463 results on '"Jordan H"'
Search Results
2. The Current Proposed Total Hip Arthroplasty Surgical Planning Guidelines Based on Classification of Spine Stiffness May be Flawed Due to Incorrect Assumptions
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Aidin E. Pour, Jordan H. Green, Thomas H. Christensen, Nishanth Muthusamy, and Ran Schwarzkopf
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Orthopedics and Sports Medicine - Published
- 2023
3. Measuring time preferences in large surveys
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Michael M. Bechtel, Amalie Jensen, Jordan H. McAllister, and Kenneth Scheve
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Sociology and Political Science ,Political Science and International Relations - Abstract
Time preferences may explain public opinion about a wide range of long-term policy problems with costs and benefits realized in the distant future. However, mass publics may discount these costs and benefits because they are later or because they are more uncertain. Standard methods to elicit individual-level time preferences tend to conflate risk and time attitudes and are susceptible to social desirability bias. A potential solution relies on a costly lab-experimental method, convex time budgets (CTB). We present and experimentally validate an affordable version of this approach for implementation in mass surveys. We find that the theoretically preferred CTB patience measure predicts attitudes toward a local, delayed investment problem but fails to predict support for more complex, future-oriented policies.
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- 2023
4. Intraoperative Use of Ultrasound for Assessing Cam Deformity and Cam Resection
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Daniel J. Kaplan, Thomas W. Fenn, Jordan H. Larson, and Shane J. Nho
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Orthopedics and Sports Medicine - Published
- 2023
5. Cardiac q‐space trajectory imaging by motion‐compensated tensor‐valued diffusion encoding in human heart in vivo
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Irvin Teh, David Shelley, Jordan H. Boyle, Fenglei Zhou, Ana‐Maria Poenar, Noor Sharrack, Richard J. Foster, Nadira Y. Yuldasheva, Geoff J. M. Parker, Erica Dall'Armellina, Sven Plein, Jürgen E. Schneider, and Filip Szczepankiewicz
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tensor-valued diffusion encoding ,motion-compensated diffusion encoding ,q-space trajectory imaging ,Radiology, Nuclear Medicine and imaging ,cardiac microstructure ,diffusion tensor imaging ,tissue characterization - Abstract
Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T scanner. We designed time-optimal gradient waveforms for tensor-valued diffusion encoding (linear and planar) with second-order motion compensation. Data were analyzed with QTI. Normal values and repeatability were investigated for the mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic and total mean kurtosis (MKi, MKa, and MKt), and orientation coherence (Cc). A phantom, consisting of two fiber blocks at adjustable angles, was used to evaluate sensitivity of parameters to orientation dispersion and diffusion time. Results: QTI data in the left ventricular myocardium were MD = 1.62 ± 0.07 μm2/ms, FA = 0.31 ± 0.03, μFA = 0.43 ± 0.07, MKa = 0.20 ± 0.07, MKi = 0.13 ± 0.03, MKt = 0.33 ± 0.09, and Cc = 0.56 ± 0.22 (mean ± SD across subjects). Phantom experiments showed that FA depends on orientation dispersion, whereas μFA was insensitive to this effect. Conclusion: We demonstrated the first tensor-valued diffusion encoding and QTI analysis in the heart in vivo, along with first measurements of myocardial μFA, MKi, MKa, and Cc. The methodology is technically feasible and provides promising novel biomarkers for myocardial tissue characterization.
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- 2023
6. A Pulse Check on the Training of Adult Cardiologists in Canada: The Expanding Role of Bootcamps for Training Program Transition
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Jordan H. Hutson, Samir Hazra, Victoria Korley, Matthew Sibbald, Ashlay Huitema, and Michael Froeschl
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Cardiology and Cardiovascular Medicine - Published
- 2023
7. 21st Century Skill of the Teachers: Readiness for Digitalized Learning
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Jordan H. Villarba, Emmanuel Jr. Julita Yap, Merriam C. Abanid, Mary Jay S. Israel, Weca C. Gemida, and Niljane P. Gravines
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General Medicine - Abstract
The study focused on the 21st Century Skill of the Teachers: Readiness for Digitalized Learning The study utilized the descriptive method and a two-part survey-to measurethe preparedness and readiness of the teachers in the quick transition of learning from face-to-face classes to a full digitalized learning environment in the COVID-19 Pandemic were used in gathering data from 25 teachers of Lamesa National High School in the province of Cebu, The researchers used a purposive sampling method to select the respondent.. This study illustrated the teachers' technical and pedagogical preparation for digitalized learning and is the best measure of how well-equipped and adaptable teachers are to changing trends in the teaching profession. Teachers' attitudes toward digital learning demonstrate a strong understanding of the value of technologically based education both during and after the COVID-19 pandemic.
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- 2023
8. The Early Impact of the COVID-19 Pandemic on Hospital Finances
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Jordan H, Rhodes, Tatiane, Santos, and Gary, Young
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Leadership and Management ,Strategy and Management ,Health Policy ,General Medicine - Abstract
The COVID-19 pandemic has caused both short- and long-term impacts on every aspect of society. Hospitals are among the most critical frontliners and have had to continually navigate the challenges caused by the pandemic. In this study, we examined hospitals' financial performance following the onset of the pandemic.We used data from the Centers for MedicareMedicaid Services Healthcare Cost Report Information System. The study sample included all general acute care and critical access hospitals that receive Medicare payments. The primary outcomes included operating margins, net patient revenues, operating expenses, and uncompensated care costs. We tested for average changes from 2019 to 2020 in hospitals' financial outcomes. We also tested for changes in financial outcomes across samples stratified by hospital characteristics: ownership type (investor-owned, nonprofit, and public), Medicaid disproportionate share hospital status, rural status, county uninsured rate quartile, and Medicaid expansion status.Our sample consisted of a balanced panel of 4,059 hospitals (8,118 observations) with data spanning 2019 and 2020. Across the full sample of hospitals, operating margins declined by an average of 5.3 percentage points between 2019 and 2020, equating to a 130% reduction from 2019 levels. Underlying these margin declines, net patient revenues declined by 3.2% on average, while operating expenses increased by 1.5%. We observed no changes in uncompensated care costs despite the large number of job losses that accompanied the pandemic. When stratifying the analysis by hospital characteristics, differences were observed across ownership types. Notably, investor-owned facilities were less affected financially than nonprofit and public hospitals. Although safety-net and rural hospitals generally fared no worse than their non-safety-net and nonrural counterparts, hospitals located in Medicaid expansion states experienced steeper declines in operating margins relative to hospitals located in nonexpansion states, driven by larger relative declines in patient revenues.The operating margin declines we observed can be attributed to supply-chain issues, persistent labor shortages, and suspension of elective services. The Affordable Care Act reforms in health insurance markets likely helped to insulate hospitals from increases in uncompensated care costs. In the shifting context of the pandemic, it is important to understand hospitals' financial performance so that measures can be taken to address further financial distress that may eventually lead to increased consolidation, hospital closures, and lower quality of care. Our findings stress the need for targeted responses that are tailored to underlying hospital characteristics. Temporary and targeted increases in inpatient and outpatient service prices can help offset revenue losses from the deferment of nonurgent care. Other policies can address the ongoing workforce challenges and supply-chain issues.
