incidence: 5.39%). In the logistic regression model, the risk factors for acquiring mediastinitis were: greater than or equal to grade II obesity (p=004), surgeon (p=004), renal failure (p=006), postoperative ICU stay exceeding 3 days (p=019), and additional cardiac surgery (p=020). The microorganisms most commonly isolated were staphylococci, and mostly S epidermidis (30.7%).ConclusionsThe surgeon, obesity, renal failure, associated valvular surgery procedure, and postoperative ICU stay exceeding 3 days, are the risk factors associated with mediastinitis in patients undergoing CABG.
Published: 2013
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43. Long-Term Outcomes and Durability of the Mitroflow Aortic Bioprosthesis

Author: Victor X, Mosquera, Alberto, Bouzas-Mosquera, Carlos, Velasco-García, Javier, Muñiz, Francisco, Estévez-Cid, Francisco, Portela-Torron, José M, Herrera-Noreña, and José J, Cuenca-Castillo
Subjects: Bioprosthesis, Male, Time Factors, Hemodynamics, Aortic Valve Stenosis, Prosthesis Design, Postoperative Complications, Echocardiography, Spain, Aortic Valve, Heart Valve Prosthesis, Materials Testing, Humans, Female, Aged, Follow-Up Studies, Retrospective Studies
Abstract: This study aims to determine the incidence and causes of structural valve deterioration (SVD) among all models of Mitroflow bioprostheses (A12/LX/DL), as well as to define their long-term clinical and hemodynamic performance.We retrospectively reviewed a series of 1023 patients who underwent aortic valve replacement with Mitroflow bioprostheses between 2001 and 2014. A small aortic root was found in 22.4% of patients. There were two cases of severe patient-prosthesis mismatch. Only 31 patients developed SVD. The rate of incidence was 8.1 cases per 1000 patient-years. Cumulative incidence of SVD was 1.4% and 3% at five and 10 years, respectively. Freedom from SVD was 97.4% and 88.2% at five and 10 years, respectively. Anticalcification phospholipid reduction treatment (PRT) for model DL was a protective factor for SVD. Multivariable analysis confirmed age70 years and use of 19 mm valve as independent predictors of SVD. Cumulative survival was 76.6% at five years and 42.3% at 10 years (mean follow-up 3.8 ± 3.1 years). In multivariable analysis, neither the use of small aortic prosthesis (p = 0.18) nor the occurrence of SVD (p = 0.85) was found to be independent predictors of long-term survival.Mitroflow valves demonstrate an acceptable rate of SVD and satisfactory long-term hemodynamic performance, particularly in patients with small aortic roots, age70 years, and cases with severe left ventricular hypertrophy. PRT might contribute to improved long-term durability. doi: 10.1111/jocs.12726 (J Card Surg 2016;31:264-273).
Published: 2016

