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1. MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

Author

Karsten Fischer, Andreas Zingg, Justina Rutkauskaite, Barbara Eicher, Catherine Townsend, Matthias Hillenbrand, Carlos Guzmán, Peggy Riese, Christoph Esslinger, Marcel Weber, Jemima Seidenberg, and Simone Schmitt

Subjects
biology, Chemistry, medicine.drug_class, Hamster, Monoclonal antibody, Virology, In vitro, Neutralization, In vivo, medicine, biology.protein, Potency, Antibody, skin and connective tissue diseases, IC50
Abstract

Fast track microfluidic screening of the antibody repertoires of 12 convalescent COVID-19 donors comprising 2.8mio antibodies yielded MTX-COVAB, a human-derived monoclonal antibody with low picomolar neutralization IC50 of SARS-CoV-2. COVAB neutralization potency is on par with the Regeneron cocktail as demonstrated in a comparative neutralization assay. MTX-COVAB shows strong efficacy in vivo and binds to all currently identified clinically relevant variants of SARS-CoV-2. MTX-COVAB completes GMP manufacturing by the end of this year and will be tested in the clinic in March 2021.

Published
2020
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