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- 2023
9. Perioperative Management in the Collegiate Athlete: An Integrated Approach
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Caitlin M. Rugg, Jordan H. Ginder, Ananyaa Bharadwaj, Rock Vomer, Gregory A. Dale, Jennifer Ketterly, Hap Zarzour, Annunziato Amendola, and Brian C. Lau
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
Collegiate athletes face rigorous physical, academic, and emotional demands. While significant attention has been paid to injury prevention among young athletes in the past two decades, orthopedic injury rates remain high among collegiate athletes, and a significant number will undergo surgical management for injuries each year. In this narrative review, we describe techniques for perioperative management of pain and stress after surgery in collegiate athletes. In particular, we outline pharmacologic and non-pharmacologic management of surgical pain, with a goal of minimizing opiate consumption. We emphasize a multi-disciplinary approach to optimizing post-operative recovery in collegiate athletes help minimize reliance on opiate pain medication. Additionally, we recommend that institutional resources should be harnessed to support athletes in their well-being, from a nutritional, psychological and sleep standpoint. Critical to success in perioperative pain management is the communication among the athletic medicine team members and with the athlete and family to address pain and stress management and encourage timely, safe return to play.
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- 2023
10. DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury
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Yosuke Shimodaira, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W.Y. Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, and Kathrin S. Michelsen
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Epithelial Barrier ,Tissue Regeneration ,Inbred C57BL ,Regenerative Medicine ,Autoimmune Disease ,Fluorescence ,Oral and gastrointestinal ,Mice ,IEC Proliferation ,Animals ,Regeneration ,Homeostasis ,Innate ,2.1 Biological and endogenous factors ,Lymphocytes ,Intestinal Mucosa ,Aetiology ,In Situ Hybridization ,Inflammation ,Hepatology ,Inflammatory Bowel Disease ,Immunity ,Gastroenterology ,Colitis ,Tumor Necrosis Factors ,Digestive Diseases ,Intestinal Permeability - Abstract
Background & aimsTumor necrosis factor (TNF) superfamily member tumor necrosis factor-like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis factor-like protein 1A and its receptor death receptor 3 (DR3) in the development of intestinal inflammation is incompletely understood. We investigated the role of DR3 expressed by intestinal epithelial cells (IECs) during intestinal homeostasis, tissue injury, and regeneration.MethodsClinical phenotype and histologic inflammation were assessed in C57BL/6 (wild-type), Tl1a-/- and Dr3-/- mice in dextran sulfate sodium (DSS)-induced colitis. We generated mice with an IEC-specific deletion of DR3 (Dr3ΔIEC) and assessed intestinal inflammation and epithelial barrier repair. Invivo intestinal permeability was assessed by fluorescein isothiocyanate dextran uptake. Proliferation of IECs was analyzed by bromodeoxyuridine incorporation. Expression of DR3 messenger RNA was assessed by fluorescent in situ hybridization. Small intestinal organoids were used to determine exvivo regenerative potential.ResultsDr3-/- mice developed more severe colonic inflammation than wild-type mice in DSS-induced colitis with significantly impaired IEC regeneration. Homeostatic proliferation of IECs was increased in Dr3-/- mice, but blunted during regeneration. Cellular localization and expression of the tight junction proteins Claudin-1 and zonula occludens-1 were altered, leading to increased homeostatic intestinal permeability. Dr3ΔIEC mice recapitulated the phenotype observed in Dr3-/- mice with increased intestinal permeability and IEC proliferation under homeostatic conditions and impaired tissue repair and increased bacterial translocation during DSS-induced colitis. Impaired regenerative potential and altered zonula occludens-1 localization also were observed in Dr3ΔIEC enteroids.ConclusionsOur findings establish a novel function of DR3 in IEC homeostasis and postinjury regeneration independent of its established role in innate lymphoid cells and T-helper cells.
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- 2023
11. A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis
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Shams Twafra, Chana G. Sokolik, Tal Sneh, Kolluru D. Srikanth, Tomer Meirson, Alessandro Genna, Jordan H. Chill, and Hava Gil-Henn
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Cancer Research ,Genetics ,macromolecular substances ,Molecular Biology - Abstract
Dissemination of cancer cells from the primary tumor into distant body tissues and organs is the leading cause of death in cancer patients. While most clinical strategies aim to reduce or impede the growth of the primary tumor, no treatment to eradicate metastatic cancer exists at present. Metastasis is mediated by feet-like cytoskeletal structures called invadopodia which allow cells to penetrate through the basement membrane and intravasate into blood vessels during their spread to distant tissues and organs. The non-receptor tyrosine kinase Pyk2 is highly expressed in breast cancer, where it mediates invadopodia formation and function via interaction with the actin-nucleation-promoting factor cortactin. Here, we designed a cell-permeable peptide inhibitor that contains the second proline-rich region (PRR2) sequence of Pyk2, which binds to the SH3 domain of cortactin and inhibits the interaction between Pyk2 and cortactin in invadopodia. The Pyk2-PRR2 peptide blocks spontaneous lung metastasis in immune-competent mice by inhibiting cortactin tyrosine phosphorylation and actin polymerization-mediated maturation and activation of invadopodia, leading to reduced MMP-dependent tumor cell invasiveness. The native structure of the Pyk2-PRR2:cortactin-SH3 complex was determined using nuclear magnetic resonance (NMR), revealing an extended class II interaction surface spanning the canonical binding groove and a second hydrophobic surface which significantly contributes to ligand affinity. Using structure-guided design, we created a mutant peptide lacking critical residues involved in binding that failed to inhibit invadopodia maturation and function and consequent metastatic dissemination in mice. Our findings shed light on the specific molecular interactions between Pyk2 and cortactin and may lead to the development of novel strategies for preventing dissemination of primary breast tumors predicted at the time of diagnosis to be highly metastatic, and of secondary tumors that have already spread to other parts of the body.
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- 2022
12. Tundra shrub expansion in a warming climate and the influence of data type on models of habitat suitability
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Seider, Jordan H., Lantz, Trevor C., and Bone, Christopher
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Global and Planetary Change ,Ecology, Evolution, Behavior and Systematics ,Earth-Surface Processes - Abstract
Warming across the low Arctic is increasing tundra vegetation productivity and facilitating the expansion of upright shrubs. We modeled the effects of warming on habitat suitability in green alder, dwarf birch, Labrador tea, bog bilberry, and lingonberry and assessed the influence of data type (true absence or pseudo-absence) on species distribution models (SDMs). We generated SDMs using the two absence data types under current (1970–2000) and future (2061–2080) climate projections. Our results show that warming leads to range expansion of all shrubs, though responses vary in magnitude and extent, with mean increases in suitability ranging from 0.080 (Labrador tea) to 0.369 (lingonberry) with true absences. Differences in driving variables and suitability projections suggest that physiological and ecological variability between species mediate responses to warming. Between data types, we observed inconsistencies in model performance, suitability projections, and variable importance. Bog bilberry and lingonberry exhibited larger differences in suitability (0.201 and 0.288, respectively), whereas alder showed similar responses (difference of 0.01). These results are important to consider when assessing changes in habitat suitability or identifying environmental or climatic determinants of species’ distributions. We suggest further development of open data repositories, facilitating access to true absence data to support conservation and land use planning.