44. Toxoplasma Gondii Serostatus in Heart Transplant Recipients: Is It an Independent Prognostic Factor?

Author: Miguel Solla-Buceta, David Couto-Mallón, José J. Cuenca-Castillo, Gonzalo Barge-Caballero, José M. Herrera-Noreña, José Manuel Vázquez-Rodríguez, Francisco Estévez-Cid, Raquel Marzoa-Rivas, Eduardo Barge-Caballero, Cayetana Barbeito-Caamaño, María J. Paniagua-Martín, and María G. Crespo-Leiro
Subjects: Adult, Graft Rejection, Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, medicine, Humans, Mortality, Aged, Proportional Hazards Models, Retrospective Studies, Heart Failure, biology, Proportional hazards model, business.industry, Incidence (epidemiology), Incidence, Confounding, Hazard ratio, Toxoplasma gondii, General Medicine, Middle Aged, biology.organism_classification, Prognosis, Confidence interval, Immunology, Multivariate Analysis, Heart Transplantation, 030211 gastroenterology & hepatology, Female, business, Serostatus, Toxoplasma, Immunosuppressive Agents, Toxoplasmosis
Abstract: Introduction and objectives To assess the potential association between recipient Toxoplasma gondii serostatus and outcomes after heart transplant (HT). Methods We conducted a retrospective single-center study of 657 HT recipients from 1991 to 2015. Survival and the incidence of adverse clinical events of T. gondii -seropositive (n = 481) vs T. gondii -seronegative (n = 176) recipients were compared by means of 2 different multivariable Cox regression models. Model 1 included solely age and sex, and model 2 included other potential confounders. Results Over a median follow-up of 2903 days (interquartile range: 898-4757), 250 seropositive recipients (52%) and 72 seronegative recipients (41%) died. Univariable analysis showed increased posttransplant mortality among T. gondii -seropositive recipients (hazard ratio [HR] = 1.31; 95% confidence interval [95%CI], 1,00-1.70). After multivariable adjustment, the statistical significance of this association was lost (model 1: HR = 1.09; 95%CI, 0.83-1.43; model 2:HR = 1.12; 95%CI, 0.85-1.47). Recipient T. gondii seropositivity was independently associated with an increased risk of acute rejection (model 1: HR = 1.36; 95%CI, 1.06-1.74; model 2: HR = 1.29; 95%CI, 1.01-1.66). Multivariable models showed no statistically significant impact of recipient T. gondii serostatus on the incidence of infection, malignancy, coronary allograft vasculopathy, or the composite outcome of cardiac death or retransplant. No significant association was found between donor-recipient T. gondii serostatus matching and posttransplant outcome. Conclusions In this study, recipient T. gondii serostatus was not an independent predictor of long-term post-HT outcome.
Published: 2016

45. Quality markers in cardiology: measures of outcomes and clinical practice--a perspective of the Spanish Society of Cardiology and of Thoracic and Cardiovascular Surgery

Author: Domingo A. Pascual-Figal, José Luis Zamorano, Esteban González Torrecilla, José Ramón González-Juanatey, José-Luis López-Sendón, Alicia M. Maceira, Lina Badimon, Alessandro Sionis, Regina Dalmau, José J. Cuenca Castillo, José Luis Pomar Moya-Prats, Fausto J. Pinto, and José Ramón López Mínguez
Subjects: medicine.medical_specialty, Standardization, Heart Diseases, media_common.quotation_subject, Cardiology, Certification, 030204 cardiovascular system & hematology, Patient Readmission, Risk Assessment, 03 medical and health sciences, Patient safety, 0302 clinical medicine, Internal medicine, Health care, Medicine, Humans, Quality (business), 030212 general & internal medicine, Societies, Medical, media_common, Accreditation, Quality of Health Care, business.industry, Professional Practice, Benchmarking, Evidence-based medicine, Length of Stay, Thoracic Surgical Procedures, Surgery, Cardiac Imaging Techniques, Current Opinion, Spain, Catheter Ablation, Patient Safety, Cardiology and Cardiovascular Medicine, business
Abstract: The complexity of the individual patient and organization of medical practice results in important institutional and country quality of care variability.1–17 Attempts to assess the quality of clinical practice have established rating systems that may yield completely different results and rating for the same hospital during the same period of time, adding confusion rather than help to prove their usefulness and, questioning whether existing measures can actually measure quality.18–35 Most important, benchmarking may be associated with progressive improvement both in performance and outcomes,18,26,28,36–38 highlighting the relevance of standardization of quality measures and the responsibility of scientific societies. The Spanish Society of Cardiology (SSC) and the Spanish Society of Thoracic and Cardiovascular Surgery (SSTCS) organized a task force to identify and define two sets of quality metrics in hospital cardiology practice: (i) outcome measures (metrics of the final quality of the practice of cardiology) and (ii) performance measures (metrics of clinical practice which are known to positively influence desirable outcomes). Beyond this objective, Scientific Societies and Health Care Authorities should be responsible for the implementation of programmes to measure quality, ensure the quality of the data, benchmarking, and certification/accreditation of cardiology services. All European Society of Cardiology (ESC)32 and American Heart Association/American College of Cardiology33 guidelines were reviewed and recommendations related to quality standards were included in the document. ### Grading of quality markers Three levels were established both for class recommendation and level of evidence considering (i) clinical and practical …
Published: 2016

