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β-adrenergic receptors (β-ARs) are broadly distributed in various tissues and regulate a panel of important physiological functions and disease states including cancer. Above all, β3-adrenergic receptor (β3-AR) plays a significant role in regulating lipolysis and thermogenesis in adipose tissue. In this study, we designed and synthesized a series of novel L-748,337 derivatives as selective human β3-AR antagonists. Among all the tested L-748,337 analogs, compound 23d was found to display 23-fold more potent β3-AR antagonist activity (EC50 = 0.5117 nM) than L-748,337 (EC50 = 11.91 nM). In vivo, compound 23d could alleviate weight loss and inhibit tumor growth in C26 tumor cachexia animal model.

Designing secure RFID protocols for EPC Gen2V2 Standard is a challenging work. To solve the problems, recently many mutual authentication protocols have been proposed. However, many of them do not maintain synchrony of the records every interrogation. In this paper, we analyze the recently proposed RFID authentication protocols and show that there is the weakness. And we propose a new mutual authentication protocol for EPC Gen2V2 Standard to maintain synchrony. Furthermore, we analyze our protocol from security and privacy, and it shows that the proposed protocol is secure and effective.

Cyclic Delay Diversity (CDD) is a simple approach to provide spatial diversity for Orthogonal Frequency Division Multiplexing (OFDM) system. CDD provides not only the multipath diversity without channel coding but also a sample receiver structure. Discrete Hartley transform (DHT) as a linear precoding based OFDM outperforms the OFDM based on discrete Fourier transform (DFT) for it intrinsic frequency diversity. In this paper a simple scheme that DHFT-OFDM system with spatial multipath diversity by using CDD technique in the frequency selective fading channel is proposed. Simulation results are provided to validate the advantages of the proposed scheme that combining CDD with DHFT-OFDM system.