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- 2022
13. Genomic Testing in Localized Prostate Cancer Can Identify Subsets of African Americans With Aggressive Disease
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Shivanshu Awasthi, G Daniel Grass, Javier Torres-Roca, Peter A S Johnstone, Julio Pow-Sang, Jasreman Dhillon, Jong Park, Robert J Rounbehler, Elai Davicioni, Alex Hakansson, Yang Liu, Angelina K Fink, Amanda DeRenzis, Jordan H Creed, Michael Poch, Roger Li, Brandon Manley, Daniel Fernandez, Arash Naghavi, Kenneth Gage, Grace Lu-Yao, Evangelia Katsoulakis, Ryan J Burri, Andrew Leone, Cesar E Ercole, Joshua D Palmer, Neha Vapiwala, Curtiland Deville, Timothy R Rebbeck, Adam P Dicker, William Kelly, and Kosj Yamoah
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Male ,Prostatectomy ,Black or African American ,Cancer Research ,Oncology ,Humans ,Prostatic Neoplasms ,Prospective Studies ,Genetic Testing ,Article - Abstract
Background Personalized genomic classifiers have transformed the management of prostate cancer (PCa) by identifying the most aggressive subsets of PCa. Nevertheless, the performance of genomic classifiers to risk classify African American men is thus far lacking in a prospective setting. Methods This is a prospective study of the Decipher genomic classifier for National Comprehensive Cancer Network low- and intermediate-risk PCa. Study-eligible non–African American men were matched to African American men. Diagnostic biopsy specimens were processed to estimate Decipher scores. Samples accrued in NCT02723734, a prospective study, were interrogated to determine the genomic risk of reclassification (GrR) between conventional clinical risk classifiers and the Decipher score. Results The final analysis included a clinically balanced cohort of 226 patients with complete genomic information (113 African American men and 113 non–African American men). A higher proportion of African American men with National Comprehensive Cancer Network–classified low-risk (18.2%) and favorable intermediate-risk (37.8%) PCa had a higher Decipher score than non–African American men. Self-identified African American men were twice more likely than non–African American men to experience GrR (relative risk [RR] = 2.23, 95% confidence interval [CI] = 1.02 to 4.90; P = .04). In an ancestry-determined race model, we consistently validated a higher risk of reclassification in African American men (RR = 5.26, 95% CI = 1.66 to 16.63; P = .004). Race-stratified analysis of GrR vs non-GrR tumors also revealed molecular differences in these tumor subtypes. Conclusions Integration of genomic classifiers with clinically based risk classification can help identify the subset of African American men with localized PCa who harbor high genomic risk of early metastatic disease. It is vital to identify and appropriately risk stratify the subset of African American men with aggressive disease who may benefit from more targeted interventions.
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- 2022
14. An Interpretable Chest CT Deep Learning Algorithm for Quantification of COVID-19 Lung Disease and Prediction of Inpatient Morbidity and Mortality
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Jordan H. Chamberlin, Gilberto Aquino, Uwe Joseph Schoepf, Sophia Nance, Franco Godoy, Landin Carson, Vincent M. Giovagnoli, Callum E. Gill, Liam J. McGill, Jim O'Doherty, Tilman Emrich, Jeremy R. Burt, Dhiraj Baruah, Akos Varga-Szemes, and Ismail M. Kabakus
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Inpatients ,COVID-19 Testing ,Deep Learning ,SARS-CoV-2 ,COVID-19 ,Humans ,Radiology, Nuclear Medicine and imaging ,Morbidity ,Tomography, X-Ray Computed ,Lung ,Algorithms ,Retrospective Studies - Abstract
The burden of coronavirus disease 2019 (COVID-19) airspace opacities is time consuming and challenging to quantify on computed tomography. The purpose of this study was to evaluate the ability of a deep convolutional neural network (dCNN) to predict inpatient outcomes associated with COVID-19 pneumonia.A previously trained dCNN was tested on an external validation cohort of 241 patients who presented to the emergency department and received a chest computed tomography scan, 93 with COVID-19 and 168 without. Airspace opacity scoring systems were defined by the extent of airspace opacity in each lobe, totaled across the entire lungs. Expert and dCNN scores were concurrently evaluated for interobserver agreement, while both dCNN identified airspace opacity scoring and raw opacity values were used in the prediction of COVID-19 diagnosis and inpatient outcomes.Interobserver agreement for airspace opacity scoring was 0.892 (95% CI 0.834-0.930). Probability of each outcome behaved as a logistic function of the opacity scoring (25% intensive care unit admission at score of 13/25, 25% intubation at 17/25, and 25% mortality at 20/25). Length of hospitalization, intensive care unit stay, and intubation were associated with larger airspace opacity score (p = 0.032, 0.039, 0.036, respectively).The tested dCNN was highly predictive of inpatient outcomes, performs at a near expert level, and provides added value for clinicians in terms of prognostication and disease severity.
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- 2022
15. State‐level scope of practice regulations for nurse practitioners impact work environments: Six state investigation
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Lusine Poghosyan, Jordan H. Stein, Jianfang Liu, Joanne Spetz, Zainab T. Osakwe, and Grant Martsolf
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Cross-Sectional Studies ,Primary Health Care ,Scope of Practice ,Humans ,Nurse Practitioners ,Physician-Nurse Relations ,United States ,General Nursing - Abstract
Nurse practitioner (NP) scope of practice (SOP) policies are different across the United States. Little is known about their impact on NP work environment in healthcare organizations. We investigated the association between SOP policies and organizational-level work environment of NPs. Through a cross-sectional survey design, data were collected from 1244 NPs in six states with variable SOP regulations (Arizona, New Jersey, Washington, Pennsylvania, Texas, and California) in 2018-2019. Arizona and Washington had full SOP-NPs had full authority to deliver care. New Jersey and Pennsylvania had reduced SOP with physician collaboration requirement; California and Texas had restricted SOP with physician supervision requirement. NPs completed mail or online surveys containing the Nurse Practitioner Primary Care Organizational Climate Questionnaire, which has these subscales: NP-Administration Relations (NP-AR), NP-Physician Relations (NP-PR), Independent Practice and Support (IPS), and Professional Visibility (PV). Regression models assessed the relationship between state-level SOP and practice-level NP work environment. NP-AR scores were higher in full SOP states compared to reduced (β = 0.22, p 0.01) and restricted (β = 0.15, p 0.01) SOP states. Similarly, IPS scores were higher in full SOP states. The PV scores were also higher in full SOP states compared to reduced (β = 0.16, p 0.001) and restricted (β = 0.12, p 0.05) SOP states. There was no relationship between SOP and NP-PR score. State-level policies affect NP work environment. In states with more favorable policies, NPs have better relationships with administration and report more role visibility and support. Efforts should be made to remove unnecessary SOP restrictions.
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- 2022
16. Swarm Foraging Under Communication and Vision Uncertainties
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Simon O. Obute, Philip Kilby, Mehmet R. Dogar, and Jordan H. Boyle
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Control and Systems Engineering ,Electrical and Electronic Engineering - Published
- 2022
17. Management of Frontal Bone Fracture in the Pediatric Population: A Literature Review
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Kelly Ho, Jordan H. Larson, Russell R. Reid, and Sanjay Naran
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Background: The purpose of this study was to review the published literature in an effort to compare conservative and surgical interventions for pediatric frontal bone fractures and to create a treatment schematic that would result in the lowest morbidity. Methods: A literature review was performed to evaluate all publications related to frontal bone fracture treatments in the pediatric population. Patient age, fracture location, treatment modality, and complications were analyzed to elucidate whether conservative or surgical management is better for pediatric frontal bone fractures and to determine which type of management yields the lowest morbidity. Results: Sixteen articles met inclusion criteria. 88.89% of the included patients who underwent surgical repair did not experience any postoperative complications. The surgical treatments employed included craniotomy, implantation of custom macroporous hydroxyapatite prostheses, split calvarial graft, cranialization, and open reduction and internal fixation with either non-resorbable or resorbable plating systems. There were 17 cases of frontal bone fractures that were treated conservatively. Eleven of the 17 cases (61.1%) that were initially treated with conservative management resulted in complications; either a growing fracture or infection. Conclusions: No clear treatment algorithm for frontal bone fractures in each pediatric age group could be generated from the published literature. We likewise could not determine a clear distinction between the indications for conservative versus surgical management. However, we were able to conclude that primary surgical management for pediatric frontal bone fractures yields high success rates and few complications, regardless of the patient’s age.