46. Cirugía cardiovascular. Definición, organización, actividad, estándares y recomendaciones

Author: Carlos-A. Mestres Lucio, Miguel Such Martínez, Juan Manuel Contreras Ayala, Juan Martínez León, Miguel Josa García-Tornel, Tomasa Centella Hernández, Francisco Portela Torrón, José María González Santos, Salvador López Checa, Joseba Zuazo Meabe, José Manuel Revuelta Soba, José M. Cortina Romero, José L. Pomar, Ángel Luis Fernández González, Emili Saura Grifol, Alfonso Cañas Cañas, and José J. Cuenca Castillo
Subjects: business.industry, lcsh:R, Especialidad, lcsh:Surgery, lcsh:Medicine, lcsh:RD1-811, Cardiovascular surgery, Recommendations, Cirugía cardiovascular, Cirugía vascular, Thoracic surgery, Vascular surgery, Organización, Specialty, Cirugía torácica, Recomendaciones, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business, Humanities, Organization
Abstract: ResuménLa cirugía cardiovascular (CCV) es una especialidad de la medicina que se ocupa de los trastornos y enfermedades del sistema cardiocirculatorio que requieren una terapéutica quirúrgica. El presente documento está dedicado a los aspectos definitorios de la especialidad y a los organizativos de la actividad profesional incluyendo la acreditación y homologación. se define asimismo la sociedad profesional, la sociedad Española de Cirugía Torácica-Cardiovascular (SECTCV) en sus aspectos relacionados con la profesión, con la formación continuada así como la comunicación en el seno y fuera de la misma al igual que la necesidad y existencia de la fundación Cirugía y Corazón (FCC). También se focaliza en la actividad en CCV y los requerimientos estructurales mínimos para llevar a cabo el componente de intervención de la CCV. Por último, se confirman las recomendaciones para su práctica y se presentan los requerimientos de calidad y del programa docente de la especialidad. Este documento de la junta directiva de la SECTCV y asesores externos de la misma confirma la realidad de la especialidad y sus contenidos como señas de identidad inalienables.AbstractCardiovascular surgery (CVS) is a branch of medicine related to the diseases of the cardio-circulatory system requiring surgical treatment. this current document is dedicated to all aspects defining the specialty and the organization of the professional activity including accreditation and credentialing. The professional society, the spanish society of thoracic-Cardiovascular surgery (SECTCV) is also defined and insights on its professional, continuing education and communication given as well as the background for the Cirugía y Corazón foundation. Attention is also given to the activity in CVS and the core requirements for practice. The recommendations for practice and quality requirements and the postgraduate teaching programme are also presented. This document of the Council of the SECTCV and its external advisors confirms the reality of the specialty and its contents as sound signs of identity.
Published: 2012
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47. Endoscopy-guided surgery of an atrio-esophageal fistula after failure of self-expandable metal stents

Author: Emilio Estévez-Prieto, Carlos Velasco-García, José J. Cuenca-Castillo, Salvador Fojón-Polanco, Benito González-Conde, Pedro Alonso-Aguirre, and Ignacio Couto-Worner
Subjects: Adult, Male, medicine.medical_specialty, Fistula, Heart Diseases, Self Expandable Metallic Stents, 030204 cardiovascular system & hematology, Endoscopy, Gastrointestinal, Treatment failure, Esophageal Fistula, 03 medical and health sciences, 0302 clinical medicine, Self-expandable metallic stent, Atrial Fibrillation, medicine, Humans, Heart Atria, Treatment Failure, 030212 general & internal medicine, medicine.diagnostic_test, business.industry, Gastroenterology, Endoscopy, Self Expandable Metal Stents, Surgery, Retreatment, Catheter Ablation, Radiology, business, Heart atrium
Published: 2017
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48. Heart Failure After Heart Transplantation. Incidence, Etiology and Outcomes