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- 2022
18. Brain lesions disrupting addiction map to a common human brain circuit
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Juho Joutsa, Khaled Moussawi, Shan H. Siddiqi, Amir Abdolahi, William Drew, Alexander L. Cohen, Thomas J. Ross, Harshawardhan U. Deshpande, Henry Z. Wang, Joel Bruss, Elliot A. Stein, Nora D. Volkow, Jordan H. Grafman, Edwin van Wijngaarden, Aaron D. Boes, and Michael D. Fox
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General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Drug addiction is a public health crisis for which new treatments are urgently needed. In rare cases, regional brain damage can lead to addiction remission. These cases may be used to identify therapeutic targets for neuromodulation. We analyzed two cohorts of patients addicted to smoking at the time of focal brain damage (cohort 1 n = 67; cohort 2 n = 62). Lesion locations were mapped to a brain atlas and the brain network functionally connected to each lesion location was computed using human connectome data (n = 1,000). Associations with addiction remission were identified. Generalizability was assessed using an independent cohort of patients with focal brain damage and alcohol addiction risk scores (n = 186). Specificity was assessed through comparison to 37 other neuropsychological variables. Lesions disrupting smoking addiction occurred in many different brain locations but were characterized by a specific pattern of brain connectivity. This pattern involved positive connectivity to the dorsal cingulate, lateral prefrontal cortex, and insula and negative connectivity to the medial prefrontal and temporal cortex. This circuit was reproducible across independent lesion cohorts, associated with reduced alcohol addiction risk, and specific to addiction metrics. Hubs that best matched the connectivity profile for addiction remission were the paracingulate gyrus, left frontal operculum, and medial fronto-polar cortex. We conclude that brain lesions disrupting addiction map to a specific human brain circuit and that hubs in this circuit provide testable targets for therapeutic neuromodulation.
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- 2022
19. Implementing a workflow-integrated motivational interviewing training program for psychiatry trainees on an inpatient consultation-liaison rotation: lessons learned
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James P. Loveless, Jordan H. Rosen, and Joanna S. Yost
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Psychiatry and Mental health - Abstract
BackgroundEffective consultation-liaison psychiatry (CLP) is proactive, collaborative, and requires providers to have proficiency with therapeutic skills beyond nosology and medication management. Motivational interviewing (MI) is an evidenced-based intervention that should be considered essential for CLP trainees to learn. Given that the demands of training and patient care are already experienced as stressful for many psychiatry trainees, the authors endeavored to create a MI training program that was integrated into trainees’ normal CLP workflow.MethodTwenty-two trainees on an inpatient CLP rotation participated in a six-week MI training program that was incorporated into their regular workflow. The program included didactic sessions with role-playing, as well as on-demand between-session coaching via an expert in MI. Trainee participation and perceptions of MI were measured via a questionnaire that was administered prior to each training session.ResultsTrainee participation in the didactic sessions was inconsistent. Questionnaire data revealed positive baseline perceptions of motivational interviewing and its usefulness in inpatient medical settings. Additionally, as trainees participated in the program, perceived knowledge of motivational interviewing as well as awareness of motivational issues among their patients increased. Finally, participation in program was not perceived as disruptive to daily workflow for the participants.DiscussionThis the first documented attempt at implementing a MI training program for CLP trainees that was integrated into their regular workflow. Preliminary data identified some encouraging trends, but also unexpected challenges. These lessons could inform how these types of training programs are implemented moving forward.
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- 2023
20. Quantitative myocardial T2 mapping adds value to Japanese circulation society diagnostic criteria for active cardiac sarcoidosis
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Jordan H. Chamberlin, Madison R. Kocher, Gilberto Aquino, Austin Fullenkamp, D. Jameson Dennis, Jeffrey Waltz, Natalie Stringer, Andrew Wortham, Akos Varga-Szemes, William J. Rieter, W. Ennis James, Brian A. Houston, Andrew D. Hardie, Ismail Kabakus, Dhiraj Baruah, Line Kemeyou, and Jeremy R. Burt
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- 2023
21. Assessing Potential Habitat for Freshwater Mussels by Transferring a Habitat Suitability Model within the Ozark Ecoregion, Missouri
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Jordan H. Hartman, Amanda E. Rosenberger, Kayla N. Key, and Garth Lindner
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General Health Professions - Published
- 2023
22. Hotspots in a cold land‐reported cases of rabies in wildlife and livestock in Mongolia from 2012–2018
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Graham A. Matulis, Doniddemberel Altantogtokh, Paul M. Lantos, Jordan H. Jones, Rachel N. Wofford, Mark Janko, Nyamdorj Tsogbadrakh, Tserendovdon Bayar, Sainkhuu Ganzorig, Bazartseren Boldbaatar, B. Katherine Poole‐Smith, Jeffrey Hertz, Jodi Fiorenzano, and Michael E. von Fricken
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Goat Diseases ,Livestock ,Sheep ,Wolves ,General Veterinary ,General Immunology and Microbiology ,Rabies ,Epidemiology ,Goats ,Public Health, Environmental and Occupational Health ,Foxes ,Sheep Diseases ,Animals, Wild ,Mongolia ,Dogs ,Infectious Diseases ,Animals, Domestic ,Animals ,Humans ,Cattle ,Dog Diseases - Abstract
The epidemiological profile of rabies virus within Mongolia remains poorly characterized despite 21,302 domestic animal cases being reported between 1970-2005. This lack of knowledge is particularly concerning given that roughly 26% of the population lives a pastoral herding lifestyle and livestock production contributes up to 18% of Mongolia's total gross domestic product (GDP). The gaps in knowledge of the rabies disease ecology within Mongolia combined with the lack of routine vaccination of domestic animals and wildlife poses a significant threat to the more than 60 million heads of livestock within Mongolia. Animal rabies case data from the General Authority for Veterinary Services and National Center for Zoonotic Diseases were used in this study. Each data point included year of report, an animal descriptor, geographic coordinates and the aimag (province) of origin. A total of 2,359 animal rabies cases were reported between 2012-2018. Cattle were the most commonly reported animal overall (861 cases), followed by goats (268), sheep (251) and dogs (221) within the domestic animal category. Red foxes were responsible for most reported wildlife cases (317) followed by wolves (151). Most rabid animals were reported in the Khuvsgul, Uvurkhangai and Govi-Altai aimags, and a positive correlation was found between livestock numbers per soum and the number of rabies cases reported. Rabies poses a significant threat to the Mongolian economy and the health of human and animal populations within Mongolia. The close association of the nomadic pastoralists with both domestic animals and wildlife represents a significant threat for disease emergence and necessitates studies that describe the ecology of rabies, which may threaten these populations.
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- 2022
23. Nanoreactors for particle synthesis
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Jordan H. Swisher, Liban Jibril, Sarah Hurst Petrosko, and Chad A. Mirkin
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Biomaterials ,Materials Chemistry ,Surfaces, Coatings and Films ,Energy (miscellaneous) ,Electronic, Optical and Magnetic Materials - Published
- 2022
24. Biophysical Determinants of Shifting Tundra Vegetation Productivity in the Beaufort Delta Region of Canada
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Jordan H. Seider, Trevor C. Lantz, Txomin Hermosilla, Michael A. Wulder, and Jonathan A. Wang
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Ecology ,Environmental Chemistry ,Ecology, Evolution, Behavior and Systematics - Abstract
Temperature increases across the circumpolar north have driven rapid increases in vegetation productivity, often described as ‘greening’. These changes have been widespread, but spatial variation in their pattern and magnitude suggests that biophysical factors also influence the response of tundra vegetation to climate warming. In this study, we used field sampling of soils and vegetation and random forests modeling to identify the determinants of trends in Landsat-derived Enhanced Vegetation Index, a surrogate for productivity, in the Beaufort Delta region of Canada between 1984 and 2016. This region has experienced notable change, with over 71% of the Tuktoyaktuk Coastlands and over 66% of the Yukon North Slope exhibiting statistically significant greening. Using both classification and regression random forests analyses, we show that increases in productivity have been more widespread and rapid at low-to-moderate elevations and in areas dominated by till blanket and glaciofluvial deposits, suggesting that nutrient and moisture availability mediate the impact of climate warming on tundra vegetation. Rapid greening in shrub-dominated vegetation types and observed increases in the cover of low and tall shrub cover (4.8% and 6.0%) also indicate that regional changes have been driven by shifts in the abundance of these functional groups. Our findings demonstrate the utility of random forests models for identifying regional drivers of tundra vegetation change. To obtain additional fine-grained insights on drivers of increased tundra productivity, we recommend future research combine spatially comprehensive time series satellite data (as used herein) with samples of high spatial resolution imagery and integrated field investigations.
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- 2022
25. Gadusol Is a Maternally Provided Sunscreen That Protects Fish Embryos From DNA Damage
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Marlen C. Rice, Jordan H. Little, Dale L. Forrister, Julane Machado, Nathan L. Clark, and James A. Gagnon
- Subjects
Article - Abstract
Ultraviolet radiation (UVR) and its deleterious effects on living cells selects for UVR-protective mechanisms. Organisms across the tree of life evolved a variety of natural sunscreens to prevent UVR-induced cellular damage and stress. However, in vertebrates, only melanin is known to act as a sunscreen. Here we demonstrate that gadusol, a transparent compound discovered over 40 years ago in fish eggs, is a maternally provided sunscreen required for survival of embryonic and larval zebrafish exposed to UVR. Mutating an enzyme involved in gadusol biosynthesis increases the formation of cyclobutane pyrimidine dimers, a hallmark of UVB-induced DNA damage. Compared to the contributions of melanin and the chorion, gadusol is the primary sunscreening mechanism in embryonic and larval fish. The gadusol biosynthetic pathway is retained in the vast majority of teleost genomes but is repeatedly lost in species whose young are no longer exposed to UVR. Our data demonstrate that gadusol is a maternally provided sunscreen that is critical for early-life survival in the most species-rich branch of the vertebrate phylogeny.
- Published
- 2023
26. Correction: A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis
- Author
-
Shams Twafra, Chana G. Sokolik, Tal Sneh, Kolluru D. Srikanth, Tomer Meirson, Alessandro Genna, Jordan H. Chill, and Hava Gil-Henn
- Subjects
Cancer Research ,Genetics ,Molecular Biology - Published
- 2022
27. Moral Distress Work Motivation and Job Satisfaction of Medical-Surgical Nurses During the COVID-19 Pandemic: A Correlation Study
- Author
-
Jordan H. Llego
- Subjects
humanities - Abstract
This research is the second part of a more comprehensive study. The purpose of this part of the study is to examines the relationship between the level of moral distress, work motivation, and job satisfaction of medical-surgical nurses in Hail Saudi Arabia. This study used a descriptive-correlation research design using the combination of three questionnaires (Moral Distress Questionnaire, Multidimensional Work Motivation Scale, and Nurses Job Satisfaction Questionnaire) through an online survey. There are 274 respondents in this study. The statistical tests used are mean, standard deviation, and Pearson-r. Results include about the relationship between moral distress and work motivation Pearson-r scored r=0.07; p=0.27; regarding the relationship between moral distress and job satisfaction Pearson-r scored r=-0.35; p=
- Published
- 2021
28. A Comparative Study on the Level of Moral Distress of Medical-Surgical Nurses in Hail Saudi Arabia during the Covid-19 Pandemic
- Author
-
Jordan H. Llego
- Subjects
humanities - Abstract
This study is a part of a wider study. The purpose of this study is to look at the differences between the level of moral distress of medical-surgical nurses in Hail Saudi Arabia and their demographics. This study used a descriptive-comparative research design using the Moral Distress Questionnaire through an online survey. There are 274 respondents in this study. The statistical test used is frequency, percentage, mean, standard deviation, t-test, and one-way ANOVA. Results include regarding sex, t-test scored t (272) =-4.48; p=
- Published
- 2021
29. Mitochondrial DNA sequence variation and risk of meningioma
- Author
-
Sepideh Mokhtari, Zachary J. Thompson, L. Burt Nabors, Claudine Samanic, Brooke L. Fridley, Sion L. Williams, Kathleen M. Egan, Jamie K. Teer, and Jordan H. Creed
- Subjects
Oncology ,mtDNA control region ,Cancer Research ,Mitochondrial DNA ,medicine.medical_specialty ,business.industry ,Genome-wide association study ,medicine.disease ,Haplogroup ,Meningioma ,Minor allele frequency ,Neurology ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Neurology (clinical) ,business ,Human mitochondrial DNA haplogroup ,Genetic association - Abstract
Risk factors for meningioma include female gender, African American race, high body mass index (BMI), and exposure to ionizing radiation. Although genome-wide association studies (GWAS) have identified two nuclear genome risk loci for meningioma (rs12770228 and rs2686876), the relation between mitochondrial DNA (mtDNA) sequence variants and meningioma is unknown. We examined the association of 42 common germline mtDNA variants (minor allele frequency ≥ 5%), haplogroups, and genes with meningioma in 1080 controls and 478 meningioma cases from a case–control study conducted at medical centers in the southeastern United States. Associations were examined separately for meningioma overall and by WHO grade (n = 409 grade I and n = 69 grade II/III). Overall, meningioma was significantly associated with being female (OR 2.85; 95% CI 2.21–3.69), self-reported African American race (OR 2.38, 95% CI 1.41–3.99), and being overweight (OR 1.48; 95% CI 1.11–1.97) or obese (OR 1.70; 95% CI 1.25–2.31). The variant m.16362T > C (rs62581341) in the mitochondrial control region was positively associated with grade II/III meningiomas (OR 2.33; 95% CI 1.14–4.77), but not grade I tumors (OR 0.99; 95% CI 0.64–1.53). Haplogroup L, a marker for African ancestry, was associated with meningioma overall (OR 2.92; 95% CI 1.01–8.44). However, after stratifying by self-reported race, this association was only apparent among the few self-reported Caucasians with this haplogroup (OR 6.35; 95% CI 1.56–25.9). No other mtDNA variant, haplogroup, or gene was associated with meningioma. Common mtDNA variants and major mtDNA haplogroups do not appear to have associations with the odds of developing meningioma.
- Published
- 2021
30. Designing the Optimal International Climate Agreement with Variability in Commitments
- Author
-
Keith E. Schnakenberg and Jordan H. McAllister
- Subjects
Organizational Behavior and Human Resource Management ,Sociology and Political Science ,media_common.quotation_subject ,Political Science and International Relations ,Econometrics ,Economics ,Law ,Agreement ,media_common - Abstract
We analyze the design of an international climate agreement. In particular, we consider two goals of such an agreement: overcoming free-rider problems and adjusting for differences in mitigation costs between countries. Previous work suggests that it is difficult to achieve both of these goals at once under asymmetric information because countries free ride by exaggerating their abatement costs. We argue that independent information collection (investigations) by an international organization can alleviate this problem. In fact, though the best implementable climate agreement without investigations fails to adjust for individual differences even with significant enforcement power, a mechanism with investigations allows adjustment and can enable implementation of the socially optimal agreement. Furthermore, when the organization has significant enforcement power, the optimal agreement is achievable even with minimal investigative resources (and vice versa). The results suggest that discussions about institutions for climate cooperation should focus on information collection as well as enforcement.