Author: Jose María Herrera-Norena, L. Seoane-Quiroga, Gonzalo Barge-Caballero, David Couto-Mallón, José Manuel Vázquez-Rodríguez, Ángela López-Sainz, C. Iglesias-Gil, Eduardo Barge-Caballero, José J. Cuenca-Castillo, María J. Paniagua-Martín, and Marisa G. Crespo-Leiro
Subjects: Pulmonary and Respiratory Medicine, Heart transplantation, Transplantation, medicine.medical_specialty, business.industry, Incidence (epidemiology), medicine.medical_treatment, medicine.disease, Internal medicine, Heart failure, Cardiology, Etiology, Medicine, Surgery, Cardiology and Cardiovascular Medicine, business
Published: 2017
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49. Initial Experience With Excimer Laser-Assisted Pacemaker and Defibrillator Lead Extraction

Author: Víctor Mosquera, José J. Cuenca-Castillo, Luisa Pérez-Álvarez, Ignacio Mosquera-Pérez, Alfonso Castro-Beiras, and Enrique Ricoy-Martínez
Subjects: Adult, Male, Pacemaker, Artificial, medicine.medical_specialty, Adolescent, medicine.medical_treatment, medicine, Humans, Endocarditis, Cardiac Surgical Procedures, Lead (electronics), Defibrillator lead, Device Removal, Aged, Retrospective Studies, Implanted pacemaker, Aged, 80 and over, Excimer laser, business.industry, Arrhythmias, Cardiac, General Medicine, Middle Aged, medicine.disease, Defibrillators, Implantable, Surgery, Equipment Failure, Female, Endothelium, Vascular, Laser Therapy, business, Implantation time
Abstract: Explantation of chronically implanted pacemaker or defibrillator leads can be technically demanding. We present the results of the first 44 leads extracted with excimer laser sheaths in 25 patients with a median lead implantation time of 7 years (range: 2 to 20 years). Indications for extraction were lead fracture in 17 patients, pocket infection in 4, septicemia in 2, and lead endocarditis in 2 cases. Complete extraction was achieved in 43 leads (97.7%), while the lead tip (4 cm) was abandoned in 1 case. There was no in-hospital mortality. The excimer laser-assisted system is a safe and efficient alternative for pacemaker and defibrillator lead extraction. This technology has resulted in excellent outcomes in our series, allowing us to treat remarkably difficult cases.
Published: 2011
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50. Utilidad de la escala INTERMACS para estratificar el pronóstico tras el trasplante cardiaco urgente

Author: María J. Paniagua-Martín, María G. Crespo-Leiro, Raquel Marzoa-Rivas, Alberto J. Pérez-Pérez, Zulaika Grille Cancela, Eduardo Barge-Caballero, Javier Muñiz, José J. Cuenca-Castillo, Paula Blanco-Canosa, Miguel Solla Buceta, Alberto Juffé-Stein, Lourdes García-Bueno, José Ángel Rodríguez-Fernández, Rosa Campo-Pérez, Alfonso Castro-Beiras, and José M. Herrera-Noreña
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Cardiology and Cardiovascular Medicine, business
Abstract: Resumen Introduccion y objetivos Analizar el valor pronostico de la escala INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) en pacientes tratados con trasplante cardiaco urgente. Metodos Analisis retrospectivo de 111 pacientes tratados con trasplante cardiaco urgente en nuestro centro entre abril de 1991 y octubre de 2009. Se asigno retrospectivamente a los pacientes a tres niveles de la escala INTERMACS en funcion de su situacion clinica previa al trasplante cardiaco. Resultados Los pacientes del grupo INTERMACS 1 (n = 31) presentaban mayor frecuencia de cardiopatia isquemica (p = 0,03) y shock tras cardiotomia (p = 0,02) que los pacientes del grupo INTERMACS 2 (n = 55) y los pacientes del grupo INTERMACS 3–4 (n = 25), asi como mayores dosis de catecolaminas (p = 0,001), mayor empleo de ventilacion mecanica (p Conclusiones Nuestros resultados indican que la escala INTERMACS resulta util para estratificar el pronostico postoperatorio tras el trasplante cardiaco urgente.
Published: 2011
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