- Published
- 2021
31. Willingness to be tested for a secondary cause of hypertension: a survey of the Australian general community
- Author
-
Jordan H. Lai, Stella M. Gwini, Gang Chen, Katrina M. Long, Grant Russell, Markus P. Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori, Martin Wolley, Christopher M. Reid, and Jun Yang
- Subjects
Internal Medicine - Abstract
Primary aldosteronism (PA) represents the most common and potentially curable cause of secondary hypertension. However, PA is not commonly screened for, and up to 34% of patients who screen positive do not complete the full diagnostic process. This suggests that the diagnostic process may pose a barrier to patients and may contribute to the under-diagnosis of PA.To evaluate the willingness of the Australian general public to undergo testing for secondary causes of hypertension and identify enablers or barriers to testing from the patients' perspective.An online survey containing questions on knowledge and attitudes towards hypertension, willingness to be tested and enablers/barriers towards testing was distributed to the Australian community.Of 520 adult respondents (mean age 50.4 years, SD 27.3 years; 28.8% hypertensive; 56.0% female), the majority of non-hypertensive and hypertensive respondents (82.7% vs 70.0%; P = 0.03) were willing to undergo testing for a secondary cause of hypertension that involved blood and urine tests. Greater knowledge of hypertensive risk modification strategies and complications was predictive of willingness to be tested, whereas age, sex, education level, geographic location, socio-economic status and cardiovascular comorbidities were not. The top three barriers to testing included fear of a serious underlying condition, lack of belief in further testing and increased stress associated with further testing.A high proportion of patients are willing to engage in testing for a secondary cause of hypertension. Education about the risks associated with hypertension and the testing process may overcome several barriers to testing.
- Published
- 2022
32. Non-Assembly 3D-Printed Walking Mechanism Utilising a Hexapod Gait
- Author
-
George Jackson-Mills, Andrew R. Barber, null Andrew Blight, null Andrew Pickering, null Jordan H. Boyle, and null Robert C. Richardson
- Abstract
Small inspection robots can allow for the exploration of environments and the collection of data from dangerous or difficult to access areas. These robots can be custom built for specific tasks, but the design and assembly process for this can be costly, both in money and time. The use of 3D Printing in creating Non-Assembly mechanisms can assist in saving time and resources by reducing the number of different components required and removing the necessity for complex assembly tasks. This paper introduces a robot to explore the capabilities of this approach, by iterating on a previous example of a robot with Non-Assembly mechanisms. This explores how altering the size, mechanism type and accompanying control circuitry can affect the efficiency of the practice. Through developing on previous knowledge, this new walking robot improves on the previous iteration by creating a more robust and reliable system, more capable of effectively exploring challenging environments accurately, while still using practices designed to save on cost and production time.
- Published
- 2022
33. The precision medicine process for treating rare disease using the artificial intelligence tool mediKanren
- Author
-
Aleksandra, Foksinska, Camerron M, Crowder, Andrew B, Crouse, Jeff, Henrikson, William E, Byrd, Gregory, Rosenblatt, Michael J, Patton, Kaiwen, He, Thi K, Tran-Nguyen, Marissa, Zheng, Stephen A, Ramsey, Nada, Amin, John, Osborne, and Jordan H, Whitlock
- Subjects
Artificial Intelligence - Abstract
There are over 6,000 different rare diseases estimated to impact 300 million people worldwide. As genetic testing becomes more common practice in the clinical setting, the number of rare disease diagnoses will continue to increase, resulting in the need for novel treatment options. Identifying treatments for these disorders is challenging due to a limited understanding of disease mechanisms, small cohort sizes, interindividual symptom variability, and little commercial incentive to develop new treatments. A promising avenue for treatment is drug repurposing, where FDA-approved drugs are repositioned as novel treatments. However, linking disease mechanisms to drug action can be extraordinarily difficult and requires a depth of knowledge across multiple fields, which is complicated by the rapid pace of biomedical knowledge discovery. To address these challenges, The Hugh Kaul Precision Medicine Institute developed an artificial intelligence tool, mediKanren, that leverages the mechanistic insight of genetic disorders to identify therapeutic options. Using knowledge graphs, mediKanren enables an efficient way to link all relevant literature and databases. This tool has allowed for a scalable process that has been used to help over 500 rare disease families. Here, we provide a description of our process, the advantages of mediKanren, and its impact on rare disease patients.
- Published
- 2022
34. Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C
- Author
-
Akira Nishio, Sharika Hasan, Heiyoung Park, Nana Park, Jordan H. Salas, Eduardo Salinas, Lela Kardava, Paul Juneau, Nicole Frumento, Guido Massaccesi, Susan Moir, Justin R. Bailey, Arash Grakoui, Marc G. Ghany, and Barbara Rehermann
- Subjects
Viral Hepatitis Vaccines ,Multidisciplinary ,Memory B Cells ,Humans ,General Physics and Astronomy ,Receptors, Chemokine ,Hepacivirus ,General Chemistry ,Hepatitis C, Chronic ,Antibodies, Neutralizing ,Hepatitis C ,General Biochemistry, Genetics and Molecular Biology - Abstract
The increasing incidence of hepatitis C virus (HCV) infections underscores the need for an effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting humoral response. However, data on the half-life of HCV-specific responses are lacking. Here we study archived sera and mononuclear cells that were prospectively collected up to 18 years after cure of chronic HCV infection to determine the role of HCV antigen in maintaining neutralizing antibody and B cell responses. We show that HCV-neutralizing activity decreases rapidly in potency and breadth after curative treatment. In contrast, HCV-specific memory B cells persist, and display a restored resting phenotype, normalized chemokine receptor expression and preserved ability to differentiate into antibody-secreting cells. The short half-life of HCV-neutralizing activity is consistent with a lack of long-lived plasma cells. The persistence of HCV-specific memory B cells and the reduced inflammation after cure provide an opportunity for vaccination to induce protective immunity against re-infection.
- Published
- 2022
35. Age and Sex Differences and Temporal Trends in the Use of Invasive and Noninvasive Procedures in Patients Hospitalized With Acute Myocardial Infarction
- Author
-
Vu Hoang Tran, Jordy Mehawej, Donna M. Abboud, Mayra Tisminetzky, Essa Hariri, Andreas Filippaios, Joel M. Gore, Jorge Yarzebski, Jordan H. Goldberg, Darleen Lessard, and Robert Goldberg
- Subjects
Hospitalization ,Male ,Cardiac Catheterization ,Percutaneous Coronary Intervention ,Myocardial Infarction ,Humans ,Female ,Coronary Artery Bypass ,Cardiology and Cardiovascular Medicine - Abstract
Background Few studies have examined age and sex differences in the receipt of cardiac diagnostic and interventional procedures in patients hospitalized with acute myocardial infarction and trends in these possible differences during recent years. Methods and Results Data from patients hospitalized with a first acute myocardial infarction at the major medical centers in the Worcester, Massachusetts, metropolitan area were utilized for this study. Logistic regression analysis was used to examine age ( Conclusions We observed a continued lower receipt of invasive cardiac procedures in women and patients aged ≥75 years with acute myocardial infarction, but age and sex gaps associated with these procedures have narrowed during recent years.
- Published
- 2022
36. Development of a lanthanum hexaboride hollow cathode for a magnetic octupole thruster
- Author
-
Jordan H. Hsieh, Mitchell M. Shen, Yueh-Heng Li, and Ping-Han Huang
- Subjects
Condensed Matter Physics ,Instrumentation ,Surfaces, Coatings and Films - Published
- 2023
37. Is It Necessary to Obtain Lateral Pelvic Radiographs in Flexed Seated Position for Preoperative Total Hip Arthroplasty Planning?
- Author
-
Aidin Eslam Pour, Jordan H. Green, Thomas H. Christensen, Nishanth Muthusamy, and Ran Schwarzkopf
- Subjects
Orthopedics and Sports Medicine ,Surgery - Published
- 2023
38. Attitude Control Calibration and Experiment Testbed to Characterize Attitude Determination and Control System Performance
- Author
-
Hsieh, Jordan H., Huang, Jing-Yuan, Yen, Thomas, Lee, Sam, Chang, Austin, and Hou, Luke
- Subjects
AM0 spectrum solar simulator ,Helmholtz cage ,air-bearing platform ,ADCD ,Small Satellite - Abstract
This paper describes the design, development, and construction of an attitude control testbed to investigate the performance of ADCS. The Testbed consists of three instruments, an air-bearing platform, a Helmholtz cage, and an AM0 spectrum solar simulator. The Testbed in this research features the capability to measure the mass properties of the tested satellite. One of the motivations of this paper is to share the experience while building this highly automated Testbed. Finally, the procedure of the mass properties measurement will be well described in this paper.
- Published
- 2022
39. A Case Report of Brachiocephalic Vein Spasm Secondary to Peripherally Inserted Central Catheter
- Author
-
Seth Russell, Jordan H Chamberlin, Jeremy R Burt, and Ismail M Kabakus
- Subjects
General Engineering - Published
- 2022
40. Analysis of the Perinatal Care System in a Remote and Mountainous District of Nepal
- Author
-
James Wylie Thomas, David Phillip Levy, Ang Jangmu Sherpa, Lakpa Lama, Allison Judkins, Amber A. Chambers, Hillary Crandall, Sarah Schoenhals, Kirk B. Bjella, Jordan H. Vaughan, Peter H. Grubb, and Bernhard Fassl
- Subjects
Epidemiology ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,Obstetrics and Gynecology ,Prenatal Care ,Delivery, Obstetric ,Birthing Centers ,Health Services Accessibility ,Perinatal Care ,Nepal ,Pregnancy ,Pediatrics, Perinatology and Child Health ,Humans ,Female ,Maternal Health Services ,Health Facilities ,Child - Abstract
Despite significant improvements in recent years, maternal and neonatal health outcomes remain poor in many regions of the world. One such area is in the remote mountainous regions of Nepal. The purpose of this study is to describe the current antenatal care practices and delivery support in a mountainous district of Nepal.This study took place in Solukhumbu District between December 2015 and February 2018. A household survey was created using evidence-based maternal and neonatal care indicators. Women who had delivered within the previous two years were surveyed regarding antenatal and delivery care they received. A standardized health facility survey was used to evaluate the operational status of health facilities. The study was approved by the Nepal Ministry of Health and the University of Utah IRB.A total of 487 households and 19 facilities were surveyed. 35.7% (174/487) of deliveries occurred in a health facility (hospital, primary health care center or birthing center). 35.2% (171/486) of deliveries were attended by a skilled birth attendant. 52.8% (47/89) of women who did not deliver in a facility noted that transportation issues and not having sufficient time to travel during labor prevented them from delivering in a facility. No health posts had staff trained in obstetric and neonatal emergencies.The majority of women in Solukhumbu District do not receive high quality antenatal and delivery care. An intervention that would make antenatal care and delivery support more accessible could improve maternal and infant outcomes in this district and other similar regions.
- Published
- 2022
41. Biomolecular Condensates Formed by Designer Minimalistic Peptides
- Author
-
Avigail Baruch Leshem, Sian Sloan-Dennison, Tlalit Massarano, Shavit Ben-David, Duncan Graham, Karen Faulds, Hugo E. Gottlieb, Jordan H. Chill, and Ayala Lampel
- Subjects
Multidisciplinary ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
Inspired by the role of intracellular liquid-liquid phase separation (LLPS) in formation of membraneless organelles, there is great interest in developing dynamic compartments formed by LLPS of intrinsically disordered proteins (IDPs) or short peptides. However, the molecular mechanisms underlying the formation of biomolecular condensates have not been fully elucidated, rendering on-demand design of synthetic condensates with tailored physico-chemical functionalities a significant challenge. To address this need, here we design a library of LLPS-promoting peptide building blocks composed of various assembly domains. We show that the LLPS propensity, dynamics, and encapsulation efficiency of compartments can be tuned by changes to the peptide composition. Specifically, with the aid of Raman and NMR spectroscopy, we show that interactions between arginine and aromatic amino acids underlie droplet formation, and that both intra- and intermolecular interactions dictate droplet dynamics. The resulting sequence-structure-function correlation could support the future development of compartments for a variety of applications.
- Published
- 2022
42. Inherent Minor Conformer of
- Author
-
Adi, Yahalom, Hadassa, Shaked, Sharon, Ruthstein, and Jordan H, Chill
- Subjects
Magnetic Resonance Spectroscopy ,Bacterial Proteins ,Type III Secretion Systems ,Bordetella pertussis ,Molecular Chaperones ,Protein Unfolding - Abstract
The pathogen
- Published
- 2022
43. Chirality-Directed Regioselectivity: An Approach for the Synthesis of Alternating Poly(Lactic-co-Glycolic Acid)
- Author
-
Yiye Lu, Jordan H. Swisher, Tara Y. Meyer, and Geoffrey W. Coates
- Subjects
chemistry.chemical_classification ,Regioselectivity ,Sequence (biology) ,General Chemistry ,Polymer ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,Enantiopure drug ,chemistry ,Polymerization ,Chirality (chemistry) ,Glycolic acid - Abstract
We report the synthesis of alternating poly(lactic-co-glycolic acid) via a regioselective ring-opening polymerization of (S)-methyl glycolide. An enantiopure aluminum salen catalyst with binaphthyl backbone facilitates the regioselective ring-opening of this unsymmetrical cyclic diester exclusively at the glycolide acyl-oxygen bond site. This living, chain-growth polymerization is able to reach low dispersities with tailored molecular weights. Quantitative regioselectivity calculations and sequence error analysis have been established for this sequence-controlled polymer.
- Published
- 2021
44. Results of Endoscopic Labral Repair With Concomitant Gluteus Medius and/or Minimus Repair Compared With Outcomes of Labral Repair Alone: A Matched Comparative Cohort Analysis at Minimum 2-Year Follow-up
- Author
-
Nolan S. Horner, Reagan S. Chapman, Jordan H. Larson, and Shane J. Nho
- Subjects
Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Abstract
Background: There is a paucity of information available to clinicians on outcomes of patients undergoing endoscopic surgery for labral repairs and femoroacetabular impingement syndrome with simultaneous repair of the gluteus medius and/or minimus muscles. Purpose: To determine whether patients with labral tears and concomitant gluteal pathology who undergo simultaneous endoscopic labral and gluteus medius and/or minimus repair experience similar outcomes to patients with isolated labral tears who undergo endoscopic labral repair alone. Study Design: Cohort study; Level of evidence, 3. Methods: A matched retrospective comparative cohort study was performed. Patients who underwent gluteus medius and/or minimus repair with concomitant labral repair between January 2012 and November 2019 were identified. These patients were matched in a 1:3 ratio by sex, age, and body mass index (BMI) to patients who underwent labral repair alone. Preoperative radiographs were assessed. Patient-reported outcomes (PROs) were assessed preoperatively and 2 years postoperatively. PRO measures included the Hip Outcome Score Activities of Daily Living and Sports subscales, modified Harris Hip Score, 12-Item International Hip Outcome Tool, and visual analog scales for pain and satisfaction. Published labral repair minimal clinically important difference (MCID) and Patient Acceptable Symptom State (PASS) thresholds were utilized for these measures. Results: A total of 31 patients who underwent gluteus medius and/or minimus repair with concomitant labral repair (27 female, 4 male; age, 50.8 ± 7.3 years; BMI, 27.9 ± 5.2) were matched with 93 patients who underwent labral repair alone (81 female, 12 male; age, 50.9 ± 8.1 years; BMI, 28.5 ± 6.2). There were no significant differences in sex ( P > .99), age ( P = .869), or BMI ( P = .592); preoperative radiographic measurements; or preoperative or 2-year postoperative PRO scores ( P≥ .081). Changes between preoperative and 2-year postoperative PRO scores were significantly different for both groups for all PROs assessed ( P < .001 for all). There were no significant differences in MCID or PASS achievement rates ( P≥ .123), with low PASS achievement rates of 40% to 60% found in both groups. Conclusion: Patients who were treated with endoscopic gluteus medius and/or minimus repair with concomitant labral repair demonstrated comparable outcomes with those who were treated with endoscopic labral repair alone.
- Published
- 2023
45. Growth restriction in preeclampsia: lessons from animal models
- Author
-
Jordan H Mallette, Breland F Crudup, and Barbara T Alexander
- Subjects
Physiology ,Physiology (medical) - Published
- 2023
46. Open Proximal Hamstring Repair
- Author
-
Sachin Allahabadi, Thomas W. Fenn, Jordan H. Larson, and Shane J. Nho
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Abstract
Background: Proximal hamstring ruptures meeting operative criteria may be treated through endoscopic, open, or combined techniques. Open techniques allow for facilitated tendon visualization and mobilization with ease of suture passage. Indications: Proximal hamstring repairs are indicated for complete 3 tendon avulsions; partial avulsions with 2 or more tendons involved with more than 2 cm of retraction in young, active patients; and partial avulsion injuries or chronic tears that remain refractory to conservative treatment. Technique Description: Through an incision along the gluteal crease, the tendon stump is identified and mobilized. Anchors are placed in the prepped ischium and sutures are passed through the tendon in a running fashion. The tendon is secured to its origin in a docking technique. Results: Patients undergoing hamstring repair have high satisfaction rates and patient-reported outcome scores. Competitive and elite athletes have demonstrated reliable return-to-sport rates at presurgical levels. Discussion: Open proximal hamstring repairs produce reliable results. The open technique is advantageous for its ease of tendon mobilization, direct visualization, and suture passage. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
- Published
- 2023
47. spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data
- Author
-
Lauren C. Peres, Brooke L. Fridley, Jordan H. Creed, Christopher M. Wilson, Christelle M Colin-Leitzinger, Nicholas H. Chakiryan, Oscar E. Ospina, Alex C. Soupir, Joseph Markowitz, Anna Coghill, and Gregory J. Kimmel
- Subjects
Statistics and Probability ,AcademicSubjects/SCI01060 ,Computer science ,business.industry ,Systems Biology ,Univariate ,Bivariate analysis ,computer.software_genre ,Applications Notes ,Biochemistry ,Computer Science Applications ,Visualization ,Computational Mathematics ,R package ,Computational Theory and Mathematics ,Metric (mathematics) ,Web application ,Data mining ,User interface ,business ,Molecular Biology ,Spatial analysis ,computer - Abstract
Summary Multiplex immunofluorescence (mIF) staining combined with quantitative digital image analysis is a novel and increasingly used technique that allows for the characterization of the tumor immune microenvironment (TIME). Generally, mIF data is used to examine the abundance of immune cells in the TIME; however, this does not capture spatial patterns of immune cells throughout the TIME, a metric increasingly recognized as important for prognosis. To address this gap, we developed an R package spatialTIME that enables spatial analysis of mIF data, as well as the iTIME web application that provides a robust but simplified user interface for describing both abundance and spatial architecture of the TIME. The spatialTIME package calculates univariate and bivariate spatial statistics (e.g. Ripley’s K, Besag’s L, Macron’s M and G or nearest neighbor distance) and creates publication quality plots for spatial organization of the cells in each tissue sample. The iTIME web application allows users to statistically compare the abundance measures with patient clinical features along with visualization of the TIME for one tissue sample at a time. Availability and implementation spatialTIME is implemented in R and can be downloaded from GitHub (https://github.com/FridleyLab/spatialTIME) or CRAN. An extensive vignette for using spatialTIME can also be found at https://cran.r-project.org/web/packages/spatialTIME/index.html. iTIME is implemented within a R Shiny application and can be accessed online (http://itime.moffitt.org/), with code available on GitHub (https://github.com/FridleyLab/iTIME). Supplementary information Supplementary data are available at Bioinformatics online.
- Published
- 2021
48. Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers
- Author
-
Michael W, Weiner, Danielle, Harvey, Susan M, Landau, Dallas P, Veitch, Thomas C, Neylan, Jordan H, Grafman, Paul S, Aisen, Ronald C, Petersen, Clifford R, Jack, Duygu, Tosun, Leslie M, Shaw, John Q, Trojanowski, Andrew J, Saykin, Jacqueline, Hayes, and Charles, De Carli
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,Health Policy ,Neurology (clinical) ,Geriatrics and Gerontology - Abstract
Epidemiological studies report an association between traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker-defined AD.We identified 289 non-demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aβ) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years.Exposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P .0001) and worse Mini-Mental State Examination scores (PTSD: P = .008; TBIPTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aβ or tau accumulation, or in most longitudinal measures.TBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.
- Published
- 2022
49. Arrhythmic Events and Mortality in Patients With Cardiogenic Shock on Inotropic Support: Results of the DOREMI Randomized Trial
- Author
-
Richard G. Jung, Pietro Di Santo, Rebecca Mathew, Trevor Simard, Simon Parlow, Willy Weng, Omar Abdel-Razek, Nikita Malhotra, Matthew Cheung, Jordan H. Hutson, Jeffrey A. Marbach, Pouya Motazedian, Michael J. Thibert, Shannon M. Fernando, Pablo B. Nery, Girish M. Nair, Juan J. Russo, Benjamin Hibbert, and F. Daniel Ramirez
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Inotropic support is widely used in the management of cardiogenic shock (CS). Existing data on the incidence and significance of arrhythmic events in patients with CS on inotropic support is at high risk of bias.The Dobutamine Compared to Milrinone (DOREMI) trial randomized patients to receive dobutamine or milrinone in a double-blind fashion. Patients with and without arrhythmic events (defined as arrhythmias requiring intervention or sustained ventricular arrhythmias) were compared to identify factors associated with their occurrence, and to examine their association with in-hospital mortality and secondary outcomes.Ninety-two patients (47.9%) had arrhythmic events, occurring equally with dobutamine and milrinone (P = 0.563). The need for vasopressor support at initiation of the inotrope and a history of atrial fibrillation were positively associated with arrhythmic events, whereas predominant right ventricular dysfunction, previous myocardial infarction, and increasing left ventricular ejection fraction were negatively associated with them. Supraventricular arrhythmic events were not associated with mortality (relative risk [RR], 0.97; 95% confidence interval [CI], 0.68-1.40; P = 0.879) but were positively associated with resuscitated cardiac arrests and hospital length of stay. Ventricular arrhythmic events were positively associated with mortality (RR, 1.66; 95% CI, 1.13-2.43; P = 0.026) and resuscitated cardiac arrests. Arrhythmic events were most often treated with amiodarone (97%) and electrical cardioversion (27%), which were not associated with mortality.Clinically relevant arrhythmic events occur in approximately one-half of patients with CS treated with dobutamine or milrinone and are associated with adverse clinical outcomes. Five factors may help to identify patients most at risk of arrhythmic events.
- Published
- 2022
50. Measures of Hip Function and Symptoms
- Author
-
Jace Bullard, Jordan H. Green, Joel Gagnier, and Jack W. Weick
- Subjects
medicine.medical_specialty ,Hip ,business.industry ,media_common.quotation_subject ,Disability Evaluation ,Text mining ,Physical medicine and rehabilitation ,Rheumatology ,Outcome Assessment, Health Care ,Humans ,Medicine ,Joint Diseases ,business ,Function (engineering) ,media_common - Published
- 2020
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